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Infection causing encephalomyelitis

MedGen UID:
167798
•Concept ID:
C0856705
•
Disease or Syndrome
Synonyms: Infectious Encephalomyelitis; Infectious encephalomyelitis
SNOMED CT: Infection causing encephalomyelitis (721249007); Infectious encephalomyelitis (721249007)

Definition

An infectious process that affects the brain and spinal cord tissues. It is usually caused by viruses. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInfection causing encephalomyelitis

Professional guidelines

PubMed

Diagnosis and Management of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.
Grach SL, Seltzer J, Chon TY, Ganesh R
Mayo Clin Proc 2023 Oct;98(10):1544-1551. doi: 10.1016/j.mayocp.2023.07.032. PMID: 37793728
Post-COVID-19 syndrome: epidemiology, diagnostic criteria and pathogenic mechanisms involved.
Carod-Artal FJ
Rev Neurol 2021 Jun 1;72(11):384-396. doi: 10.33588/rn.7211.2021230. PMID: 34042167
Guidelines for diagnosis and treatment in neurology - Lyme neuroborreliosis.
Rauer S, Kastenbauer S, Hofmann H, Fingerle V, Huppertz HI, Hunfeld KP, Krause A, Ruf B, Dersch R; Consensus group
Ger Med Sci 2020;18:Doc03. Epub 2020 Feb 27 doi: 10.3205/000279. PMID: 32341686Free PMC Article

Recent clinical studies

Etiology

Brain fog of post-COVID-19 condition and Chronic Fatigue Syndrome, same medical disorder?
Azcue N, Gómez-Esteban JC, Acera M, Tijero B, Fernandez T, Ayo-Mentxakatorre N, Pérez-Concha T, Murueta-Goyena A, Lafuente JV, Prada Á, López de Munain A, Ruiz-Irastorza G, Ribacoba L, Gabilondo I, Del Pino R
J Transl Med 2022 Dec 6;20(1):569. doi: 10.1186/s12967-022-03764-2. PMID: 36474290Free PMC Article
Unexplained post-acute infection syndromes.
Choutka J, Jansari V, Hornig M, Iwasaki A
Nat Med 2022 May;28(5):911-923. Epub 2022 May 18 doi: 10.1038/s41591-022-01810-6. PMID: 35585196
Chronic Fatigue and Postexertional Malaise in People Living With Long COVID: An Observational Study.
Twomey R, DeMars J, Franklin K, Culos-Reed SN, Weatherald J, Wrightson JG
Phys Ther 2022 Apr 1;102(4) doi: 10.1093/ptj/pzac005. PMID: 35079817Free PMC Article
Post-COVID-19 syndrome: epidemiology, diagnostic criteria and pathogenic mechanisms involved.
Carod-Artal FJ
Rev Neurol 2021 Jun 1;72(11):384-396. doi: 10.33588/rn.7211.2021230. PMID: 34042167
Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments.
Yong SJ
Infect Dis (Lond) 2021 Oct;53(10):737-754. Epub 2021 May 22 doi: 10.1080/23744235.2021.1924397. PMID: 34024217Free PMC Article

Diagnosis

Diagnosis and Management of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.
Grach SL, Seltzer J, Chon TY, Ganesh R
Mayo Clin Proc 2023 Oct;98(10):1544-1551. doi: 10.1016/j.mayocp.2023.07.032. PMID: 37793728
Understanding, diagnosing, and treating Myalgic encephalomyelitis/chronic fatigue syndrome - State of the art: Report of the 2nd international meeting at the Charité Fatigue Center.
Steiner S, Fehrer A, Hoheisel F, Schoening S, Aschenbrenner A, Babel N, Bellmann-Strobl J, Finke C, Fluge Ø, Froehlich L, Goebel A, Grande B, Haas JP, Hohberger B, Jason LA, Komaroff AL, Lacerda E, Liebl M, Maier A, Mella O, Nacul L, Paul F, Prusty BK, Puta C, Riemekasten G, Ries W, Rowe PC, Sawitzki B, Shoenfeld Y, Schultze JL, Seifert M, Sepúlveda N, Sotzny F, Stein E, Stingl M, Ufer F, Veauthier C, Westermeier F, Wirth K, Wolfarth B, Zalewski P, Behrends U, Scheibenbogen C
Autoimmun Rev 2023 Nov;22(11):103452. Epub 2023 Sep 22 doi: 10.1016/j.autrev.2023.103452. PMID: 37742748
Unexplained post-acute infection syndromes.
Choutka J, Jansari V, Hornig M, Iwasaki A
Nat Med 2022 May;28(5):911-923. Epub 2022 May 18 doi: 10.1038/s41591-022-01810-6. PMID: 35585196
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Where will the drugs come from?
Toogood PL, Clauw DJ, Phadke S, Hoffman D
Pharmacol Res 2021 Mar;165:105465. Epub 2021 Jan 30 doi: 10.1016/j.phrs.2021.105465. PMID: 33529750
MOG antibody-associated encephalomyelitis/encephalitis.
Salama S, Khan M, Pardo S, Izbudak I, Levy M
Mult Scler 2019 Oct;25(11):1427-1433. Epub 2019 Mar 25 doi: 10.1177/1352458519837705. PMID: 30907249Free PMC Article

Therapy

Autoimmune autonomic nervous system imbalance and conditions: Chronic fatigue syndrome, fibromyalgia, silicone breast implants, COVID and post-COVID syndrome, sick building syndrome, post-orthostatic tachycardia syndrome, autoimmune diseases and autoimmune/inflammatory syndrome induced by adjuvants.
Malkova AM, Shoenfeld Y
Autoimmun Rev 2023 Jan;22(1):103230. Epub 2022 Nov 5 doi: 10.1016/j.autrev.2022.103230. PMID: 36347462
Measles.
Hübschen JM, Gouandjika-Vasilache I, Dina J
Lancet 2022 Feb 12;399(10325):678-690. Epub 2022 Jan 28 doi: 10.1016/S0140-6736(21)02004-3. PMID: 35093206
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Where will the drugs come from?
Toogood PL, Clauw DJ, Phadke S, Hoffman D
Pharmacol Res 2021 Mar;165:105465. Epub 2021 Jan 30 doi: 10.1016/j.phrs.2021.105465. PMID: 33529750
MOG antibody-associated encephalomyelitis/encephalitis.
Salama S, Khan M, Pardo S, Izbudak I, Levy M
Mult Scler 2019 Oct;25(11):1427-1433. Epub 2019 Mar 25 doi: 10.1177/1352458519837705. PMID: 30907249Free PMC Article
Neurologic and neuropsychiatric syndrome features of mold and mycotoxin exposure.
Empting LD
Toxicol Ind Health 2009 Oct-Nov;25(9-10):577-81. doi: 10.1177/0748233709348393. PMID: 19854819

Prognosis

Post-COVID-More than chronic fatigue?
Seifart U
Herz 2023 Jun;48(3):229-233. Epub 2023 Apr 27 doi: 10.1007/s00059-023-05170-w. PMID: 37106076Free PMC Article
Bioinformatics and systems biology approach to identify the pathogenetic link of Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.
Lv Y, Zhang T, Cai J, Huang C, Zhan S, Liu J
Front Immunol 2022;13:952987. Epub 2022 Sep 16 doi: 10.3389/fimmu.2022.952987. PMID: 36189286Free PMC Article
Neurological consequences of COVID-19.
Brola W, Wilski M
Pharmacol Rep 2022 Dec;74(6):1208-1222. Epub 2022 Sep 30 doi: 10.1007/s43440-022-00424-6. PMID: 36180640Free PMC Article
Neurological Complications of Dengue Fever.
Trivedi S, Chakravarty A
Curr Neurol Neurosci Rep 2022 Aug;22(8):515-529. Epub 2022 Jun 21 doi: 10.1007/s11910-022-01213-7. PMID: 35727463Free PMC Article
Genetic control of alphavirus pathogenesis.
Baxter VK, Heise MT
Mamm Genome 2018 Aug;29(7-8):408-424. Epub 2018 Aug 27 doi: 10.1007/s00335-018-9776-1. PMID: 30151711Free PMC Article

Clinical prediction guides

Dengue, chikungunya and zika arbovirus infections in Caribbean children.
Christie CDC, Lue AM, Melbourne-Chambers RH
Curr Opin Pediatr 2023 Apr 1;35(2):155-165. Epub 2023 Feb 22 doi: 10.1097/MOP.0000000000001229. PMID: 36801979Free PMC Article
Bioinformatics and systems biology approach to identify the pathogenetic link of Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.
Lv Y, Zhang T, Cai J, Huang C, Zhan S, Liu J
Front Immunol 2022;13:952987. Epub 2022 Sep 16 doi: 10.3389/fimmu.2022.952987. PMID: 36189286Free PMC Article
Analysis of post COVID-19 condition and its overlap with myalgic encephalomyelitis/chronic fatigue syndrome.
Sukocheva OA, Maksoud R, Beeraka NM, Madhunapantula SV, Sinelnikov M, Nikolenko VN, Neganova ME, Klochkov SG, Amjad Kamal M, Staines DR, Marshall-Gradisnik S
J Adv Res 2022 Sep;40:179-196. Epub 2021 Nov 26 doi: 10.1016/j.jare.2021.11.013. PMID: 36100326Free PMC Article
Neurological Complications of Dengue Fever.
Trivedi S, Chakravarty A
Curr Neurol Neurosci Rep 2022 Aug;22(8):515-529. Epub 2022 Jun 21 doi: 10.1007/s11910-022-01213-7. PMID: 35727463Free PMC Article
Chronic Fatigue and Postexertional Malaise in People Living With Long COVID: An Observational Study.
Twomey R, DeMars J, Franklin K, Culos-Reed SN, Weatherald J, Wrightson JG
Phys Ther 2022 Apr 1;102(4) doi: 10.1093/ptj/pzac005. PMID: 35079817Free PMC Article

Recent systematic reviews

Evaluation of viral infection as an etiology of ME/CFS: a systematic review and meta-analysis.
Hwang JH, Lee JS, Oh HM, Lee EJ, Lim EJ, Son CG
J Transl Med 2023 Oct 28;21(1):763. doi: 10.1186/s12967-023-04635-0. PMID: 37898798Free PMC Article
Acute disseminated encephalomyelitis (ADEM) following COVID-19 vaccination: A systematic review.
Nabizadeh F, Noori M, Rahmani S, Hosseini H
J Clin Neurosci 2023 May;111:57-70. Epub 2023 Mar 22 doi: 10.1016/j.jocn.2023.03.008. PMID: 36963124Free PMC Article
Genetics of COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome: a systematic review.
Tziastoudi M, Cholevas C, Stefanidis I, Theoharides TC
Ann Clin Transl Neurol 2022 Nov;9(11):1838-1857. Epub 2022 Oct 6 doi: 10.1002/acn3.51631. PMID: 36204816Free PMC Article
Autoimmune encephalitis associated with COVID-19: A systematic review.
Nabizadeh F, Balabandian M, Sodeifian F, Rezaei N, Rostami MR, Naser Moghadasi A
Mult Scler Relat Disord 2022 Jun;62:103795. Epub 2022 Apr 6 doi: 10.1016/j.msard.2022.103795. PMID: 35472834Free PMC Article
Association of CNS demyelination and COVID-19 infection: an updated systematic review.
Ismail II, Salama S
J Neurol 2022 Feb;269(2):541-576. Epub 2021 Aug 12 doi: 10.1007/s00415-021-10752-x. PMID: 34386902Free PMC Article

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