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Metastatic Digestive System Neuroendocrine Carcinoma

MedGen UID:
1650372
•Concept ID:
C4744461
•
Neoplastic Process
Synonym: Metastatic Gastrointestinal System Neuroendocrine Carcinoma

Definition

A neuroendocrine carcinoma that arises from any part of the digestive system and has metastasized to another anatomic site. [from NCI]

Professional guidelines

PubMed

Evolution of Treatment in Advanced Cholangiocarcinoma: Old and New towards Precision Oncology.
Capuozzo M, Santorsola M, Landi L, Granata V, Perri F, Celotto V, Gualillo O, Nasti G, Ottaiano A
Int J Mol Sci 2022 Dec 1;23(23) doi: 10.3390/ijms232315124. PMID: 36499450Free PMC Article
Management of Primary Hepatopancreatobiliary and Ampulla Large Cell Neuroendocrine Carcinoma.
Zhu J, Xiao W, Li Y
J Laparoendosc Adv Surg Tech A 2022 Jun;32(6):639-645. Epub 2021 Oct 11 doi: 10.1089/lap.2021.0482. PMID: 34637632
Immunotherapy and potential predictive biomarkers in the treatment of neuroendocrine neoplasia.
Xu G, Wang Y, Zhang H, She X, Yang J
Future Oncol 2021 Mar;17(9):1069-1081. Epub 2020 Nov 2 doi: 10.2217/fon-2020-0703. PMID: 33136448

Recent clinical studies

Etiology

Aspirin for Metabolic Dysfunction-Associated Steatotic Liver Disease Without Cirrhosis: A Randomized Clinical Trial.
Simon TG, Wilechansky RM, Stoyanova S, Grossman A, Dichtel LE, Lauer GM, Miller KK, Hoshida Y, Corey KE, Loomba R, Chung RT, Chan AT
JAMA 2024 Mar 19;331(11):920-929. doi: 10.1001/jama.2024.1215. PMID: 38502074Free PMC Article
Management of Gastric Neuroendocrine Tumors: A Review.
Sok C, Ajay PS, Tsagkalidis V, Kooby DA, Shah MM
Ann Surg Oncol 2024 Mar;31(3):1509-1518. Epub 2023 Dec 7 doi: 10.1245/s10434-023-14712-9. PMID: 38062290Free PMC Article
Mixed neuroendocrine-nonneuroendocrine neoplasms of the gastrointestinal system: An update.
Elpek GO
World J Gastroenterol 2022 Feb 28;28(8):794-810. doi: 10.3748/wjg.v28.i8.794. PMID: 35317101Free PMC Article
Management of Primary Hepatopancreatobiliary and Ampulla Large Cell Neuroendocrine Carcinoma.
Zhu J, Xiao W, Li Y
J Laparoendosc Adv Surg Tech A 2022 Jun;32(6):639-645. Epub 2021 Oct 11 doi: 10.1089/lap.2021.0482. PMID: 34637632
Radiology of the neuroendocrine neoplasms of the gastrointestinal tract: a comprehensive review.
Malla S, Kumar P, Madhusudhan KS
Abdom Radiol (NY) 2021 Mar;46(3):919-935. Epub 2020 Sep 22 doi: 10.1007/s00261-020-02773-3. PMID: 32960304

Diagnosis

Adult pancreatoblastoma: Current concepts in pathology.
Omiyale AO
World J Gastroenterol 2021 Jul 14;27(26):4172-4181. doi: 10.3748/wjg.v27.i26.4172. PMID: 34326617Free PMC Article
Radiology of the neuroendocrine neoplasms of the gastrointestinal tract: a comprehensive review.
Malla S, Kumar P, Madhusudhan KS
Abdom Radiol (NY) 2021 Mar;46(3):919-935. Epub 2020 Sep 22 doi: 10.1007/s00261-020-02773-3. PMID: 32960304
Digestive System Mixed Neuroendocrine-Non-Neuroendocrine Neoplasms.
de Mestier L, Cros J, Neuzillet C, Hentic O, Egal A, Muller N, Bouché O, Cadiot G, Ruszniewski P, Couvelard A, Hammel P
Neuroendocrinology 2017;105(4):412-425. Epub 2017 Aug 12 doi: 10.1159/000475527. PMID: 28803232
Pancreatic panniculitis.
Mahawish K, Iyasere IT
BMJ Case Rep 2014 Aug 22;2014 doi: 10.1136/bcr-2014-204290. PMID: 25150233Free PMC Article
Hypervascular liver lesions.
Kamaya A, Maturen KE, Tye GA, Liu YI, Parti NN, Desser TS
Semin Ultrasound CT MR 2009 Oct;30(5):387-407. doi: 10.1053/j.sult.2009.06.001. PMID: 19842564

Therapy

Aspirin for Metabolic Dysfunction-Associated Steatotic Liver Disease Without Cirrhosis: A Randomized Clinical Trial.
Simon TG, Wilechansky RM, Stoyanova S, Grossman A, Dichtel LE, Lauer GM, Miller KK, Hoshida Y, Corey KE, Loomba R, Chung RT, Chan AT
JAMA 2024 Mar 19;331(11):920-929. doi: 10.1001/jama.2024.1215. PMID: 38502074Free PMC Article
Updates and Expert Opinions on Liver Transplantation for Gastrointestinal Malignancies.
Shannon AH, Ruff SM, Schenk AD, Washburn K, Pawlik TM
Medicina (Kaunas) 2023 Jul 13;59(7) doi: 10.3390/medicina59071290. PMID: 37512101Free PMC Article
Neuroendocrine Carcinoma of the Anus and Rectum: Patient Characteristics and Treatment Options.
Ueberroth BE, Liu AJ, Starr JS, Hobday TJ, Ashman JB, Mishra N, Bekaii-Saab TS, Halfdanarson TR, Sonbol MB
Clin Colorectal Cancer 2021 Jun;20(2):e139-e149. Epub 2020 Dec 17 doi: 10.1016/j.clcc.2020.12.001. PMID: 33551318
Are There Indications for Total Pancreatectomy in 2016?
Andrén-Sandberg Å, Ansorge C, Yadav TD
Dig Surg 2016;33(4):329-34. Epub 2016 May 25 doi: 10.1159/000445018. PMID: 27215746
Liver transplantation for malignancies.
Eghtesad B, Aucejo F
J Gastrointest Cancer 2014 Sep;45(3):353-62. doi: 10.1007/s12029-014-9590-2. PMID: 24604263

Prognosis

Aspirin for Metabolic Dysfunction-Associated Steatotic Liver Disease Without Cirrhosis: A Randomized Clinical Trial.
Simon TG, Wilechansky RM, Stoyanova S, Grossman A, Dichtel LE, Lauer GM, Miller KK, Hoshida Y, Corey KE, Loomba R, Chung RT, Chan AT
JAMA 2024 Mar 19;331(11):920-929. doi: 10.1001/jama.2024.1215. PMID: 38502074Free PMC Article
Mixed neuroendocrine-nonneuroendocrine neoplasms of the gastrointestinal system: An update.
Elpek GO
World J Gastroenterol 2022 Feb 28;28(8):794-810. doi: 10.3748/wjg.v28.i8.794. PMID: 35317101Free PMC Article
Radiology of the neuroendocrine neoplasms of the gastrointestinal tract: a comprehensive review.
Malla S, Kumar P, Madhusudhan KS
Abdom Radiol (NY) 2021 Mar;46(3):919-935. Epub 2020 Sep 22 doi: 10.1007/s00261-020-02773-3. PMID: 32960304
Digestive System Mixed Neuroendocrine-Non-Neuroendocrine Neoplasms.
de Mestier L, Cros J, Neuzillet C, Hentic O, Egal A, Muller N, Bouché O, Cadiot G, Ruszniewski P, Couvelard A, Hammel P
Neuroendocrinology 2017;105(4):412-425. Epub 2017 Aug 12 doi: 10.1159/000475527. PMID: 28803232
Endocrine manifestations of von Hippel-Lindau disease.
Cassol C, Mete O
Arch Pathol Lab Med 2015 Feb;139(2):263-8. doi: 10.5858/arpa.2013-0520-RS. PMID: 25611110

Clinical prediction guides

Liver Transplant as a Treatment of Primary and Secondary Liver Neoplasms.
Gorji L, Brown ZJ, Limkemann A, Schenk AD, Pawlik TM
JAMA Surg 2024 Feb 1;159(2):211-218. doi: 10.1001/jamasurg.2023.6083. PMID: 38055245
Clinicopathological features and lymph node and distant metastasis patterns in patients with gastroenteropancreatic mixed neuroendocrine-non-neuroendocrine neoplasm.
Zhang P, Li Z, Li J, Li J, Zhang X, Lu Z, Sun Y, Li Y, Zhou J, Wang X, Peng Z, Shen L, Lu M
Cancer Med 2021 Jul;10(14):4855-4863. Epub 2021 Jun 10 doi: 10.1002/cam4.4031. PMID: 34109756Free PMC Article
Immunotherapy and potential predictive biomarkers in the treatment of neuroendocrine neoplasia.
Xu G, Wang Y, Zhang H, She X, Yang J
Future Oncol 2021 Mar;17(9):1069-1081. Epub 2020 Nov 2 doi: 10.2217/fon-2020-0703. PMID: 33136448
Breast metastasis and lung large-cell neuroendocrine carcinoma: first clinical observation.
Papa A, Rossi L, Verrico M, Di Cristofano C, Moretti V, Strudel M, Zoratto F, Minozzi M, Tomao S
Clin Respir J 2017 Sep;11(5):574-578. Epub 2015 Oct 20 doi: 10.1111/crj.12385. PMID: 26365150
Liver transplantation for metastatic neuroendocrine tumors: Outcomes and prognostic variables.
Sher LS, Levi DM, Wecsler JS, Lo M, Petrovic LM, Groshen S, Ji L, Uso TD, Tector AJ, Hamilton AS, Marsh JW, Schwartz ME
J Surg Oncol 2015 Aug;112(2):125-32. Epub 2015 Jul 14 doi: 10.1002/jso.23973. PMID: 26171686Free PMC Article

Recent systematic reviews

Synchronous or metachronous presentation of pancreatic neuroendocrine tumor versus secondary lesion to pancreas in patients affected by renal cell carcinoma. Systematic review.
Persano I, Parlagreco E, La Salvia A, Audisio M, Volante M, Buttigliero C, Scagliotti GV, Brizzi MP
Semin Oncol 2022 Dec;49(6):476-481. Epub 2023 Feb 2 doi: 10.1053/j.seminoncol.2023.01.007. PMID: 36759234
Mixed adenoneuroendocrine carcinoma (MANEC) of the lower gastrointestinal tract: A systematic review with Bayesian hierarchical survival analysis.
Grossi U, Bonis A, Carrington EV, Mazzobel E, Santoro GA, Cattaneo L, Centonze G, Gallo G, Kazemi Nava A, Romano M, Di Tanna GL, Zanus G
Eur J Surg Oncol 2021 Nov;47(11):2893-2899. Epub 2021 May 14 doi: 10.1016/j.ejso.2021.05.021. PMID: 34052038
Unexpected Prolonged Survival After Extended and Emergent Resection of Pancreatic Metastases from Renal Cell Carcinoma.
Brozzetti S, Sterpetti AV
J Gastrointest Cancer 2019 Dec;50(4):1055-1058. doi: 10.1007/s12029-019-00209-w. PMID: 30767105
Liver transplantation for hepatic tumors: a systematic review.
Ravaioli M, Ercolani G, Neri F, Cescon M, Stacchini G, Del Gaudio M, Cucchetti A, Pinna AD
World J Gastroenterol 2014 May 14;20(18):5345-52. doi: 10.3748/wjg.v20.i18.5345. PMID: 24833864Free PMC Article

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