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New Primary Tumor

MedGen UID:
1649150
•Concept ID:
C4745081
•
Finding

Definition

A finding indicating the development of a tumor in a patient with a history of a previously diagnosed tumor with a different histopathologic profile in another anatomic site as compared to the most recent one. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNew Primary Tumor

Professional guidelines

PubMed

True recurrences and new primary tumors have different clinical features in invasive breast cancer patients with ipsilateral breast tumor relapse after breast-conserving treatment.
Yoshida T, Takei H, Kurosumi M, Ninomiya J, Ishikawa Y, Hayashi Y, Tozuka K, Oba H, Kawanowa K, Inoue K, Tabei T
Breast J 2010 Mar-Apr;16(2):127-33. Epub 2009 Dec 21 doi: 10.1111/j.1524-4741.2009.00884.x. PMID: 20030655
Role of the physician versus the patient in the detection of recurrent disease following treatment for head and neck cancer.
Agrawal A, deSilva BW, Buckley BM, Schuller DE
Laryngoscope 2004 Feb;114(2):232-5. doi: 10.1097/00005537-200402000-00011. PMID: 14755196
True recurrence vs. new primary ipsilateral breast tumor relapse: an analysis of clinical and pathologic differences and their implications in natural history, prognoses, and therapeutic management.
Smith TE, Lee D, Turner BC, Carter D, Haffty BG
Int J Radiat Oncol Biol Phys 2000 Dec 1;48(5):1281-9. doi: 10.1016/s0360-3016(00)01378-x. PMID: 11121624

Recent clinical studies

Etiology

Second invasive breast cancers in patients treated with breast-conserving therapy.
Wang J, Tang H, Yin K, Li X, Xie X, Hughes KS
Eur J Surg Oncol 2021 Oct;47(10):2492-2498. Epub 2021 Jun 10 doi: 10.1016/j.ejso.2021.06.013. PMID: 34134902
Recurrent and second primary squamous cell carcinoma of the head and neck: when and how to reirradiate.
Strojan P, Corry J, Eisbruch A, Vermorken JB, Mendenhall WM, Lee AW, Haigentz M Jr, Beitler JJ, de Bree R, Takes RP, Paleri V, Kelly CG, Genden EM, Bradford CR, Harrison LB, Rinaldo A, Ferlito A
Head Neck 2015 Jan;37(1):134-50. Epub 2014 Jan 31 doi: 10.1002/hed.23542. PMID: 24481720
True recurrences and new primary tumors have different clinical features in invasive breast cancer patients with ipsilateral breast tumor relapse after breast-conserving treatment.
Yoshida T, Takei H, Kurosumi M, Ninomiya J, Ishikawa Y, Hayashi Y, Tozuka K, Oba H, Kawanowa K, Inoue K, Tabei T
Breast J 2010 Mar-Apr;16(2):127-33. Epub 2009 Dec 21 doi: 10.1111/j.1524-4741.2009.00884.x. PMID: 20030655
Ipsilateral breast tumor recurrence: is there any evidence for benefit of further systemic therapy?
Sirohi B, Leary A, Johnston SR
Breast J 2009 May-Jun;15(3):268-78. doi: 10.1111/j.1524-4741.2009.00716.x. PMID: 19645782
Incidence and sites of distant metastases from head and neck cancer.
Ferlito A, Shaha AR, Silver CE, Rinaldo A, Mondin V
ORL J Otorhinolaryngol Relat Spec 2001 Jul-Aug;63(4):202-7. doi: 10.1159/000055740. PMID: 11408812

Diagnosis

Ipsilateral breast tumor recurrence after breast-conserving surgery: insights into biology and treatment.
Qu FL, Wu SY, Li JJ, Shao ZM
Breast Cancer Res Treat 2023 Nov;202(2):215-220. Epub 2023 Aug 1 doi: 10.1007/s10549-023-07071-2. PMID: 37528263
Ipsilateral in-breast tumor recurrence after breast conserving therapy: true recurrence versus new primary tumor.
Alexandrova E, Sergieva S, Kostova P, Mihaylova I, Katzarov D, Milev A
J BUON 2015 Jul-Aug;20(4):1001-8. PMID: 26416048
Exome sequencing of contralateral breast cancer identifies metastatic disease.
Klevebring D, Lindberg J, Rockberg J, Hilliges C, Hall P, Sandberg M, Czene K
Breast Cancer Res Treat 2015 Jun;151(2):319-24. Epub 2015 Apr 29 doi: 10.1007/s10549-015-3403-6. PMID: 25922084
Ipsilateral breast tumor relapse: local recurrence versus new primary tumor and the effect of whole-breast radiotherapy on the rate of new primaries.
Gujral DM, Sumo G, Owen JR, Ashton A, Bliss JM, Haviland J, Yarnold JR
Int J Radiat Oncol Biol Phys 2011 Jan 1;79(1):19-25. Epub 2010 May 13 doi: 10.1016/j.ijrobp.2009.10.074. PMID: 20471183
Is it necessary to biopsy the obvious?
Chen MY, Gelfand DW, Bechtold RE, Cremer SA, Casolo BJ, Savage PD
AJR Am J Roentgenol 2000 Jan;174(1):135-9. doi: 10.2214/ajr.174.1.1740135. PMID: 10628469

Therapy

Residual fibroglandular breast tissue after mastectomy is associated with an increased risk of a local recurrence or a new primary breast cancer".
Deutschmann C, Singer CF, Gschwantler-Kaulich D, Pfeiler G, Leser C, Baltzer PAT, Helbich TH, Kraus C, Korbatits R, Marzogi A, Clauser P
BMC Cancer 2023 Mar 28;23(1):281. doi: 10.1186/s12885-023-10764-y. PMID: 36978031Free PMC Article
Second invasive breast cancers in patients treated with breast-conserving therapy.
Wang J, Tang H, Yin K, Li X, Xie X, Hughes KS
Eur J Surg Oncol 2021 Oct;47(10):2492-2498. Epub 2021 Jun 10 doi: 10.1016/j.ejso.2021.06.013. PMID: 34134902
Recurrent and second primary squamous cell carcinoma of the head and neck: when and how to reirradiate.
Strojan P, Corry J, Eisbruch A, Vermorken JB, Mendenhall WM, Lee AW, Haigentz M Jr, Beitler JJ, de Bree R, Takes RP, Paleri V, Kelly CG, Genden EM, Bradford CR, Harrison LB, Rinaldo A, Ferlito A
Head Neck 2015 Jan;37(1):134-50. Epub 2014 Jan 31 doi: 10.1002/hed.23542. PMID: 24481720
Ipsilateral breast tumor relapse: local recurrence versus new primary tumor and the effect of whole-breast radiotherapy on the rate of new primaries.
Gujral DM, Sumo G, Owen JR, Ashton A, Bliss JM, Haviland J, Yarnold JR
Int J Radiat Oncol Biol Phys 2011 Jan 1;79(1):19-25. Epub 2010 May 13 doi: 10.1016/j.ijrobp.2009.10.074. PMID: 20471183
Ipsilateral breast tumor recurrence: is there any evidence for benefit of further systemic therapy?
Sirohi B, Leary A, Johnston SR
Breast J 2009 May-Jun;15(3):268-78. doi: 10.1111/j.1524-4741.2009.00716.x. PMID: 19645782

Prognosis

Second invasive breast cancers in patients treated with breast-conserving therapy.
Wang J, Tang H, Yin K, Li X, Xie X, Hughes KS
Eur J Surg Oncol 2021 Oct;47(10):2492-2498. Epub 2021 Jun 10 doi: 10.1016/j.ejso.2021.06.013. PMID: 34134902
Ipsilateral in-breast tumor recurrence after breast conserving therapy: true recurrence versus new primary tumor.
Alexandrova E, Sergieva S, Kostova P, Mihaylova I, Katzarov D, Milev A
J BUON 2015 Jul-Aug;20(4):1001-8. PMID: 26416048
Exome sequencing of contralateral breast cancer identifies metastatic disease.
Klevebring D, Lindberg J, Rockberg J, Hilliges C, Hall P, Sandberg M, Czene K
Breast Cancer Res Treat 2015 Jun;151(2):319-24. Epub 2015 Apr 29 doi: 10.1007/s10549-015-3403-6. PMID: 25922084
High-dose, conventionally fractionated thoracic reirradiation for lung tumors.
Griffioen GH, Dahele M, de Haan PF, van de Ven PM, Slotman BJ, Senan S
Lung Cancer 2014 Mar;83(3):356-62. Epub 2013 Dec 24 doi: 10.1016/j.lungcan.2013.12.006. PMID: 24433824
Incidence and sites of distant metastases from head and neck cancer.
Ferlito A, Shaha AR, Silver CE, Rinaldo A, Mondin V
ORL J Otorhinolaryngol Relat Spec 2001 Jul-Aug;63(4):202-7. doi: 10.1159/000055740. PMID: 11408812

Clinical prediction guides

Tumor heterogeneity in VHL drives metastasis in clear cell renal cell carcinoma.
Hu J, Tan P, Ishihara M, Bayley NA, Schokrpur S, Reynoso JG, Zhang Y, Lim RJ, Dumitras C, Yang L, Dubinett SM, Jat PS, Van Snick J, Huang J, Chin AI, Prins RM, Graeber TG, Xu H, Wu L
Signal Transduct Target Ther 2023 Apr 17;8(1):155. doi: 10.1038/s41392-023-01362-2. PMID: 37069149Free PMC Article
Influence of XRCC4 expression by breast cancer cells on ipsilateral recurrence after breast-conserving therapy.
Kitagawa M, Someya M, Hasegawa T, Mikami T, Asaishi K, Hasegawa T, Matsumoto Y, Kutomi G, Takemasa I, Sakata KI
Strahlenther Onkol 2019 Jul;195(7):648-658. Epub 2019 Apr 17 doi: 10.1007/s00066-019-01468-z. PMID: 30997540
Recurrent and second primary squamous cell carcinoma of the head and neck: when and how to reirradiate.
Strojan P, Corry J, Eisbruch A, Vermorken JB, Mendenhall WM, Lee AW, Haigentz M Jr, Beitler JJ, de Bree R, Takes RP, Paleri V, Kelly CG, Genden EM, Bradford CR, Harrison LB, Rinaldo A, Ferlito A
Head Neck 2015 Jan;37(1):134-50. Epub 2014 Jan 31 doi: 10.1002/hed.23542. PMID: 24481720
High-resolution mapping of DNA breakpoints to define true recurrences among ipsilateral breast cancers.
Bollet MA, Servant N, Neuvial P, Decraene C, Lebigot I, Meyniel JP, De Rycke Y, Savignoni A, Rigaill G, Hupé P, Fourquet A, Sigal-Zafrani B, Barillot E, Thiery JP
J Natl Cancer Inst 2008 Jan 2;100(1):48-58. Epub 2007 Dec 25 doi: 10.1093/jnci/djm266. PMID: 18159071
Is it necessary to biopsy the obvious?
Chen MY, Gelfand DW, Bechtold RE, Cremer SA, Casolo BJ, Savage PD
AJR Am J Roentgenol 2000 Jan;174(1):135-9. doi: 10.2214/ajr.174.1.1740135. PMID: 10628469

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