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Paneth Cell Reduction

MedGen UID:
1676412
Concept ID:
C4764172
Finding

Definition

Decrease in Paneth cell granules and loss of Paneth cells within the small intestine. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPaneth Cell Reduction

Professional guidelines

PubMed

Bloch EM, Shoham S, Casadevall A, Sachais BS, Shaz B, Winters JL, van Buskirk C, Grossman BJ, Joyner M, Henderson JP, Pekosz A, Lau B, Wesolowski A, Katz L, Shan H, Auwaerter PG, Thomas D, Sullivan DJ, Paneth N, Gehrie E, Spitalnik S, Hod EA, Pollack L, Nicholson WT, Pirofski LA, Bailey JA, Tobian AA
J Clin Invest 2020 Jun 1;130(6):2757-2765. doi: 10.1172/JCI138745. PMID: 32254064Free PMC Article

Recent clinical studies

Etiology

Ren X, Liu Q, Zhou P, Zhou T, Wang D, Mei Q, Flavell RA, Liu Z, Li M, Pan W, Zhu S
Nat Commun 2024 Apr 9;15(1):3080. doi: 10.1038/s41467-024-47235-2. PMID: 38594251Free PMC Article
Gonzalez EA, Liu Y, Wang D, Jeziorek M, Bandyopadhyay S, Rao A, Gao N, Etchegaray JP
Proc Natl Acad Sci U S A 2023 Sep 12;120(37):e2221405120. Epub 2023 Sep 5 doi: 10.1073/pnas.2221405120. PMID: 37669386Free PMC Article
Lu R, Zhang YG, Xia Y, Zhang J, Kaser A, Blumberg R, Sun J
Gastroenterology 2021 Mar;160(4):1269-1283. Epub 2020 Nov 18 doi: 10.1053/j.gastro.2020.11.015. PMID: 33217447Free PMC Article
Kip AM, Ceulemans LJ, Hundscheid IHR, Canovai E, Hartog H, Brown RM, Corcos O, Joly F, De Hertogh G, Gupte G, Dejong CHC, Olde Damink SWM, Pirenne J, Mirza D, Lenaerts K
Transplantation 2020 Sep;104(9):1952-1958. doi: 10.1097/TP.0000000000003257. PMID: 32265415
Kumari R, Palaniyandi S, Hildebrandt GC
Dig Dis Sci 2019 Mar;64(3):669-677. Epub 2018 Dec 7 doi: 10.1007/s10620-018-5369-9. PMID: 30523482

Diagnosis

Darnaud M, Dos Santos A, Gonzalez P, Augui S, Lacoste C, Desterke C, De Hertogh G, Valentino E, Braun E, Zheng J, Boisgard R, Neut C, Dubuquoy L, Chiappini F, Samuel D, Lepage P, Guerrieri F, Doré J, Bréchot C, Moniaux N, Faivre J
Gastroenterology 2018 Mar;154(4):1009-1023.e14. Epub 2017 Nov 11 doi: 10.1053/j.gastro.2017.11.003. PMID: 29133078
Scott H, Brandtzaeg P
Gut 1981 Oct;22(10):812-6. doi: 10.1136/gut.22.10.812. PMID: 7028576Free PMC Article

Therapy

Kaji I, Roland JT, Rathan-Kumar S, Engevik AC, Burman A, Goldstein AE, Watanabe M, Goldenring JR
JCI Insight 2021 Aug 23;6(16) doi: 10.1172/jci.insight.150416. PMID: 34197342Free PMC Article
Bloch EM, Shoham S, Casadevall A, Sachais BS, Shaz B, Winters JL, van Buskirk C, Grossman BJ, Joyner M, Henderson JP, Pekosz A, Lau B, Wesolowski A, Katz L, Shan H, Auwaerter PG, Thomas D, Sullivan DJ, Paneth N, Gehrie E, Spitalnik S, Hod EA, Pollack L, Nicholson WT, Pirofski LA, Bailey JA, Tobian AA
J Clin Invest 2020 Jun 1;130(6):2757-2765. doi: 10.1172/JCI138745. PMID: 32254064Free PMC Article
Kumari R, Palaniyandi S, Hildebrandt GC
Dig Dis Sci 2019 Mar;64(3):669-677. Epub 2018 Dec 7 doi: 10.1007/s10620-018-5369-9. PMID: 30523482
Lu L, Jiang M, Zhu C, He J, Fan S
Free Radic Biol Med 2019 Jan;130:244-255. Epub 2018 Oct 21 doi: 10.1016/j.freeradbiomed.2018.10.410. PMID: 30352304
Liu L , Dong W , Wang S , Zhang Y , Liu T , Xie R , Wang B , Cao H
Food Funct 2018 Nov 14;9(11):5588-5597. doi: 10.1039/c8fo01143e. PMID: 30339173

Prognosis

Shumway AJ, Shanahan MT, Hollville E, Chen K, Beasley C, Villanueva JW, Albert S, Lian G, Cure MR, Schaner M, Zhu LC, Bantumilli S, Deshmukh M, Furey TS, Sheikh SZ, Sethupathy P
JCI Insight 2024 Feb 22;9(4) doi: 10.1172/jci.insight.168800. PMID: 38385744Free PMC Article
Kumari R, Palaniyandi S, Hildebrandt GC
Dig Dis Sci 2019 Mar;64(3):669-677. Epub 2018 Dec 7 doi: 10.1007/s10620-018-5369-9. PMID: 30523482
Zilbauer M, Jenke A, Wenzel G, Goedde D, Postberg J, Phillips AD, Lucas M, Noble-Jamieson G, Torrente F, Salvestrini C, Heuschkel R, Wirth S
Inflamm Bowel Dis 2011 Oct;17(10):2076-86. Epub 2010 Dec 16 doi: 10.1002/ibd.21577. PMID: 21910169
Wehkamp J, Stange EF
Ann N Y Acad Sci 2006 Aug;1072:321-31. doi: 10.1196/annals.1326.030. PMID: 17057212

Clinical prediction guides

Ren X, Liu Q, Zhou P, Zhou T, Wang D, Mei Q, Flavell RA, Liu Z, Li M, Pan W, Zhu S
Nat Commun 2024 Apr 9;15(1):3080. doi: 10.1038/s41467-024-47235-2. PMID: 38594251Free PMC Article
Wahida A, Müller M, Hiergeist A, Popper B, Steiger K, Branca C, Tschurtschenthaler M, Engleitner T, Donakonda S, De Coninck J, Öllinger R, Pfautsch MK, Müller N, Silva M, Usluer S, Thiele Orberg E, Böttcher JP, Pfarr N, Anton M, Slotta-Huspenina JB, Nerlich AG, Madl T, Basic M, Bleich A, Berx G, Ruland J, Knolle PA, Rad R, Adolph TE, Vandenabeele P, Kanegane H, Gessner A, Jost PJ, Yabal M
Sci Immunol 2021 Nov 5;6(65):eabf7235. doi: 10.1126/sciimmunol.abf7235. PMID: 34739338
Lu R, Zhang YG, Xia Y, Zhang J, Kaser A, Blumberg R, Sun J
Gastroenterology 2021 Mar;160(4):1269-1283. Epub 2020 Nov 18 doi: 10.1053/j.gastro.2020.11.015. PMID: 33217447Free PMC Article
Kumari R, Palaniyandi S, Hildebrandt GC
Dig Dis Sci 2019 Mar;64(3):669-677. Epub 2018 Dec 7 doi: 10.1007/s10620-018-5369-9. PMID: 30523482
Zhou Y, Rychahou P, Wang Q, Weiss HL, Evers BM
Cell Death Dis 2015 Feb 5;6(2):e1631. doi: 10.1038/cddis.2014.588. PMID: 25654764Free PMC Article

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