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Recurrent Ovarian Transitional Cell Carcinoma

MedGen UID:
1650819
•Concept ID:
C4727422
•
Neoplastic Process

Definition

The reemergence of ovarian transitional cell carcinoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Ovarian Transitional Cell Carcinoma

Professional guidelines

PubMed

Bevacizumab combined with chemotherapy in the treatment of recurrence or platinum-refractory ovarian cancer: a retrospective study of 37 cases.
Li Y, Yang Y, Shang YM, Zheng H
Indian J Cancer 2014 Mar;51 Suppl 3:e92-4. doi: 10.4103/0019-509X.154079. PMID: 25818742
Patterns of recurrence in patients treated with bevacizumab in the primary treatment of advanced epithelial ovarian cancer.
Rauh-Hain JA, Guseh SH, Esselen KM, Growdon WB, Schorge JO, Horowitz NS, Krasner CN, del Carmen MG, Birrer MJ, Dizon DS
Int J Gynecol Cancer 2013 Sep;23(7):1219-25. doi: 10.1097/IGC.0b013e31829f17c9. PMID: 23975042
When 'never-events' occur despite adherence to clinical guidelines: the case of venous thromboembolism in clear cell cancer of the ovary compared with other epithelial histologic subtypes.
Duska LR, Garrett L, Henretta M, Ferriss JS, Lee L, Horowitz N
Gynecol Oncol 2010 Mar;116(3):374-7. doi: 10.1016/j.ygyno.2009.10.069. PMID: 19922988

Recent clinical studies

Etiology

Molecular analysis of endometrial serous carcinoma reveals distinct clinicopathologic and genomic subgroups.
Lin DI, Fine A, Danziger NA, Huang RSP, Mata DA, Decker B, Killian JK, Ramkissoon SH, Lechpammer M, Janovitz T, Ross JS, Sokol ES, Elvin JA
Gynecol Oncol 2022 Mar;164(3):558-565. Epub 2022 Jan 5 doi: 10.1016/j.ygyno.2021.12.030. PMID: 34998597
Phase 1 and 2 study of carboplatin and pralatrexate in patients with recurrent, platinum-sensitive ovarian, fallopian tube, or primary peritoneal cancer.
Del Carmen MG, Supko JG, Horick NK, Rauh-Hain JA, Clark RM, Campos SM, Krasner CN, Atkinson T, Birrer MJ
Cancer 2016 Nov 15;122(21):3297-3306. Epub 2016 Jul 15 doi: 10.1002/cncr.30196. PMID: 27421044
Prognostic relevance of uncommon ovarian histology in women with stage III/IV epithelial ovarian cancer.
Mackay HJ, Brady MF, Oza AM, Reuss A, Pujade-Lauraine E, Swart AM, Siddiqui N, Colombo N, Bookman MA, Pfisterer J, du Bois A; Gynecologic Cancer InterGroup
Int J Gynecol Cancer 2010 Aug;20(6):945-52. doi: 10.1111/IGC.0b013e3181dd0110. PMID: 20683400
Transitional cell carcinoma of the endometrium and endometrial carcinoma with transitional cell differentiation.
Lininger RA, Ashfaq R, Albores-Saavedra J, Tavassoli FA
Cancer 1997 May 15;79(10):1933-43. PMID: 9149020
Ovarian carcinomas with transitional cell carcinoma pattern.
Silva EG, Robey-Cafferty SS, Smith TL, Gershenson DM
Am J Clin Pathol 1990 Apr;93(4):457-65. doi: 10.1093/ajcp/93.4.457. PMID: 2321577

Diagnosis

Extrauterine Mesonephric-like Carcinoma: A Comprehensive Single Institution Study of 33 Cases.
Euscher ED, Marques-Piubelli ML, Ramalingam P, Wistuba I, Lawson BC, Frumovitz M, Malpica A
Am J Surg Pathol 2023 Jun 1;47(6):635-648. Epub 2023 Apr 6 doi: 10.1097/PAS.0000000000002039. PMID: 37026792
Molecular analysis of endometrial serous carcinoma reveals distinct clinicopathologic and genomic subgroups.
Lin DI, Fine A, Danziger NA, Huang RSP, Mata DA, Decker B, Killian JK, Ramkissoon SH, Lechpammer M, Janovitz T, Ross JS, Sokol ES, Elvin JA
Gynecol Oncol 2022 Mar;164(3):558-565. Epub 2022 Jan 5 doi: 10.1016/j.ygyno.2021.12.030. PMID: 34998597
Recurrent urothelial carcinoma-like FGFR3 genomic alterations in malignant Brenner tumors of the ovary.
Lin DI, Killian JK, Venstrom JM, Ramkissoon SH, Ross JS, Elvin JA
Mod Pathol 2021 May;34(5):983-993. Epub 2020 Oct 19 doi: 10.1038/s41379-020-00699-1. PMID: 33077920
Papillary squamotransitional cell carcinoma of the uterine cervix: a case report and review of the literature.
Gitas G, Ertan K, Rody A, Baum S, Tsolakidis D, Alkatout I
J Med Case Rep 2019 Oct 27;13(1):319. doi: 10.1186/s13256-019-2217-2. PMID: 31655625Free PMC Article
Mutational profiles of Brenner tumors show distinctive features uncoupling urothelial carcinomas and ovarian carcinoma with transitional cell histology.
Pfarr N, Darb-Esfahani S, Leichsenring J, Taube E, Boxberg M, Braicu I, Jesinghaus M, Penzel R, Endris V, Noske A, Weichert W, Schirmacher P, Denkert C, Stenzinger A
Genes Chromosomes Cancer 2017 Oct;56(10):758-766. Epub 2017 Jul 25 doi: 10.1002/gcc.22480. PMID: 28639280

Therapy

Phase 1 and 2 study of carboplatin and pralatrexate in patients with recurrent, platinum-sensitive ovarian, fallopian tube, or primary peritoneal cancer.
Del Carmen MG, Supko JG, Horick NK, Rauh-Hain JA, Clark RM, Campos SM, Krasner CN, Atkinson T, Birrer MJ
Cancer 2016 Nov 15;122(21):3297-3306. Epub 2016 Jul 15 doi: 10.1002/cncr.30196. PMID: 27421044
New insights on the pathogenesis of ovarian carcinoma: molecular basis and clinical implications.
Gadducci A, Guerrieri ME, Genazzani AR
Gynecol Endocrinol 2012 Aug;28(8):582-6. Epub 2012 Feb 4 doi: 10.3109/09513590.2011.649595. PMID: 22304686
Prognostic relevance of uncommon ovarian histology in women with stage III/IV epithelial ovarian cancer.
Mackay HJ, Brady MF, Oza AM, Reuss A, Pujade-Lauraine E, Swart AM, Siddiqui N, Colombo N, Bookman MA, Pfisterer J, du Bois A; Gynecologic Cancer InterGroup
Int J Gynecol Cancer 2010 Aug;20(6):945-52. doi: 10.1111/IGC.0b013e3181dd0110. PMID: 20683400
Renal-ovarian axis: a case report and review.
Gavallos G, Tawfik O, Herrell D, Langenstroer P
Urology 2003 Oct;62(4):749. doi: 10.1016/s0090-4295(03)00585-5. PMID: 14550464
Ovarian carcinomas with transitional cell carcinoma pattern.
Silva EG, Robey-Cafferty SS, Smith TL, Gershenson DM
Am J Clin Pathol 1990 Apr;93(4):457-65. doi: 10.1093/ajcp/93.4.457. PMID: 2321577

Prognosis

Extrauterine Mesonephric-like Carcinoma: A Comprehensive Single Institution Study of 33 Cases.
Euscher ED, Marques-Piubelli ML, Ramalingam P, Wistuba I, Lawson BC, Frumovitz M, Malpica A
Am J Surg Pathol 2023 Jun 1;47(6):635-648. Epub 2023 Apr 6 doi: 10.1097/PAS.0000000000002039. PMID: 37026792
Molecular analysis of endometrial serous carcinoma reveals distinct clinicopathologic and genomic subgroups.
Lin DI, Fine A, Danziger NA, Huang RSP, Mata DA, Decker B, Killian JK, Ramkissoon SH, Lechpammer M, Janovitz T, Ross JS, Sokol ES, Elvin JA
Gynecol Oncol 2022 Mar;164(3):558-565. Epub 2022 Jan 5 doi: 10.1016/j.ygyno.2021.12.030. PMID: 34998597
Recurrent urothelial carcinoma-like FGFR3 genomic alterations in malignant Brenner tumors of the ovary.
Lin DI, Killian JK, Venstrom JM, Ramkissoon SH, Ross JS, Elvin JA
Mod Pathol 2021 May;34(5):983-993. Epub 2020 Oct 19 doi: 10.1038/s41379-020-00699-1. PMID: 33077920
Papillary squamotransitional cell carcinoma of the uterine cervix: a case report and review of the literature.
Gitas G, Ertan K, Rody A, Baum S, Tsolakidis D, Alkatout I
J Med Case Rep 2019 Oct 27;13(1):319. doi: 10.1186/s13256-019-2217-2. PMID: 31655625Free PMC Article
Ovarian carcinomas with transitional cell carcinoma pattern.
Silva EG, Robey-Cafferty SS, Smith TL, Gershenson DM
Am J Clin Pathol 1990 Apr;93(4):457-65. doi: 10.1093/ajcp/93.4.457. PMID: 2321577

Clinical prediction guides

Extrauterine Mesonephric-like Carcinoma: A Comprehensive Single Institution Study of 33 Cases.
Euscher ED, Marques-Piubelli ML, Ramalingam P, Wistuba I, Lawson BC, Frumovitz M, Malpica A
Am J Surg Pathol 2023 Jun 1;47(6):635-648. Epub 2023 Apr 6 doi: 10.1097/PAS.0000000000002039. PMID: 37026792
Molecular analysis of endometrial serous carcinoma reveals distinct clinicopathologic and genomic subgroups.
Lin DI, Fine A, Danziger NA, Huang RSP, Mata DA, Decker B, Killian JK, Ramkissoon SH, Lechpammer M, Janovitz T, Ross JS, Sokol ES, Elvin JA
Gynecol Oncol 2022 Mar;164(3):558-565. Epub 2022 Jan 5 doi: 10.1016/j.ygyno.2021.12.030. PMID: 34998597
Mutational profiles of Brenner tumors show distinctive features uncoupling urothelial carcinomas and ovarian carcinoma with transitional cell histology.
Pfarr N, Darb-Esfahani S, Leichsenring J, Taube E, Boxberg M, Braicu I, Jesinghaus M, Penzel R, Endris V, Noske A, Weichert W, Schirmacher P, Denkert C, Stenzinger A
Genes Chromosomes Cancer 2017 Oct;56(10):758-766. Epub 2017 Jul 25 doi: 10.1002/gcc.22480. PMID: 28639280
Prognostic value of CA 125 in transitional cell carcinoma of the bladder.
Manvar AM, Wallen EM, Pruthi RS, Nielsen ME
Expert Rev Anticancer Ther 2010 Dec;10(12):1877-81. doi: 10.1586/era.10.186. PMID: 21110754
Prognostic relevance of uncommon ovarian histology in women with stage III/IV epithelial ovarian cancer.
Mackay HJ, Brady MF, Oza AM, Reuss A, Pujade-Lauraine E, Swart AM, Siddiqui N, Colombo N, Bookman MA, Pfisterer J, du Bois A; Gynecologic Cancer InterGroup
Int J Gynecol Cancer 2010 Aug;20(6):945-52. doi: 10.1111/IGC.0b013e3181dd0110. PMID: 20683400

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