U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Grade 1 Ovarian Teratoma

MedGen UID:
1667906
•Concept ID:
C4745251
•
Neoplastic Process

Definition

A teratoma that arises from the ovary. It contains mature tissue elements and a limited amount of immature tissue elements. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 1 Ovarian Teratoma

Professional guidelines

PubMed

Characteristics, treatment and outcomes of women with immature ovarian teratoma, 1998-2012.
Jorge S, Jones NL, Chen L, Hou JY, Tergas AI, Burke WM, Ananth CV, Neugut AI, Herhshman DL, Wright JD
Gynecol Oncol 2016 Aug;142(2):261-6. Epub 2016 Jun 1 doi: 10.1016/j.ygyno.2016.05.024. PMID: 27222024Free PMC Article
Management of Ovarian Cancer In Younger Women.
Uma Devi K, Purushotham N, Jayashree N
Rev Recent Clin Trials 2015;10(4):263-9. doi: 10.2174/1574887110666150923112047. PMID: 26411956
Ovarian immature teratoma: treatment and outcome in a single institutional cohort.
Vicus D, Beiner ME, Clarke B, Klachook S, Le LW, Laframboise S, Mackay H
Gynecol Oncol 2011 Oct;123(1):50-3. Epub 2011 Jul 20 doi: 10.1016/j.ygyno.2011.06.037. PMID: 21764111

Recent clinical studies

Etiology

Adjuvant chemotherapy does not improve outcome in children with ovarian immature teratoma: A comparative analysis of clinical trial data from the Malignant Germ Cell International Consortium.
Vieira AGS, Puthenpura V, Krailo M, Fallahazad N, Brougham MFH, Murray MJ, Frazier AL, Lopes LF, Pashankar F
Pediatr Blood Cancer 2023 Aug;70(8):e30426. Epub 2023 May 26 doi: 10.1002/pbc.30426. PMID: 37243320
Adjuvant and post-surgical treatment in non-epithelial ovarian cancer.
El Helali A, Kwok GST, Tse KY
Best Pract Res Clin Obstet Gynaecol 2022 Jan;78:74-85. Epub 2021 Aug 4 doi: 10.1016/j.bpobgyn.2021.06.001. PMID: 34493450
Extragonadal teratomas in women and adolescent girls: A systematic review.
Kanneganti A, Bhadiraju P, Tong PSY
Eur J Obstet Gynecol Reprod Biol 2021 Jul;262:134-141. Epub 2021 May 7 doi: 10.1016/j.ejogrb.2021.05.005. PMID: 34022590
Pediatric ovarian immature teratoma: Histological grading and clinical characteristics.
Shinkai T, Masumoto K, Chiba F, Shirane K, Tanaka Y, Aiyoshi T, Sasaki T, Ono K, Gotoh C, Urita Y, Takayasu H, Suzuki R, Sakashita S
J Pediatr Surg 2020 Apr;55(4):707-710. Epub 2019 May 11 doi: 10.1016/j.jpedsurg.2019.04.037. PMID: 31130350
Management of Ovarian Cancer In Younger Women.
Uma Devi K, Purushotham N, Jayashree N
Rev Recent Clin Trials 2015;10(4):263-9. doi: 10.2174/1574887110666150923112047. PMID: 26411956

Diagnosis

Ovary-Sparing Surgery for Ovarian Teratoma in an Infant with Nonbilious Vomiting.
Gerry BV, Parrado RH, Hannay M, Cina RA
Am Surg 2023 Jun;89(6):2774-2776. Epub 2021 Nov 3 doi: 10.1177/00031348211048817. PMID: 34730441
Addressing the diagnostic and therapeutic dilemmas of ovarian immature teratoma: Report from a clinicopathologic consensus conference.
Pashankar F, Hanley K, Lockley M, Stoneham S, Nucci MR, Reyes-Múgica M, Elishaev E, Vang R, Veneris J, Rytting H, Olson T, Hazard K, Covens A, Arora R, Billmire D, Al-Ibraheemi A, Ulbright TM, Frazier L, Hirsch MS
Eur J Cancer 2022 Sep;173:59-70. Epub 2022 Jul 18 doi: 10.1016/j.ejca.2022.06.006. PMID: 35863107
Adjuvant and post-surgical treatment in non-epithelial ovarian cancer.
El Helali A, Kwok GST, Tse KY
Best Pract Res Clin Obstet Gynaecol 2022 Jan;78:74-85. Epub 2021 Aug 4 doi: 10.1016/j.bpobgyn.2021.06.001. PMID: 34493450
Ovarian tumors: a survey of selected advances of note during the life of this journal.
Young RH
Hum Pathol 2020 Jan;95:169-206. Epub 2019 Oct 22 doi: 10.1016/j.humpath.2019.09.002. PMID: 31654691
Struma ovarii.
Ayhan A, Yanik F, Tuncer R, Tuncer ZS, Ruacan S
Int J Gynaecol Obstet 1993 Aug;42(2):143-6. doi: 10.1016/0020-7292(93)90628-a. PMID: 7901063

Therapy

Adjuvant chemotherapy does not improve outcome in children with ovarian immature teratoma: A comparative analysis of clinical trial data from the Malignant Germ Cell International Consortium.
Vieira AGS, Puthenpura V, Krailo M, Fallahazad N, Brougham MFH, Murray MJ, Frazier AL, Lopes LF, Pashankar F
Pediatr Blood Cancer 2023 Aug;70(8):e30426. Epub 2023 May 26 doi: 10.1002/pbc.30426. PMID: 37243320
Proposed Risk Stratification and Patterns of Radioactive Iodine Therapy in Malignant Struma Ovarii.
Egan C, Stefanova D, Thiesmeyer JW, Lee YJ, Greenberg J, Beninato T, Zarnegar R, Christos PJ, Klein IL, Fahey TJ 3rd, Finnerty BM
Thyroid 2022 Sep;32(9):1101-1108. Epub 2022 Aug 11 doi: 10.1089/thy.2022.0145. PMID: 35765923
Teratoma Removal, Steroid, IVIG, Rituximab and Tocilizumab (T-SIRT) in Anti-NMDAR Encephalitis.
Lee WJ, Lee ST, Shin YW, Lee HS, Shin HR, Kim DY, Kim S, Lim JA, Moon J, Park KI, Kim HS, Chu K, Lee SK
Neurotherapeutics 2021 Jan;18(1):474-487. doi: 10.1007/s13311-020-00921-7. PMID: 32880854Free PMC Article
Immature Ovarian Teratoma: When to Give Adjuvant Therapy?
Faure-Conter C, Pashankar F
J Pediatr Hematol Oncol 2017 Oct;39(7):487-489. doi: 10.1097/MPH.0000000000000950. PMID: 28859031
Management of Ovarian Cancer In Younger Women.
Uma Devi K, Purushotham N, Jayashree N
Rev Recent Clin Trials 2015;10(4):263-9. doi: 10.2174/1574887110666150923112047. PMID: 26411956

Prognosis

Teratoma Removal, Steroid, IVIG, Rituximab and Tocilizumab (T-SIRT) in Anti-NMDAR Encephalitis.
Lee WJ, Lee ST, Shin YW, Lee HS, Shin HR, Kim DY, Kim S, Lim JA, Moon J, Park KI, Kim HS, Chu K, Lee SK
Neurotherapeutics 2021 Jan;18(1):474-487. doi: 10.1007/s13311-020-00921-7. PMID: 32880854Free PMC Article
Recurrent High-grade Ovarian Immature Teratoma with Peritoneal Dissemination.
Brind'Amour A, De Guerke L, Fortin S, Gervais MK, Dubé P, Sidéris L
J Pediatr Adolesc Gynecol 2020 Oct;33(5):586-589. Epub 2020 Jun 11 doi: 10.1016/j.jpag.2020.06.002. PMID: 32535217
Ovarian tumors: a survey of selected advances of note during the life of this journal.
Young RH
Hum Pathol 2020 Jan;95:169-206. Epub 2019 Oct 22 doi: 10.1016/j.humpath.2019.09.002. PMID: 31654691
Pediatric ovarian immature teratoma: Histological grading and clinical characteristics.
Shinkai T, Masumoto K, Chiba F, Shirane K, Tanaka Y, Aiyoshi T, Sasaki T, Ono K, Gotoh C, Urita Y, Takayasu H, Suzuki R, Sakashita S
J Pediatr Surg 2020 Apr;55(4):707-710. Epub 2019 May 11 doi: 10.1016/j.jpedsurg.2019.04.037. PMID: 31130350
Management of Ovarian Cancer In Younger Women.
Uma Devi K, Purushotham N, Jayashree N
Rev Recent Clin Trials 2015;10(4):263-9. doi: 10.2174/1574887110666150923112047. PMID: 26411956

Clinical prediction guides

Primary ovarian carcinoid arising in associated mature cystic teratoma.
Zhang W, Chen Q
BMC Womens Health 2022 Mar 17;22(1):76. doi: 10.1186/s12905-022-01660-x. PMID: 35300659Free PMC Article
Teratoma Removal, Steroid, IVIG, Rituximab and Tocilizumab (T-SIRT) in Anti-NMDAR Encephalitis.
Lee WJ, Lee ST, Shin YW, Lee HS, Shin HR, Kim DY, Kim S, Lim JA, Moon J, Park KI, Kim HS, Chu K, Lee SK
Neurotherapeutics 2021 Jan;18(1):474-487. doi: 10.1007/s13311-020-00921-7. PMID: 32880854Free PMC Article
Pediatric growing teratoma syndrome of the ovary: A case report and review of the literature.
Oyama T, Noda T, Washio K, Shimada A
Medicine (Baltimore) 2020 Sep 18;99(38):e22297. doi: 10.1097/MD.0000000000022297. PMID: 32957389Free PMC Article
Ovarian tumors: a survey of selected advances of note during the life of this journal.
Young RH
Hum Pathol 2020 Jan;95:169-206. Epub 2019 Oct 22 doi: 10.1016/j.humpath.2019.09.002. PMID: 31654691
Characteristics, treatment and outcomes of women with immature ovarian teratoma, 1998-2012.
Jorge S, Jones NL, Chen L, Hou JY, Tergas AI, Burke WM, Ananth CV, Neugut AI, Herhshman DL, Wright JD
Gynecol Oncol 2016 Aug;142(2):261-6. Epub 2016 Jun 1 doi: 10.1016/j.ygyno.2016.05.024. PMID: 27222024Free PMC Article

Recent systematic reviews

Extragonadal teratomas in women and adolescent girls: A systematic review.
Kanneganti A, Bhadiraju P, Tong PSY
Eur J Obstet Gynecol Reprod Biol 2021 Jul;262:134-141. Epub 2021 May 7 doi: 10.1016/j.ejogrb.2021.05.005. PMID: 34022590
Evidence of metachronous development of ovarian teratomas: a case report of bilateral mature cystic teratomas of the ovaries and systematic literature review.
Wang WC, Lai YC
J Ovarian Res 2017 Mar 14;10(1):17. doi: 10.1186/s13048-017-0313-8. PMID: 28288660Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...