U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Metastatic Lip and Oral Cavity Carcinoma

MedGen UID:
1670926
•Concept ID:
C4744556
•
Neoplastic Process

Definition

A carcinoma that arises from the lip and/or oral cavity and has metastasized to another anatomic site. [from NCI]

Professional guidelines

PubMed

Lower lip basal cell and squamous cell carcinomas: a reappraisal of the similarities and differences in clinical presentation and management.
Hwang JR, Khachemoune A
Arch Dermatol Res 2023 Mar;315(2):117-125. Epub 2022 Mar 21 doi: 10.1007/s00403-022-02345-z. PMID: 35312855
Cheilitis glandularis: clinico-histopathological diagnostic criteria.
Reiter S, Vered M, Yarom N, Goldsmith C, Gorsky M
Oral Dis 2011 Apr;17(3):335-9. Epub 2010 Oct 28 doi: 10.1111/j.1601-0825.2010.01762.x. PMID: 21029266
Supraomohyoid neck dissection in the management of cervical lymph node metastases of squamous cell carcinoma of the lower lip.
Gooris PJ, Vermey A, de Visscher JG, Burlage FR, Roodenburg JL
Head Neck 2002 Jul;24(7):678-83. doi: 10.1002/hed.10079. PMID: 12112542

Recent clinical studies

Etiology

Lower lip basal cell and squamous cell carcinomas: a reappraisal of the similarities and differences in clinical presentation and management.
Hwang JR, Khachemoune A
Arch Dermatol Res 2023 Mar;315(2):117-125. Epub 2022 Mar 21 doi: 10.1007/s00403-022-02345-z. PMID: 35312855
Resuming Oral Feeding in Patients With Oral Squamous Cell Carcinoma With Free Anterolateral Thigh Flap Reconstruction.
Chiang TY, Huang CH, Kuan CH, Horng SY, Hsieh JH, Wu YF, Chuang SY, Yu YH, Ho CC, Cheng NC, Tai HC
Ann Plast Surg 2021 Feb 1;86(2S Suppl 1):S108-S112. doi: 10.1097/SAP.0000000000002652. PMID: 33438960
Squamous Cell Carcinoma of the Lip-A Review of Squamous Cell Carcinogenesis of the Mucosal and Cutaneous Junction.
Bota JP, Lyons AB, Carroll BT
Dermatol Surg 2017 Apr;43(4):494-506. doi: 10.1097/DSS.0000000000001020. PMID: 28157733
Distant metastases from lip and oral cavity cancer.
Betka J
ORL J Otorhinolaryngol Relat Spec 2001 Jul-Aug;63(4):217-21. doi: 10.1159/000055744. PMID: 11408816
Carcinoma of the lip.
Zitsch RP 3rd
Otolaryngol Clin North Am 1993 Apr;26(2):265-77. PMID: 8460042

Diagnosis

Head and Neck Cancer Incidence in the United States Before and During the COVID-19 Pandemic.
Semprini J, Pagedar NA, Boakye EA, Osazuwa-Peters N
JAMA Otolaryngol Head Neck Surg 2024 Mar 1;150(3):193-200. doi: 10.1001/jamaoto.2023.4322. PMID: 38206603Free PMC Article
Lower lip basal cell and squamous cell carcinomas: a reappraisal of the similarities and differences in clinical presentation and management.
Hwang JR, Khachemoune A
Arch Dermatol Res 2023 Mar;315(2):117-125. Epub 2022 Mar 21 doi: 10.1007/s00403-022-02345-z. PMID: 35312855
Squamous Cell Carcinoma of the Lip-A Review of Squamous Cell Carcinogenesis of the Mucosal and Cutaneous Junction.
Bota JP, Lyons AB, Carroll BT
Dermatol Surg 2017 Apr;43(4):494-506. doi: 10.1097/DSS.0000000000001020. PMID: 28157733
Lip squamous cell carcinoma in a Brazilian population: epidemiological study and clinicopathological associations.
Souza RL, Fonseca-Fonseca T, Oliveira-Santos CC, Corrêa GT, Santos FB, Cardoso CM, Sant' Ana-Haikal D, Guimarães AL, Batista-De Paula AM
Med Oral Patol Oral Cir Bucal 2011 Sep 1;16(6):e757-62. doi: 10.4317/medoral.16954. PMID: 21196879
Distant metastases from lip and oral cavity cancer.
Betka J
ORL J Otorhinolaryngol Relat Spec 2001 Jul-Aug;63(4):217-21. doi: 10.1159/000055744. PMID: 11408816

Therapy

Safety and Efficacy of Pembrolizumab With Chemoradiotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma: A Phase IB Study.
Powell SF, Gold KA, Gitau MM, Sumey CJ, Lohr MM, McGraw SC, Nowak RK, Jensen AW, Blanchard MJ, Fischer CD, Bykowski J, Ellison CA, Black LJ, Thompson PA, Callejas-Valera JL, Lee JH, Cohen EEW, Spanos WC
J Clin Oncol 2020 Jul 20;38(21):2427-2437. Epub 2020 Jun 1 doi: 10.1200/JCO.19.03156. PMID: 32479189Free PMC Article
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC).
Cohen EEW, Bell RB, Bifulco CB, Burtness B, Gillison ML, Harrington KJ, Le QT, Lee NY, Leidner R, Lewis RL, Licitra L, Mehanna H, Mell LK, Raben A, Sikora AG, Uppaluri R, Whitworth F, Zandberg DP, Ferris RL
J Immunother Cancer 2019 Jul 15;7(1):184. doi: 10.1186/s40425-019-0662-5. PMID: 31307547Free PMC Article
Classifying pain in transoral endoscopic thyroidectomy.
Zhang D, Caruso E, Sun H, Anuwong A, Tufano R, Materazzi G, Dionigi G, Kim HY
J Endocrinol Invest 2019 Nov;42(11):1345-1351. Epub 2019 Jun 11 doi: 10.1007/s40618-019-01071-0. PMID: 31187465
High-dose-rate brachytherapy using molds for lip and oral cavity tumors.
Unetsubo T, Matsuzaki H, Takemoto M, Katsui K, Hara M, Katayama N, Waki T, Kanazawa S, Asaumi J
Radiat Oncol 2015 Apr 8;10:81. doi: 10.1186/s13014-015-0390-z. PMID: 25888772Free PMC Article
Treatment of squamous cell carcinoma of the lip using Foscan-mediated photodynamic therapy.
Kübler AC, de Carpentier J, Hopper C, Leonard AG, Putnam G
Int J Oral Maxillofac Surg 2001 Dec;30(6):504-9. doi: 10.1054/ijom.2001.0160. PMID: 11829232

Prognosis

Head and Neck Cancer Incidence in the United States Before and During the COVID-19 Pandemic.
Semprini J, Pagedar NA, Boakye EA, Osazuwa-Peters N
JAMA Otolaryngol Head Neck Surg 2024 Mar 1;150(3):193-200. doi: 10.1001/jamaoto.2023.4322. PMID: 38206603Free PMC Article
Squamous Cell Carcinoma of the Lip-A Review of Squamous Cell Carcinogenesis of the Mucosal and Cutaneous Junction.
Bota JP, Lyons AB, Carroll BT
Dermatol Surg 2017 Apr;43(4):494-506. doi: 10.1097/DSS.0000000000001020. PMID: 28157733
High-dose-rate brachytherapy using molds for lip and oral cavity tumors.
Unetsubo T, Matsuzaki H, Takemoto M, Katsui K, Hara M, Katayama N, Waki T, Kanazawa S, Asaumi J
Radiat Oncol 2015 Apr 8;10:81. doi: 10.1186/s13014-015-0390-z. PMID: 25888772Free PMC Article
Living with oral cancer: epidemiology with particular reference to prevalence and life-style changes that influence survival.
Warnakulasuriya S
Oral Oncol 2010 Jun;46(6):407-10. Epub 2010 Apr 18 doi: 10.1016/j.oraloncology.2010.02.015. PMID: 20403722
Distant metastases from lip and oral cavity cancer.
Betka J
ORL J Otorhinolaryngol Relat Spec 2001 Jul-Aug;63(4):217-21. doi: 10.1159/000055744. PMID: 11408816

Clinical prediction guides

Head and Neck Cancer Incidence in the United States Before and During the COVID-19 Pandemic.
Semprini J, Pagedar NA, Boakye EA, Osazuwa-Peters N
JAMA Otolaryngol Head Neck Surg 2024 Mar 1;150(3):193-200. doi: 10.1001/jamaoto.2023.4322. PMID: 38206603Free PMC Article
Resuming Oral Feeding in Patients With Oral Squamous Cell Carcinoma With Free Anterolateral Thigh Flap Reconstruction.
Chiang TY, Huang CH, Kuan CH, Horng SY, Hsieh JH, Wu YF, Chuang SY, Yu YH, Ho CC, Cheng NC, Tai HC
Ann Plast Surg 2021 Feb 1;86(2S Suppl 1):S108-S112. doi: 10.1097/SAP.0000000000002652. PMID: 33438960
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC).
Cohen EEW, Bell RB, Bifulco CB, Burtness B, Gillison ML, Harrington KJ, Le QT, Lee NY, Leidner R, Lewis RL, Licitra L, Mehanna H, Mell LK, Raben A, Sikora AG, Uppaluri R, Whitworth F, Zandberg DP, Ferris RL
J Immunother Cancer 2019 Jul 15;7(1):184. doi: 10.1186/s40425-019-0662-5. PMID: 31307547Free PMC Article
Participation of hypoxia-inducible factor-1α and lymphangiogenesis in metastatic and non-metastatic lower lip squamous cell carcinoma.
de Aquino Martins ARL, Santos HBP, Mafra RP, Nonaka CFW, Souza LB, Pinto LP
J Craniomaxillofac Surg 2018 Oct;46(10):1741-1747. Epub 2018 Jul 29 doi: 10.1016/j.jcms.2018.07.020. PMID: 30119998
Lip squamous cell carcinoma in a Brazilian population: epidemiological study and clinicopathological associations.
Souza RL, Fonseca-Fonseca T, Oliveira-Santos CC, Corrêa GT, Santos FB, Cardoso CM, Sant' Ana-Haikal D, Guimarães AL, Batista-De Paula AM
Med Oral Patol Oral Cir Bucal 2011 Sep 1;16(6):e757-62. doi: 10.4317/medoral.16954. PMID: 21196879

Recent systematic reviews

Cribriform adenocarcinoma of the tongue and minor salivary glands: a systematic review of an uncommon clinicopathological entity.
De Luca P, Tassone D, de Campora L, Simone M, Marra P, Colacurcio V, Scarpa A, Costarelli L, Camaioni A
Eur Arch Otorhinolaryngol 2022 Jun;279(6):2719-2725. Epub 2021 Oct 23 doi: 10.1007/s00405-021-07140-6. PMID: 34687340
Diagnostic tests for oral cancer and potentially malignant disorders in patients presenting with clinically evident lesions.
Walsh T, Macey R, Kerr AR, Lingen MW, Ogden GR, Warnakulasuriya S
Cochrane Database Syst Rev 2021 Jul 20;7(7):CD010276. doi: 10.1002/14651858.CD010276.pub3. PMID: 34282854Free PMC Article
Diagnostic tests for oral cancer and potentially malignant disorders in patients presenting with clinically evident lesions.
Macey R, Walsh T, Brocklehurst P, Kerr AR, Liu JL, Lingen MW, Ogden GR, Warnakulasuriya S, Scully C
Cochrane Database Syst Rev 2015 May 29;2015(5):CD010276. doi: 10.1002/14651858.CD010276.pub2. PMID: 26021841Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...