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Abnormal conus terminalis morphology

MedGen UID:
1671014
•Concept ID:
C4732765
•
Anatomical Abnormality
Synonym: Abnormal conus medullaris morphology
 
HPO: HP:0031938

Definition

Any structural anomaly of the conus terminalis, which is the distal bulbous part of the spinal cord at the location where the spinal cord tapers and ends (usually between the L1 and L2 lumbar vertebrae). [from HPO]

Professional guidelines

PubMed

Diagnostic criteria for chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS).
Tobin WO, Guo Y, Krecke KN, Parisi JE, Lucchinetti CF, Pittock SJ, Mandrekar J, Dubey D, Debruyne J, Keegan BM
Brain 2017 Sep 1;140(9):2415-2425. doi: 10.1093/brain/awx200. PMID: 29050399
International Spine Radiosurgery Consortium consensus guidelines for target volume definition in spinal stereotactic radiosurgery.
Cox BW, Spratt DE, Lovelock M, Bilsky MH, Lis E, Ryu S, Sheehan J, Gerszten PC, Chang E, Gibbs I, Soltys S, Sahgal A, Deasy J, Flickinger J, Quader M, Mindea S, Yamada Y
Int J Radiat Oncol Biol Phys 2012 Aug 1;83(5):e597-605. Epub 2012 May 19 doi: 10.1016/j.ijrobp.2012.03.009. PMID: 22608954
Differential diagnosis of T2 hyperintense spinal cord lesions: part B.
Bou-Haidar P, Peduto AJ, Karunaratne N
J Med Imaging Radiat Oncol 2009 Apr;53(2):152-9. doi: 10.1111/j.1754-9485.2009.02067.x. PMID: 19527360

Recent clinical studies

Etiology

Imaging of Congenital Spine Malformations.
White C, Milla SS, Maloney JA, Neuberger I
Clin Perinatol 2022 Sep;49(3):623-640. doi: 10.1016/j.clp.2022.05.003. PMID: 36113926
Spinal cavernous malformations.
Clark AJ, Wang DD, Lawton MT
Handb Clin Neurol 2017;143:303-308. doi: 10.1016/B978-0-444-63640-9.00030-8. PMID: 28552154
Spinal cord malformations.
Zerah M, Kulkarni AV
Handb Clin Neurol 2013;112:975-91. doi: 10.1016/B978-0-444-52910-7.00018-0. PMID: 23622306
Iatrogenic spinal deformity.
Jagannathan J, Sansur CA, Shaffrey CI
Neurosurgery 2008 Sep;63(3 Suppl):104-16. doi: 10.1227/01.NEU.0000320386.08993.BE. PMID: 18812912
Tethered cord syndrome: an updated review.
Lew SM, Kothbauer KF
Pediatr Neurosurg 2007;43(3):236-48. doi: 10.1159/000098836. PMID: 17409793

Diagnosis

Spinal Vascular Shunts: A Patterned Approach.
Kona MP, Buch K, Singh J, Rohatgi S
AJNR Am J Neuroradiol 2021 Dec;42(12):2110-2118. Epub 2021 Oct 14 doi: 10.3174/ajnr.A7312. PMID: 34649916Free PMC Article
Incomplete Cord Syndromes: Clinical and Imaging Review.
Kunam VK, Velayudhan V, Chaudhry ZA, Bobinski M, Smoker WRK, Reede DL
Radiographics 2018 Jul-Aug;38(4):1201-1222. doi: 10.1148/rg.2018170178. PMID: 29995620
Spinal arteriovenous fistulae: surgical management.
Day AL, Turkmani AH, Chen PR
Handb Clin Neurol 2017;143:189-198. doi: 10.1016/B978-0-444-63640-9.00018-7. PMID: 28552141
Spinal cord malformations.
Zerah M, Kulkarni AV
Handb Clin Neurol 2013;112:975-91. doi: 10.1016/B978-0-444-52910-7.00018-0. PMID: 23622306
Tethered cord syndrome: an updated review.
Lew SM, Kothbauer KF
Pediatr Neurosurg 2007;43(3):236-48. doi: 10.1159/000098836. PMID: 17409793

Therapy

Superficial abdominal reflex in syringomyelia: Associations with Chiari I malformation.
Nadel JL, Ziats C, Mossner JM, Starr JB, Smith BW, Kelly MP, Muraszko KM, Farley FA, Maher CO, Garton HJL, Strahle JM
J Clin Neurosci 2022 Apr;98:1-5. Epub 2022 Jan 31 doi: 10.1016/j.jocn.2021.12.037. PMID: 35114475
Subacute ascending numbness.
Arshi B, Shaw S
Clin Toxicol (Phila) 2014 Sep-Oct;52(8):905-6. doi: 10.3109/15563650.2014.953170. PMID: 25200456
Stem cell therapies for spinal cord injury.
Sahni V, Kessler JA
Nat Rev Neurol 2010 Jul;6(7):363-72. Epub 2010 Jun 15 doi: 10.1038/nrneurol.2010.73. PMID: 20551948Free PMC Article
Shunt nephritis.
Noe HN, Roy S 3rd
J Urol 1981 May;125(5):731-3. doi: 10.1016/s0022-5347(17)55183-6. PMID: 7230350
Neuropathology.
Kaufman MA, Roizin L, Gold G
Prog Neurol Psychiatry 1968;23:110-33. PMID: 4304824

Prognosis

Long-term urology outcomes of anorectal malformation.
Chong C, Hamza Y, Tan YW, Paul A, Garriboli M, Wright AJ, Olsburgh J, Taylor C, Sinha MD, Mishra P, Taghizadeh A
J Pediatr Urol 2022 Apr;18(2):150.e1-150.e6. Epub 2022 Feb 7 doi: 10.1016/j.jpurol.2022.01.019. PMID: 35283020
Incomplete Cord Syndromes: Clinical and Imaging Review.
Kunam VK, Velayudhan V, Chaudhry ZA, Bobinski M, Smoker WRK, Reede DL
Radiographics 2018 Jul-Aug;38(4):1201-1222. doi: 10.1148/rg.2018170178. PMID: 29995620
Vascular Disorders of the Spinal Cord.
Kramer CL
Continuum (Minneap Minn) 2018 Apr;24(2, Spinal Cord Disorders):407-426. doi: 10.1212/CON.0000000000000595. PMID: 29613893
Vascular diseases of the spinal cord.
Rubin MN, Rabinstein AA
Neurol Clin 2013 Feb;31(1):153-81. doi: 10.1016/j.ncl.2012.09.004. PMID: 23186899
Spinal vascular malformations.
Krings T, Mull M, Gilsbach JM, Thron A
Eur Radiol 2005 Feb;15(2):267-78. Epub 2004 Oct 22 doi: 10.1007/s00330-004-2510-2. PMID: 15538580

Clinical prediction guides

Segmentation of the human spinal cord.
De Leener B, Taso M, Cohen-Adad J, Callot V
MAGMA 2016 Apr;29(2):125-53. Epub 2016 Jan 2 doi: 10.1007/s10334-015-0507-2. PMID: 26724926
Pearls: myelopathy.
Kumar N
Semin Neurol 2010 Feb;30(1):38-43. Epub 2010 Feb 1 doi: 10.1055/s-0029-1244993. PMID: 20127580
Spinal dural arteriovenous fistulas.
Krings T, Geibprasert S
AJNR Am J Neuroradiol 2009 Apr;30(4):639-48. Epub 2009 Feb 12 doi: 10.3174/ajnr.A1485. PMID: 19213818Free PMC Article
Anorectal malformations.
Levitt MA, Peña A
Orphanet J Rare Dis 2007 Jul 26;2:33. doi: 10.1186/1750-1172-2-33. PMID: 17651510Free PMC Article
Coccygeal pits.
Weprin BE, Oakes WJ
Pediatrics 2000 May;105(5):E69. doi: 10.1542/peds.105.5.e69. PMID: 10799633

Recent systematic reviews

White matter microstructure in children and adolescents with ADHD.
Connaughton M, Whelan R, O'Hanlon E, McGrath J
Neuroimage Clin 2022;33:102957. Epub 2022 Feb 7 doi: 10.1016/j.nicl.2022.102957. PMID: 35149304Free PMC Article
Novel Clinical Insights into Spinal Hemangioblastoma in Adults: A Systematic Review.
Jankovic D, Hanissian A, Rotim K, Splavski B, Arnautovic KI
World Neurosurg 2022 Feb;158:1-10. Epub 2021 Oct 21 doi: 10.1016/j.wneu.2021.10.105. PMID: 34687932
Neuropsychological and neuroimaging underpinnings of schizoaffective disorder: a systematic review.
Madre M, Canales-Rodríguez EJ, Ortiz-Gil J, Murru A, Torrent C, Bramon E, Perez V, Orth M, Brambilla P, Vieta E, Amann BL
Acta Psychiatr Scand 2016 Jul;134(1):16-30. Epub 2016 Mar 29 doi: 10.1111/acps.12564. PMID: 27028168
Neuroinflammation and white matter pathology in schizophrenia: systematic review.
Najjar S, Pearlman DM
Schizophr Res 2015 Jan;161(1):102-12. Epub 2014 Jun 16 doi: 10.1016/j.schres.2014.04.041. PMID: 24948485
Advances in MR imaging for cervical spondylotic myelopathy.
Ellingson BM, Salamon N, Holly LT
Eur Spine J 2015 Apr;24 Suppl 2(Suppl 2):197-208. Epub 2013 Aug 6 doi: 10.1007/s00586-013-2915-1. PMID: 23917647Free PMC Article

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