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Disseminated viral infection

MedGen UID:
1645137
•Concept ID:
C4703485
•
Disease or Syndrome
HPO: HP:0031696

Definition

A viral infection that fails to be contained by the immune sytem and spreads throughout the body. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDisseminated viral infection

Professional guidelines

PubMed

Global Perspectives on Improving Chronic Disease Prevention and Management in Diverse Settings.
Airhihenbuwa CO, Tseng TS, Sutton VD, Price L
Prev Chronic Dis 2021 Apr 8;18:E33. doi: 10.5888/pcd18.210055. PMID: 33830913Free PMC Article
Advances and Perspectives in the Management of Varicella-Zoster Virus Infections.
Andrei G, Snoeck R
Molecules 2021 Feb 20;26(4) doi: 10.3390/molecules26041132. PMID: 33672709Free PMC Article
Adenovirus: Epidemiology, Global Spread of Novel Serotypes, and Advances in Treatment and Prevention.
Lynch JP 3rd, Kajon AE
Semin Respir Crit Care Med 2016 Aug;37(4):586-602. Epub 2016 Aug 3 doi: 10.1055/s-0036-1584923. PMID: 27486739Free PMC Article

Recent clinical studies

Etiology

Recurrent eczema herpeticum - a retrospective European multicenter study evaluating the clinical characteristics of eczema herpeticum cases in atopic dermatitis patients.
Seegräber M, Worm M, Werfel T, Svensson A, Novak N, Simon D, Darsow U, Augustin M, Wollenberg A
J Eur Acad Dermatol Venereol 2020 May;34(5):1074-1079. Epub 2020 Jan 30 doi: 10.1111/jdv.16090. PMID: 31733162
Antiviral immunity of Anopheles gambiae is highly compartmentalized, with distinct roles for RNA interference and gut microbiota.
Carissimo G, Pondeville E, McFarlane M, Dietrich I, Mitri C, Bischoff E, Antoniewski C, Bourgouin C, Failloux AB, Kohl A, Vernick KD
Proc Natl Acad Sci U S A 2015 Jan 13;112(2):E176-85. Epub 2014 Dec 29 doi: 10.1073/pnas.1412984112. PMID: 25548172Free PMC Article
Astrovirus infection in hospitalized infants with severe combined immunodeficiency after allogeneic hematopoietic stem cell transplantation.
Wunderli W, Meerbach A, Güngör T, Berger C, Greiner O, Caduff R, Trkola A, Bossart W, Gerlach D, Schibler M, Cordey S, McKee TA, Van Belle S, Kaiser L, Tapparel C
PLoS One 2011;6(11):e27483. Epub 2011 Nov 11 doi: 10.1371/journal.pone.0027483. PMID: 22096580Free PMC Article
Acute viral infections in patients with systemic lupus erythematosus: description of 23 cases and review of the literature.
Ramos-Casals M, Cuadrado MJ, Alba P, Sanna G, Brito-Zerón P, Bertolaccini L, Babini A, Moreno A, D'Cruz D, Khamashta MA
Medicine (Baltimore) 2008 Nov;87(6):311-318. doi: 10.1097/MD.0b013e31818ec711. PMID: 19011502
Multiplexed, real-time PCR for quantitative detection of human adenovirus.
Gu Z, Belzer SW, Gibson CS, Bankowski MJ, Hayden RT
J Clin Microbiol 2003 Oct;41(10):4636-41. doi: 10.1128/JCM.41.10.4636-4641.2003. PMID: 14532195Free PMC Article

Diagnosis

A Nationwide Study of GATA2 Deficiency in Norway-the Majority of Patients Have Undergone Allo-HSCT.
Jørgensen SF, Buechner J, Myhre AE, Galteland E, Spetalen S, Kulseth MA, Sorte HS, Holla ØL, Lundman E, Alme C, Heier I, Flægstad T, Fløisand Y, Benneche A, Fevang B, Aukrust P, Stray-Pedersen A, Gedde-Dahl T, Nordøy I
J Clin Immunol 2022 Feb;42(2):404-420. Epub 2021 Dec 10 doi: 10.1007/s10875-021-01189-y. PMID: 34893945Free PMC Article
Analytical characterization of an assay designed to detect and identify diverse agents of disseminated viral infection.
Metzgar D, Lovari R, Ray K, Baynes D, Drapp D, Frinder M, Vijesurier R, Stemler M, Ofsaiof R, Carolan H, Welk J, Toleno D, Ranken R, Hall TA, Massire C, Sampath R, Blyn LB, Goveia J, Schneider G
J Clin Virol 2014 Mar;59(3):177-83. Epub 2013 Dec 29 doi: 10.1016/j.jcv.2013.12.005. PMID: 24440177
Astrovirus infection in hospitalized infants with severe combined immunodeficiency after allogeneic hematopoietic stem cell transplantation.
Wunderli W, Meerbach A, Güngör T, Berger C, Greiner O, Caduff R, Trkola A, Bossart W, Gerlach D, Schibler M, Cordey S, McKee TA, Van Belle S, Kaiser L, Tapparel C
PLoS One 2011;6(11):e27483. Epub 2011 Nov 11 doi: 10.1371/journal.pone.0027483. PMID: 22096580Free PMC Article
Innate immunity in atopic dermatitis.
Wollenberg A, Räwer HC, Schauber J
Clin Rev Allergy Immunol 2011 Dec;41(3):272-81. doi: 10.1007/s12016-010-8227-x. PMID: 21181301
Acute viral infections in patients with systemic lupus erythematosus: description of 23 cases and review of the literature.
Ramos-Casals M, Cuadrado MJ, Alba P, Sanna G, Brito-Zerón P, Bertolaccini L, Babini A, Moreno A, D'Cruz D, Khamashta MA
Medicine (Baltimore) 2008 Nov;87(6):311-318. doi: 10.1097/MD.0b013e31818ec711. PMID: 19011502

Therapy

Severe viral hepatitis in a patient with chronic lymphocytic leukemia (CLL) complicated with autoimmune hemolytic anemia (AIHA), treated with steroids.
Orvain C, Ducancelle A, Eymerit-Morin C, Rousselet MC, Oberti F, Hunault-Berger M, Tanguy-Schmidt A
J Clin Virol 2015 Jan;62:66-8. Epub 2014 Nov 18 doi: 10.1016/j.jcv.2014.11.013. PMID: 25542474
Eczema herpeticum.
Wollenberg A
Chem Immunol Allergy 2012;96:89-95. Epub 2012 Mar 13 doi: 10.1159/000331892. PMID: 22433376
Astrovirus infection in hospitalized infants with severe combined immunodeficiency after allogeneic hematopoietic stem cell transplantation.
Wunderli W, Meerbach A, Güngör T, Berger C, Greiner O, Caduff R, Trkola A, Bossart W, Gerlach D, Schibler M, Cordey S, McKee TA, Van Belle S, Kaiser L, Tapparel C
PLoS One 2011;6(11):e27483. Epub 2011 Nov 11 doi: 10.1371/journal.pone.0027483. PMID: 22096580Free PMC Article
Acute viral infections in patients with systemic lupus erythematosus: description of 23 cases and review of the literature.
Ramos-Casals M, Cuadrado MJ, Alba P, Sanna G, Brito-Zerón P, Bertolaccini L, Babini A, Moreno A, D'Cruz D, Khamashta MA
Medicine (Baltimore) 2008 Nov;87(6):311-318. doi: 10.1097/MD.0b013e31818ec711. PMID: 19011502
Cytomegalovirus retinitis in adults. A manifestation of disseminated viral infection.
Murray HW, Knox DL, Green WR, Susel RM
Am J Med 1977 Oct;63(4):574-84. doi: 10.1016/0002-9343(77)90203-0. PMID: 199061

Prognosis

A Nationwide Study of GATA2 Deficiency in Norway-the Majority of Patients Have Undergone Allo-HSCT.
Jørgensen SF, Buechner J, Myhre AE, Galteland E, Spetalen S, Kulseth MA, Sorte HS, Holla ØL, Lundman E, Alme C, Heier I, Flægstad T, Fløisand Y, Benneche A, Fevang B, Aukrust P, Stray-Pedersen A, Gedde-Dahl T, Nordøy I
J Clin Immunol 2022 Feb;42(2):404-420. Epub 2021 Dec 10 doi: 10.1007/s10875-021-01189-y. PMID: 34893945Free PMC Article
Eczema herpeticum emerging during atopic dermatitis in infancy.
Ertuğrul A, Emeksiz ZŞ, Severcan EU, Özmen S, Bostancı İ
Turk J Pediatr 2020;62(3):514-519. doi: 10.24953/turkjped.2020.03.025. PMID: 32558432
Severe viral hepatitis in a patient with chronic lymphocytic leukemia (CLL) complicated with autoimmune hemolytic anemia (AIHA), treated with steroids.
Orvain C, Ducancelle A, Eymerit-Morin C, Rousselet MC, Oberti F, Hunault-Berger M, Tanguy-Schmidt A
J Clin Virol 2015 Jan;62:66-8. Epub 2014 Nov 18 doi: 10.1016/j.jcv.2014.11.013. PMID: 25542474
Acute viral infections in patients with systemic lupus erythematosus: description of 23 cases and review of the literature.
Ramos-Casals M, Cuadrado MJ, Alba P, Sanna G, Brito-Zerón P, Bertolaccini L, Babini A, Moreno A, D'Cruz D, Khamashta MA
Medicine (Baltimore) 2008 Nov;87(6):311-318. doi: 10.1097/MD.0b013e31818ec711. PMID: 19011502
Fatal disseminated adenoviral infection in a renal transplant patient.
Ardehali H, Volmar K, Roberts C, Forman M, Becker LC
Transplantation 2001 Apr 15;71(7):998-9. doi: 10.1097/00007890-200104150-00029. PMID: 11349739

Clinical prediction guides

A Nationwide Study of GATA2 Deficiency in Norway-the Majority of Patients Have Undergone Allo-HSCT.
Jørgensen SF, Buechner J, Myhre AE, Galteland E, Spetalen S, Kulseth MA, Sorte HS, Holla ØL, Lundman E, Alme C, Heier I, Flægstad T, Fløisand Y, Benneche A, Fevang B, Aukrust P, Stray-Pedersen A, Gedde-Dahl T, Nordøy I
J Clin Immunol 2022 Feb;42(2):404-420. Epub 2021 Dec 10 doi: 10.1007/s10875-021-01189-y. PMID: 34893945Free PMC Article
Fatal pulmonary disease and encephalic complication in a man with HSV-1 Infection: a case report.
Astuto M, Palermo CI, Costanzo CM, Ettorre GC, Palmucci S, Franchina C, Russo R, Valastro P, Timpanaro V, Scalia G
J Clin Virol 2014 Jan;59(1):59-62. Epub 2013 Nov 23 doi: 10.1016/j.jcv.2013.11.006. PMID: 24326294
Pneumonia and pericarditis in a child with HRV-C infection: a case report.
Tapparel C, L'Huillier AG, Rougemont AL, Beghetti M, Barazzone-Argiroffo C, Kaiser L
J Clin Virol 2009 Jun;45(2):157-60. Epub 2009 May 7 doi: 10.1016/j.jcv.2009.03.014. PMID: 19427260Free PMC Article
Pathologic and virologic study of fatal Lassa fever in man.
Walker DH, McCormick JB, Johnson KM, Webb PA, Komba-Kono G, Elliott LH, Gardner JJ
Am J Pathol 1982 Jun;107(3):349-56. PMID: 7081389Free PMC Article

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