U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Neonatal Respiratory Insufficiency, AE

MedGen UID:
1660442
•Concept ID:
C4743806
•
Finding
Synonym: Neonatal Respiratory Insufficiency, Adverse Event

Definition

An adverse event in a newborn characterized by significant impairment of gas exchange resulting in compensatory breathing efforts and eventually hypoxia and/or hypercarbia. Note: Consider this adverse event for any patient whose respiratory condition deteriorates from baseline. If any specific diagnosis is identified: use diagnosis-specific scale (e.g. respiratory distress syndrome (RDS), pulmonary hemorrhage). [from NCI]

Professional guidelines

PubMed

Neonatal respiratory extracorporeal membrane oxygenation and primary diagnosis: trends between two decades.
Sharma J, Sherman A, Rimal A, Haney B, Weiner J, Pallotto E
J Perinatol 2020 Feb;40(2):269-274. Epub 2019 Nov 7 doi: 10.1038/s41372-019-0547-y. PMID: 31700091
Elective induction of labor at 39 weeks compared with expectant management: a meta-analysis of cohort studies.
Grobman WA, Caughey AB
Am J Obstet Gynecol 2019 Oct;221(4):304-310. Epub 2019 Feb 25 doi: 10.1016/j.ajog.2019.02.046. PMID: 30817905
Prenatal diagnosis and management of congenital diaphragmatic hernia.
Basurto D, Russo FM, Van der Veeken L, Van der Merwe J, Hooper S, Benachi A, De Bie F, Gomez O, Deprest J
Best Pract Res Clin Obstet Gynaecol 2019 Jul;58:93-106. Epub 2019 Jan 5 doi: 10.1016/j.bpobgyn.2018.12.010. PMID: 30772144

Recent clinical studies

Etiology

Pediatric ECLS Neurologic Management and Outcomes.
Callier K, Dantes G, Johnson K, Linden AF
Semin Pediatr Surg 2023 Aug;32(4):151331. Epub 2023 Oct 17 doi: 10.1016/j.sempedsurg.2023.151331. PMID: 37944407
Effect of Nitric Oxide via Cardiopulmonary Bypass on Ventilator-Free Days in Young Children Undergoing Congenital Heart Disease Surgery: The NITRIC Randomized Clinical Trial.
Schlapbach LJ, Gibbons KS, Horton SB, Johnson K, Long DA, Buckley DHF, Erickson S, Festa M, d'Udekem Y, Alphonso N, Winlaw DS, Delzoppo C, van Loon K, Jones M, Young PJ, Butt W, Schibler A; NITRIC Study Group, the Australian and New Zealand Intensive Care Society Clinical Trials Group (ANZICS CTG), and the ANZICS Paediatric Study Group (PSG)
JAMA 2022 Jul 5;328(1):38-47. doi: 10.1001/jama.2022.9376. PMID: 35759691Free PMC Article
Vitamin K and ECMO for neonatal hypoxic respiratory failure.
Lock NE, Sawyer AA, Wise L, Bhatia J, Stansfield BK
Perfusion 2022 Jul;37(5):484-492. Epub 2021 Mar 24 doi: 10.1177/02676591211003870. PMID: 33761796
Continuous positive airway pressure (CPAP) for respiratory distress in preterm infants.
Ho JJ, Subramaniam P, Davis PG
Cochrane Database Syst Rev 2020 Oct 15;10(10):CD002271. doi: 10.1002/14651858.CD002271.pub3. PMID: 33058208Free PMC Article
Elective induction of labor at 39 weeks compared with expectant management: a meta-analysis of cohort studies.
Grobman WA, Caughey AB
Am J Obstet Gynecol 2019 Oct;221(4):304-310. Epub 2019 Feb 25 doi: 10.1016/j.ajog.2019.02.046. PMID: 30817905

Diagnosis

Pediatric vascular anomalies with airway compromise.
Gorostidi F, Glasson N, Salati V, Sandu K
J Oral Pathol Med 2022 Nov;51(10):888-896. Epub 2022 Apr 6 doi: 10.1111/jop.13297. PMID: 35347777Free PMC Article
Robin Sequence: Neonatal Mandibular Distraction.
Morrison KA, Collares MV, Flores RL
Clin Plast Surg 2021 Jul;48(3):363-373. Epub 2021 May 8 doi: 10.1016/j.cps.2021.03.005. PMID: 34051891
Neonatal respiratory extracorporeal membrane oxygenation and primary diagnosis: trends between two decades.
Sharma J, Sherman A, Rimal A, Haney B, Weiner J, Pallotto E
J Perinatol 2020 Feb;40(2):269-274. Epub 2019 Nov 7 doi: 10.1038/s41372-019-0547-y. PMID: 31700091
Tracheomalacia.
Wright CD
Chest Surg Clin N Am 2003 May;13(2):349-57, viii. doi: 10.1016/s1052-3359(03)00036-x. PMID: 12755319
Naloxone.
Handal KA, Schauben JL, Salamone FR
Ann Emerg Med 1983 Jul;12(7):438-45. doi: 10.1016/s0196-0644(83)80343-6. PMID: 6309038

Therapy

Sedation and analgesia from prolonged pain and stress during mechanical ventilation in preterm infants: is dexmedetomidine an alternative to current practice?
Ojha S, Abramson J, Dorling J
BMJ Paediatr Open 2022 May;6(1) doi: 10.1136/bmjpo-2022-001460. PMID: 36053596Free PMC Article
Effect of Nitric Oxide via Cardiopulmonary Bypass on Ventilator-Free Days in Young Children Undergoing Congenital Heart Disease Surgery: The NITRIC Randomized Clinical Trial.
Schlapbach LJ, Gibbons KS, Horton SB, Johnson K, Long DA, Buckley DHF, Erickson S, Festa M, d'Udekem Y, Alphonso N, Winlaw DS, Delzoppo C, van Loon K, Jones M, Young PJ, Butt W, Schibler A; NITRIC Study Group, the Australian and New Zealand Intensive Care Society Clinical Trials Group (ANZICS CTG), and the ANZICS Paediatric Study Group (PSG)
JAMA 2022 Jul 5;328(1):38-47. doi: 10.1001/jama.2022.9376. PMID: 35759691Free PMC Article
Continuous positive airway pressure (CPAP) for respiratory distress in preterm infants.
Ho JJ, Subramaniam P, Davis PG
Cochrane Database Syst Rev 2020 Oct 15;10(10):CD002271. doi: 10.1002/14651858.CD002271.pub3. PMID: 33058208Free PMC Article
Extracorporeal Membrane Oxygenation for Hemodynamic Support.
Straube T, Cheifetz IM, Jackson KW
Clin Perinatol 2020 Sep;47(3):671-684. Epub 2020 May 26 doi: 10.1016/j.clp.2020.05.016. PMID: 32713457
Elective induction of labor at 39 weeks compared with expectant management: a meta-analysis of cohort studies.
Grobman WA, Caughey AB
Am J Obstet Gynecol 2019 Oct;221(4):304-310. Epub 2019 Feb 25 doi: 10.1016/j.ajog.2019.02.046. PMID: 30817905

Prognosis

Continuous positive airway pressure (CPAP) for respiratory distress in preterm infants.
Ho JJ, Subramaniam P, Davis PG
Cochrane Database Syst Rev 2020 Oct 15;10(10):CD002271. doi: 10.1002/14651858.CD002271.pub3. PMID: 33058208Free PMC Article
Elective induction of labor at 39 weeks compared with expectant management: a meta-analysis of cohort studies.
Grobman WA, Caughey AB
Am J Obstet Gynecol 2019 Oct;221(4):304-310. Epub 2019 Feb 25 doi: 10.1016/j.ajog.2019.02.046. PMID: 30817905
Prenatal diagnosis and management of congenital diaphragmatic hernia.
Basurto D, Russo FM, Van der Veeken L, Van der Merwe J, Hooper S, Benachi A, De Bie F, Gomez O, Deprest J
Best Pract Res Clin Obstet Gynaecol 2019 Jul;58:93-106. Epub 2019 Jan 5 doi: 10.1016/j.bpobgyn.2018.12.010. PMID: 30772144
Inhaled nitric oxide for respiratory failure in preterm infants.
Barrington KJ, Finer N, Pennaforte T
Cochrane Database Syst Rev 2017 Jan 3;1(1):CD000509. doi: 10.1002/14651858.CD000509.pub5. PMID: 28045472Free PMC Article
Extracorporeal life support.
Skinner SC, Hirschl RB, Bartlett RH
Semin Pediatr Surg 2006 Nov;15(4):242-50. doi: 10.1053/j.sempedsurg.2006.07.003. PMID: 17055954

Clinical prediction guides

Sedation and analgesia from prolonged pain and stress during mechanical ventilation in preterm infants: is dexmedetomidine an alternative to current practice?
Ojha S, Abramson J, Dorling J
BMJ Paediatr Open 2022 May;6(1) doi: 10.1136/bmjpo-2022-001460. PMID: 36053596Free PMC Article
Vitamin K and ECMO for neonatal hypoxic respiratory failure.
Lock NE, Sawyer AA, Wise L, Bhatia J, Stansfield BK
Perfusion 2022 Jul;37(5):484-492. Epub 2021 Mar 24 doi: 10.1177/02676591211003870. PMID: 33761796
Heliox for croup in children.
Moraa I, Sturman N, McGuire TM, van Driel ML
Cochrane Database Syst Rev 2021 Aug 16;8(8):CD006822. doi: 10.1002/14651858.CD006822.pub6. PMID: 34397099Free PMC Article
Elective induction of labor at 39 weeks compared with expectant management: a meta-analysis of cohort studies.
Grobman WA, Caughey AB
Am J Obstet Gynecol 2019 Oct;221(4):304-310. Epub 2019 Feb 25 doi: 10.1016/j.ajog.2019.02.046. PMID: 30817905
Prenatal diagnosis and management of congenital diaphragmatic hernia.
Basurto D, Russo FM, Van der Veeken L, Van der Merwe J, Hooper S, Benachi A, De Bie F, Gomez O, Deprest J
Best Pract Res Clin Obstet Gynaecol 2019 Jul;58:93-106. Epub 2019 Jan 5 doi: 10.1016/j.bpobgyn.2018.12.010. PMID: 30772144

Recent systematic reviews

Cervical pessary for preventing preterm birth in singleton pregnancies.
Abdel-Aleem H, Shaaban OM, Abdel-Aleem MA, Aboelfadle Mohamed A
Cochrane Database Syst Rev 2022 Dec 1;12(12):CD014508. doi: 10.1002/14651858.CD014508. PMID: 36453699Free PMC Article
Heliox for croup in children.
Moraa I, Sturman N, McGuire TM, van Driel ML
Cochrane Database Syst Rev 2021 Aug 16;8(8):CD006822. doi: 10.1002/14651858.CD006822.pub6. PMID: 34397099Free PMC Article
Continuous positive airway pressure (CPAP) for respiratory distress in preterm infants.
Ho JJ, Subramaniam P, Davis PG
Cochrane Database Syst Rev 2020 Oct 15;10(10):CD002271. doi: 10.1002/14651858.CD002271.pub3. PMID: 33058208Free PMC Article
Elective induction of labor at 39 weeks compared with expectant management: a meta-analysis of cohort studies.
Grobman WA, Caughey AB
Am J Obstet Gynecol 2019 Oct;221(4):304-310. Epub 2019 Feb 25 doi: 10.1016/j.ajog.2019.02.046. PMID: 30817905
Inhaled nitric oxide for respiratory failure in preterm infants.
Barrington KJ, Finer N, Pennaforte T
Cochrane Database Syst Rev 2017 Jan 3;1(1):CD000509. doi: 10.1002/14651858.CD000509.pub5. PMID: 28045472Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...