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Isolated asymptomatic elevation of creatine phosphokinase

MedGen UID:
1668524
•Concept ID:
C4751434
•
Finding
Synonyms: hyperCKmia; Idiopathic asymptomatic hyperCKemia; idiopathic asymptomatic hyperCKemia; isolated asymptomatic elevation of creatine phosphokinase; Isolated asymptomatic hyperCKemia; isolated asymptomatic hyperCKemia; isolated hyperCKemia
SNOMED CT: Isolated asymptomatic elevation of creatine phosphokinase (773990006)
 
Monarch Initiative: MONDO:0016103
Orphanet: ORPHA206599

Definition

A rare neurologic disease with characteristics of persistent elevation of the serum creatine phosphokinase (CK) without any clinical, neuro-physical or histopathological evidence of neuromuscular disease using available laboratory procedures. It is usually an incidental finding, diagnosed after exclusion of other possible causes of elevated CK levels. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIsolated asymptomatic elevation of creatine phosphokinase

Professional guidelines

PubMed

Multicenter study of high-dose daptomycin for treatment of enterococcal infections.
Casapao AM, Kullar R, Davis SL, Levine DP, Zhao JJ, Potoski BA, Goff DA, Crank CW, Segreti J, Sakoulas G, Cosgrove SE, Rybak MJ
Antimicrob Agents Chemother 2013 Sep;57(9):4190-6. Epub 2013 Jun 17 doi: 10.1128/AAC.00526-13. PMID: 23774437Free PMC Article
Clinical experience with daptomycin for the treatment of patients with knee and hip periprosthetic joint infections.
Corona Pérez-Cardona PS, Barro Ojeda V, Rodriguez Pardo D, Pigrau Serrallach C, Guerra Farfán E, Amat Mateu C, Flores Sanchez X
J Antimicrob Chemother 2012 Jul;67(7):1749-54. Epub 2012 Apr 17 doi: 10.1093/jac/dks119. PMID: 22511636

Recent clinical studies

Etiology

Statin Associated Muscular Adverse Effects.
Kammoun R, Charfi O, Lakhoua G, Zaiem A, Daghfous R, Kastalli S, Aouinti I, Aidli SE
Curr Drug Saf 2024;19(1):114-116. doi: 10.2174/1574886318666230227143627. PMID: 36847228
Myositis and neuromuscular side-effects induced by immune checkpoint inhibitors.
Moreira A, Loquai C, Pföhler C, Kähler KC, Knauss S, Heppt MV, Gutzmer R, Dimitriou F, Meier F, Mitzel-Rink H, Schuler G, Terheyden P, Thoms KM, Türk M, Dummer R, Zimmer L, Schröder R, Heinzerling L
Eur J Cancer 2019 Jan;106:12-23. Epub 2018 Nov 17 doi: 10.1016/j.ejca.2018.09.033. PMID: 30453170
Atorvastatin-induced necrotizing autoimmune myositis: An emerging dominant entity in patients with autoimmune myositis presenting with a pure polymyositis phenotype.
Troyanov Y, Landon-Cardinal O, Fritzler MJ, Ferreira J, Targoff IN, Rich E, Goulet M, Goulet JR, Bourré-Tessier J, Robitaille Y, Drouin J, Albert A, Senécal JL
Medicine (Baltimore) 2017 Jan;96(3):e5694. doi: 10.1097/MD.0000000000005694. PMID: 28099331Free PMC Article
Multicenter study of high-dose daptomycin for treatment of enterococcal infections.
Casapao AM, Kullar R, Davis SL, Levine DP, Zhao JJ, Potoski BA, Goff DA, Crank CW, Segreti J, Sakoulas G, Cosgrove SE, Rybak MJ
Antimicrob Agents Chemother 2013 Sep;57(9):4190-6. Epub 2013 Jun 17 doi: 10.1128/AAC.00526-13. PMID: 23774437Free PMC Article
Drug-induced myopathies.
Bannwarth B
Expert Opin Drug Saf 2002 May;1(1):65-70. doi: 10.1517/14740338.1.1.65. PMID: 12904161

Diagnosis

Myositis and neuromuscular side-effects induced by immune checkpoint inhibitors.
Moreira A, Loquai C, Pföhler C, Kähler KC, Knauss S, Heppt MV, Gutzmer R, Dimitriou F, Meier F, Mitzel-Rink H, Schuler G, Terheyden P, Thoms KM, Türk M, Dummer R, Zimmer L, Schröder R, Heinzerling L
Eur J Cancer 2019 Jan;106:12-23. Epub 2018 Nov 17 doi: 10.1016/j.ejca.2018.09.033. PMID: 30453170
Atorvastatin-induced necrotizing autoimmune myositis: An emerging dominant entity in patients with autoimmune myositis presenting with a pure polymyositis phenotype.
Troyanov Y, Landon-Cardinal O, Fritzler MJ, Ferreira J, Targoff IN, Rich E, Goulet M, Goulet JR, Bourré-Tessier J, Robitaille Y, Drouin J, Albert A, Senécal JL
Medicine (Baltimore) 2017 Jan;96(3):e5694. doi: 10.1097/MD.0000000000005694. PMID: 28099331Free PMC Article
Caveolinopathies in Greece.
Papadopoulos C, Papadimas GK, Kekou K, Spengos K, Svigou M, Kitsiou-Tzeli S, Manta P
Neurologist 2015 Jul;20(1):8-12. doi: 10.1097/NRL.0000000000000036. PMID: 26185955
Multiple macroenzymes in a patient with AIDS: diagnosis using ultrafiltration.
Wyness SP, Yee MA, La'ulu SL, Tosiello L, Straseski JA
Am J Clin Pathol 2014 Aug;142(2):266-8. doi: 10.1309/AJCPWA9QHR9WHPNA. PMID: 25015871
Clinical and laboratory features of Macedonian children with OCRL mutations.
Tasic V, Lozanovski VJ, Korneti P, Ristoska-Bojkovska N, Sabolic-Avramovska V, Gucev Z, Ludwig M
Pediatr Nephrol 2011 Apr;26(4):557-62. Epub 2011 Jan 20 doi: 10.1007/s00467-010-1758-9. PMID: 21249396

Therapy

Statin Associated Muscular Adverse Effects.
Kammoun R, Charfi O, Lakhoua G, Zaiem A, Daghfous R, Kastalli S, Aouinti I, Aidli SE
Curr Drug Saf 2024;19(1):114-116. doi: 10.2174/1574886318666230227143627. PMID: 36847228
Myositis and neuromuscular side-effects induced by immune checkpoint inhibitors.
Moreira A, Loquai C, Pföhler C, Kähler KC, Knauss S, Heppt MV, Gutzmer R, Dimitriou F, Meier F, Mitzel-Rink H, Schuler G, Terheyden P, Thoms KM, Türk M, Dummer R, Zimmer L, Schröder R, Heinzerling L
Eur J Cancer 2019 Jan;106:12-23. Epub 2018 Nov 17 doi: 10.1016/j.ejca.2018.09.033. PMID: 30453170
Isolation and Identification of Rickettsia raoultii in Human Cases: A Surveillance Study in 3 Medical Centers in China.
Li H, Zhang PH, Huang Y, Du J, Cui N, Yang ZD, Tang F, Fu FX, Li XM, Cui XM, Fan YD, Xing B, Li XK, Tong YG, Cao WC, Liu W
Clin Infect Dis 2018 Mar 19;66(7):1109-1115. doi: 10.1093/cid/cix917. PMID: 29069294
Multicenter study of high-dose daptomycin for treatment of enterococcal infections.
Casapao AM, Kullar R, Davis SL, Levine DP, Zhao JJ, Potoski BA, Goff DA, Crank CW, Segreti J, Sakoulas G, Cosgrove SE, Rybak MJ
Antimicrob Agents Chemother 2013 Sep;57(9):4190-6. Epub 2013 Jun 17 doi: 10.1128/AAC.00526-13. PMID: 23774437Free PMC Article
Drug-induced myopathies.
Bannwarth B
Expert Opin Drug Saf 2002 May;1(1):65-70. doi: 10.1517/14740338.1.1.65. PMID: 12904161

Prognosis

Isolated elevated serum transaminases leading to the diagnosis of asymptomatic Pompe disease.
Hoeksma M, Boon M, Niezen-Koning KE, van Overbeek-van Gils L, van Spronsen FJ
Eur J Pediatr 2007 Aug;166(8):871-4. Epub 2006 Oct 17 doi: 10.1007/s00431-006-0315-9. PMID: 17043839

Clinical prediction guides

Statin Associated Muscular Adverse Effects.
Kammoun R, Charfi O, Lakhoua G, Zaiem A, Daghfous R, Kastalli S, Aouinti I, Aidli SE
Curr Drug Saf 2024;19(1):114-116. doi: 10.2174/1574886318666230227143627. PMID: 36847228
Treatment of severe leptospirosis with therapeutic plasma exchange in a pediatric patient.
Ekinci F, Yıldızdaş RD, Horoz ÖÖ, Alabaz D, Tolunay İ, Petmezci E
Turk J Pediatr 2018;60(5):566-570. doi: 10.24953/turkjped.2018.05.015. PMID: 30968640
Isolation and Identification of Rickettsia raoultii in Human Cases: A Surveillance Study in 3 Medical Centers in China.
Li H, Zhang PH, Huang Y, Du J, Cui N, Yang ZD, Tang F, Fu FX, Li XM, Cui XM, Fan YD, Xing B, Li XK, Tong YG, Cao WC, Liu W
Clin Infect Dis 2018 Mar 19;66(7):1109-1115. doi: 10.1093/cid/cix917. PMID: 29069294
Atorvastatin-induced necrotizing autoimmune myositis: An emerging dominant entity in patients with autoimmune myositis presenting with a pure polymyositis phenotype.
Troyanov Y, Landon-Cardinal O, Fritzler MJ, Ferreira J, Targoff IN, Rich E, Goulet M, Goulet JR, Bourré-Tessier J, Robitaille Y, Drouin J, Albert A, Senécal JL
Medicine (Baltimore) 2017 Jan;96(3):e5694. doi: 10.1097/MD.0000000000005694. PMID: 28099331Free PMC Article
Multicenter study of high-dose daptomycin for treatment of enterococcal infections.
Casapao AM, Kullar R, Davis SL, Levine DP, Zhao JJ, Potoski BA, Goff DA, Crank CW, Segreti J, Sakoulas G, Cosgrove SE, Rybak MJ
Antimicrob Agents Chemother 2013 Sep;57(9):4190-6. Epub 2013 Jun 17 doi: 10.1128/AAC.00526-13. PMID: 23774437Free PMC Article

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