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Breast Carcinoma Metastatic in the Lymph Nodes

MedGen UID:
1659340
•Concept ID:
C4727106
•
Neoplastic Process
Synonym: Breast Carcinoma Metastatic in Lymph Node

Definition

A carcinoma that arises from the breast and has spread to the lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast Carcinoma Metastatic in the Lymph Nodes

Professional guidelines

PubMed

AIRO Breast Cancer Group Best Clinical Practice 2022 Update.
Ciabattoni A, Gregucci F, De Rose F, Falivene S, Fozza A, Daidone A, Morra A, Smaniotto D, Barbara R, Lozza L, Vidali C, Borghesi S, Palumbo I, Huscher A, Perrucci E, Baldissera A, Tolento G, Rovea P, Franco P, De Santis MC, Grazia AD, Marino L, Meduri B, Cucciarelli F, Aristei C, Bertoni F, Guenzi M, Leonardi MC, Livi L, Nardone L, De Felice F, Rosetto ME, Mazzuoli L, Anselmo P, Arcidiacono F, Barbarino R, Martinetti M, Pasinetti N, Desideri I, Marazzi F, Ivaldi G, Bonzano E, Cavallari M, Cerreta V, Fusco V, Sarno L, Bonanni A, Mangiacotti MG, Prisco A, Buonfrate G, Andrulli D, Fontana A, Bagnoli R, Marinelli L, Reverberi C, Scalabrino G, Corazzi F, Doino D, Di Genesio-Pagliuca M, Lazzari M, Mascioni F, Pace MP, Mazza M, Vitucci P, Spera A, Macchia G, Boccardi M, Evangelista G, Sola B, La Porta MR, Fiorentino A, Levra NG, Ippolito E, Silipigni S, Osti MF, Mignogna M, Alessandro M, Ursini LA, Nuzzo M, Meattini I, D'Ermo G
Tumori 2022 Jul;108(2_suppl):1-144. doi: 10.1177/03008916221088885. PMID: 36112842
Indications and Strategy for Active Surveillance of Adult Low-Risk Papillary Thyroid Microcarcinoma: Consensus Statements from the Japan Association of Endocrine Surgery Task Force on Management for Papillary Thyroid Microcarcinoma.
Sugitani I, Ito Y, Takeuchi D, Nakayama H, Masaki C, Shindo H, Teshima M, Horiguchi K, Yoshida Y, Kanai T, Hirokawa M, Hames KY, Tabei I, Miyauchi A
Thyroid 2021 Feb;31(2):183-192. Epub 2020 Nov 2 doi: 10.1089/thy.2020.0330. PMID: 33023426Free PMC Article
Treatment of breast cancer.
Maughan KL, Lutterbie MA, Ham PS
Am Fam Physician 2010 Jun 1;81(11):1339-46. PMID: 20521754

Recent clinical studies

Etiology

Radiation Treatment for Breast Cancer.
Bauer A
Surg Clin North Am 2023 Feb;103(1):187-199. Epub 2022 Oct 17 doi: 10.1016/j.suc.2022.08.015. PMID: 36410350
Ultrasound Evaluation of the Axilla in the Breast Imaging Setting.
Teichgraeber DC, Perez F, Guirguis MS, Kapoor MM, Whitman GJ
Ultrasound Q 2021 Jan 13;37(1):43-51. doi: 10.1097/RUQ.0000000000000546. PMID: 33464028
Intraoperative assessment of sentinel lymph nodes in early-stage breast cancer.
Costin AI, Păun I, Vârcuş F, Răcăreanu MM, Lomaca I, Costin AG, Iovan L, Radu L, Mihai GM
Rom J Morphol Embryol 2018;59(4):1033-1039. PMID: 30845281
Contemporary management of the axilla in breast cancer.
Nurudeen S, Hunt KK
Clin Adv Hematol Oncol 2018 Dec;16(12):823-831. PMID: 30843891
Sentinel-lymph-node biopsy in patients with breast cancer before and after neoadjuvant chemotherapy (SENTINA): a prospective, multicentre cohort study.
Kuehn T, Bauerfeind I, Fehm T, Fleige B, Hausschild M, Helms G, Lebeau A, Liedtke C, von Minckwitz G, Nekljudova V, Schmatloch S, Schrenk P, Staebler A, Untch M
Lancet Oncol 2013 Jun;14(7):609-18. Epub 2013 May 15 doi: 10.1016/S1470-2045(13)70166-9. PMID: 23683750

Diagnosis

Ultrasound Evaluation of the Axilla in the Breast Imaging Setting.
Teichgraeber DC, Perez F, Guirguis MS, Kapoor MM, Whitman GJ
Ultrasound Q 2021 Jan 13;37(1):43-51. doi: 10.1097/RUQ.0000000000000546. PMID: 33464028
Occult breast cancer: Where are we at?
Ofri A, Moore K
Breast 2020 Dec;54:211-215. Epub 2020 Oct 27 doi: 10.1016/j.breast.2020.10.012. PMID: 33130487Free PMC Article
Intraoperative assessment of sentinel lymph nodes in early-stage breast cancer.
Costin AI, Păun I, Vârcuş F, Răcăreanu MM, Lomaca I, Costin AG, Iovan L, Radu L, Mihai GM
Rom J Morphol Embryol 2018;59(4):1033-1039. PMID: 30845281
Axillary Lymph Node Inclusions.
Cimino-Mathews A
Surg Pathol Clin 2018 Mar;11(1):43-59. Epub 2017 Nov 29 doi: 10.1016/j.path.2017.09.004. PMID: 29413659
Iatrogenically false positive sentinel lymph nodes in breast cancer: Methods of recognition and evaluation.
Nayak A, Bleiweiss IJ
Semin Diagn Pathol 2018 Jul;35(4):228-235. Epub 2017 Sep 20 doi: 10.1053/j.semdp.2017.09.001. PMID: 28964593

Therapy

Preservation of Axillary Lymph Nodes Compared with Complete Dissection in T1-2 Breast Cancer Patients Presenting One or Two Metastatic Sentinel Lymph Nodes: The SINODAR-ONE Multicenter Randomized Clinical Trial.
Tinterri C, Gentile D, Gatzemeier W, Sagona A, Barbieri E, Testori A, Errico V, Bottini A, Marrazzo E, Dani C, Dozin B, Boni L, Bruzzi P, Fernandes B, Franceschini D, Spoto R, Torrisi R, Scorsetti M, Santoro A, Canavese G; SINODAR-ONE Collaborative Group
Ann Surg Oncol 2022 Sep;29(9):5732-5744. Epub 2022 May 12 doi: 10.1245/s10434-022-11866-w. PMID: 35552930
Internal mammary and medial supraclavicular lymph node chain irradiation in stage I-III breast cancer (EORTC 22922/10925): 15-year results of a randomised, phase 3 trial.
Poortmans PM, Weltens C, Fortpied C, Kirkove C, Peignaux-Casasnovas K, Budach V, van der Leij F, Vonk E, Weidner N, Rivera S, van Tienhoven G, Fourquet A, Noel G, Valli M, Guckenberger M, Koiter E, Racadot S, Abdah-Bortnyak R, Van Limbergen EF, Engelen A, De Brouwer P, Struikmans H, Bartelink H; European Organisation for Research and Treatment of Cancer Radiation Oncology and Breast Cancer Groups
Lancet Oncol 2020 Dec;21(12):1602-1610. Epub 2020 Nov 2 doi: 10.1016/S1470-2045(20)30472-1. PMID: 33152277
Effect of Axillary Dissection vs No Axillary Dissection on 10-Year Overall Survival Among Women With Invasive Breast Cancer and Sentinel Node Metastasis: The ACOSOG Z0011 (Alliance) Randomized Clinical Trial.
Giuliano AE, Ballman KV, McCall L, Beitsch PD, Brennan MB, Kelemen PR, Ollila DW, Hansen NM, Whitworth PW, Blumencranz PW, Leitch AM, Saha S, Hunt KK, Morrow M
JAMA 2017 Sep 12;318(10):918-926. doi: 10.1001/jama.2017.11470. PMID: 28898379Free PMC Article
Survival and axillary recurrence following sentinel node-positive breast cancer without completion axillary lymph node dissection: the randomized controlled SENOMAC trial.
de Boniface J, Frisell J, Andersson Y, Bergkvist L, Ahlgren J, Rydén L, Olofsson Bagge R, Sund M, Johansson H, Lundstedt D; SENOMAC Trialists’ Group
BMC Cancer 2017 May 26;17(1):379. doi: 10.1186/s12885-017-3361-y. PMID: 28549453Free PMC Article
Sentinel-lymph-node biopsy in patients with breast cancer before and after neoadjuvant chemotherapy (SENTINA): a prospective, multicentre cohort study.
Kuehn T, Bauerfeind I, Fehm T, Fleige B, Hausschild M, Helms G, Lebeau A, Liedtke C, von Minckwitz G, Nekljudova V, Schmatloch S, Schrenk P, Staebler A, Untch M
Lancet Oncol 2013 Jun;14(7):609-18. Epub 2013 May 15 doi: 10.1016/S1470-2045(13)70166-9. PMID: 23683750

Prognosis

Ultrasound Evaluation of the Axilla in the Breast Imaging Setting.
Teichgraeber DC, Perez F, Guirguis MS, Kapoor MM, Whitman GJ
Ultrasound Q 2021 Jan 13;37(1):43-51. doi: 10.1097/RUQ.0000000000000546. PMID: 33464028
Intraoperative assessment of sentinel lymph nodes in early-stage breast cancer.
Costin AI, Păun I, Vârcuş F, Răcăreanu MM, Lomaca I, Costin AG, Iovan L, Radu L, Mihai GM
Rom J Morphol Embryol 2018;59(4):1033-1039. PMID: 30845281
Molecular patterns of cancer colonisation in lymph nodes of breast cancer patients.
Chatterjee G, Pai T, Hardiman T, Avery-Kiejda K, Scott RJ, Spencer J, Pinder SE, Grigoriadis A
Breast Cancer Res 2018 Nov 20;20(1):143. doi: 10.1186/s13058-018-1070-3. PMID: 30458865Free PMC Article
Eight-year follow up result of the OTOASOR trial: The Optimal Treatment Of the Axilla - Surgery Or Radiotherapy after positive sentinel lymph node biopsy in early-stage breast cancer: A randomized, single centre, phase III, non-inferiority trial.
Sávolt Á, Péley G, Polgár C, Udvarhelyi N, Rubovszky G, Kovács E, Győrffy B, Kásler M, Mátrai Z
Eur J Surg Oncol 2017 Apr;43(4):672-679. Epub 2017 Jan 16 doi: 10.1016/j.ejso.2016.12.011. PMID: 28139362
Sentinel-lymph-node biopsy in patients with breast cancer before and after neoadjuvant chemotherapy (SENTINA): a prospective, multicentre cohort study.
Kuehn T, Bauerfeind I, Fehm T, Fleige B, Hausschild M, Helms G, Lebeau A, Liedtke C, von Minckwitz G, Nekljudova V, Schmatloch S, Schrenk P, Staebler A, Untch M
Lancet Oncol 2013 Jun;14(7):609-18. Epub 2013 May 15 doi: 10.1016/S1470-2045(13)70166-9. PMID: 23683750

Clinical prediction guides

Pathologic Evaluation of Lymph Nodes in Breast Cancer: Contemporary Approaches and Clinical Implications.
Balla A, Weaver DL
Surg Pathol Clin 2022 Mar;15(1):15-27. Epub 2022 Jan 31 doi: 10.1016/j.path.2021.11.002. PMID: 35236631
Endosalpingiosis Is Negative for GATA3.
White MJ, Vang R, Argani P, Cimino-Mathews A
Arch Pathol Lab Med 2021 Nov 1;145(11):1448-1452. doi: 10.5858/arpa.2020-0359-OA. PMID: 33571371
Prediction of axillary nodal burden in patients with invasive lobular carcinoma using MRI.
Ha SM, Chang JM, Kim SY, Lee SH, Kim ES, Kim YS, Cho N, Moon WK
Breast Cancer Res Treat 2021 Apr;186(2):463-473. Epub 2021 Jan 3 doi: 10.1007/s10549-020-06056-9. PMID: 33389406
Lymph Node Imaging in Patients with Primary Breast Cancer: Concurrent Diagnostic Tools.
Marino MA, Avendano D, Zapata P, Riedl CC, Pinker K
Oncologist 2020 Feb;25(2):e231-e242. Epub 2019 Oct 14 doi: 10.1634/theoncologist.2019-0427. PMID: 32043792Free PMC Article
The significance of intramammary lymph nodes in breast cancer: a systematic review and meta-analysis.
Abdullgaffar B, Gopal P, Abdulrahim M, Ghazi E, Mohamed E
Int J Surg Pathol 2012 Dec;20(6):555-63. Epub 2012 May 30 doi: 10.1177/1066896912448425. PMID: 22649167

Recent systematic reviews

A systematic review and meta-analysis of vascularized lymph node transfer for breast cancer-related lymphedema.
Winters H, Tielemans HJP, Paulus V, Hummelink S, Slater NJ, Ulrich DJO
J Vasc Surg Venous Lymphat Disord 2022 May;10(3):786-795.e1. Epub 2021 Sep 8 doi: 10.1016/j.jvsv.2021.08.023. PMID: 34508873
Evaluation of pathological complete response as surrogate endpoint in neoadjuvant randomised clinical trials of early stage breast cancer: systematic review and meta-analysis.
Conforti F, Pala L, Sala I, Oriecuia C, De Pas T, Specchia C, Graffeo R, Pagan E, Queirolo P, Pennacchioli E, Colleoni M, Viale G, Bagnardi V, Gelber RD
BMJ 2021 Dec 21;375:e066381. doi: 10.1136/bmj-2021-066381. PMID: 34933868Free PMC Article
Axillary staging in ductal carcinoma in situ with microinvasion: A meta-analysis.
Choi B, Jegatheeswaran L, Nakhoul M, Haria P, Srivastava R, Karki S, Lupi M, Patel V, Chakravorty A, Babu E
Surg Oncol 2021 Jun;37:101557. Epub 2021 Mar 31 doi: 10.1016/j.suronc.2021.101557. PMID: 33819852
Microsurgical techniques for the treatment of breast cancer-related lymphedema: a systematic review.
Penha TR, Ijsbrandy C, Hendrix NA, Heuts EM, Voogd AC, von Meyenfeldt MF, van der Hulst RR
J Reconstr Microsurg 2013 Feb;29(2):99-106. Epub 2012 Dec 19 doi: 10.1055/s-0032-1329919. PMID: 23254539
The significance of intramammary lymph nodes in breast cancer: a systematic review and meta-analysis.
Abdullgaffar B, Gopal P, Abdulrahim M, Ghazi E, Mohamed E
Int J Surg Pathol 2012 Dec;20(6):555-63. Epub 2012 May 30 doi: 10.1177/1066896912448425. PMID: 22649167

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