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Squamous cell carcinoma of liver and intrahepatic biliary tract

MedGen UID:
1668494
•Concept ID:
C4749400
•
Neoplastic Process
Synonyms: Squamous cell carcinoma of liver and IBT; squamous cell carcinoma of liver and IBT; squamous cell carcinoma of liver and intrahepatic biliary tract
SNOMED CT: Squamous cell carcinoma of liver and intrahepatic biliary tract (770684008)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0018534
Orphanet: ORPHA424975

Definition

Squamous cell carcinoma of liver and intrahepatic biliary tract is an extremely rare, primary, malignant liver and biliray tract epithelial tumor originating in the intrahepatic bile duct epithelium histologically characterized by the presence of keratinization and/or intracellular bridges. Patients typically present abdominal pain in the right upper quadrant, jaundice, nausea, vomiting, anorexia, weight loss, fever and/or dyspepsia. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSquamous cell carcinoma of liver and intrahepatic biliary tract

Professional guidelines

PubMed

Single-center experience in the diagnosis and treatment of lymphoepithelioma-like hepatic carcinoma.
Jia J, Guo H, Liu J, Sun Q, Cao G, Zhou S, Shuai M, Gao F, Zheng S, Zhang M
J Cancer Res Clin Oncol 2023 Sep;149(11):8691-8697. Epub 2023 May 1 doi: 10.1007/s00432-023-04808-w. PMID: 37126105

Recent clinical studies

Etiology

Clinicopathological features of a rare cancer: Intrahepatic lymphoepithelioma-like cholangiocarcinoma with Epstein-Barr virus infection.
Zheng L, Zhou N, Yang X, Wei Y, Yi C, Gou H
Clin Res Hepatol Gastroenterol 2023 Dec;47(10):102244. Epub 2023 Nov 7 doi: 10.1016/j.clinre.2023.102244. PMID: 37944749
Single-center experience in the diagnosis and treatment of lymphoepithelioma-like hepatic carcinoma.
Jia J, Guo H, Liu J, Sun Q, Cao G, Zhou S, Shuai M, Gao F, Zheng S, Zhang M
J Cancer Res Clin Oncol 2023 Sep;149(11):8691-8697. Epub 2023 May 1 doi: 10.1007/s00432-023-04808-w. PMID: 37126105
Primary adenosquamous carcinoma of the liver detected during cancer surveillance in a patient with primary sclerosing cholangitis.
Daiku K, Fukuda K, Morimoto O, Takiuchi D, Shimakoshi H, Kegasawa T, Yamaguchi Y, Kogita S, Sawai Y, Nakahara M, Igura T, Shibata K, Imai Y
Clin J Gastroenterol 2020 Dec;13(6):1273-1279. Epub 2020 Aug 12 doi: 10.1007/s12328-020-01204-6. PMID: 32785892
Hepatitis C and Risk of Nonhepatic Malignancies.
Balakrishnan M, Glover MT, Kanwal F
Clin Liver Dis 2017 Aug;21(3):543-554. Epub 2017 Apr 22 doi: 10.1016/j.cld.2017.03.009. PMID: 28689592
Resection of the liver and inferior vena cava for hepatic malignancy.
Hemming AW, Mekeel KL, Zendejas I, Kim RD, Sicklick JK, Reed AI
J Am Coll Surg 2013 Jul;217(1):115-24; discussion 124-5. Epub 2013 Feb 1 doi: 10.1016/j.jamcollsurg.2012.12.003. PMID: 23376028

Diagnosis

Potential missed opportunities for diagnosis of lymphoepithelioma-like intrahepatic cholangiocarcinoma: report of a rare case.
Tang W, Huang Y, Yu S, Wang T, Yang J, Zhao Z
J Int Med Res 2023 Nov;51(11):3000605231210174. doi: 10.1177/03000605231210174. PMID: 37994034Free PMC Article
Single-center experience in the diagnosis and treatment of lymphoepithelioma-like hepatic carcinoma.
Jia J, Guo H, Liu J, Sun Q, Cao G, Zhou S, Shuai M, Gao F, Zheng S, Zhang M
J Cancer Res Clin Oncol 2023 Sep;149(11):8691-8697. Epub 2023 May 1 doi: 10.1007/s00432-023-04808-w. PMID: 37126105
Advanced primary adenosquamous carcinoma of the liver with a small cell carcinoma component: an autopsy case report.
Nosaka T, Ohtani M, Namikawa S, Takahashi K, Naito T, Ofuji K, Matsuda H, Hiramatsu K, Imamura Y, Nakamoto Y
Clin J Gastroenterol 2021 Oct;14(5):1496-1502. Epub 2021 Jul 3 doi: 10.1007/s12328-021-01474-8. PMID: 34216375
Primary adenosquamous carcinoma of the liver detected during cancer surveillance in a patient with primary sclerosing cholangitis.
Daiku K, Fukuda K, Morimoto O, Takiuchi D, Shimakoshi H, Kegasawa T, Yamaguchi Y, Kogita S, Sawai Y, Nakahara M, Igura T, Shibata K, Imai Y
Clin J Gastroenterol 2020 Dec;13(6):1273-1279. Epub 2020 Aug 12 doi: 10.1007/s12328-020-01204-6. PMID: 32785892
Biliary squamous cell carcinoma.
La Greca G, Conti P, Urrico GS, Catanuto G, Di Carlo I, Russello D, Latteri F
Chir Ital 2004 Mar-Apr;56(2):289-95. PMID: 15152526

Therapy

Usefulness of cholangioscopy in patients with focal stricture of the intrahepatic duct unrelated to intrahepatic stones.
Seo DW, Kim MH, Lee SK, Myung SJ, Kang GH, Ha HK, Suh DJ, Min YI
Gastrointest Endosc 1999 Feb;49(2):204-9. doi: 10.1016/s0016-5107(99)70487-6. PMID: 9925699

Prognosis

Single-center experience in the diagnosis and treatment of lymphoepithelioma-like hepatic carcinoma.
Jia J, Guo H, Liu J, Sun Q, Cao G, Zhou S, Shuai M, Gao F, Zheng S, Zhang M
J Cancer Res Clin Oncol 2023 Sep;149(11):8691-8697. Epub 2023 May 1 doi: 10.1007/s00432-023-04808-w. PMID: 37126105
The protease-inhibitor SerpinB3 as a critical modulator of the stem-like subset in human cholangiocarcinoma.
Correnti M, Cappon A, Pastore M, Piombanti B, Lori G, Oliveira DVPN, Munoz-Garrido P, Lewinska M, Andersen JB, Coulouarn C, Sulpice L, Peraldo Neia C, Cavalloni G, Quarta S, Biasiolo A, Fassan M, Ramazzotti M, Parri M, Recalcati S, di Tommaso L, Campani C, Invernizzi P, Torzilli G, Marra F, Pontisso P, Raggi C
Liver Int 2022 Jan;42(1):233-248. Epub 2021 Sep 16 doi: 10.1111/liv.15049. PMID: 34478594Free PMC Article
Primary adenosquamous carcinoma of the liver detected during cancer surveillance in a patient with primary sclerosing cholangitis.
Daiku K, Fukuda K, Morimoto O, Takiuchi D, Shimakoshi H, Kegasawa T, Yamaguchi Y, Kogita S, Sawai Y, Nakahara M, Igura T, Shibata K, Imai Y
Clin J Gastroenterol 2020 Dec;13(6):1273-1279. Epub 2020 Aug 12 doi: 10.1007/s12328-020-01204-6. PMID: 32785892
Resection of the liver and inferior vena cava for hepatic malignancy.
Hemming AW, Mekeel KL, Zendejas I, Kim RD, Sicklick JK, Reed AI
J Am Coll Surg 2013 Jul;217(1):115-24; discussion 124-5. Epub 2013 Feb 1 doi: 10.1016/j.jamcollsurg.2012.12.003. PMID: 23376028
Biliary squamous cell carcinoma.
La Greca G, Conti P, Urrico GS, Catanuto G, Di Carlo I, Russello D, Latteri F
Chir Ital 2004 Mar-Apr;56(2):289-95. PMID: 15152526

Clinical prediction guides

Single-center experience in the diagnosis and treatment of lymphoepithelioma-like hepatic carcinoma.
Jia J, Guo H, Liu J, Sun Q, Cao G, Zhou S, Shuai M, Gao F, Zheng S, Zhang M
J Cancer Res Clin Oncol 2023 Sep;149(11):8691-8697. Epub 2023 May 1 doi: 10.1007/s00432-023-04808-w. PMID: 37126105
The protease-inhibitor SerpinB3 as a critical modulator of the stem-like subset in human cholangiocarcinoma.
Correnti M, Cappon A, Pastore M, Piombanti B, Lori G, Oliveira DVPN, Munoz-Garrido P, Lewinska M, Andersen JB, Coulouarn C, Sulpice L, Peraldo Neia C, Cavalloni G, Quarta S, Biasiolo A, Fassan M, Ramazzotti M, Parri M, Recalcati S, di Tommaso L, Campani C, Invernizzi P, Torzilli G, Marra F, Pontisso P, Raggi C
Liver Int 2022 Jan;42(1):233-248. Epub 2021 Sep 16 doi: 10.1111/liv.15049. PMID: 34478594Free PMC Article
Glypican-3 expression in gastrointestinal and pancreatic epithelial neoplasms.
Mounajjed T, Zhang L, Wu TT
Hum Pathol 2013 Apr;44(4):542-50. Epub 2012 Oct 15 doi: 10.1016/j.humpath.2012.06.016. PMID: 23079207
Expression of Ep-CAM in normal, regenerating, metaplastic, and neoplastic liver.
de Boer CJ, van Krieken JH, Janssen-van Rhijn CM, Litvinov SV
J Pathol 1999 Jun;188(2):201-6. doi: 10.1002/(SICI)1096-9896(199906)188:2<201::AID-PATH339>3.0.CO;2-8. PMID: 10398165
Clinicopathologic studies on perineural invasion of bile duct carcinoma.
Bhuiya MR, Nimura Y, Kamiya J, Kondo S, Fukata S, Hayakawa N, Shionoya S
Ann Surg 1992 Apr;215(4):344-9. doi: 10.1097/00000658-199204000-00007. PMID: 1558415Free PMC Article

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