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Pituitary Gland Diffuse Large B-Cell Lymphoma

MedGen UID:
1648726
•Concept ID:
C4744384
•
Neoplastic Process
Synonym: Primary Pituitary Gland Diffuse Large B-Cell Lymphoma

Definition

A rare diffuse large B-cell lymphoma that arises from the pituitary gland. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPituitary Gland Diffuse Large B-Cell Lymphoma

Recent clinical studies

Diagnosis

Intravascular large B-cell lymphoma causing hypopituitarism and respiratory failure due to infiltration into pulmonary capillaries.
Kosaka T, Honda Y, Homma Y, Nakata M
BMJ Case Rep 2022 May 24;15(5) doi: 10.1136/bcr-2021-247880. PMID: 35609931Free PMC Article
Autopsy case report of intravascular large B-cell lymphoma with neoplastic PD-L1 expression.
Sakakibara A, Inagaki Y, Imaoka E, Ishikawa E, Shimada S, Shimada K, Suzuki Y, Nakamura S, Satou A, Kohno K
J Clin Exp Hematop 2018 Mar 16;58(1):32-35. Epub 2018 Feb 8 doi: 10.3960/jslrt.17037. PMID: 29415979Free PMC Article
Primary pituitary diffuse large B-cell lymphoma with somatotroph hyperplasia and acromegaly: case report.
Ravindra VM, Raheja A, Corn H, Driscoll M, Welt C, Simmons DL, Couldwell WT
J Neurosurg 2017 May;126(5):1725-1730. Epub 2016 Aug 12 doi: 10.3171/2016.5.JNS16828. PMID: 27518527
Pituitary lymphoma developing within pituitary adenoma.
Morita K, Nakamura F, Kamikubo Y, Mizuno N, Miyauchi M, Yamamoto G, Nannya Y, Ichikawa M, Kurokawa M
Int J Hematol 2012 Jun;95(6):721-4. Epub 2012 Apr 21 doi: 10.1007/s12185-012-1075-0. PMID: 22527852
Lymphoma metastasizing to the pituitary: an unusual presentation of a treatable disease.
Megan Ogilvie C, Payne S, Evanson J, Lister TA, Grossman AB
Pituitary 2005;8(2):139-46. doi: 10.1007/s11102-005-4535-1. PMID: 16379034

Therapy

Autopsy case report of intravascular large B-cell lymphoma with neoplastic PD-L1 expression.
Sakakibara A, Inagaki Y, Imaoka E, Ishikawa E, Shimada S, Shimada K, Suzuki Y, Nakamura S, Satou A, Kohno K
J Clin Exp Hematop 2018 Mar 16;58(1):32-35. Epub 2018 Feb 8 doi: 10.3960/jslrt.17037. PMID: 29415979Free PMC Article
FDG-PET/CT is a pivotal imaging modality to diagnose rare intravascular large B-cell lymphoma: case report and review of literature.
Colavolpe C, Ebbo M, Trousse D, Khibri H, Franques J, Chetaille B, Coso D, Ouvrier MJ, Gastaud L, Guedj E, Schleinitz N
Hematol Oncol 2015 Jun;33(2):99-109. Epub 2014 May 21 doi: 10.1002/hon.2140. PMID: 24850057
Diffuse large cell non-Hodgkin lymphoma with pituitary and bilateral adrenal involvement.
Wang XL, Lü ZH, Mu YM, Dou JT, Lu JM, Zhong WW, Pan CY
Intern Med J 2012 Mar;42(3):329-32. doi: 10.1111/j.1445-5994.2011.02691.x. PMID: 22432986
Intravascular large B-cell lymphoma as a cause of hypopituitarism: gradual and late reversal of hypopituitarism after long-term remission of lymphoma with immunochemotherapy.
Pekic S, Milicevic S, Colovic N, Colovic M, Popovic V
Endocrine 2008 Aug-Dec;34(1-3):11-6. Epub 2008 Oct 21 doi: 10.1007/s12020-008-9109-3. PMID: 18937075
Pituitary stalk thickening and primary central nervous system lymphoma.
Capra M, Wherrett D, Weitzman S, Dirks P, Hawkins C, Bouffet E
J Neurooncol 2004 Mar-Apr;67(1-2):227-31. doi: 10.1023/b:neon.0000021863.06620.48. PMID: 15072472

Prognosis

Hypopituitarism and cranial nerve involvement mimicking Tolosa-Hunt syndrome as the initially presenting feature of diffuse large B-cell lymphoma: a case report.
Kishimoto S, Morita S, Kurimoto C, Kitahara C, Tsuji T, Uraki S, Takeshima K, Furukawa Y, Iwakura H, Furuta H, Nishi M, Matsuoka TA
BMC Endocr Disord 2022 Mar 14;22(1):65. doi: 10.1186/s12902-022-00973-0. PMID: 35287660Free PMC Article
Autopsy case report of intravascular large B-cell lymphoma with neoplastic PD-L1 expression.
Sakakibara A, Inagaki Y, Imaoka E, Ishikawa E, Shimada S, Shimada K, Suzuki Y, Nakamura S, Satou A, Kohno K
J Clin Exp Hematop 2018 Mar 16;58(1):32-35. Epub 2018 Feb 8 doi: 10.3960/jslrt.17037. PMID: 29415979Free PMC Article
Hypophyseal metastases: A report of three cases and literature review.
Ravnik J, Smigoc T, Bunc G, Lanisnik B, Ksela U, Ravnik M, Velnar T
Neurol Neurochir Pol 2016 Nov-Dec;50(6):511-516. Epub 2016 Sep 4 doi: 10.1016/j.pjnns.2016.08.007. PMID: 27633123
Anterior panhypopituitarism in diffuse large B-cell stage IV lymphoma.
Valeros KA, Khoo E
J Clin Neurosci 2014 Aug;21(8):1464-6. Epub 2014 Apr 16 doi: 10.1016/j.jocn.2013.10.042. PMID: 24746111
Lymphoma metastasizing to the pituitary: an unusual presentation of a treatable disease.
Megan Ogilvie C, Payne S, Evanson J, Lister TA, Grossman AB
Pituitary 2005;8(2):139-46. doi: 10.1007/s11102-005-4535-1. PMID: 16379034

Clinical prediction guides

Clinical features of anti-pituitary-specific transcription factor-1 (PIT-1) hypophysitis: a new aspect of paraneoplastic autoimmune condition.
Urai S, Iguchi G, Kanie K, Bando H, Yamamoto M, Oi Y, Kashitani Y, Iida K, Kanzawa M, Fukuoka H, Takahashi M, Shintani Y, Ogawa W, Takahashi Y
Eur J Endocrinol 2024 Jan 3;190(1):K1-K7. doi: 10.1093/ejendo/lvad179. PMID: 38146732
Intravascular large B-cell lymphoma causing hypopituitarism and respiratory failure due to infiltration into pulmonary capillaries.
Kosaka T, Honda Y, Homma Y, Nakata M
BMJ Case Rep 2022 May 24;15(5) doi: 10.1136/bcr-2021-247880. PMID: 35609931Free PMC Article

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