U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Locally Advanced Chordoma

MedGen UID:
1654752
•Concept ID:
C4727171
•
Neoplastic Process

Definition

A chordoma that has spread from its original site of growth to nearby tissues. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Chordoma

Professional guidelines

PubMed

Medical treatment of advanced chordomas.
Colia V, Stacchiotti S
Eur J Cancer 2017 Sep;83:220-228. Epub 2017 Jul 25 doi: 10.1016/j.ejca.2017.06.038. PMID: 28750274
Contemporary management of clival chordomas.
Campbell RG, Prevedello DM, Ditzel Filho L, Otto BA, Carrau RL
Curr Opin Otolaryngol Head Neck Surg 2015 Apr;23(2):153-61. doi: 10.1097/MOO.0000000000000140. PMID: 25692630
Chordoma: current concepts, management, and future directions.
Walcott BP, Nahed BV, Mohyeldin A, Coumans JV, Kahle KT, Ferreira MJ
Lancet Oncol 2012 Feb;13(2):e69-76. doi: 10.1016/S1470-2045(11)70337-0. PMID: 22300861

Recent clinical studies

Etiology

Pembrolizumab in patients with rare and ultra-rare sarcomas (AcSé Pembrolizumab): analysis of a subgroup from a non-randomised, open-label, phase 2, basket trial.
Blay JY, Chevret S, Le Cesne A, Brahmi M, Penel N, Cousin S, Bertucci F, Bompas E, Ryckewaert T, Soibinet P, Boudou-Rouquette P, Saada Bouzid E, Soulie P, Valentin T, Lotz JP, Tosi D, Neviere Z, Cancel M, Ray-Coquard I, Gambotti L, Legrand F, Lamrani-Ghaouti A, Simon C, Even C, Massard C
Lancet Oncol 2023 Aug;24(8):892-902. Epub 2023 Jul 7 doi: 10.1016/S1470-2045(23)00282-6. PMID: 37429302
Economics of the Management of Craniospinal Chordoma and Chondrosarcoma and the feasibility of the bundled payment model.
Aljuboori Z, Ugiliweneza B, Wang D, Andaluz N, Boakye M, Williams B
BMC Neurol 2020 Aug 21;20(1):312. doi: 10.1186/s12883-020-01850-w. PMID: 32825828Free PMC Article
Systematic assessment of clinical outcomes and toxicities of proton radiotherapy for reirradiation.
Verma V, Rwigema JM, Malyapa RS, Regine WF, Simone CB 2nd
Radiother Oncol 2017 Oct;125(1):21-30. Epub 2017 Sep 20 doi: 10.1016/j.radonc.2017.08.005. PMID: 28941560
Proton therapy for sarcomas.
Keole S, Ashman JB, Daniels TB
Cancer J 2014 Nov-Dec;20(6):409-14. doi: 10.1097/PPO.0000000000000084. PMID: 25415687
The evolution of systemic therapy in sarcoma.
Constantinidou A, Pollack S, Loggers E, Rodler E, Jones RL
Expert Rev Anticancer Ther 2013 Feb;13(2):211-23. doi: 10.1586/era.12.161. PMID: 23406562

Diagnosis

Chordoma of the sacrum and mobile spine: a narrative review.
Pennington Z, Ehresman J, McCarthy EF, Ahmed AK, Pittman PD, Lubelski D, Goodwin CR, Sciubba DM
Spine J 2021 Mar;21(3):500-517. Epub 2020 Oct 10 doi: 10.1016/j.spinee.2020.10.009. PMID: 33589095
Cardiac Metastasis of Sacral Chordoma.
Stefàno PL, Barletta G, Andrei V, Cerillo AG, Nesi G, Pilato G, Pradella S, Santi R, Del Bene MR
Ann Thorac Surg 2021 May;111(5):e319-e321. Epub 2020 Oct 29 doi: 10.1016/j.athoracsur.2020.07.093. PMID: 33129773
New Prospects for Molecular Targets for Chordomas.
Ozair MZ, Shah PP, Mathios D, Lim M, Moss NS
Neurosurg Clin N Am 2020 Apr;31(2):289-300. Epub 2020 Jan 25 doi: 10.1016/j.nec.2019.11.004. PMID: 32147018Free PMC Article
Contemporary management of clival chordomas.
Campbell RG, Prevedello DM, Ditzel Filho L, Otto BA, Carrau RL
Curr Opin Otolaryngol Head Neck Surg 2015 Apr;23(2):153-61. doi: 10.1097/MOO.0000000000000140. PMID: 25692630
Chordoma: current concepts, management, and future directions.
Walcott BP, Nahed BV, Mohyeldin A, Coumans JV, Kahle KT, Ferreira MJ
Lancet Oncol 2012 Feb;13(2):e69-76. doi: 10.1016/S1470-2045(11)70337-0. PMID: 22300861

Therapy

Pembrolizumab in patients with rare and ultra-rare sarcomas (AcSé Pembrolizumab): analysis of a subgroup from a non-randomised, open-label, phase 2, basket trial.
Blay JY, Chevret S, Le Cesne A, Brahmi M, Penel N, Cousin S, Bertucci F, Bompas E, Ryckewaert T, Soibinet P, Boudou-Rouquette P, Saada Bouzid E, Soulie P, Valentin T, Lotz JP, Tosi D, Neviere Z, Cancel M, Ray-Coquard I, Gambotti L, Legrand F, Lamrani-Ghaouti A, Simon C, Even C, Massard C
Lancet Oncol 2023 Aug;24(8):892-902. Epub 2023 Jul 7 doi: 10.1016/S1470-2045(23)00282-6. PMID: 37429302
Chordoma: a case series and review of the literature.
Alan O, Akin Telli T, Ercelep O, Tanrikulu Simsek E, Basoglu Tuylu T, Mutis A, Hasanov R, Kaya S, Akgül Babacan N, Dane F, Yumuk PF
J Med Case Rep 2018 Aug 27;12(1):239. doi: 10.1186/s13256-018-1784-y. PMID: 30145982Free PMC Article
Medical treatment of advanced chordomas.
Colia V, Stacchiotti S
Eur J Cancer 2017 Sep;83:220-228. Epub 2017 Jul 25 doi: 10.1016/j.ejca.2017.06.038. PMID: 28750274
Proton therapy for sarcomas.
Keole S, Ashman JB, Daniels TB
Cancer J 2014 Nov-Dec;20(6):409-14. doi: 10.1097/PPO.0000000000000084. PMID: 25415687
Chordoma: current concepts, management, and future directions.
Walcott BP, Nahed BV, Mohyeldin A, Coumans JV, Kahle KT, Ferreira MJ
Lancet Oncol 2012 Feb;13(2):e69-76. doi: 10.1016/S1470-2045(11)70337-0. PMID: 22300861

Prognosis

Shedding light on emerging therapeutic targets for chordoma.
Martinez Moreno M, Wang E, Schroeder C, Sullivan P, Gokaslan Z
Expert Opin Ther Targets 2023 Jul-Dec;27(8):705-713. Epub 2023 Aug 30 doi: 10.1080/14728222.2023.2248382. PMID: 37647357
Chordoma: a case series and review of the literature.
Alan O, Akin Telli T, Ercelep O, Tanrikulu Simsek E, Basoglu Tuylu T, Mutis A, Hasanov R, Kaya S, Akgül Babacan N, Dane F, Yumuk PF
J Med Case Rep 2018 Aug 27;12(1):239. doi: 10.1186/s13256-018-1784-y. PMID: 30145982Free PMC Article
Contemporary management of clival chordomas.
Campbell RG, Prevedello DM, Ditzel Filho L, Otto BA, Carrau RL
Curr Opin Otolaryngol Head Neck Surg 2015 Apr;23(2):153-61. doi: 10.1097/MOO.0000000000000140. PMID: 25692630
Molecular targeted therapies in advanced or metastatic chordoma patients: facts and hypotheses.
Lebellec L, Aubert S, Zaïri F, Ryckewaert T, Chauffert B, Penel N
Crit Rev Oncol Hematol 2015 Jul;95(1):125-31. Epub 2015 Jan 30 doi: 10.1016/j.critrevonc.2015.01.010. PMID: 25682222
Chordoma: current concepts, management, and future directions.
Walcott BP, Nahed BV, Mohyeldin A, Coumans JV, Kahle KT, Ferreira MJ
Lancet Oncol 2012 Feb;13(2):e69-76. doi: 10.1016/S1470-2045(11)70337-0. PMID: 22300861

Clinical prediction guides

Shedding light on emerging therapeutic targets for chordoma.
Martinez Moreno M, Wang E, Schroeder C, Sullivan P, Gokaslan Z
Expert Opin Ther Targets 2023 Jul-Dec;27(8):705-713. Epub 2023 Aug 30 doi: 10.1080/14728222.2023.2248382. PMID: 37647357
Randomized, Double-Blind, Placebo-Controlled Phase II Study of Yeast-Brachyury Vaccine (GI-6301) in Combination with Standard-of-Care Radiotherapy in Locally Advanced, Unresectable Chordoma.
DeMaria PJ, Bilusic M, Park DM, Heery CR, Donahue RN, Madan RA, Bagheri MH, Strauss J, Shen V, Marté JL, Steinberg SM, Schlom J, Gilbert MR, Gulley JL
Oncologist 2021 May;26(5):e847-e858. Epub 2021 Mar 9 doi: 10.1002/onco.13720. PMID: 33594772Free PMC Article
Genomic and transcriptomic characterization of skull base chordoma.
Sa JK, Lee IH, Hong SD, Kong DS, Nam DH
Oncotarget 2017 Jan 3;8(1):1321-1328. doi: 10.18632/oncotarget.13616. PMID: 27901492Free PMC Article
Chordoma: the entity.
Yakkioui Y, van Overbeeke JJ, Santegoeds R, van Engeland M, Temel Y
Biochim Biophys Acta 2014 Dec;1846(2):655-69. Epub 2014 Sep 3 doi: 10.1016/j.bbcan.2014.07.012. PMID: 25193090
Chordoma: clinical characteristics, management and prognosis of a case series of 25 patients.
Ferraresi V, Nuzzo C, Zoccali C, Marandino F, Vidiri A, Salducca N, Zeuli M, Giannarelli D, Cognetti F, Biagini R
BMC Cancer 2010 Jan 28;10:22. doi: 10.1186/1471-2407-10-22. PMID: 20109225Free PMC Article

Recent systematic reviews

Efficacy and safety of carbon ion radiotherapy for bone sarcomas: a systematic review and meta-analysis.
Dong M, Liu R, Zhang Q, Luo H, Wang D, Wang Y, Chen J, Ou Y, Wang X
Radiat Oncol 2022 Oct 25;17(1):172. doi: 10.1186/s13014-022-02089-0. PMID: 36284346Free PMC Article
Surgical management of chordoma: A systematic review.
Denaro L, Berton A, Ciuffreda M, Loppini M, Candela V, Brandi ML, Longo UG
J Spinal Cord Med 2020 Nov;43(6):797-812. Epub 2018 Jul 26 doi: 10.1080/10790268.2018.1483593. PMID: 30048230Free PMC Article
Systematic assessment of clinical outcomes and toxicities of proton radiotherapy for reirradiation.
Verma V, Rwigema JM, Malyapa RS, Regine WF, Simone CB 2nd
Radiother Oncol 2017 Oct;125(1):21-30. Epub 2017 Sep 20 doi: 10.1016/j.radonc.2017.08.005. PMID: 28941560
Clivus chordomas: a systematic review and meta-analysis of contemporary surgical management.
Labidi M, Watanabe K, Bouazza S, Bresson D, Bernat AL, George B, Froelich S
J Neurosurg Sci 2016 Dec;60(4):476-84. Epub 2016 Jun 15 PMID: 27303859
Proton therapy in chordoma of the base of the skull: a systematic review.
Amichetti M, Cianchetti M, Amelio D, Enrici RM, Minniti G
Neurosurg Rev 2009 Oct;32(4):403-16. Epub 2009 Mar 25 doi: 10.1007/s10143-009-0194-4. PMID: 19319583

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...