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Xanthoma of bone

MedGen UID:
1644154
•Concept ID:
C1390512
•
Disease or Syndrome
Synonym: Bone xanthoma
SNOMED CT: Xanthoma of bone (765481009); Bone xanthoma (765481009)
 
HPO: HP:0034629

Definition

Xanthoma of bone is an exceedingly rare benign primary bone tumor histologically characterized by mononuclear macrophage-like cells, abundant foam cells, and multinucleated giant cells. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVXanthoma of bone

Professional guidelines

PubMed

Differential Clinical Presentation, Intraoperative Management Strategies, and Surgical Outcomes After Endoscopic Endonasal Treatment of Cystic Sellar Masses.
Tafreshi AR, Du R, Rutkowski MJ, Donoho DA, Shiroishi MS, Liu CJ, Kim PE, Carmichael JD, Zada G
World Neurosurg 2020 Jan;133:e241-e251. Epub 2019 Sep 7 doi: 10.1016/j.wneu.2019.08.234. PMID: 31505289
Long-term bone density evaluation in cerebrotendinous xanthomatosis: evidence of improvement after chenodeoxycholic acid treatment.
Martini G, Mignarri A, Ruvio M, Valenti R, Franci B, Del Puppo M, Federico A, Nuti R, Dotti MT
Calcif Tissue Int 2013 Mar;92(3):282-6. Epub 2012 Dec 2 doi: 10.1007/s00223-012-9677-3. PMID: 23212544
Failure in the treatment of long-standing osteoporosis in cerebrotendinous xanthomatosis.
Chang WN, Lui CC
J Formos Med Assoc 1997 Mar;96(3):225-7. PMID: 9080765

Recent clinical studies

Etiology

Multifocal Xanthoma of Bone.
Schryver EM, McCandless MG, Al Hmada Y, Barr JS
J Am Acad Orthop Surg Glob Res Rev 2021 May 19;5(5):e20.00261-4. doi: 10.5435/JAAOSGlobal-D-20-00261. PMID: 34010236
Musculoskeletal imaging features of non-Langerhans cell histiocytoses.
Choraria A, Andrei V, Rajakulasingam R, Saifuddin A
Skeletal Radiol 2021 Oct;50(10):1921-1940. Epub 2021 Mar 31 doi: 10.1007/s00256-021-03765-0. PMID: 33787962
Oral verruciform xanthoma in chronic graft-versus-host disease patients.
Bar O, Elad S, Avni B, Abu-Tair J, Zaharia B, Hanut A, Zadik Y
Support Care Cancer 2021 Jan;29(1):79-84. Epub 2020 Aug 15 doi: 10.1007/s00520-020-05681-w. PMID: 32803727
Review of xanthomatous lesions of the sella.
Kleinschmidt-DeMasters BK, Lillehei KO, Hankinson TC
Brain Pathol 2017 May;27(3):377-395. doi: 10.1111/bpa.12498. PMID: 28236350Free PMC Article
Xanthoma of bone.
Bertoni F, Unni KK, McLeod RA, Sim FH
Am J Clin Pathol 1988 Oct;90(4):377-84. doi: 10.1093/ajcp/90.4.377. PMID: 3140652

Diagnosis

Multifocal Xanthoma of Bone.
Schryver EM, McCandless MG, Al Hmada Y, Barr JS
J Am Acad Orthop Surg Glob Res Rev 2021 May 19;5(5):e20.00261-4. doi: 10.5435/JAAOSGlobal-D-20-00261. PMID: 34010236
Musculoskeletal imaging features of non-Langerhans cell histiocytoses.
Choraria A, Andrei V, Rajakulasingam R, Saifuddin A
Skeletal Radiol 2021 Oct;50(10):1921-1940. Epub 2021 Mar 31 doi: 10.1007/s00256-021-03765-0. PMID: 33787962
Erdheim-Chester disease.
Opie KM, Kaye J, Vinciullo C
Australas J Dermatol 2003 Aug;44(3):194-8. doi: 10.1046/j.1440-0960.2003.00677.x. PMID: 12869045
Necrobiotic xanthogranuloma.
Mehregan DA, Winkelmann RK
Arch Dermatol 1992 Jan;128(1):94-100. PMID: 1739294
Xanthoma of bone.
Bertoni F, Unni KK, McLeod RA, Sim FH
Am J Clin Pathol 1988 Oct;90(4):377-84. doi: 10.1093/ajcp/90.4.377. PMID: 3140652

Therapy

Necrobiotic Xanthogranuloma.
Dellatorre G, Miqueloto JK
JAMA Dermatol 2020 Jun 1;156(6):696. doi: 10.1001/jamadermatol.2020.0897. PMID: 32374351
Adult Orbital and Adnexal Xanthogranulomatous Disease.
Davies MJ, Whitehead K, Quagliotto G, Wood D, Patheja RS, Sullivan TJ
Asia Pac J Ophthalmol (Phila) 2017 Sep-Oct;6(5):435-443. Epub 2017 Aug 22 doi: 10.22608/APO.2017246. PMID: 28829109
Necrobiotic xanthogranuloma.
Jaén-Águila F, Vargas-Hitos JA, Jiménez-Alonso J
QJM 2014 Oct;107(10):859. Epub 2014 Mar 22 doi: 10.1093/qjmed/hcu066. PMID: 24659748
Hyperlipidemic myeloma: review of 53 cases.
Misselwitz B, Goede JS, Pestalozzi BC, Schanz U, Seebach JD
Ann Hematol 2010 Jun;89(6):569-77. Epub 2009 Nov 17 doi: 10.1007/s00277-009-0849-9. PMID: 19921193
Cerebrotendinous xanthomatosis as a multisystem disease mimicking premature ageing.
Dotti MT, Salen G, Federico A
Dev Neurosci 1991;13(4-5):371-6. doi: 10.1159/000112187. PMID: 1817044

Prognosis

Idiopathic Lipogranulomatous Orbital Inflammation: A Case Report and Literature Review.
Huang S, Tan L, Juniat V, James C, Selva D
Orbit 2022 Aug;41(4):493-497. Epub 2021 Feb 22 doi: 10.1080/01676830.2021.1888303. PMID: 33618590
Erdheim-Chester disease: a rare multisystem histiocytic disorder associated with interstitial lung disease.
Shamburek RD, Brewer HB Jr, Gochuico BR
Am J Med Sci 2001 Jan;321(1):66-75. doi: 10.1097/00000441-200101000-00010. PMID: 11202482
Necrobiotic xanthogranuloma.
Mehregan DA, Winkelmann RK
Arch Dermatol 1992 Jan;128(1):94-100. PMID: 1739294
Cerebrotendinous xanthomatosis as a multisystem disease mimicking premature ageing.
Dotti MT, Salen G, Federico A
Dev Neurosci 1991;13(4-5):371-6. doi: 10.1159/000112187. PMID: 1817044
Xanthoma of bone.
Bertoni F, Unni KK, McLeod RA, Sim FH
Am J Clin Pathol 1988 Oct;90(4):377-84. doi: 10.1093/ajcp/90.4.377. PMID: 3140652

Clinical prediction guides

Xanthoma of the Jaw Bones: Cases Series and Review of Literature.
Venkat S, Islam MN, Bhattacharyya I, Cohen DM, Kratochvil FJ, Woods TR, Ganatra S, Alramadhan SA
Head Neck Pathol 2024 Mar 19;18(1):19. doi: 10.1007/s12105-024-01615-8. PMID: 38502367Free PMC Article
Non-dermatologic isolated intracranial necrobiotic xanthogranuloma.
Popoola D, Housley SB, Jacoby WT, Lim J, Cappuzzo JM, Levy EI
BMJ Case Rep 2023 Aug 30;16(8) doi: 10.1136/bcr-2022-254122. PMID: 37648279Free PMC Article
Intraosseous xanthoma of the mandible: A multi-institutional case series with a literature review.
de Arruda JAA, Almeida TFA, Abreu LG, do Amaral MBF, Anbinder AL, Flores RM, Agostini M, Romañach MJ, Silva TA, de Andrade BAB, Mesquita RA
J Oral Pathol Med 2019 Nov;48(10):935-942. Epub 2019 Sep 17 doi: 10.1111/jop.12940. PMID: 31355943
Alagille syndrome today.
Alagille D
Clin Invest Med 1996 Oct;19(5):325-30. PMID: 8889270
Clinical spectrum of histiocytic tumors of the orbit.
Shields JA, Shields CL
Trans Pa Acad Ophthalmol Otolaryngol 1990;42:931-7. PMID: 2084989

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