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Acute Submassive Pulmonary Embolism

MedGen UID:
1657654
•Concept ID:
C4725175
•
Disease or Syndrome

Definition

Acute pulmonary embolism with evidence of right ventricular dysfunction, but not associated with systemic hypotension. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute Submassive Pulmonary Embolism

Professional guidelines

PubMed

Catheter-directed therapies for the treatment of high risk (massive) and intermediate risk (submassive) acute pulmonary embolism.
Harvey JJ, Huang S, Uberoi R
Cochrane Database Syst Rev 2022 Aug 8;8(8):CD013083. doi: 10.1002/14651858.CD013083.pub2. PMID: 35938605Free PMC Article
Indigo Aspiration System for Treatment of Pulmonary Embolism: Results of the EXTRACT-PE Trial.
Sista AK, Horowitz JM, Tapson VF, Rosenberg M, Elder MD, Schiro BJ, Dohad S, Amoroso NE, Dexter DJ, Loh CT, Leung DA, Bieneman BK, Perkowski PE, Chuang ML, Benenati JF; EXTRACT-PE Investigators
JACC Cardiovasc Interv 2021 Feb 8;14(3):319-329. Epub 2021 Jan 13 doi: 10.1016/j.jcin.2020.09.053. PMID: 33454291
Treatment of Massive or Submassive Acute Pulmonary Embolism With Catheter-Directed Thrombolysis.
Mostafa A, Briasoulis A, Telila T, Belgrave K, Grines C
Am J Cardiol 2016 Mar 15;117(6):1014-20. Epub 2015 Dec 31 doi: 10.1016/j.amjcard.2015.12.041. PMID: 26833207

Recent clinical studies

Etiology

Predictors of reduced cardiac index in patients with acute submassive pulmonary embolism.
Ammari Z, Al-Sarie M, Ea A, Sangera R, George JC, Varghese V, Brewster PS, Xie Y, Chen T, Sun Z, Gupta R
Catheter Cardiovasc Interv 2021 Feb 1;97(2):292-298. Epub 2020 Sep 25 doi: 10.1002/ccd.29269. PMID: 32975377
Percutaneous thrombectomy in patients with massive and very high-risk submassive acute pulmonary embolism.
Toma C, Khandhar S, Zalewski AM, D'Auria SJ, Tu TM, Jaber WA
Catheter Cardiovasc Interv 2020 Dec;96(7):1465-1470. Epub 2020 Aug 31 doi: 10.1002/ccd.29246. PMID: 32866345
Diuretics versus volume expansion in acute submassive pulmonary embolism.
Schouver ED, Chiche O, Bouvier P, Doyen D, Cerboni P, Moceri P, Ferrari E
Arch Cardiovasc Dis 2017 Nov;110(11):616-625. Epub 2017 Oct 10 doi: 10.1016/j.acvd.2017.01.016. PMID: 29030065
Catheter-Directed Therapy for Acute Submassive Pulmonary Embolism: Summary of Current Evidence and Protocols.
Kesselman A, Kuo WT
Tech Vasc Interv Radiol 2017 Sep;20(3):193-196. Epub 2017 Jul 8 doi: 10.1053/j.tvir.2017.07.009. PMID: 29029714
Ultrasound-accelerated catheter-directed thrombolysis for acute submassive pulmonary embolism.
Bagla S, Smirniotopoulos JB, van Breda A, Sheridan MJ, Sterling KM
J Vasc Interv Radiol 2015 Jul;26(7):1001-6. Epub 2015 Feb 18 doi: 10.1016/j.jvir.2014.12.017. PMID: 25704224

Diagnosis

Comparison of Efficacy and Safety between Thrombolysis Plus Anticoagulation vs. Anticoagulation Alone for the Treatment of Acute Submassive Pulmonary Embolism: A Systematic Review and Meta-analysis.
Pan Q, Gao H, Wang Y, Chen Q
Curr Vasc Pharmacol 2022;20(6):491-500. doi: 10.2174/1570161120666220811155353. PMID: 35959626
One-Year Echocardiographic, Functional, and Quality of Life Outcomes After Ultrasound-Facilitated Catheter-Based Fibrinolysis for Pulmonary Embolism.
Piazza G, Sterling KM, Tapson VF, Ouriel K, Sharp ASP, Liu PY, Goldhaber SZ
Circ Cardiovasc Interv 2020 Aug;13(8):e009012. Epub 2020 Aug 6 doi: 10.1161/CIRCINTERVENTIONS.120.009012. PMID: 32757658Free PMC Article
Refractory Hypoxemia in a Patient with Submassive Pulmonary Embolism and an Intracardiac Shunt: A Case Report and Review of the Literature.
Liew J, Stevens J, Slatore C
Perm J 2018;22:17-061. doi: 10.7812/TPP/17-061. PMID: 29616915Free PMC Article
Diuretics versus volume expansion in acute submassive pulmonary embolism.
Schouver ED, Chiche O, Bouvier P, Doyen D, Cerboni P, Moceri P, Ferrari E
Arch Cardiovasc Dis 2017 Nov;110(11):616-625. Epub 2017 Oct 10 doi: 10.1016/j.acvd.2017.01.016. PMID: 29030065
Ultrasound-accelerated catheter-directed thrombolysis for acute submassive pulmonary embolism.
Bagla S, Smirniotopoulos JB, van Breda A, Sheridan MJ, Sterling KM
J Vasc Interv Radiol 2015 Jul;26(7):1001-6. Epub 2015 Feb 18 doi: 10.1016/j.jvir.2014.12.017. PMID: 25704224

Therapy

The future of anesthesia for interventional radiology.
Amin A, Lane JS
Curr Opin Anaesthesiol 2018 Aug;31(4):469-472. doi: 10.1097/ACO.0000000000000609. PMID: 29771696
Diuretics versus volume expansion in acute submassive pulmonary embolism.
Schouver ED, Chiche O, Bouvier P, Doyen D, Cerboni P, Moceri P, Ferrari E
Arch Cardiovasc Dis 2017 Nov;110(11):616-625. Epub 2017 Oct 10 doi: 10.1016/j.acvd.2017.01.016. PMID: 29030065
Catheter-Directed Therapy for Acute Submassive Pulmonary Embolism: Summary of Current Evidence and Protocols.
Kesselman A, Kuo WT
Tech Vasc Interv Radiol 2017 Sep;20(3):193-196. Epub 2017 Jul 8 doi: 10.1053/j.tvir.2017.07.009. PMID: 29029714
A Survey of Submassive Pulmonary Embolism Treatment Preferences among Medical and Endovascular Physicians.
Taslakian B, Chawala D, Sista AK
J Vasc Interv Radiol 2017 Dec;28(12):1693-1699.e2. Epub 2017 Aug 9 doi: 10.1016/j.jvir.2017.06.037. PMID: 28802551
Ultrasound-accelerated catheter-directed thrombolysis for acute submassive pulmonary embolism.
Bagla S, Smirniotopoulos JB, van Breda A, Sheridan MJ, Sterling KM
J Vasc Interv Radiol 2015 Jul;26(7):1001-6. Epub 2015 Feb 18 doi: 10.1016/j.jvir.2014.12.017. PMID: 25704224

Prognosis

Mechanical thrombectomy is associated with shorter length of hospital stay and lower readmission rates compared with conservative therapy for acute submassive pulmonary embolism: a propensity-matched analysis.
Khazi ZM, Pierce J, Azizaddini S, Davis R, Bhat AP
Diagn Interv Radiol 2023 Nov 7;29(6):794-799. Epub 2023 Mar 24 doi: 10.4274/dir.2022.221622. PMID: 36994497Free PMC Article
Intravascular Ultrasound-Guided Catheter-Based Aspiration Thrombectomy in Patients With Acute Submassive Pulmonary Embolism: A Case Series.
Kumar G, Effoe VS, Kumar A, Verma I, Sachdeva R
Cardiovasc Revasc Med 2022 Mar;36:138-143. Epub 2021 May 19 doi: 10.1016/j.carrev.2021.05.016. PMID: 34099409
Predictors of reduced cardiac index in patients with acute submassive pulmonary embolism.
Ammari Z, Al-Sarie M, Ea A, Sangera R, George JC, Varghese V, Brewster PS, Xie Y, Chen T, Sun Z, Gupta R
Catheter Cardiovasc Interv 2021 Feb 1;97(2):292-298. Epub 2020 Sep 25 doi: 10.1002/ccd.29269. PMID: 32975377
Percutaneous thrombectomy in patients with massive and very high-risk submassive acute pulmonary embolism.
Toma C, Khandhar S, Zalewski AM, D'Auria SJ, Tu TM, Jaber WA
Catheter Cardiovasc Interv 2020 Dec;96(7):1465-1470. Epub 2020 Aug 31 doi: 10.1002/ccd.29246. PMID: 32866345
The future of anesthesia for interventional radiology.
Amin A, Lane JS
Curr Opin Anaesthesiol 2018 Aug;31(4):469-472. doi: 10.1097/ACO.0000000000000609. PMID: 29771696

Clinical prediction guides

Mechanical thrombectomy is associated with shorter length of hospital stay and lower readmission rates compared with conservative therapy for acute submassive pulmonary embolism: a propensity-matched analysis.
Khazi ZM, Pierce J, Azizaddini S, Davis R, Bhat AP
Diagn Interv Radiol 2023 Nov 7;29(6):794-799. Epub 2023 Mar 24 doi: 10.4274/dir.2022.221622. PMID: 36994497Free PMC Article
Predictors of reduced cardiac index in patients with acute submassive pulmonary embolism.
Ammari Z, Al-Sarie M, Ea A, Sangera R, George JC, Varghese V, Brewster PS, Xie Y, Chen T, Sun Z, Gupta R
Catheter Cardiovasc Interv 2021 Feb 1;97(2):292-298. Epub 2020 Sep 25 doi: 10.1002/ccd.29269. PMID: 32975377
Ultrasound-Accelerated, Catheter-Directed Thrombolysis for Submassive Pulmonary Embolism: Single-Center Retrospective Review with Intermediate-Term Outcomes.
Makary MS, Fogler BD, Dube PP, Flanders VL, Natarajan K, Garcia-Cortes R, Foster T, Dowell JD
J Vasc Interv Radiol 2020 Mar;31(3):438-443. Epub 2020 Jan 22 doi: 10.1016/j.jvir.2019.11.008. PMID: 31982316
Diuretics versus volume expansion in acute submassive pulmonary embolism.
Schouver ED, Chiche O, Bouvier P, Doyen D, Cerboni P, Moceri P, Ferrari E
Arch Cardiovasc Dis 2017 Nov;110(11):616-625. Epub 2017 Oct 10 doi: 10.1016/j.acvd.2017.01.016. PMID: 29030065
A Survey of Submassive Pulmonary Embolism Treatment Preferences among Medical and Endovascular Physicians.
Taslakian B, Chawala D, Sista AK
J Vasc Interv Radiol 2017 Dec;28(12):1693-1699.e2. Epub 2017 Aug 9 doi: 10.1016/j.jvir.2017.06.037. PMID: 28802551

Recent systematic reviews

Comparison of Efficacy and Safety between Thrombolysis Plus Anticoagulation vs. Anticoagulation Alone for the Treatment of Acute Submassive Pulmonary Embolism: A Systematic Review and Meta-analysis.
Pan Q, Gao H, Wang Y, Chen Q
Curr Vasc Pharmacol 2022;20(6):491-500. doi: 10.2174/1570161120666220811155353. PMID: 35959626

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