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Neonatal Bradyarrhythmia, AE

MedGen UID:
1666949
•Concept ID:
C4743805
•
Finding
Synonym: Neonatal Bradyarrhythmia, Adverse Event

Definition

An adverse event in a newborn characterized by non-sinus rhythm with an abnormally low heart rate for age. [from NCI]

Professional guidelines

PubMed

Pharmacological interventions for the management of pain and discomfort during lumbar puncture in newborn infants.
Pessano S, Romantsik O, Olsson E, Hedayati E, Bruschettini M
Cochrane Database Syst Rev 2023 Sep 28;9(9):CD015594. doi: 10.1002/14651858.CD015594.pub2. PMID: 37767875Free PMC Article
Diagnosis and Surgical Management of Neonatal Hydrocephalus.
Pindrik J, Schulz L, Drapeau A
Semin Pediatr Neurol 2022 Jul;42:100969. Epub 2022 Apr 8 doi: 10.1016/j.spen.2022.100969. PMID: 35868728
Beta-blockers for prevention and treatment of retinopathy of prematurity in preterm infants.
Kaempfen S, Neumann RP, Jost K, Schulzke SM
Cochrane Database Syst Rev 2018 Mar 2;3(3):CD011893. doi: 10.1002/14651858.CD011893.pub2. PMID: 29499081Free PMC Article

Recent clinical studies

Etiology

Placental Location in Maternal-Fetal Surgery for Myelomeningocele.
Lillegard JB, Eyerly-Webb SA, Watson DA, Bahtiyar MO, Bennett KA, Emery SP, Fisher AJ, Goldstein RB, Goodnight WH, Lim FY, McCullough LB, Moehrlen U, Moldenhauer JS, Moon-Grady AJ, Ruano R, Skupski DW, Treadwell MC, Tsao K, Wagner AJ, Zaretsky MV; fMMC Consortium Sponsored by NAFTnet
Fetal Diagn Ther 2022;49(3):117-124. Epub 2021 Dec 10 doi: 10.1159/000521379. PMID: 34915495
Techniques for preventing hypotension during spinal anaesthesia for caesarean section.
Chooi C, Cox JJ, Lumb RS, Middleton P, Chemali M, Emmett RS, Simmons SW, Cyna AM
Cochrane Database Syst Rev 2020 Jul 1;7(7):CD002251. doi: 10.1002/14651858.CD002251.pub4. PMID: 32619039Free PMC Article
At risk populations: from children to the elderly.
Higuet A, Hachimi Idrissi S, Watelet JB
B-ENT 2016;Suppl 26(1):139-154. PMID: 29461739
Chest physiotherapy for acute bronchiolitis in paediatric patients between 0 and 24 months old.
Roqué i Figuls M, Giné-Garriga M, Granados Rugeles C, Perrotta C, Vilaró J
Cochrane Database Syst Rev 2016 Feb 1;2(2):CD004873. doi: 10.1002/14651858.CD004873.pub5. PMID: 26833493Free PMC Article
Cooling for newborns with hypoxic ischaemic encephalopathy.
Jacobs SE, Berg M, Hunt R, Tarnow-Mordi WO, Inder TE, Davis PG
Cochrane Database Syst Rev 2013 Jan 31;2013(1):CD003311. doi: 10.1002/14651858.CD003311.pub3. PMID: 23440789Free PMC Article

Diagnosis

Positioning for lumbar puncture in newborn infants.
Pessano S, Bruschettini M, Prescott MG, Romantsik O
Cochrane Database Syst Rev 2023 Dec 14;12(12):CD015592. doi: 10.1002/14651858.CD015592.pub3. PMID: 38096386Free PMC Article
Positioning for lumbar puncture in newborn infants.
Pessano S, Bruschettini M, Prescott MG, Romantsik O
Cochrane Database Syst Rev 2023 Oct 23;10(10):CD015592. doi: 10.1002/14651858.CD015592.pub2. PMID: 37870133Free PMC Article
Opioids for procedural pain in neonates.
Kinoshita M, Olsson E, Borys F, Bruschettini M
Cochrane Database Syst Rev 2023 Jun 23;6(6):CD015056. doi: 10.1002/14651858.CD015056.pub3. PMID: 37350685Free PMC Article
Diagnosis and Surgical Management of Neonatal Hydrocephalus.
Pindrik J, Schulz L, Drapeau A
Semin Pediatr Neurol 2022 Jul;42:100969. Epub 2022 Apr 8 doi: 10.1016/j.spen.2022.100969. PMID: 35868728
Cardiorespiratory events in preterm infants: interventions and consequences.
Di Fiore JM, Poets CF, Gauda E, Martin RJ, MacFarlane P
J Perinatol 2016 Apr;36(4):251-8. Epub 2015 Nov 19 doi: 10.1038/jp.2015.165. PMID: 26583943

Therapy

Sedation and analgesia from prolonged pain and stress during mechanical ventilation in preterm infants: is dexmedetomidine an alternative to current practice?
Ojha S, Abramson J, Dorling J
BMJ Paediatr Open 2022 May;6(1) doi: 10.1136/bmjpo-2022-001460. PMID: 36053596Free PMC Article
Diagnosis and Surgical Management of Neonatal Hydrocephalus.
Pindrik J, Schulz L, Drapeau A
Semin Pediatr Neurol 2022 Jul;42:100969. Epub 2022 Apr 8 doi: 10.1016/j.spen.2022.100969. PMID: 35868728
Placental Location in Maternal-Fetal Surgery for Myelomeningocele.
Lillegard JB, Eyerly-Webb SA, Watson DA, Bahtiyar MO, Bennett KA, Emery SP, Fisher AJ, Goldstein RB, Goodnight WH, Lim FY, McCullough LB, Moehrlen U, Moldenhauer JS, Moon-Grady AJ, Ruano R, Skupski DW, Treadwell MC, Tsao K, Wagner AJ, Zaretsky MV; fMMC Consortium Sponsored by NAFTnet
Fetal Diagn Ther 2022;49(3):117-124. Epub 2021 Dec 10 doi: 10.1159/000521379. PMID: 34915495
Chest physiotherapy for acute bronchiolitis in paediatric patients between 0 and 24 months old.
Roqué i Figuls M, Giné-Garriga M, Granados Rugeles C, Perrotta C, Vilaró J
Cochrane Database Syst Rev 2016 Feb 1;2(2):CD004873. doi: 10.1002/14651858.CD004873.pub5. PMID: 26833493Free PMC Article
Cooling for newborns with hypoxic ischaemic encephalopathy.
Jacobs SE, Berg M, Hunt R, Tarnow-Mordi WO, Inder TE, Davis PG
Cochrane Database Syst Rev 2013 Jan 31;2013(1):CD003311. doi: 10.1002/14651858.CD003311.pub3. PMID: 23440789Free PMC Article

Prognosis

Increasing use of newer antiseizure medication during pregnancy: An observational study with special focus on lacosamide.
Hoeltzenbein M, Slimi S, Fietz AK, Stegherr R, Onken M, Beyersmann J, Dathe K, Schaefer C
Seizure 2023 Apr;107:107-113. Epub 2023 Feb 20 doi: 10.1016/j.seizure.2023.02.015. PMID: 37003184
Gabapentin in Infants: Critical Evaluation of a Novel Sedative/Analgesic Medication.
McPherson C
Neonatal Netw 2021 Jul 1;40(4):267-272. doi: 10.1891/11-T-687. PMID: 34330877
Anaesthesia, surgery, and life-threatening allergic reactions: epidemiology and clinical features of perioperative anaphylaxis in the 6th National Audit Project (NAP6).
Harper NJN, Cook TM, Garcez T, Farmer L, Floss K, Marinho S, Torevell H, Warner A, Ferguson K, Hitchman J, Egner W, Kemp H, Thomas M, Lucas DN, Nasser S, Karanam S, Kong KL, Farooque S, Bellamy M, McGuire N
Br J Anaesth 2018 Jul;121(1):159-171. Epub 2018 May 21 doi: 10.1016/j.bja.2018.04.014. PMID: 29935567
Co-bedding in neonatal nursery for promoting growth and neurodevelopment in stable preterm twins.
Lai NM, Foong SC, Foong WC, Tan K
Cochrane Database Syst Rev 2016 Apr 14;4(4):CD008313. doi: 10.1002/14651858.CD008313.pub3. PMID: 27075527Free PMC Article
Beta-adrenoceptor blocking drugs: adverse reactions and drug interactions.
Kendall MJ, Beeley L
Pharmacol Ther 1983;21(3):351-69. doi: 10.1016/0163-7258(83)90060-8. PMID: 6138787

Clinical prediction guides

Sedation and analgesia from prolonged pain and stress during mechanical ventilation in preterm infants: is dexmedetomidine an alternative to current practice?
Ojha S, Abramson J, Dorling J
BMJ Paediatr Open 2022 May;6(1) doi: 10.1136/bmjpo-2022-001460. PMID: 36053596Free PMC Article
Techniques for preventing hypotension during spinal anaesthesia for caesarean section.
Chooi C, Cox JJ, Lumb RS, Middleton P, Chemali M, Emmett RS, Simmons SW, Cyna AM
Cochrane Database Syst Rev 2020 Jul 1;7(7):CD002251. doi: 10.1002/14651858.CD002251.pub4. PMID: 32619039Free PMC Article
Dexmedetomidine: the new all-in-one drug in paediatric anaesthesia?
Sottas CE, Anderson BJ
Curr Opin Anaesthesiol 2017 Aug;30(4):441-451. doi: 10.1097/ACO.0000000000000488. PMID: 28537937
Chest physiotherapy for acute bronchiolitis in paediatric patients between 0 and 24 months old.
Roqué i Figuls M, Giné-Garriga M, Granados Rugeles C, Perrotta C, Vilaró J
Cochrane Database Syst Rev 2016 Feb 1;2(2):CD004873. doi: 10.1002/14651858.CD004873.pub5. PMID: 26833493Free PMC Article
The therapeutic value of atropine for critical care intubation.
Jones P
Arch Dis Child 2016 Jan;101(1):77-80. Epub 2015 Jul 21 doi: 10.1136/archdischild-2014-308137. PMID: 26199407

Recent systematic reviews

Videolaryngoscopy versus direct laryngoscopy for tracheal intubation in neonates.
Lingappan K, Neveln N, Arnold JL, Fernandes CJ, Pammi M
Cochrane Database Syst Rev 2023 May 12;5(5):CD009975. doi: 10.1002/14651858.CD009975.pub4. PMID: 37171122Free PMC Article
The Risk for Neonatal Hypoglycemia and Bradycardia after Beta-Blocker Use during Pregnancy or Lactation: A Systematic Review and Meta-Analysis.
de Bruin R, van Dalen SL, Franx SJ, Ramaswamy VV, Simons SHP, Flint RB, van den Bosch GE
Int J Environ Res Public Health 2022 Aug 4;19(15) doi: 10.3390/ijerph19159616. PMID: 35954977Free PMC Article
Techniques for preventing hypotension during spinal anaesthesia for caesarean section.
Chooi C, Cox JJ, Lumb RS, Middleton P, Chemali M, Emmett RS, Simmons SW, Cyna AM
Cochrane Database Syst Rev 2020 Jul 1;7(7):CD002251. doi: 10.1002/14651858.CD002251.pub4. PMID: 32619039Free PMC Article
Chest physiotherapy for acute bronchiolitis in paediatric patients between 0 and 24 months old.
Roqué i Figuls M, Giné-Garriga M, Granados Rugeles C, Perrotta C, Vilaró J
Cochrane Database Syst Rev 2016 Feb 1;2(2):CD004873. doi: 10.1002/14651858.CD004873.pub5. PMID: 26833493Free PMC Article
Cooling for newborns with hypoxic ischaemic encephalopathy.
Jacobs SE, Berg M, Hunt R, Tarnow-Mordi WO, Inder TE, Davis PG
Cochrane Database Syst Rev 2013 Jan 31;2013(1):CD003311. doi: 10.1002/14651858.CD003311.pub3. PMID: 23440789Free PMC Article

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