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Acute Hepatitis E Infection

MedGen UID:
1682899
•Concept ID:
C4763852
•
Disease or Syndrome

Definition

A new infection by the hepatitis E virus, which is usually spread by the fecal-oral route. Signs and symptoms may include fever, fatigue, loss of appetite, nausea, vomiting, abdominal pain, jaundice, dark urine, clay-colored stools and joint pain. There is no specific anti-viral treatment, the infection resolves on its own. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute Hepatitis E Infection

Professional guidelines

PubMed

Treatment Options for Hepatitis A and E: A Non-Systematic Review.
Gabrielli F, Alberti F, Russo C, Cursaro C, Seferi H, Margotti M, Andreone P
Viruses 2023 Apr 28;15(5) doi: 10.3390/v15051080. PMID: 37243166Free PMC Article
Hepatitis E virus: Epidemiology, diagnosis, clinical manifestations, and treatment.
Aslan AT, Balaban HY
World J Gastroenterol 2020 Oct 7;26(37):5543-5560. doi: 10.3748/wjg.v26.i37.5543. PMID: 33071523Free PMC Article
EASL Clinical Practice Guidelines on hepatitis E virus infection.
European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; European Association for the Study of the Liver
J Hepatol 2018 Jun;68(6):1256-1271. Epub 2018 Mar 31 doi: 10.1016/j.jhep.2018.03.005. PMID: 29609832

Recent clinical studies

Etiology

Favourable outcome of acute hepatitis E infection in patients with ANCA-associated vasculitis.
Zeisbrich M, Wendel S, Finzel S, Voll RE, Venhoff N
Orphanet J Rare Dis 2022 Dec 13;17(1):433. doi: 10.1186/s13023-022-02586-1. PMID: 36514177Free PMC Article
Gut microbiota dysbiosis associated with plasma levels of Interferon-γ and viral load in patients with acute hepatitis E infection.
Wu J, Bortolanza M, Zhai G, Shang A, Ling Z, Jiang B, Shen X, Yao Y, Yu J, Li L, Cao H
J Med Virol 2022 Feb;94(2):692-702. Epub 2021 Sep 28 doi: 10.1002/jmv.27356. PMID: 34549810
Severe acute hepatitis E infection presenting with acute abdomen and meningoencephalitis.
Gynthersen RMM, Rønn CP, Brandt CT, Mens H
BMJ Case Rep 2020 Dec 13;13(12) doi: 10.1136/bcr-2020-236922. PMID: 33318241Free PMC Article
Neuralgic amyotrophy and hepatitis E virus infection.
van Eijk JJ, Madden RG, van der Eijk AA, Hunter JG, Reimerink JH, Bendall RP, Pas SD, Ellis V, van Alfen N, Beynon L, Southwell L, McLean B, Jacobs BC, van Engelen BG, Dalton HR
Neurology 2014 Feb 11;82(6):498-503. Epub 2014 Jan 8 doi: 10.1212/WNL.0000000000000112. PMID: 24401685Free PMC Article
Acute hepatitis E infection accounts for some cases of suspected drug-induced liver injury.
Davern TJ, Chalasani N, Fontana RJ, Hayashi PH, Protiva P, Kleiner DE, Engle RE, Nguyen H, Emerson SU, Purcell RH, Tillmann HL, Gu J, Serrano J, Hoofnagle JH; Drug-Induced Liver Injury Network (DILIN)
Gastroenterology 2011 Nov;141(5):1665-72.e1-9. Epub 2011 Aug 16 doi: 10.1053/j.gastro.2011.07.051. PMID: 21855518Free PMC Article

Diagnosis

Acute Hepatitis E Infection during Chemotherapy for Lung Cancer: A Case Report.
Okumura H, Miyamoto A, Suzuki F, Takaya H
Chemotherapy 2023;68(3):155-159. Epub 2023 Apr 25 doi: 10.1159/000530802. PMID: 37166305
Favourable outcome of acute hepatitis E infection in patients with ANCA-associated vasculitis.
Zeisbrich M, Wendel S, Finzel S, Voll RE, Venhoff N
Orphanet J Rare Dis 2022 Dec 13;17(1):433. doi: 10.1186/s13023-022-02586-1. PMID: 36514177Free PMC Article
Guillain-Barré Syndrome After Acute Hepatitis E Infection: A Case Report and Literature Review.
Rose MQ, Santos CD, Rubin DI, Siegel JL, Freeman WD
Crit Care Nurse 2021 Aug 1;41(4):47-53. doi: 10.4037/ccn2021129. PMID: 34333618
Severe acute hepatitis E infection presenting with acute abdomen and meningoencephalitis.
Gynthersen RMM, Rønn CP, Brandt CT, Mens H
BMJ Case Rep 2020 Dec 13;13(12) doi: 10.1136/bcr-2020-236922. PMID: 33318241Free PMC Article
Acute Hepatitis E Viral Infection in Pregnancy and Maternal Morbidity.
Khaskheli MN, Baloch S, Sheeba A, Baloch S
J Coll Physicians Surg Pak 2015 Oct;25(10):734-7. doi: 10.2015/JCPSP.734737. PMID: 26454389

Therapy

Complete remission of primary membranous nephropathy following hepatitis E infection.
Takanohashi S, Sugiura T, Koyano A, Ueno T, Rachi H, Shiratori K, Shimasaki M, Igarashi H, Kitayama Y, Togawa A
CEN Case Rep 2023 Nov;12(4):384-389. Epub 2023 Mar 2 doi: 10.1007/s13730-023-00780-z. PMID: 36864232Free PMC Article
Favourable outcome of acute hepatitis E infection in patients with ANCA-associated vasculitis.
Zeisbrich M, Wendel S, Finzel S, Voll RE, Venhoff N
Orphanet J Rare Dis 2022 Dec 13;17(1):433. doi: 10.1186/s13023-022-02586-1. PMID: 36514177Free PMC Article
Neuralgic amyotrophy complicating acute hepatitis E infection: a rare association.
Theochari E, Vincent-Smith L, Ellis C
BMJ Case Rep 2015 Mar 4;2015 doi: 10.1136/bcr-2014-207669. PMID: 25739795Free PMC Article
First case of anti-ganglioside GM1-positive Guillain-Barré syndrome due to hepatitis E virus infection.
Maurissen I, Jeurissen A, Strauven T, Sprengers D, De Schepper B
Infection 2012 Jun;40(3):323-6. Epub 2011 Aug 30 doi: 10.1007/s15010-011-0185-6. PMID: 21877179
Hepatitis E outbreak on cruise ship.
Said B, Ijaz S, Kafatos G, Booth L, Thomas HL, Walsh A, Ramsay M, Morgan D; Hepatitis E Incident Investigation Team
Emerg Infect Dis 2009 Nov;15(11):1738-44. doi: 10.3201/eid1511.091094. PMID: 19891860Free PMC Article

Prognosis

Favourable outcome of acute hepatitis E infection in patients with ANCA-associated vasculitis.
Zeisbrich M, Wendel S, Finzel S, Voll RE, Venhoff N
Orphanet J Rare Dis 2022 Dec 13;17(1):433. doi: 10.1186/s13023-022-02586-1. PMID: 36514177Free PMC Article
Dynamic changes of serum metabolites associated with infection and severity of patients with acute hepatitis E infection.
Wu J, Xu Y, Cui Y, Bortolanza M, Wang M, Jiang B, Yan M, Liang W, Yao Y, Pan Q, Yang J, Yu J, Wang D, Cao H, Li L
J Med Virol 2022 Jun;94(6):2714-2726. Epub 2022 Mar 7 doi: 10.1002/jmv.27669. PMID: 35199373
Gut microbiota dysbiosis associated with plasma levels of Interferon-γ and viral load in patients with acute hepatitis E infection.
Wu J, Bortolanza M, Zhai G, Shang A, Ling Z, Jiang B, Shen X, Yao Y, Yu J, Li L, Cao H
J Med Virol 2022 Feb;94(2):692-702. Epub 2021 Sep 28 doi: 10.1002/jmv.27356. PMID: 34549810
Neuralgic amyotrophy and hepatitis E virus infection.
van Eijk JJ, Madden RG, van der Eijk AA, Hunter JG, Reimerink JH, Bendall RP, Pas SD, Ellis V, van Alfen N, Beynon L, Southwell L, McLean B, Jacobs BC, van Engelen BG, Dalton HR
Neurology 2014 Feb 11;82(6):498-503. Epub 2014 Jan 8 doi: 10.1212/WNL.0000000000000112. PMID: 24401685Free PMC Article
Effect of acute hepatitis E infection in patients with liver cirrhosis.
Kc S, Sharma D, Basnet BK, Mishra AK
JNMA J Nepal Med Assoc 2009 Jul-Sep;48(175):226-9. PMID: 20795462

Clinical prediction guides

Acute Hepatitis E Infection during Chemotherapy for Lung Cancer: A Case Report.
Okumura H, Miyamoto A, Suzuki F, Takaya H
Chemotherapy 2023;68(3):155-159. Epub 2023 Apr 25 doi: 10.1159/000530802. PMID: 37166305
Favourable outcome of acute hepatitis E infection in patients with ANCA-associated vasculitis.
Zeisbrich M, Wendel S, Finzel S, Voll RE, Venhoff N
Orphanet J Rare Dis 2022 Dec 13;17(1):433. doi: 10.1186/s13023-022-02586-1. PMID: 36514177Free PMC Article
Dynamic changes of serum metabolites associated with infection and severity of patients with acute hepatitis E infection.
Wu J, Xu Y, Cui Y, Bortolanza M, Wang M, Jiang B, Yan M, Liang W, Yao Y, Pan Q, Yang J, Yu J, Wang D, Cao H, Li L
J Med Virol 2022 Jun;94(6):2714-2726. Epub 2022 Mar 7 doi: 10.1002/jmv.27669. PMID: 35199373
Immune dissociation during acute hepatitis E infection.
Debes JD, Groothuismink ZMA, Doukas M, de Man RA, Boonstra A
Int J Infect Dis 2019 Oct;87:39-42. Epub 2019 Aug 10 doi: 10.1016/j.ijid.2019.08.006. PMID: 31408707Free PMC Article
Acute Hepatitis E Viral Infection in Pregnancy and Maternal Morbidity.
Khaskheli MN, Baloch S, Sheeba A, Baloch S
J Coll Physicians Surg Pak 2015 Oct;25(10):734-7. doi: 10.2015/JCPSP.734737. PMID: 26454389

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