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Mantle cell lymphoma

MedGen UID:
1668377
Concept ID:
C4721414
Neoplastic Process
Synonyms: Centrocytic Small-Cell Lymphoma; Centrocytic Small-Cell Lymphomas; Diffuse Lymphocytic Lymphoma, Poorly Differentiated; Diffuse Lymphocytic Lymphoma, Poorly-Differentiated; Lymphocytic Lymphoma, Diffuse, Poorly Differentiated; Lymphocytic Lymphoma, Diffuse, Poorly-Differentiated; Lymphoma, Centrocytic Small Cell; Lymphoma, Centrocytic Small-Cell; Lymphoma, Lymphocytic, Diffuse, Intermediate Differentiated; Lymphoma, Lymphocytic, Diffuse, Poorly-Differentiated; Lymphoma, Mantle Cell; Lymphoma, Mantle-Cell; Lymphoma, Mantle-Zone; Lymphoma, Small-Cell, Centrocytic; Lymphomas, Centrocytic Small-Cell; Lymphomas, Mantle-Cell; Lymphomas, Mantle-Zone; Mantle Cell Lymphoma; Mantle Zone Lymphoma; Mantle-Cell Lymphoma; Mantle-Cell Lymphomas; Mantle-Zone Lymphoma; Mantle-Zone Lymphomas; Small-Cell Lymphoma, Centrocytic; Small-Cell Lymphomas, Centrocytic
SNOMED CT: Mantle cell lymphoma (74654000); Mantle cell lymphoma (443487006)
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
Concept ID:
C0600599
Genetic Function
Source: Orphanet
A mode of inheritance that depends on genetic determinants in more than one gene.
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0018876
OMIM®: 607585
Orphanet: ORPHA52416

Definition

Mantle cell lymphoma is a rare form of malignant non-Hodgkin lymphoma (see this term) affecting B lymphocytes in the lymph nodes in a region called the ``mantle zone''. [from ORDO]

Professional guidelines

PubMed

Hayden PJ, Roddie C, Bader P, Basak GW, Bonig H, Bonini C, Chabannon C, Ciceri F, Corbacioglu S, Ellard R, Sanchez-Guijo F, Jäger U, Hildebrandt M, Hudecek M, Kersten MJ, Köhl U, Kuball J, Mielke S, Mohty M, Murray J, Nagler A, Rees J, Rioufol C, Saccardi R, Snowden JA, Styczynski J, Subklewe M, Thieblemont C, Topp M, Ispizua ÁU, Chen D, Vrhovac R, Gribben JG, Kröger N, Einsele H, Yakoub-Agha I
Ann Oncol 2022 Mar;33(3):259-275. Epub 2021 Dec 16 doi: 10.1016/j.annonc.2021.12.003. PMID: 34923107
Jain P, Wang M
Am J Hematol 2019 Jun;94(6):710-725. Epub 2019 Apr 19 doi: 10.1002/ajh.25487. PMID: 30963600
Paydas S
Crit Rev Oncol Hematol 2019 Apr;136:56-63. Epub 2019 Feb 10 doi: 10.1016/j.critrevonc.2019.02.001. PMID: 30878129

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) B-Cell Lymphomas, 2024

Recent clinical studies

Etiology

Silkenstedt E, Dreyling M
Hematol Oncol 2023 Jun;41 Suppl 1:36-42. doi: 10.1002/hon.3149. PMID: 37294961
Kumar A, Eyre TA, Lewis KL, Thompson MC, Cheah CY
Am Soc Clin Oncol Educ Book 2022 Apr;42:1-15. doi: 10.1200/EDBK_349509. PMID: 35561299
Jain P, Wang ML
Am J Hematol 2022 May;97(5):638-656. doi: 10.1002/ajh.26523. PMID: 35266562
Silkenstedt E, Linton K, Dreyling M
Br J Haematol 2021 Oct;195(2):162-173. Epub 2021 Mar 30 doi: 10.1111/bjh.17419. PMID: 33783838
Maddocks K
Blood 2018 Oct 18;132(16):1647-1656. Epub 2018 Aug 28 doi: 10.1182/blood-2018-03-791392. PMID: 30154113

Diagnosis

Silkenstedt E, Dreyling M
Hematol Oncol 2023 Jun;41 Suppl 1:36-42. doi: 10.1002/hon.3149. PMID: 37294961
Kumar A, Eyre TA, Lewis KL, Thompson MC, Cheah CY
Am Soc Clin Oncol Educ Book 2022 Apr;42:1-15. doi: 10.1200/EDBK_349509. PMID: 35561299
Silkenstedt E, Linton K, Dreyling M
Br J Haematol 2021 Oct;195(2):162-173. Epub 2021 Mar 30 doi: 10.1111/bjh.17419. PMID: 33783838
Navarro A, Beà S, Jares P, Campo E
Hematol Oncol Clin North Am 2020 Oct;34(5):795-807. Epub 2020 Jul 22 doi: 10.1016/j.hoc.2020.05.002. PMID: 32861278Free PMC Article
Maddocks K
Blood 2018 Oct 18;132(16):1647-1656. Epub 2018 Aug 28 doi: 10.1182/blood-2018-03-791392. PMID: 30154113

Therapy

Huang Z, Chavda VP, Bezbaruah R, Dhamne H, Yang DH, Zhao HB
Mol Cancer 2023 Mar 31;22(1):67. doi: 10.1186/s12943-023-01755-5. PMID: 37004047Free PMC Article
Kumar A, Eyre TA, Lewis KL, Thompson MC, Cheah CY
Am Soc Clin Oncol Educ Book 2022 Apr;42:1-15. doi: 10.1200/EDBK_349509. PMID: 35561299
Jain P, Zhao S, Lee HJ, Hill HA, Ok CY, Kanagal-Shamanna R, Hagemeister FB, Fowler N, Fayad L, Yao Y, Liu Y, Moghrabi OB, Navsaria L, Feng L, Nogueras Gonzalez GM, Xu G, Thirumurthi S, Santos D, Iliescu C, Tang G, Medeiros LJ, Vega F, Avellaneda M, Badillo M, Flowers CR, Wang L, Wang ML
J Clin Oncol 2022 Jan 10;40(2):202-212. Epub 2021 Nov 19 doi: 10.1200/JCO.21.01797. PMID: 34797699Free PMC Article
Burger JA
Cancer J 2019 Nov/Dec;25(6):386-393. doi: 10.1097/PPO.0000000000000412. PMID: 31764119Free PMC Article
Wang M, Rule S, Zinzani PL, Goy A, Casasnovas O, Smith SD, Damaj G, Doorduijn J, Lamy T, Morschhauser F, Panizo C, Shah B, Davies A, Eek R, Dupuis J, Jacobsen E, Kater AP, Le Gouill S, Oberic L, Robak T, Covey T, Dua R, Hamdy A, Huang X, Izumi R, Patel P, Rothbaum W, Slatter JG, Jurczak W
Lancet 2018 Feb 17;391(10121):659-667. Epub 2017 Dec 11 doi: 10.1016/S0140-6736(17)33108-2. PMID: 29241979Free PMC Article

Prognosis

Wang M, Munoz J, Goy A, Locke FL, Jacobson CA, Hill BT, Timmerman JM, Holmes H, Jaglowski S, Flinn IW, McSweeney PA, Miklos DB, Pagel JM, Kersten MJ, Bouabdallah K, Khanal R, Topp MS, Houot R, Beitinjaneh A, Peng W, Fang X, Shen RR, Siddiqi R, Kloos I, Reagan PM
J Clin Oncol 2023 Jan 20;41(3):555-567. Epub 2022 Jun 4 doi: 10.1200/JCO.21.02370. PMID: 35658525Free PMC Article
Silkenstedt E, Linton K, Dreyling M
Br J Haematol 2021 Oct;195(2):162-173. Epub 2021 Mar 30 doi: 10.1111/bjh.17419. PMID: 33783838
Jain P, Wang M
Am J Hematol 2019 Jun;94(6):710-725. Epub 2019 Apr 19 doi: 10.1002/ajh.25487. PMID: 30963600
Paydas S
Crit Rev Oncol Hematol 2019 Apr;136:56-63. Epub 2019 Feb 10 doi: 10.1016/j.critrevonc.2019.02.001. PMID: 30878129
Maddocks K
Blood 2018 Oct 18;132(16):1647-1656. Epub 2018 Aug 28 doi: 10.1182/blood-2018-03-791392. PMID: 30154113

Clinical prediction guides

Jain P, Wang M
Am J Hematol 2019 Jun;94(6):710-725. Epub 2019 Apr 19 doi: 10.1002/ajh.25487. PMID: 30963600
Maddocks K
Blood 2018 Oct 18;132(16):1647-1656. Epub 2018 Aug 28 doi: 10.1182/blood-2018-03-791392. PMID: 30154113
Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E, Lister TA; Alliance, Australasian Leukaemia and Lymphoma Group; Eastern Cooperative Oncology Group; European Mantle Cell Lymphoma Consortium; Italian Lymphoma Foundation; European Organisation for Research; Treatment of Cancer/Dutch Hemato-Oncology Group; Grupo Español de Médula Ósea; German High-Grade Lymphoma Study Group; German Hodgkin's Study Group; Japanese Lymphorra Study Group; Lymphoma Study Association; NCIC Clinical Trials Group; Nordic Lymphoma Study Group; Southwest Oncology Group; United Kingdom National Cancer Research Institute
J Clin Oncol 2014 Sep 20;32(27):3059-68. doi: 10.1200/JCO.2013.54.8800. PMID: 25113753Free PMC Article
Wang ML, Rule S, Martin P, Goy A, Auer R, Kahl BS, Jurczak W, Advani RH, Romaguera JE, Williams ME, Barrientos JC, Chmielowska E, Radford J, Stilgenbauer S, Dreyling M, Jedrzejczak WW, Johnson P, Spurgeon SE, Li L, Zhang L, Newberry K, Ou Z, Cheng N, Fang B, McGreivy J, Clow F, Buggy JJ, Chang BY, Beaupre DM, Kunkel LA, Blum KA
N Engl J Med 2013 Aug 8;369(6):507-16. Epub 2013 Jun 19 doi: 10.1056/NEJMoa1306220. PMID: 23782157Free PMC Article
Hoster E, Dreyling M, Klapper W, Gisselbrecht C, van Hoof A, Kluin-Nelemans HC, Pfreundschuh M, Reiser M, Metzner B, Einsele H, Peter N, Jung W, Wörmann B, Ludwig WD, Dührsen U, Eimermacher H, Wandt H, Hasford J, Hiddemann W, Unterhalt M; German Low Grade Lymphoma Study Group (GLSG); European Mantle Cell Lymphoma Network
Blood 2008 Jan 15;111(2):558-65. Epub 2007 Oct 25 doi: 10.1182/blood-2007-06-095331. PMID: 17962512

Recent systematic reviews

Zinzi A, Gaio M, Liguori V, Cagnotta C, Paolino D, Paolisso G, Castaldo G, Nicoletti GF, Rossi F, Capuano A, Rafaniello C
Pharmacol Res 2023 Apr;190:106742. Epub 2023 Mar 22 doi: 10.1016/j.phrs.2023.106742. PMID: 36963592
Roufarshbaf M, Javeri M, Akbari V, Matin PH, Farrokhi P, Sadeghi E, Heidari Z, Moghaddas A
Daru 2022 Dec;30(2):367-378. Epub 2022 Sep 3 doi: 10.1007/s40199-022-00444-w. PMID: 36057010Free PMC Article
Hill HA, Qi X, Jain P, Nomie K, Wang Y, Zhou S, Wang ML
Blood Adv 2020 Jul 14;4(13):2927-2938. doi: 10.1182/bloodadvances.2019001350. PMID: 32598477Free PMC Article
Parrott M, Rule S, Kelleher M, Wilson J
Clin Lymphoma Myeloma Leuk 2018 Jan;18(1):13-25.e6. Epub 2017 Oct 13 doi: 10.1016/j.clml.2017.10.004. PMID: 29122536
Njue A, Colosia A, Trask PC, Olivares R, Khan S, Abbe A, Police R, Wang J, Ruiz-Soto R, Kaye JA, Awan F
Clin Lymphoma Myeloma Leuk 2015 Jan;15(1):1-12.e7. Epub 2014 Jun 11 doi: 10.1016/j.clml.2014.03.006. PMID: 25052050

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) B-Cell Lymphomas, 2024

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