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Unresectable Skin Squamous Cell Carcinoma

MedGen UID:
1675867
•Concept ID:
C4763539
•
Neoplastic Process

Definition

Skin squamous cell carcinoma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Skin Squamous Cell Carcinoma

Professional guidelines

PubMed

Update of the Management of Cutaneous Squamous-cell Carcinoma.
Maubec E
Acta Derm Venereol 2020 Jun 3;100(11):adv00143. doi: 10.2340/00015555-3498. PMID: 32346744Free PMC Article
Definitive and Postoperative Radiation Therapy for Basal and Squamous Cell Cancers of the Skin: Executive Summary of an American Society for Radiation Oncology Clinical Practice Guideline.
Likhacheva A, Awan M, Barker CA, Bhatnagar A, Bradfield L, Brady MS, Buzurovic I, Geiger JL, Parvathaneni U, Zaky S, Devlin PM
Pract Radiat Oncol 2020 Jan-Feb;10(1):8-20. Epub 2019 Dec 9 doi: 10.1016/j.prro.2019.10.014. PMID: 31831330
Optimal treatment of unresectable nonmelanoma skin cancers.
Olencki T
J Natl Compr Canc Netw 2014 May;12(5 Suppl):789-92. doi: 10.6004/jnccn.2014.0191. PMID: 24853218

Recent clinical studies

Etiology

Cutaneous Malignancies of the Head and Neck.
In GK, Thomas JS, Silk AW
Hematol Oncol Clin North Am 2021 Oct;35(5):991-1008. Epub 2021 Jul 16 doi: 10.1016/j.hoc.2021.05.008. PMID: 34281755
Matrix metalloproteinases in keratinocyte carcinomas.
Riihilä P, Nissinen L, Kähäri VM
Exp Dermatol 2021 Jan;30(1):50-61. Epub 2020 Sep 17 doi: 10.1111/exd.14183. PMID: 32869366Free PMC Article
Targeted Therapy and Traditional Chemotherapy in Melanoma and Cutaneous Squamous Cell Carcinoma.
Ma VT, Haring CT, Warrier G, Swiecicki PL
Facial Plast Surg 2020 Apr;36(2):186-193. Epub 2020 May 15 doi: 10.1055/s-0040-1709126. PMID: 32413927
Update of the Management of Cutaneous Squamous-cell Carcinoma.
Maubec E
Acta Derm Venereol 2020 Jun 3;100(11):adv00143. doi: 10.2340/00015555-3498. PMID: 32346744Free PMC Article
Cutaneous head and neck basal and squamous cell carcinomas with perineural invasion.
Mendenhall WM, Ferlito A, Takes RP, Bradford CR, Corry J, Fagan JJ, Rinaldo A, Strojan P, Rodrigo JP
Oral Oncol 2012 Oct;48(10):918-922. Epub 2012 Mar 15 doi: 10.1016/j.oraloncology.2012.02.015. PMID: 22425152

Diagnosis

Cutaneous Malignancies of the Head and Neck.
In GK, Thomas JS, Silk AW
Hematol Oncol Clin North Am 2021 Oct;35(5):991-1008. Epub 2021 Jul 16 doi: 10.1016/j.hoc.2021.05.008. PMID: 34281755
Screening and Intervention for Skin Cancer in the Galapagos.
Ayasse MT, Marquez JE, Lozeau DF, Slutsky JB, Kaufmann TL, Lee Y, Scriven RJ, Dagum AB
Ann Plast Surg 2020 Jul;85(S1 Suppl 1):S143-S148. doi: 10.1097/SAP.0000000000002345. PMID: 32355081
Stage IV cutaneous squamous cell carcinoma: treatment outcomes in a series of 42 patients.
Chapalain M, Baroudjian B, Dupont A, Lhote R, Lambert J, Bagot M, Lebbe C, Basset-Seguin N
J Eur Acad Dermatol Venereol 2020 Jun;34(6):1202-1209. Epub 2019 Oct 6 doi: 10.1111/jdv.16007. PMID: 31587382
Cutaneous Complications of Targeted Melanoma Therapy.
de Golian E, Kwong BY, Swetter SM, Pugliese SB
Curr Treat Options Oncol 2016 Nov;17(11):57. doi: 10.1007/s11864-016-0434-0. PMID: 27645330
Cutaneous head and neck basal and squamous cell carcinomas with perineural invasion.
Mendenhall WM, Ferlito A, Takes RP, Bradford CR, Corry J, Fagan JJ, Rinaldo A, Strojan P, Rodrigo JP
Oral Oncol 2012 Oct;48(10):918-922. Epub 2012 Mar 15 doi: 10.1016/j.oraloncology.2012.02.015. PMID: 22425152

Therapy

Therapeutic Cancer Vaccines for Nonmelanoma Skin Cancer.
Wu SE, Chen YH, Hung CT, Yang BH
Curr Treat Options Oncol 2023 May;24(5):496-514. Epub 2023 Mar 28 doi: 10.1007/s11864-023-01074-3. PMID: 36976454
Update of the Management of Cutaneous Squamous-cell Carcinoma.
Maubec E
Acta Derm Venereol 2020 Jun 3;100(11):adv00143. doi: 10.2340/00015555-3498. PMID: 32346744Free PMC Article
The Landmark Series: Non-melanoma Skin Cancers.
Lee AY, Berman RS
Ann Surg Oncol 2020 Jan;27(1):22-27. Epub 2019 Sep 23 doi: 10.1245/s10434-019-07831-9. PMID: 31549317
Systemic Immunotherapy for Advanced Cutaneous Squamous Cell Carcinoma.
Ogata D, Tsuchida T
Curr Treat Options Oncol 2019 Mar 14;20(4):30. doi: 10.1007/s11864-019-0629-2. PMID: 30874952
Therapy of advanced squamous cell carcinoma of the skin.
Bejar C, Maubec E
Curr Treat Options Oncol 2014 Jun;15(2):302-20. doi: 10.1007/s11864-014-0280-x. PMID: 24643778

Prognosis

Molecular and immune targets in cutaneous squamous cell carcinoma.
Galambus J, Tsai KY
Mol Carcinog 2023 Jan;62(1):38-51. Epub 2022 Aug 24 doi: 10.1002/mc.23451. PMID: 36000298
Update of the Management of Cutaneous Squamous-cell Carcinoma.
Maubec E
Acta Derm Venereol 2020 Jun 3;100(11):adv00143. doi: 10.2340/00015555-3498. PMID: 32346744Free PMC Article
Cemiplimab for the treatment of advanced cutaneous squamous cell carcinoma.
Hernández-Guerrero T, Doger B, Moreno V
Drugs Today (Barc) 2019 Aug;55(8):485-494. doi: 10.1358/dot.2019.55.8.3005176. PMID: 31461085
Systemic Immunotherapy for Advanced Cutaneous Squamous Cell Carcinoma.
Ogata D, Tsuchida T
Curr Treat Options Oncol 2019 Mar 14;20(4):30. doi: 10.1007/s11864-019-0629-2. PMID: 30874952
Therapy of advanced squamous cell carcinoma of the skin.
Bejar C, Maubec E
Curr Treat Options Oncol 2014 Jun;15(2):302-20. doi: 10.1007/s11864-014-0280-x. PMID: 24643778

Clinical prediction guides

Immune checkpoint inhibitors for treatment of periorbital squamous cell carcinoma.
Goldfarb JA, Ferrarotto R, Gross N, Goepfert R, Debnam JM, Gunn B, Nagarajan P, Esmaeli B
Br J Ophthalmol 2023 Mar;107(3):320-323. Epub 2021 Oct 8 doi: 10.1136/bjophthalmol-2021-319417. PMID: 34625433
Clinical outcomes among unresectable, locally advanced, and metastatic cutaneous squamous cell carcinoma patients treated with systemic therapy.
Cowey CL, Robert NJ, Espirito JL, Davies K, Frytak J, Lowy I, Fury MG
Cancer Med 2020 Oct;9(20):7381-7387. Epub 2020 Jun 24 doi: 10.1002/cam4.3146. PMID: 32578965Free PMC Article
Stage IV cutaneous squamous cell carcinoma: treatment outcomes in a series of 42 patients.
Chapalain M, Baroudjian B, Dupont A, Lhote R, Lambert J, Bagot M, Lebbe C, Basset-Seguin N
J Eur Acad Dermatol Venereol 2020 Jun;34(6):1202-1209. Epub 2019 Oct 6 doi: 10.1111/jdv.16007. PMID: 31587382
Pembrolizumab and concurrent hypo-fractionated radiotherapy for advanced non-resectable cutaneous squamous cell carcinoma.
Lavaud J, Blom A, Longvert C, Fort M, Funck-Brentano E, Saiag P
Eur J Dermatol 2019 Dec 1;29(6):636-640. doi: 10.1684/ejd.2019.3671. PMID: 31903954
Therapy of advanced squamous cell carcinoma of the skin.
Bejar C, Maubec E
Curr Treat Options Oncol 2014 Jun;15(2):302-20. doi: 10.1007/s11864-014-0280-x. PMID: 24643778

Recent systematic reviews

What's new in skin cancer? An analysis of guidelines and systematic reviews published in 2008-2009.
Macbeth AE, Grindlay DJ, Williams HC
Clin Exp Dermatol 2011 Jul;36(5):453-8. Epub 2011 Jun 14 doi: 10.1111/j.1365-2230.2011.04087.x. PMID: 21671988

Supplemental Content

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