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Retinopathy of Prematurity, AE

MedGen UID:
1656011
Concept ID:
C4722185
Finding
Synonym: Retinopathy of Prematurity, Adverse Event

Definition

An adverse event characterized by a retinal condition of very immature infants that may be characterized by non-vascularized retinae that may lead to neovascularization, scarring, retinal detachment, and blindness. [from NCI]

Professional guidelines

PubMed

Bancalari A, Schade R
Am J Perinatol 2022 Jan;39(1):22-30. Epub 2020 Jun 16 doi: 10.1055/s-0040-1713181. PMID: 32544962
Barnett JM, Hubbard GB
Curr Opin Ophthalmol 2021 Sep 1;32(5):475-481. doi: 10.1097/ICU.0000000000000783. PMID: 34231532Free PMC Article
Tran KD, Cernichiaro-Espinosa LA, Berrocal AM
Asia Pac J Ophthalmol (Phila) 2018 Jan-Feb;7(1):56-62. Epub 2018 Jan 26 doi: 10.22608/APO.2017436. PMID: 29376233

Recent clinical studies

Etiology

Stahl A, Sukgen EA, Wu WC, Lepore D, Nakanishi H, Mazela J, Moshfeghi DM, Vitti R, Athanikar A, Chu K, Iveli P, Zhao F, Schmelter T, Leal S, Köfüncü E, Azuma N; FIREFLEYE Study Group
JAMA 2022 Jul 26;328(4):348-359. doi: 10.1001/jama.2022.10564. PMID: 35881122Free PMC Article
Barnett JM, Hubbard GB
Curr Opin Ophthalmol 2021 Sep 1;32(5):475-481. doi: 10.1097/ICU.0000000000000783. PMID: 34231532Free PMC Article
Kim SJ, Port AD, Swan R, Campbell JP, Chan RVP, Chiang MF
Surv Ophthalmol 2018 Sep-Oct;63(5):618-637. Epub 2018 Apr 19 doi: 10.1016/j.survophthal.2018.04.002. PMID: 29679617Free PMC Article
Hellström A, Smith LE, Dammann O
Lancet 2013 Oct 26;382(9902):1445-57. Epub 2013 Jun 17 doi: 10.1016/S0140-6736(13)60178-6. PMID: 23782686Free PMC Article
Mintz-Hittner HA, Kennedy KA, Chuang AZ; BEAT-ROP Cooperative Group
N Engl J Med 2011 Feb 17;364(7):603-15. doi: 10.1056/NEJMoa1007374. PMID: 21323540Free PMC Article

Diagnosis

Hansen ML, Pellicer A, Hyttel-Sørensen S, Ergenekon E, Szczapa T, Hagmann C, Naulaers G, Mintzer J, Fumagalli M, Dimitriou G, Dempsey E, Tkaczyk J, Cheng G, Fredly S, Heuchan AM, Pichler G, Fuchs H, Nesargi S, Hahn GH, Piris-Borregas S, Širc J, Alsina-Casanova M, Stocker M, Ozkan H, Sarafidis K, Hopper AO, Karen T, Rzepecka-Weglarz B, Oguz SS, Arruza L, Memisoglu AC, Del Rio Florentino R, Baserga M, Maton P, Truttmann AC, de Las Cuevas I, Agergaard P, Zafra P, Bender L, Lauterbach R, Lecart C, de Buyst J, El-Khuffash A, Curley A, Vaccarello OO, Miletin J, Papathoma E, Vesoulis Z, Vento G, Cornette L, Lopez LS, Yasa B, Klamer A, Agosti M, Baud O, Mastretta E, Cetinkaya M, McCall K, Zeng S, Hatzidaki E, Bargiel A, Marciniak S, Gao X, Huijia L, Chalak L, Yang L, Rao SA, Xu X, Gonzalez BL, Wilinska M, Yin Z, Sadowska-Krawczenko I, Serrano-Viñuales I, Krolak-Olejnik B, Ybarra MM, Morales-Betancourt C, Korček P, Teresa-Palacio M, Mosca F, Hergenhan A, Koksal N, Tsoni K, Kadri MM, Knöpfli C, Rafinska-Wazny E, Akin MS, Nordvik T, Peng Z, Kersin SG, Thewissen L, Alarcon A, Healy D, Urlesberger B, Baş M, Baumgartner J, Skylogianni E, Karadyova V, Valverde E, Bergon-Sendin E, Kucera J, Pisoni S, Wang L, Smits A, Sanchez-Salmador R, Rasmussen MI, Olsen MH, Jensen AK, Gluud C, Jakobsen JC, Greisen G
N Engl J Med 2023 Apr 20;388(16):1501-1511. doi: 10.1056/NEJMoa2207554. PMID: 37075142
Lahoti S, Jones R, Beck KD, Padidam S, Apple D, Lin X, Quiram P, Young RC, Desireddi J, Harper CA 3rd
Ophthalmic Surg Lasers Imaging Retina 2021 Aug;52(8):458-463. Epub 2021 Aug 1 doi: 10.3928/23258160-20210727-10. PMID: 34410189
Sharma A, Shetty A, Reddy YCVG
Nepal J Ophthalmol 2020 Jul;12(24):298-307. doi: 10.3126/nepjoph.v12i2.28993. PMID: 33978625
Franz AR, Engel C, Bassler D, Rüdiger M, Thome UH, Maier RF, Krägeloh-Mann I, Kron M, Essers J, Bührer C, Rellensmann G, Rossi R, Bittrich HJ, Roll C, Höhn T, Ehrhardt H, Avenarius S, Körner HT, Stein A, Buxmann H, Vochem M, Poets CF; ETTNO Investigators
JAMA 2020 Aug 11;324(6):560-570. doi: 10.1001/jama.2020.10690. PMID: 32780138Free PMC Article
Hellström A, Hård AL
Early Hum Dev 2019 Nov;138:104846. Epub 2019 Aug 29 doi: 10.1016/j.earlhumdev.2019.104846. PMID: 31474316

Therapy

Bancalari A, Schade R
Am J Perinatol 2022 Jan;39(1):22-30. Epub 2020 Jun 16 doi: 10.1055/s-0040-1713181. PMID: 32544962
Barnett JM, Hubbard GB
Curr Opin Ophthalmol 2021 Sep 1;32(5):475-481. doi: 10.1097/ICU.0000000000000783. PMID: 34231532Free PMC Article
Kim SJ, Port AD, Swan R, Campbell JP, Chan RVP, Chiang MF
Surv Ophthalmol 2018 Sep-Oct;63(5):618-637. Epub 2018 Apr 19 doi: 10.1016/j.survophthal.2018.04.002. PMID: 29679617Free PMC Article
Hellström A, Smith LE, Dammann O
Lancet 2013 Oct 26;382(9902):1445-57. Epub 2013 Jun 17 doi: 10.1016/S0140-6736(13)60178-6. PMID: 23782686Free PMC Article
Mintz-Hittner HA, Kennedy KA, Chuang AZ; BEAT-ROP Cooperative Group
N Engl J Med 2011 Feb 17;364(7):603-15. doi: 10.1056/NEJMoa1007374. PMID: 21323540Free PMC Article

Prognosis

Lahoti S, Jones R, Beck KD, Padidam S, Apple D, Lin X, Quiram P, Young RC, Desireddi J, Harper CA 3rd
Ophthalmic Surg Lasers Imaging Retina 2021 Aug;52(8):458-463. Epub 2021 Aug 1 doi: 10.3928/23258160-20210727-10. PMID: 34410189
Ho JJ, Subramaniam P, Davis PG
Cochrane Database Syst Rev 2020 Oct 15;10(10):CD002271. doi: 10.1002/14651858.CD002271.pub3. PMID: 33058208Free PMC Article
Juul SE, Comstock BA, Wadhawan R, Mayock DE, Courtney SE, Robinson T, Ahmad KA, Bendel-Stenzel E, Baserga M, LaGamma EF, Downey LC, Rao R, Fahim N, Lampland A, Frantz ID III, Khan JY, Weiss M, Gilmore MM, Ohls RK, Srinivasan N, Perez JE, McKay V, Vu PT, Lowe J, Kuban K, O'Shea TM, Hartman AL, Heagerty PJ; PENUT Trial Consortium
N Engl J Med 2020 Jan 16;382(3):233-243. doi: 10.1056/NEJMoa1907423. PMID: 31940698Free PMC Article
Kim SJ, Port AD, Swan R, Campbell JP, Chan RVP, Chiang MF
Surv Ophthalmol 2018 Sep-Oct;63(5):618-637. Epub 2018 Apr 19 doi: 10.1016/j.survophthal.2018.04.002. PMID: 29679617Free PMC Article
Halliday HL
Neonatology 2017;111(4):415-422. Epub 2017 May 25 doi: 10.1159/000458460. PMID: 28538237

Clinical prediction guides

Lahoti S, Jones R, Beck KD, Padidam S, Apple D, Lin X, Quiram P, Young RC, Desireddi J, Harper CA 3rd
Ophthalmic Surg Lasers Imaging Retina 2021 Aug;52(8):458-463. Epub 2021 Aug 1 doi: 10.3928/23258160-20210727-10. PMID: 34410189
Lee A, Shirley M
Paediatr Drugs 2021 Jan;23(1):111-117. Epub 2021 Jan 15 doi: 10.1007/s40272-020-00433-z. PMID: 33447937
Franz AR, Engel C, Bassler D, Rüdiger M, Thome UH, Maier RF, Krägeloh-Mann I, Kron M, Essers J, Bührer C, Rellensmann G, Rossi R, Bittrich HJ, Roll C, Höhn T, Ehrhardt H, Avenarius S, Körner HT, Stein A, Buxmann H, Vochem M, Poets CF; ETTNO Investigators
JAMA 2020 Aug 11;324(6):560-570. doi: 10.1001/jama.2020.10690. PMID: 32780138Free PMC Article
Juul SE, Comstock BA, Wadhawan R, Mayock DE, Courtney SE, Robinson T, Ahmad KA, Bendel-Stenzel E, Baserga M, LaGamma EF, Downey LC, Rao R, Fahim N, Lampland A, Frantz ID III, Khan JY, Weiss M, Gilmore MM, Ohls RK, Srinivasan N, Perez JE, McKay V, Vu PT, Lowe J, Kuban K, O'Shea TM, Hartman AL, Heagerty PJ; PENUT Trial Consortium
N Engl J Med 2020 Jan 16;382(3):233-243. doi: 10.1056/NEJMoa1907423. PMID: 31940698Free PMC Article
Kim SJ, Port AD, Swan R, Campbell JP, Chan RVP, Chiang MF
Surv Ophthalmol 2018 Sep-Oct;63(5):618-637. Epub 2018 Apr 19 doi: 10.1016/j.survophthal.2018.04.002. PMID: 29679617Free PMC Article

Recent systematic reviews

Kaushal M, Razak A, Patel W, Pullattayil AK, Kaushal A
J Perinatol 2021 Jun;41(6):1225-1235. Epub 2020 Dec 8 doi: 10.1038/s41372-020-00884-9. PMID: 33293666
Ho JJ, Subramaniam P, Davis PG
Cochrane Database Syst Rev 2020 Oct 15;10(10):CD002271. doi: 10.1002/14651858.CD002271.pub3. PMID: 33058208Free PMC Article
Almadhoob A, Ohlsson A
Cochrane Database Syst Rev 2020 Jan 27;1(1):CD010333. doi: 10.1002/14651858.CD010333.pub3. PMID: 31986231Free PMC Article
Disher T, Cameron C, Mitra S, Cathcart K, Campbell-Yeo M
Pediatrics 2018 Jul;142(1) Epub 2018 Jun 1 doi: 10.1542/peds.2018-0401. PMID: 29858451
Kaempfen S, Neumann RP, Jost K, Schulzke SM
Cochrane Database Syst Rev 2018 Mar 2;3(3):CD011893. doi: 10.1002/14651858.CD011893.pub2. PMID: 29499081Free PMC Article

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