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Malignant teratoma

MedGen UID:
1652407
•Concept ID:
C4722083
•
Neoplastic Process
Synonyms: Grade 3 Teratoma; Malignant Teratoma; malignant teratoma; teratoma, malignant
 
Monarch Initiative: MONDO:0003514

Definition

A teratoma composed exclusively of immature tissues. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant teratoma

Professional guidelines

PubMed

Primary Mediastinal Nonseminomas: A Population-Based Surveillance, Epidemiology, and End Results Analysis.
Yang X, Zhao K, Mei J, Wei S, Xia L, Pu Y, Liu L
J Surg Res 2021 Nov;267:25-36. Epub 2021 Jun 11 doi: 10.1016/j.jss.2021.04.022. PMID: 34126390
Treatment and survival of primary intracranial germ cell tumors: a population-based study using SEER database.
Denyer S, Bhimani AD, Patil SN, Mudreac A, Behbahani M, Mehta AI
J Cancer Res Clin Oncol 2020 Mar;146(3):671-685. Epub 2019 Nov 19 doi: 10.1007/s00432-019-03088-7. PMID: 31745701
Malignant teratoma of the ovary: prognostic factors and treatment.
Curry SL, Smith JP, Gallagher HS
Am J Obstet Gynecol 1978 Aug 15;131(8):845-9. doi: 10.1016/s0002-9378(16)33128-3. PMID: 686082

Recent clinical studies

Etiology

Clinical Features and Survival Outcomes in Children and Adolescents With Malignant Mediastinal Germ Cell Tumors Based on Surveillance, Epidemiology, and End Results Database Analysis.
Wu P, Yang Y, Yu Z, Zhao L, Feng S
J Surg Res 2023 Aug;288:362-371. Epub 2023 Apr 14 doi: 10.1016/j.jss.2023.03.018. PMID: 37062232
The differences between gonadal and extra-gonadal malignant teratomas in both genders and the effects of chemotherapy.
Sun H, Ding H, Wang J, Zhang E, Fang Y, Li Z, Yu X, Wang C, Zhao Y, Chen K, Wen S, Li L, Shan S, Hong L, Chen F, Su P
BMC Cancer 2019 Apr 30;19(1):408. doi: 10.1186/s12885-019-5598-0. PMID: 31039746Free PMC Article
Dermoid Cyst and its bizarre presentation.
Pradhan P, Thapa M
JNMA J Nepal Med Assoc 2014 Apr-Jun;52(194):837-44. PMID: 26905716
Sinonasal teratocarcinosarcoma.
Su YY, Friedman M, Huang CC, Wilson M, Lin HC
Am J Otolaryngol 2010 Jul-Aug;31(4):300-3. Epub 2009 May 19 doi: 10.1016/j.amjoto.2009.02.022. PMID: 20015764
Vasectomy and the human testis.
McDonald SW
BMJ 1990 Sep 29;301(6753):618-9. doi: 10.1136/bmj.301.6753.618. PMID: 2224212Free PMC Article

Diagnosis

Malignant teratoma of the thyroid.
Bidaye R, Mahmood A, Abdawn Z, Ahmad I
BMJ Case Rep 2021 Jul 28;14(7) doi: 10.1136/bcr-2021-242534. PMID: 34321262Free PMC Article
Malignant teratoma of the thyroid: A difficult diagnosis by fine-needle aspiration.
Starling CE, Sabra J, Brady B, Horton M, Traweek ST
Diagn Cytopathol 2019 Sep;47(9):930-934. Epub 2019 May 23 doi: 10.1002/dc.24216. PMID: 31120625
Dermoid Cyst and its bizarre presentation.
Pradhan P, Thapa M
JNMA J Nepal Med Assoc 2014 Apr-Jun;52(194):837-44. PMID: 26905716
Sinonasal teratocarcinosarcoma.
Su YY, Friedman M, Huang CC, Wilson M, Lin HC
Am J Otolaryngol 2010 Jul-Aug;31(4):300-3. Epub 2009 May 19 doi: 10.1016/j.amjoto.2009.02.022. PMID: 20015764
Malignant teratoma of the thyroid: aggressive chemoradiation therapy is required after surgery.
Tsang RW, Brierley JD, Asa SL, Sturgeon JF
Thyroid 2003 Apr;13(4):401-4. doi: 10.1089/105072503321669901. PMID: 12804109

Therapy

Metastatic malignant struma ovarii: a case report and review of the literature on the management of malignant struma ovarii.
Taelman V, Boer M, Taelman P
Acta Clin Belg 2022 Jun;77(3):721-725. Epub 2021 Jun 30 doi: 10.1080/17843286.2021.1944583. PMID: 34191687
Cervical malignant teratoma masquerading as a hematoma: a case report.
Lin HJ, Hsu CY, Tsai SC
J Int Med Res 2021 Feb;49(2):300060520984597. doi: 10.1177/0300060520984597. PMID: 33530806Free PMC Article
Treatment and survival of primary intracranial germ cell tumors: a population-based study using SEER database.
Denyer S, Bhimani AD, Patil SN, Mudreac A, Behbahani M, Mehta AI
J Cancer Res Clin Oncol 2020 Mar;146(3):671-685. Epub 2019 Nov 19 doi: 10.1007/s00432-019-03088-7. PMID: 31745701
The differences between gonadal and extra-gonadal malignant teratomas in both genders and the effects of chemotherapy.
Sun H, Ding H, Wang J, Zhang E, Fang Y, Li Z, Yu X, Wang C, Zhao Y, Chen K, Wen S, Li L, Shan S, Hong L, Chen F, Su P
BMC Cancer 2019 Apr 30;19(1):408. doi: 10.1186/s12885-019-5598-0. PMID: 31039746Free PMC Article
Vasectomy and the human testis.
McDonald SW
BMJ 1990 Sep 29;301(6753):618-9. doi: 10.1136/bmj.301.6753.618. PMID: 2224212Free PMC Article

Prognosis

Clinical Features and Survival Outcomes in Children and Adolescents With Malignant Mediastinal Germ Cell Tumors Based on Surveillance, Epidemiology, and End Results Database Analysis.
Wu P, Yang Y, Yu Z, Zhao L, Feng S
J Surg Res 2023 Aug;288:362-371. Epub 2023 Apr 14 doi: 10.1016/j.jss.2023.03.018. PMID: 37062232
Primary Mediastinal Nonseminomas: A Population-Based Surveillance, Epidemiology, and End Results Analysis.
Yang X, Zhao K, Mei J, Wei S, Xia L, Pu Y, Liu L
J Surg Res 2021 Nov;267:25-36. Epub 2021 Jun 11 doi: 10.1016/j.jss.2021.04.022. PMID: 34126390
A SEER database study of malignant teratomas in the head and neck region.
Ramsey T, Curran K, Mouzakes J, Gildener-Leapman N, Galati L
Int J Pediatr Otorhinolaryngol 2021 May;144:110672. Epub 2021 Mar 11 doi: 10.1016/j.ijporl.2021.110672. PMID: 33740550
Prevalence, clinical features and prognosis of malignant solid tumors in infants: a 14-year study.
Zhi T, Zhang WL, Zhang Y, Wang YZ, Huang DS
Bosn J Basic Med Sci 2021 Oct 1;21(5):598-606. doi: 10.17305/bjbms.2020.5121. PMID: 33259778Free PMC Article
The differences between gonadal and extra-gonadal malignant teratomas in both genders and the effects of chemotherapy.
Sun H, Ding H, Wang J, Zhang E, Fang Y, Li Z, Yu X, Wang C, Zhao Y, Chen K, Wen S, Li L, Shan S, Hong L, Chen F, Su P
BMC Cancer 2019 Apr 30;19(1):408. doi: 10.1186/s12885-019-5598-0. PMID: 31039746Free PMC Article

Clinical prediction guides

Primary Mediastinal Nonseminomas: A Population-Based Surveillance, Epidemiology, and End Results Analysis.
Yang X, Zhao K, Mei J, Wei S, Xia L, Pu Y, Liu L
J Surg Res 2021 Nov;267:25-36. Epub 2021 Jun 11 doi: 10.1016/j.jss.2021.04.022. PMID: 34126390
Malignant thyroid teratoma: an integrated analysis of case series/case reports.
Vuong HG, Nguyen TPX, Ngo HTT, Hassell L, Kakudo K
Endocr Relat Cancer 2021 Jun 17;28(7):495-503. doi: 10.1530/ERC-21-0142. PMID: 34010145
The differences between gonadal and extra-gonadal malignant teratomas in both genders and the effects of chemotherapy.
Sun H, Ding H, Wang J, Zhang E, Fang Y, Li Z, Yu X, Wang C, Zhao Y, Chen K, Wen S, Li L, Shan S, Hong L, Chen F, Su P
BMC Cancer 2019 Apr 30;19(1):408. doi: 10.1186/s12885-019-5598-0. PMID: 31039746Free PMC Article
Tumours around the foramen of Monro: clinical and neuroimaging features and their differential diagnosis.
Nishio S, Morioka T, Suzuki S, Fukui M
J Clin Neurosci 2002 Mar;9(2):137-41. doi: 10.1054/jocn.2000.0910. PMID: 11922700
Clues from natural history and results of treatment supporting the monoclonal origin of germ cell tumours.
Oliver RT
Cancer Surv 1990;9(2):333-68. PMID: 1964626

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