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Refractory Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System

MedGen UID:
1677524
•Concept ID:
C4763396
•
Neoplastic Process

Definition

Primary diffuse large B-cell lymphoma of the central nervous system that does not respond to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System

Professional guidelines

PubMed

ASTCT Clinical Practice Recommendations for Transplantation and Cellular Therapies in Diffuse Large B Cell Lymphoma.
Epperla N, Kumar A, Abutalib SA, Awan FT, Chen YB, Gopal AK, Holter-Chakrabarty J, Kekre N, Lee CJ, Lekakis L, Lin Y, Mei M, Nathan S, Nastoupil L, Oluwole O, Phillips AA, Reid E, Rezvani AR, Trotman J, Zurko J, Kharfan-Dabaja MA, Sauter CS, Perales MA, Locke FL, Carpenter PA, Hamadani M
Transplant Cell Ther 2023 Sep;29(9):548-555. Epub 2023 Jul 5 doi: 10.1016/j.jtct.2023.06.012. PMID: 37419325
Introduction of novel agents in the treatment of primary CNS lymphoma.
Grommes C, Nayak L, Tun HW, Batchelor TT
Neuro Oncol 2019 Feb 19;21(3):306-313. doi: 10.1093/neuonc/noy193. PMID: 30423172Free PMC Article
ESMO Consensus Conference on malignant lymphoma: management of 'ultra-high-risk' patients.
Hutchings M, Ladetto M, Buske C, de Nully Brown P, Ferreri AJM, Pfreundschuh M, Schmitz N, Balari AS, van Imhoff G, Walewski J; ESMO Lymphoma Consensus Conference Panel Members
Ann Oncol 2018 Aug 1;29(8):1687-1700. doi: 10.1093/annonc/mdy167. PMID: 29924296

Recent clinical studies

Etiology

ASTCT Clinical Practice Recommendations for Transplantation and Cellular Therapies in Diffuse Large B Cell Lymphoma.
Epperla N, Kumar A, Abutalib SA, Awan FT, Chen YB, Gopal AK, Holter-Chakrabarty J, Kekre N, Lee CJ, Lekakis L, Lin Y, Mei M, Nathan S, Nastoupil L, Oluwole O, Phillips AA, Reid E, Rezvani AR, Trotman J, Zurko J, Kharfan-Dabaja MA, Sauter CS, Perales MA, Locke FL, Carpenter PA, Hamadani M
Transplant Cell Ther 2023 Sep;29(9):548-555. Epub 2023 Jul 5 doi: 10.1016/j.jtct.2023.06.012. PMID: 37419325
Ibrutinib monotherapy for relapse or refractory primary CNS lymphoma and primary vitreoretinal lymphoma: Final analysis of the phase II 'proof-of-concept' iLOC study by the Lymphoma study association (LYSA) and the French oculo-cerebral lymphoma (LOC) network.
Soussain C, Choquet S, Blonski M, Leclercq D, Houillier C, Rezai K, Bijou F, Houot R, Boyle E, Gressin R, Nicolas-Virelizier E, Barrie M, Moluçon-Chabrot C, Lelez ML, Clavert A, Coisy S, Leruez S, Touitou V, Cassoux N, Daniau M, Ertault de la Bretonnière M, El Yamani A, Ghesquières H, Hoang-Xuan K
Eur J Cancer 2019 Aug;117:121-130. Epub 2019 Jul 3 doi: 10.1016/j.ejca.2019.05.024. PMID: 31279304
Lenalidomide in combination with intravenous rituximab (REVRI) in relapsed/refractory primary CNS lymphoma or primary intraocular lymphoma: a multicenter prospective 'proof of concept' phase II study of the French Oculo-Cerebral lymphoma (LOC) Network and the Lymphoma Study Association (LYSA)†.
Ghesquieres H, Chevrier M, Laadhari M, Chinot O, Choquet S, Moluçon-Chabrot C, Beauchesne P, Gressin R, Morschhauser F, Schmitt A, Gyan E, Hoang-Xuan K, Nicolas-Virelizier E, Cassoux N, Touitou V, Le Garff-Tavernier M, Savignoni A, Turbiez I, Soumelis V, Houillier C, Soussain C
Ann Oncol 2019 Apr 1;30(4):621-628. doi: 10.1093/annonc/mdz032. PMID: 30698644
Ibrutinib.
Charalambous A, Schwarzbich MA, Witzens-Harig M
Recent Results Cancer Res 2018;212:133-168. doi: 10.1007/978-3-319-91439-8_7. PMID: 30069629
Primary CNS lymphoma.
Phillips EH, Fox CP, Cwynarski K
Curr Hematol Malig Rep 2014 Sep;9(3):243-53. doi: 10.1007/s11899-014-0217-2. PMID: 24969265Free PMC Article

Diagnosis

ASTCT Clinical Practice Recommendations for Transplantation and Cellular Therapies in Diffuse Large B Cell Lymphoma.
Epperla N, Kumar A, Abutalib SA, Awan FT, Chen YB, Gopal AK, Holter-Chakrabarty J, Kekre N, Lee CJ, Lekakis L, Lin Y, Mei M, Nathan S, Nastoupil L, Oluwole O, Phillips AA, Reid E, Rezvani AR, Trotman J, Zurko J, Kharfan-Dabaja MA, Sauter CS, Perales MA, Locke FL, Carpenter PA, Hamadani M
Transplant Cell Ther 2023 Sep;29(9):548-555. Epub 2023 Jul 5 doi: 10.1016/j.jtct.2023.06.012. PMID: 37419325
How we treat primary central nervous system lymphoma.
Calimeri T, Steffanoni S, Gagliardi F, Chiara A, Ferreri AJM
ESMO Open 2021 Aug;6(4):100213. Epub 2021 Jul 13 doi: 10.1016/j.esmoop.2021.100213. PMID: 34271311Free PMC Article
Ibrutinib in primary central nervous system diffuse large B-cell lymphoma.
T Low J, B Peters K
CNS Oncol 2020 Mar 1;9(1):CNS51. Epub 2020 Mar 6 doi: 10.2217/cns-2019-0022. PMID: 32141313Free PMC Article
Ibrutinib.
Charalambous A, Schwarzbich MA, Witzens-Harig M
Recent Results Cancer Res 2018;212:133-168. doi: 10.1007/978-3-319-91439-8_7. PMID: 30069629
Primary CNS lymphoma.
Phillips EH, Fox CP, Cwynarski K
Curr Hematol Malig Rep 2014 Sep;9(3):243-53. doi: 10.1007/s11899-014-0217-2. PMID: 24969265Free PMC Article

Therapy

ASTCT Clinical Practice Recommendations for Transplantation and Cellular Therapies in Diffuse Large B Cell Lymphoma.
Epperla N, Kumar A, Abutalib SA, Awan FT, Chen YB, Gopal AK, Holter-Chakrabarty J, Kekre N, Lee CJ, Lekakis L, Lin Y, Mei M, Nathan S, Nastoupil L, Oluwole O, Phillips AA, Reid E, Rezvani AR, Trotman J, Zurko J, Kharfan-Dabaja MA, Sauter CS, Perales MA, Locke FL, Carpenter PA, Hamadani M
Transplant Cell Ther 2023 Sep;29(9):548-555. Epub 2023 Jul 5 doi: 10.1016/j.jtct.2023.06.012. PMID: 37419325
Toxicity and efficacy of CAR T-cell therapy in primary and secondary CNS lymphoma: a meta-analysis of 128 patients.
Cook MR, Dorris CS, Makambi KH, Luo Y, Munshi PN, Donato M, Rowley S, Saad A, Goy A, Dunleavy K, Ali A
Blood Adv 2023 Jan 10;7(1):32-39. doi: 10.1182/bloodadvances.2022008525. PMID: 36260735Free PMC Article
How we treat primary central nervous system lymphoma.
Calimeri T, Steffanoni S, Gagliardi F, Chiara A, Ferreri AJM
ESMO Open 2021 Aug;6(4):100213. Epub 2021 Jul 13 doi: 10.1016/j.esmoop.2021.100213. PMID: 34271311Free PMC Article
Ibrutinib monotherapy for relapse or refractory primary CNS lymphoma and primary vitreoretinal lymphoma: Final analysis of the phase II 'proof-of-concept' iLOC study by the Lymphoma study association (LYSA) and the French oculo-cerebral lymphoma (LOC) network.
Soussain C, Choquet S, Blonski M, Leclercq D, Houillier C, Rezai K, Bijou F, Houot R, Boyle E, Gressin R, Nicolas-Virelizier E, Barrie M, Moluçon-Chabrot C, Lelez ML, Clavert A, Coisy S, Leruez S, Touitou V, Cassoux N, Daniau M, Ertault de la Bretonnière M, El Yamani A, Ghesquières H, Hoang-Xuan K
Eur J Cancer 2019 Aug;117:121-130. Epub 2019 Jul 3 doi: 10.1016/j.ejca.2019.05.024. PMID: 31279304
Ibrutinib Unmasks Critical Role of Bruton Tyrosine Kinase in Primary CNS Lymphoma.
Grommes C, Pastore A, Palaskas N, Tang SS, Campos C, Schartz D, Codega P, Nichol D, Clark O, Hsieh WY, Rohle D, Rosenblum M, Viale A, Tabar VS, Brennan CW, Gavrilovic IT, Kaley TJ, Nolan CP, Omuro A, Pentsova E, Thomas AA, Tsyvkin E, Noy A, Palomba ML, Hamlin P, Sauter CS, Moskowitz CH, Wolfe J, Dogan A, Won M, Glass J, Peak S, Lallana EC, Hatzoglou V, Reiner AS, Gutin PH, Huse JT, Panageas KS, Graeber TG, Schultz N, DeAngelis LM, Mellinghoff IK
Cancer Discov 2017 Sep;7(9):1018-1029. Epub 2017 Jun 15 doi: 10.1158/2159-8290.CD-17-0613. PMID: 28619981Free PMC Article

Prognosis

Diffuse large B-cell lymphoma involving the central nervous system: biologic rationale for targeted therapy.
Roschewski M, Hodson DJ
Haematologica 2024 Feb 1;109(2):388-400. doi: 10.3324/haematol.2021.278613. PMID: 37706315Free PMC Article
Ibrutinib in primary central nervous system diffuse large B-cell lymphoma.
T Low J, B Peters K
CNS Oncol 2020 Mar 1;9(1):CNS51. Epub 2020 Mar 6 doi: 10.2217/cns-2019-0022. PMID: 32141313Free PMC Article
Molecular profiling of primary central nervous system lymphomas - predictive and prognostic value?
Ho KG, Grommes C
Curr Opin Neurol 2019 Dec;32(6):886-894. doi: 10.1097/WCO.0000000000000759. PMID: 31592789Free PMC Article
Ibrutinib monotherapy for relapse or refractory primary CNS lymphoma and primary vitreoretinal lymphoma: Final analysis of the phase II 'proof-of-concept' iLOC study by the Lymphoma study association (LYSA) and the French oculo-cerebral lymphoma (LOC) network.
Soussain C, Choquet S, Blonski M, Leclercq D, Houillier C, Rezai K, Bijou F, Houot R, Boyle E, Gressin R, Nicolas-Virelizier E, Barrie M, Moluçon-Chabrot C, Lelez ML, Clavert A, Coisy S, Leruez S, Touitou V, Cassoux N, Daniau M, Ertault de la Bretonnière M, El Yamani A, Ghesquières H, Hoang-Xuan K
Eur J Cancer 2019 Aug;117:121-130. Epub 2019 Jul 3 doi: 10.1016/j.ejca.2019.05.024. PMID: 31279304
Lenalidomide in combination with intravenous rituximab (REVRI) in relapsed/refractory primary CNS lymphoma or primary intraocular lymphoma: a multicenter prospective 'proof of concept' phase II study of the French Oculo-Cerebral lymphoma (LOC) Network and the Lymphoma Study Association (LYSA)†.
Ghesquieres H, Chevrier M, Laadhari M, Chinot O, Choquet S, Moluçon-Chabrot C, Beauchesne P, Gressin R, Morschhauser F, Schmitt A, Gyan E, Hoang-Xuan K, Nicolas-Virelizier E, Cassoux N, Touitou V, Le Garff-Tavernier M, Savignoni A, Turbiez I, Soumelis V, Houillier C, Soussain C
Ann Oncol 2019 Apr 1;30(4):621-628. doi: 10.1093/annonc/mdz032. PMID: 30698644

Clinical prediction guides

Toxicity and efficacy of CAR T-cell therapy in primary and secondary CNS lymphoma: a meta-analysis of 128 patients.
Cook MR, Dorris CS, Makambi KH, Luo Y, Munshi PN, Donato M, Rowley S, Saad A, Goy A, Dunleavy K, Ali A
Blood Adv 2023 Jan 10;7(1):32-39. doi: 10.1182/bloodadvances.2022008525. PMID: 36260735Free PMC Article
Prognostic value of circulating lymphocyte subsets in primary central nervous system lymphoma.
Berthelot A, Bequet C, Harlay V, Petrirena G, Campello C, Barrié M, Appay R, Chinot O, Tabouret E
J Neurooncol 2022 Aug;159(1):15-22. Epub 2022 Jun 28 doi: 10.1007/s11060-022-04032-5. PMID: 35763119
Implications of recent molecular achievements in early diagnosis and precision treatments for primary CNS lymphoma.
Calimeri T, Steffanoni S, Foppoli M, Ponzoni M, Ferreri AJM
Expert Opin Ther Targets 2021 Sep;25(9):749-760. Epub 2021 Oct 26 doi: 10.1080/14728222.2021.1988927. PMID: 34606736
Molecular profiling of primary central nervous system lymphomas - predictive and prognostic value?
Ho KG, Grommes C
Curr Opin Neurol 2019 Dec;32(6):886-894. doi: 10.1097/WCO.0000000000000759. PMID: 31592789Free PMC Article
Lenalidomide in combination with intravenous rituximab (REVRI) in relapsed/refractory primary CNS lymphoma or primary intraocular lymphoma: a multicenter prospective 'proof of concept' phase II study of the French Oculo-Cerebral lymphoma (LOC) Network and the Lymphoma Study Association (LYSA)†.
Ghesquieres H, Chevrier M, Laadhari M, Chinot O, Choquet S, Moluçon-Chabrot C, Beauchesne P, Gressin R, Morschhauser F, Schmitt A, Gyan E, Hoang-Xuan K, Nicolas-Virelizier E, Cassoux N, Touitou V, Le Garff-Tavernier M, Savignoni A, Turbiez I, Soumelis V, Houillier C, Soussain C
Ann Oncol 2019 Apr 1;30(4):621-628. doi: 10.1093/annonc/mdz032. PMID: 30698644

Recent systematic reviews

Chimeric Antigen Receptor T-Cell (CAR T-Cell) Therapy for Primary and Secondary Central Nervous System Lymphoma: A Systematic Review of Literature.
Asghar N, Masood A, Dhaliwal A, Khurana S, Davis J, Hashmi H, Husnain M
Clin Lymphoma Myeloma Leuk 2023 Jan;23(1):15-21. Epub 2022 Oct 7 doi: 10.1016/j.clml.2022.09.008. PMID: 36328891
Toxicity and efficacy of CAR T-cell therapy in primary and secondary CNS lymphoma: a meta-analysis of 128 patients.
Cook MR, Dorris CS, Makambi KH, Luo Y, Munshi PN, Donato M, Rowley S, Saad A, Goy A, Dunleavy K, Ali A
Blood Adv 2023 Jan 10;7(1):32-39. doi: 10.1182/bloodadvances.2022008525. PMID: 36260735Free PMC Article

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