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Recurrent Lung Adenocarcinoma

MedGen UID:
167748
•Concept ID:
C0854983
•
Neoplastic Process
Synonyms: Lung Adenocarcinoma, Recurrent; Recurrent Adenocarcinoma of Lung; Recurrent Adenocarcinoma of the Lung

Definition

The re-emergence of lung adenocarcinoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Lung Adenocarcinoma

Professional guidelines

PubMed

Comparison of endostatin combined with PT-DC versus bevacizumab combined with PT-DC in the first-line treatment of advanced lung adenocarcinoma: a retrospective propensity score-matched cohort study.
Chen X, Nie J, Dai L, Hu W, Zhang J, Han J, Ma X, Tian G, Han S, Wu D, Wang Y, Long J, Zhang Z, Fang J
Ann Palliat Med 2021 Jul;10(7):7847-7856. doi: 10.21037/apm-21-1401. PMID: 34353072

Recent clinical studies

Etiology

Comparison of endostatin combined with PT-DC versus bevacizumab combined with PT-DC in the first-line treatment of advanced lung adenocarcinoma: a retrospective propensity score-matched cohort study.
Chen X, Nie J, Dai L, Hu W, Zhang J, Han J, Ma X, Tian G, Han S, Wu D, Wang Y, Long J, Zhang Z, Fang J
Ann Palliat Med 2021 Jul;10(7):7847-7856. doi: 10.21037/apm-21-1401. PMID: 34353072
Cumulative smoking dose affects the clinical outcomes of EGFR-mutated lung adenocarcinoma patients treated with EGFR-TKIs: a retrospective study.
Kim IA, Lee JS, Kim HJ, Kim WS, Lee KY
BMC Cancer 2018 Jul 28;18(1):768. doi: 10.1186/s12885-018-4691-0. PMID: 30055587Free PMC Article
Pneumatosis intestinalis after gefitinib therapy for pulmonary adenocarcinoma: a case report.
Maeda A, Nakata M, Shimizu K, Yukawa T, Saisho S, Okita R
World J Surg Oncol 2016 Jun 29;14(1):175. doi: 10.1186/s12957-016-0926-1. PMID: 27495256Free PMC Article
Presence of podoplanin-positive cancer-associated fibroblasts in surgically resected primary lung adenocarcinoma predicts a shorter progression-free survival period in patients with recurrences who received platinum-based chemotherapy.
Koriyama H, Ishii G, Yoh K, Neri S, Morise M, Umemura S, Matsumoto S, Niho S, Ohmatsu H, Tsuboi M, Goto K, Ochiai A
J Cancer Res Clin Oncol 2015 Jul;141(7):1163-70. Epub 2014 Dec 2 doi: 10.1007/s00432-014-1891-0. PMID: 25446816
The characteristics and failure pattern of gefitinib responders with postoperative recurrence of pulmonary adenocarcinoma.
Shoji F, Yano T, Yoshino I, Mori D, Yamasaki F, Kohno H, Maehara Y
Eur J Surg Oncol 2008 Jan;34(1):89-93. Epub 2007 Apr 20 doi: 10.1016/j.ejso.2007.03.005. PMID: 17449217

Diagnosis

Late recurrence of lung adenocarcinoma harboring EGFR exon 20 insertion (A763_Y764insFQEA) mutation successfully treated with osimertinib.
Kunimasa K, Nishino K, Kukita Y, Matsumoto S, Kawachi H, Kawamura T, Inoue T, Tamiya M, Honma K, Sugimoto N, Yamasaki T, Imamura F, Goto K, Kumagai T
Cancer Genet 2021 Aug;256-257:57-61. Epub 2021 Apr 10 doi: 10.1016/j.cancergen.2021.04.001. PMID: 33901930
Hyperprogression on immunotherapy with complete response to chemotherapy in a NSCLC patient with high PD-L1 and STK11: A case report.
Fricke J, Mambetsariev I, Pharaon R, Subbiah S, Rajurkar S, Salgia R
Medicine (Baltimore) 2020 Nov 13;99(46):e22323. doi: 10.1097/MD.0000000000022323. PMID: 33181636Free PMC Article
Granulomatosis with polyangiitis in a patient treated with dabrafenib and trametinib for BRAF V600E positive lung adenocarcinoma.
Dimou A, Barron G, Merrick DT, Kolfenbach J, Doebele RC
BMC Cancer 2020 Mar 4;20(1):177. doi: 10.1186/s12885-020-6661-6. PMID: 32131760Free PMC Article
Immune-related pancreatitis secondary to nivolumab in a patient with recurrent lung adenocarcinoma: A case report.
Ikeuchi K, Okuma Y, Tabata T
Lung Cancer 2016 Sep;99:148-50. Epub 2016 Jul 5 doi: 10.1016/j.lungcan.2016.07.001. PMID: 27565931
Presence of podoplanin-positive cancer-associated fibroblasts in surgically resected primary lung adenocarcinoma predicts a shorter progression-free survival period in patients with recurrences who received platinum-based chemotherapy.
Koriyama H, Ishii G, Yoh K, Neri S, Morise M, Umemura S, Matsumoto S, Niho S, Ohmatsu H, Tsuboi M, Goto K, Ochiai A
J Cancer Res Clin Oncol 2015 Jul;141(7):1163-70. Epub 2014 Dec 2 doi: 10.1007/s00432-014-1891-0. PMID: 25446816

Therapy

Comparison of endostatin combined with PT-DC versus bevacizumab combined with PT-DC in the first-line treatment of advanced lung adenocarcinoma: a retrospective propensity score-matched cohort study.
Chen X, Nie J, Dai L, Hu W, Zhang J, Han J, Ma X, Tian G, Han S, Wu D, Wang Y, Long J, Zhang Z, Fang J
Ann Palliat Med 2021 Jul;10(7):7847-7856. doi: 10.21037/apm-21-1401. PMID: 34353072
Histological transformation of lung adenocarcinoma to small cell lung cancer with mutant C797S conferring acquired resistance to osimertinib.
Ren X, Cai X, Li J, Zhang X, Yu J, Song X, Zhang H, Song X
J Int Med Res 2020 Jun;48(6):300060520927918. doi: 10.1177/0300060520927918. PMID: 32600081Free PMC Article
Granulomatosis with polyangiitis in a patient treated with dabrafenib and trametinib for BRAF V600E positive lung adenocarcinoma.
Dimou A, Barron G, Merrick DT, Kolfenbach J, Doebele RC
BMC Cancer 2020 Mar 4;20(1):177. doi: 10.1186/s12885-020-6661-6. PMID: 32131760Free PMC Article
Nivolumab-induced adrenalitis.
Iqbal I, Khan MAA, Ullah W, Nabwani D
BMJ Case Rep 2019 Dec 1;12(11) doi: 10.1136/bcr-2019-231829. PMID: 31791986Free PMC Article
Immune-related pancreatitis secondary to nivolumab in a patient with recurrent lung adenocarcinoma: A case report.
Ikeuchi K, Okuma Y, Tabata T
Lung Cancer 2016 Sep;99:148-50. Epub 2016 Jul 5 doi: 10.1016/j.lungcan.2016.07.001. PMID: 27565931

Prognosis

An 81-Year-Old Man With Shortness of Breath After Chemotherapy and Radiation Therapy for Lung Cancer.
Mehta AK, Khan Z, Deepak J
Chest 2019 Sep;156(3):e63-e67. doi: 10.1016/j.chest.2019.04.091. PMID: 31511162
Cumulative smoking dose affects the clinical outcomes of EGFR-mutated lung adenocarcinoma patients treated with EGFR-TKIs: a retrospective study.
Kim IA, Lee JS, Kim HJ, Kim WS, Lee KY
BMC Cancer 2018 Jul 28;18(1):768. doi: 10.1186/s12885-018-4691-0. PMID: 30055587Free PMC Article
Progressive hypoventilation due to mixed CD8(+) and CD4(+) lymphocytic polymyositis following tremelimumab - durvalumab treatment.
John S, Antonia SJ, Rose TA, Seifert RP, Centeno BA, Wagner AS, Creelan BC
J Immunother Cancer 2017 Jul 18;5(1):54. doi: 10.1186/s40425-017-0258-x. PMID: 28716137Free PMC Article
Presence of podoplanin-positive cancer-associated fibroblasts in surgically resected primary lung adenocarcinoma predicts a shorter progression-free survival period in patients with recurrences who received platinum-based chemotherapy.
Koriyama H, Ishii G, Yoh K, Neri S, Morise M, Umemura S, Matsumoto S, Niho S, Ohmatsu H, Tsuboi M, Goto K, Ochiai A
J Cancer Res Clin Oncol 2015 Jul;141(7):1163-70. Epub 2014 Dec 2 doi: 10.1007/s00432-014-1891-0. PMID: 25446816
Thai female non-smoker with recurrent lung adenocarcinoma who has dramatic and prolonged response to gefitinib for over one year.
Charoentum C
J Med Assoc Thai 2006 Jun;89(6):882-6. PMID: 16850692

Clinical prediction guides

Comparison of endostatin combined with PT-DC versus bevacizumab combined with PT-DC in the first-line treatment of advanced lung adenocarcinoma: a retrospective propensity score-matched cohort study.
Chen X, Nie J, Dai L, Hu W, Zhang J, Han J, Ma X, Tian G, Han S, Wu D, Wang Y, Long J, Zhang Z, Fang J
Ann Palliat Med 2021 Jul;10(7):7847-7856. doi: 10.21037/apm-21-1401. PMID: 34353072
Hyperprogression on immunotherapy with complete response to chemotherapy in a NSCLC patient with high PD-L1 and STK11: A case report.
Fricke J, Mambetsariev I, Pharaon R, Subbiah S, Rajurkar S, Salgia R
Medicine (Baltimore) 2020 Nov 13;99(46):e22323. doi: 10.1097/MD.0000000000022323. PMID: 33181636Free PMC Article
Cumulative smoking dose affects the clinical outcomes of EGFR-mutated lung adenocarcinoma patients treated with EGFR-TKIs: a retrospective study.
Kim IA, Lee JS, Kim HJ, Kim WS, Lee KY
BMC Cancer 2018 Jul 28;18(1):768. doi: 10.1186/s12885-018-4691-0. PMID: 30055587Free PMC Article
Presence of podoplanin-positive cancer-associated fibroblasts in surgically resected primary lung adenocarcinoma predicts a shorter progression-free survival period in patients with recurrences who received platinum-based chemotherapy.
Koriyama H, Ishii G, Yoh K, Neri S, Morise M, Umemura S, Matsumoto S, Niho S, Ohmatsu H, Tsuboi M, Goto K, Ochiai A
J Cancer Res Clin Oncol 2015 Jul;141(7):1163-70. Epub 2014 Dec 2 doi: 10.1007/s00432-014-1891-0. PMID: 25446816
Molecular imaging to identify tumor recurrence following chemoradiation in a hostile surgical environment.
Okusanya OT, Deshpande C, Barbosa EM Jr, Aggarwal C, Simone CB 2nd, Jiang J, Judy R, DeJesus E, Albelda S, Nie S, Low PS, Singhal S
Mol Imaging 2014;13 doi: 10.2310/7290.2014.00051. PMID: 25442640Free PMC Article

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