U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Periventricular Leukomalacia, AE

MedGen UID:
1655107
•Concept ID:
C4723745
•
Finding
Synonym: Periventricular Leukomalacia, Adverse Event

Definition

An adverse event in a newborn characterized by a form of cerebral white matter injury usually seen in preterm infants that is characterized by necrotic degeneration or gliosis of white matter adjacent to the cerebral ventricles that may evolve into focal cysts. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPeriventricular Leukomalacia, AE

Professional guidelines

PubMed

Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates.
Pammi M, Haque KN
Cochrane Database Syst Rev 2023 Jun 20;6(6):CD004205. doi: 10.1002/14651858.CD004205.pub4. PMID: 37338074Free PMC Article
Pentoxifylline for treatment of sepsis and necrotizing enterocolitis in neonates.
Pammi M, Haque KN
Cochrane Database Syst Rev 2015 Mar 9;(3):CD004205. doi: 10.1002/14651858.CD004205.pub3. PMID: 25751631
Vasopressin and its analogues for the treatment of refractory hypotension in neonates.
Shivanna B, Rios D, Rossano J, Fernandes CJ, Pammi M
Cochrane Database Syst Rev 2013 Mar 28;(3):CD009171. doi: 10.1002/14651858.CD009171.pub2. PMID: 23543571

Recent clinical studies

Etiology

Carbon dioxide levels in neonates: what are safe parameters?
Wong SK, Chim M, Allen J, Butler A, Tyrrell J, Hurley T, McGovern M, Omer M, Lagan N, Meehan J, Cummins EP, Molloy EJ
Pediatr Res 2022 Apr;91(5):1049-1056. Epub 2021 Jul 6 doi: 10.1038/s41390-021-01473-y. PMID: 34230621Free PMC Article
Sound reduction management in the neonatal intensive care unit for preterm or very low birth weight infants.
Almadhoob A, Ohlsson A
Cochrane Database Syst Rev 2020 Jan 27;1(1):CD010333. doi: 10.1002/14651858.CD010333.pub3. PMID: 31986231Free PMC Article
Gardnerella vaginalis in perinatology: An overview of the clinicopathological correlation.
Wong YP, Tan GC, Wong KK, Anushia S, Cheah FC
Malays J Pathol 2018 Dec;40(3):267-286. PMID: 30580358
Perioperative neuroprotective strategies.
Nelson DP, Andropoulos DB, Fraser CD Jr
Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2008:49-56. doi: 10.1053/j.pcsu.2008.01.003. PMID: 18396225
Periventricular leukomalacia following neonatal and infant cardiac surgery.
Gaynor JW
Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2004;7:133-40. doi: 10.1053/j.pcsu.2004.02.007. PMID: 15283363

Diagnosis

Placental fetal vascular malperfusion, neonatal neurologic morbidity, and infant neurodevelopmental outcomes: a systematic review and meta-analysis.
Spinillo A, Dominoni M, Mas FD, Cesari S, Fiandrino G, Gardella B
Am J Obstet Gynecol 2023 Dec;229(6):632-640.e2. Epub 2023 Jun 12 doi: 10.1016/j.ajog.2023.06.014. PMID: 37315755
One vs 2 courses of antenatal corticosteroids in pregnancies at risk of preterm birth: a secondary analysis of the MACS trial.
Baghlaf H, Snelgrove JW, Li Q, Huszti E, McDonald SD, Asztalos E, Palermo MSF, Murphy KE
Am J Obstet Gynecol MFM 2023 Jul;5(7):101002. Epub 2023 May 4 doi: 10.1016/j.ajogmf.2023.101002. PMID: 37149145
Sound reduction management in the neonatal intensive care unit for preterm or very low birth weight infants.
Almadhoob A, Ohlsson A
Cochrane Database Syst Rev 2020 Jan 27;1(1):CD010333. doi: 10.1002/14651858.CD010333.pub3. PMID: 31986231Free PMC Article
Cerebral near-infrared spectroscopy monitoring for prevention of brain injury in very preterm infants.
Hyttel-Sorensen S, Greisen G, Als-Nielsen B, Gluud C
Cochrane Database Syst Rev 2017 Sep 4;9(9):CD011506. doi: 10.1002/14651858.CD011506.pub2. PMID: 28869278Free PMC Article
Periventricular leukomalacia following neonatal and infant cardiac surgery.
Gaynor JW
Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2004;7:133-40. doi: 10.1053/j.pcsu.2004.02.007. PMID: 15283363

Therapy

Carbon dioxide levels in neonates: what are safe parameters?
Wong SK, Chim M, Allen J, Butler A, Tyrrell J, Hurley T, McGovern M, Omer M, Lagan N, Meehan J, Cummins EP, Molloy EJ
Pediatr Res 2022 Apr;91(5):1049-1056. Epub 2021 Jul 6 doi: 10.1038/s41390-021-01473-y. PMID: 34230621Free PMC Article
Sound reduction management in the neonatal intensive care unit for preterm or very low birth weight infants.
Almadhoob A, Ohlsson A
Cochrane Database Syst Rev 2020 Jan 27;1(1):CD010333. doi: 10.1002/14651858.CD010333.pub3. PMID: 31986231Free PMC Article
What is the basis for a genetic approach in neonatal disorders?
Bhandari V, Gruen JR
Semin Perinatol 2015 Dec;39(8):568-73. Epub 2015 Oct 23 doi: 10.1053/j.semperi.2015.09.003. PMID: 26471062
Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy.
Morgan RA, Chinnasamy N, Abate-Daga D, Gros A, Robbins PF, Zheng Z, Dudley ME, Feldman SA, Yang JC, Sherry RM, Phan GQ, Hughes MS, Kammula US, Miller AD, Hessman CJ, Stewart AA, Restifo NP, Quezado MM, Alimchandani M, Rosenberg AZ, Nath A, Wang T, Bielekova B, Wuest SC, Akula N, McMahon FJ, Wilde S, Mosetter B, Schendel DJ, Laurencot CM, Rosenberg SA
J Immunother 2013 Feb;36(2):133-51. doi: 10.1097/CJI.0b013e3182829903. PMID: 23377668Free PMC Article
Perioperative neuroprotective strategies.
Nelson DP, Andropoulos DB, Fraser CD Jr
Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2008:49-56. doi: 10.1053/j.pcsu.2008.01.003. PMID: 18396225

Prognosis

One vs 2 courses of antenatal corticosteroids in pregnancies at risk of preterm birth: a secondary analysis of the MACS trial.
Baghlaf H, Snelgrove JW, Li Q, Huszti E, McDonald SD, Asztalos E, Palermo MSF, Murphy KE
Am J Obstet Gynecol MFM 2023 Jul;5(7):101002. Epub 2023 May 4 doi: 10.1016/j.ajogmf.2023.101002. PMID: 37149145
Higher versus lower amino acid intake in parenteral nutrition for newborn infants.
Osborn DA, Schindler T, Jones LJ, Sinn JK, Bolisetty S
Cochrane Database Syst Rev 2018 Mar 5;3(3):CD005949. doi: 10.1002/14651858.CD005949.pub2. PMID: 29505664Free PMC Article
Enteral lactoferrin supplementation for prevention of sepsis and necrotizing enterocolitis in preterm infants.
Pammi M, Suresh G
Cochrane Database Syst Rev 2017 Jun 28;6(6):CD007137. doi: 10.1002/14651858.CD007137.pub5. PMID: 28658720Free PMC Article
What is the basis for a genetic approach in neonatal disorders?
Bhandari V, Gruen JR
Semin Perinatol 2015 Dec;39(8):568-73. Epub 2015 Oct 23 doi: 10.1053/j.semperi.2015.09.003. PMID: 26471062
Volume-targeted versus pressure-limited ventilation for preterm infants: a systematic review and meta-analysis.
Wheeler KI, Klingenberg C, Morley CJ, Davis PG
Neonatology 2011;100(3):219-27. Epub 2011 Jun 22 doi: 10.1159/000326080. PMID: 21701210

Clinical prediction guides

Prediction of Periventricular Leukomalacia in Neonates after Cardiac Surgery Using Machine Learning Algorithms.
Jalali A, Simpao AF, Gálvez JA, Licht DJ, Nataraj C
J Med Syst 2018 Aug 17;42(10):177. doi: 10.1007/s10916-018-1029-z. PMID: 30116905
Intravenous midazolam infusion for sedation of infants in the neonatal intensive care unit.
Ng E, Taddio A, Ohlsson A
Cochrane Database Syst Rev 2017 Jan 31;1(1):CD002052. doi: 10.1002/14651858.CD002052.pub3. PMID: 28141899Free PMC Article
What is the basis for a genetic approach in neonatal disorders?
Bhandari V, Gruen JR
Semin Perinatol 2015 Dec;39(8):568-73. Epub 2015 Oct 23 doi: 10.1053/j.semperi.2015.09.003. PMID: 26471062
Vasopressin and its analogues for the treatment of refractory hypotension in neonates.
Shivanna B, Rios D, Rossano J, Fernandes CJ, Pammi M
Cochrane Database Syst Rev 2013 Mar 28;(3):CD009171. doi: 10.1002/14651858.CD009171.pub2. PMID: 23543571
Oxidative and nitrative injury in periventricular leukomalacia: a review.
Haynes RL, Baud O, Li J, Kinney HC, Volpe JJ, Folkerth DR
Brain Pathol 2005 Jul;15(3):225-33. doi: 10.1111/j.1750-3639.2005.tb00525.x. PMID: 16196389Free PMC Article

Recent systematic reviews

Nasal interfaces for neonatal resuscitation.
Ni Chathasaigh CM, Davis PG, O'Donnell CP, McCarthy LK
Cochrane Database Syst Rev 2023 Oct 3;10(10):CD009102. doi: 10.1002/14651858.CD009102.pub2. PMID: 37787113Free PMC Article
Placental fetal vascular malperfusion, neonatal neurologic morbidity, and infant neurodevelopmental outcomes: a systematic review and meta-analysis.
Spinillo A, Dominoni M, Mas FD, Cesari S, Fiandrino G, Gardella B
Am J Obstet Gynecol 2023 Dec;229(6):632-640.e2. Epub 2023 Jun 12 doi: 10.1016/j.ajog.2023.06.014. PMID: 37315755
Carbon dioxide levels in neonates: what are safe parameters?
Wong SK, Chim M, Allen J, Butler A, Tyrrell J, Hurley T, McGovern M, Omer M, Lagan N, Meehan J, Cummins EP, Molloy EJ
Pediatr Res 2022 Apr;91(5):1049-1056. Epub 2021 Jul 6 doi: 10.1038/s41390-021-01473-y. PMID: 34230621Free PMC Article
Sound reduction management in the neonatal intensive care unit for preterm or very low birth weight infants.
Almadhoob A, Ohlsson A
Cochrane Database Syst Rev 2020 Jan 27;1(1):CD010333. doi: 10.1002/14651858.CD010333.pub3. PMID: 31986231Free PMC Article
Vasopressin and its analogues for the treatment of refractory hypotension in neonates.
Shivanna B, Rios D, Rossano J, Fernandes CJ, Pammi M
Cochrane Database Syst Rev 2013 Mar 28;(3):CD009171. doi: 10.1002/14651858.CD009171.pub2. PMID: 23543571

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...