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Hereditary Gastric Diffuse Adenocarcinoma

MedGen UID:
1655189
Concept ID:
C4721859
Neoplastic Process
Synonym: Gastric Cancer, Familial Diffuse
SNOMED CT: Hereditary diffuse carcinoma of stomach (716859000); Hereditary diffuse gastric cancer (716859000); Familial diffuse gastric cancer (716859000); E-cadherin-associated hereditary gastric cancer (716859000)

Definition

An autosomal dominant inherited adenocarcinoma that arises from the gastric mucosa and is characterized by the presence of poorly cohesive malignant cells and absence of glandular formations. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHereditary Gastric Diffuse Adenocarcinoma

Professional guidelines

PubMed

Jacobson BC, Bhatt A, Greer KB, Lee LS, Park WG, Sauer BG, Shami VM
Am J Gastroenterol 2023 Jan 1;118(1):46-58. Epub 2022 Sep 6 doi: 10.14309/ajg.0000000000002100. PMID: 36602835
Lordick F, Carneiro F, Cascinu S, Fleitas T, Haustermans K, Piessen G, Vogel A, Smyth EC; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2022 Oct;33(10):1005-1020. Epub 2022 Jul 29 doi: 10.1016/j.annonc.2022.07.004. PMID: 35914639
Xia JY, Aadam AA
J Surg Oncol 2022 Jun;125(7):1104-1109. doi: 10.1002/jso.26844. PMID: 35481909Free PMC Article

Recent clinical studies

Etiology

Röcken C
J Cancer Res Clin Oncol 2023 Jan;149(1):467-481. Epub 2022 Oct 19 doi: 10.1007/s00432-022-04408-0. PMID: 36260159Free PMC Article
López MJ, Carbajal J, Alfaro AL, Saravia LG, Zanabria D, Araujo JM, Quispe L, Zevallos A, Buleje JL, Cho CE, Sarmiento M, Pinto JA, Fajardo W
Crit Rev Oncol Hematol 2023 Jan;181:103841. Epub 2022 Oct 11 doi: 10.1016/j.critrevonc.2022.103841. PMID: 36240980
Smyth EC, Nilsson M, Grabsch HI, van Grieken NC, Lordick F
Lancet 2020 Aug 29;396(10251):635-648. doi: 10.1016/S0140-6736(20)31288-5. PMID: 32861308
Machlowska J, Baj J, Sitarz M, Maciejewski R, Sitarz R
Int J Mol Sci 2020 Jun 4;21(11) doi: 10.3390/ijms21114012. PMID: 32512697Free PMC Article
Karimi P, Islami F, Anandasabapathy S, Freedman ND, Kamangar F
Cancer Epidemiol Biomarkers Prev 2014 May;23(5):700-13. Epub 2014 Mar 11 doi: 10.1158/1055-9965.EPI-13-1057. PMID: 24618998Free PMC Article

Diagnosis

Lordick F, Carneiro F, Cascinu S, Fleitas T, Haustermans K, Piessen G, Vogel A, Smyth EC; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2022 Oct;33(10):1005-1020. Epub 2022 Jul 29 doi: 10.1016/j.annonc.2022.07.004. PMID: 35914639
Ajani JA, D'Amico TA, Bentrem DJ, Chao J, Cooke D, Corvera C, Das P, Enzinger PC, Enzler T, Fanta P, Farjah F, Gerdes H, Gibson MK, Hochwald S, Hofstetter WL, Ilson DH, Keswani RN, Kim S, Kleinberg LR, Klempner SJ, Lacy J, Ly QP, Matkowskyj KA, McNamara M, Mulcahy MF, Outlaw D, Park H, Perry KA, Pimiento J, Poultsides GA, Reznik S, Roses RE, Strong VE, Su S, Wang HL, Wiesner G, Willett CG, Yakoub D, Yoon H, McMillian N, Pluchino LA
J Natl Compr Canc Netw 2022 Feb;20(2):167-192. doi: 10.6004/jnccn.2022.0008. PMID: 35130500
Smyth EC, Nilsson M, Grabsch HI, van Grieken NC, Lordick F
Lancet 2020 Aug 29;396(10251):635-648. doi: 10.1016/S0140-6736(20)31288-5. PMID: 32861308
Song Z, Wu Y, Yang J, Yang D, Fang X
Tumour Biol 2017 Jul;39(7):1010428317714626. doi: 10.1177/1010428317714626. PMID: 28671042
Karimi P, Islami F, Anandasabapathy S, Freedman ND, Kamangar F
Cancer Epidemiol Biomarkers Prev 2014 May;23(5):700-13. Epub 2014 Mar 11 doi: 10.1158/1055-9965.EPI-13-1057. PMID: 24618998Free PMC Article

Therapy

Chao J, Fuchs CS, Shitara K, Tabernero J, Muro K, Van Cutsem E, Bang YJ, De Vita F, Landers G, Yen CJ, Chau I, Elme A, Lee J, Özgüroglu M, Catenacci D, Yoon HH, Chen E, Adelberg D, Shih CS, Shah S, Bhagia P, Wainberg ZA
JAMA Oncol 2021 Jun 1;7(6):895-902. doi: 10.1001/jamaoncol.2021.0275. PMID: 33792646Free PMC Article
Sexton RE, Al Hallak MN, Diab M, Azmi AS
Cancer Metastasis Rev 2020 Dec;39(4):1179-1203. Epub 2020 Sep 7 doi: 10.1007/s10555-020-09925-3. PMID: 32894370Free PMC Article
Ford AC, Yuan Y, Moayyedi P
Gut 2020 Dec;69(12):2113-2121. Epub 2020 Mar 23 doi: 10.1136/gutjnl-2020-320839. PMID: 32205420
Bang YJ, Van Cutsem E, Fuchs CS, Ohtsu A, Tabernero J, Ilson DH, Hyung WJ, Strong VE, Goetze TO, Yoshikawa T, Tang LH, Hwang PMT, Webb N, Adelberg D, Shitara K
Future Oncol 2019 Mar;15(9):943-952. Epub 2019 Feb 19 doi: 10.2217/fon-2018-0581. PMID: 30777447
Yoshida K, Yamaguchi K, Okumura N, Tanahashi T, Kodera Y
Gastric Cancer 2016 Apr;19(2):329-338. Epub 2015 Dec 7 doi: 10.1007/s10120-015-0575-z. PMID: 26643880Free PMC Article

Prognosis

Sedeta E, Sung H, Laversanne M, Bray F, Jemal A
Cancer Epidemiol Biomarkers Prev 2023 Jul 5;32(7):894-905. doi: 10.1158/1055-9965.EPI-22-1133. PMID: 37195435
Yang WJ, Zhao HP, Yu Y, Wang JH, Guo L, Liu JY, Pu J, Lv J
World J Gastroenterol 2023 Apr 28;29(16):2452-2468. doi: 10.3748/wjg.v29.i16.2452. PMID: 37179585Free PMC Article
Gullo I, Grillo F, Mastracci L, Vanoli A, Carneiro F, Saragoni L, Limarzi F, Ferro J, Parente P, Fassan M
Pathologica 2020 Sep;112(3):166-185. doi: 10.32074/1591-951X-166. PMID: 33179620Free PMC Article
Pietrantonio F, Miceli R, Raimondi A, Kim YW, Kang WK, Langley RE, Choi YY, Kim KM, Nankivell MG, Morano F, Wotherspoon A, Valeri N, Kook MC, An JY, Grabsch HI, Fucà G, Noh SH, Sohn TS, Kim S, Di Bartolomeo M, Cunningham D, Lee J, Cheong JH, Smyth EC
J Clin Oncol 2019 Dec 10;37(35):3392-3400. Epub 2019 Sep 12 doi: 10.1200/JCO.19.01124. PMID: 31513484
Brenner H, Rothenbacher D, Arndt V
Methods Mol Biol 2009;472:467-77. doi: 10.1007/978-1-60327-492-0_23. PMID: 19107449

Clinical prediction guides

Carneiro F
Best Pract Res Clin Gastroenterol 2022 Jun-Aug;58-59:101800. Epub 2022 May 4 doi: 10.1016/j.bpg.2022.101800. PMID: 35988963
Gullo I, Grillo F, Mastracci L, Vanoli A, Carneiro F, Saragoni L, Limarzi F, Ferro J, Parente P, Fassan M
Pathologica 2020 Sep;112(3):166-185. doi: 10.32074/1591-951X-166. PMID: 33179620Free PMC Article
Ren N, Liang B, Li Y
Biosci Rep 2020 Oct 30;40(10) doi: 10.1042/BSR20200980. PMID: 33015704Free PMC Article
Digklia A, Wagner AD
World J Gastroenterol 2016 Feb 28;22(8):2403-14. doi: 10.3748/wjg.v22.i8.2403. PMID: 26937129Free PMC Article
Pasechnikov V, Chukov S, Fedorov E, Kikuste I, Leja M
World J Gastroenterol 2014 Oct 14;20(38):13842-62. doi: 10.3748/wjg.v20.i38.13842. PMID: 25320521Free PMC Article

Recent systematic reviews

Wu X, Chen L, Cheng J, Qian J, Fang Z, Wu J
Nutrients 2022 Oct 12;14(20) doi: 10.3390/nu14204260. PMID: 36296944Free PMC Article
Ford AC, Yuan Y, Moayyedi P
Gut 2020 Dec;69(12):2113-2121. Epub 2020 Mar 23 doi: 10.1136/gutjnl-2020-320839. PMID: 32205420
Poorolajal J, Moradi L, Mohammadi Y, Cheraghi Z, Gohari-Ensaf F
Epidemiol Health 2020;42:e2020004. Epub 2020 Feb 2 doi: 10.4178/epih.e2020004. PMID: 32023777Free PMC Article
Yusefi AR, Bagheri Lankarani K, Bastani P, Radinmanesh M, Kavosi Z
Asian Pac J Cancer Prev 2018 Mar 27;19(3):591-603. doi: 10.22034/APJCP.2018.19.3.591. PMID: 29579788Free PMC Article
Lee YC, Chiang TH, Chou CK, Tu YK, Liao WC, Wu MS, Graham DY
Gastroenterology 2016 May;150(5):1113-1124.e5. Epub 2016 Feb 2 doi: 10.1053/j.gastro.2016.01.028. PMID: 26836587

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