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Abnormal circulating cysteine concentration

MedGen UID:
1684824
•Concept ID:
C5139050
•
Finding
Synonym: Abnormality of cysteine metabolism
 
HPO: HP:0010918

Definition

An abnormality of a cysteine metabolic process. [from HPO]

Conditions with this feature

Cysteine Peptiduria
MedGen UID:
346587
•Concept ID:
C1857438
•
Disease or Syndrome
See: Condition Record
Cysteine Peptiduria

Recent clinical studies

Etiology

Highly specific monitoring and imaging of endogenous and exogenous cysteine in living cells.
Song X, Yang Y, Ru J, Wang Y, Qiu F, Feng Y, Zhang G, Liu W
Talanta 2019 Nov 1;204:561-568. Epub 2019 Jun 8 doi: 10.1016/j.talanta.2019.06.020. PMID: 31357334
Increased serum levels of soluble CD163 in patients with scleroderma.
Shimizu K, Ogawa F, Yoshizaki A, Akiyama Y, Kuwatsuka Y, Okazaki S, Tomita H, Takenaka M, Sato S
Clin Rheumatol 2012 Jul;31(7):1059-64. Epub 2012 Mar 29 doi: 10.1007/s10067-012-1972-x. PMID: 22453843
L-cysteine, N-acetyl-L-cysteine, and glutathione protect Xenopus laevis embryos against acrylamide-induced malformations and mortality in the frog embryo teratogenesis assay.
Rayburn JR, Friedman M
J Agric Food Chem 2010 Oct 27;58(20):11172-8. Epub 2010 Sep 28 doi: 10.1021/jf1023998. PMID: 20873821
Methods for measuring sulfur amino acid metabolism.
Hoffer LJ
Curr Opin Clin Nutr Metab Care 2002 Sep;5(5):511-7. doi: 10.1097/00075197-200209000-00009. PMID: 12172474
The effect of a subnormal vitamin B-6 status on homocysteine metabolism.
Ubbink JB, van der Merwe A, Delport R, Allen RH, Stabler SP, Riezler R, Vermaak WJ
J Clin Invest 1996 Jul 1;98(1):177-84. doi: 10.1172/JCI118763. PMID: 8690790Free PMC Article

Diagnosis

Highly specific monitoring and imaging of endogenous and exogenous cysteine in living cells.
Song X, Yang Y, Ru J, Wang Y, Qiu F, Feng Y, Zhang G, Liu W
Talanta 2019 Nov 1;204:561-568. Epub 2019 Jun 8 doi: 10.1016/j.talanta.2019.06.020. PMID: 31357334
Attention deficit/hyperactivity disorder: is there a correlation between dopamine transporter density and cerebral blood flow?
da Silva N Jr, Szobot CM, Anselmi CE, Jackowski AP, Chi SM, Hoexter MQ, Anselmi OE, Pechansky F, Bressan RA, Rohde LA
Clin Nucl Med 2011 Aug;36(8):656-60. doi: 10.1097/RLU.0b013e318219b49d. PMID: 21716015
Brain perfusion abnormalities in patients with euthyroid autoimmune thyroiditis.
Piga M, Serra A, Deiana L, Loi GL, Satta L, Di Liberto M, Mariotti S
Eur J Nucl Med Mol Imaging 2004 Dec;31(12):1639-44. Epub 2004 Jul 31 doi: 10.1007/s00259-004-1625-7. PMID: 15290119
Cerebral hypoperfusion detected by SPECT in patients with systemic lupus erythematosus is related to clinical activity and cumulative tissue damage.
López-Longo FJ, Carol N, Almoguera MI, Olazarán J, Alonso-Farto JC, Ortega A, Monteagudo I, González CM, Carreño L
Lupus 2003;12(11):813-9. doi: 10.1191/0961203303lu470oa. PMID: 14667096
Human ACTH hypersensitivity syndrome associated with abnormalities of the ACTH receptor gene.
Hiroi N, Yakushiji F, Shimojo M, Watanabe S, Sugano S, Yamaguchi N, Miyachi Y
Clin Endocrinol (Oxf) 1998 Feb;48(2):129-34. doi: 10.1046/j.1365-2265.1998.3971187.x. PMID: 9579221

Therapy

Attention deficit/hyperactivity disorder: is there a correlation between dopamine transporter density and cerebral blood flow?
da Silva N Jr, Szobot CM, Anselmi CE, Jackowski AP, Chi SM, Hoexter MQ, Anselmi OE, Pechansky F, Bressan RA, Rohde LA
Clin Nucl Med 2011 Aug;36(8):656-60. doi: 10.1097/RLU.0b013e318219b49d. PMID: 21716015
L-cysteine, N-acetyl-L-cysteine, and glutathione protect Xenopus laevis embryos against acrylamide-induced malformations and mortality in the frog embryo teratogenesis assay.
Rayburn JR, Friedman M
J Agric Food Chem 2010 Oct 27;58(20):11172-8. Epub 2010 Sep 28 doi: 10.1021/jf1023998. PMID: 20873821
Brain perfusion abnormalities in patients with euthyroid autoimmune thyroiditis.
Piga M, Serra A, Deiana L, Loi GL, Satta L, Di Liberto M, Mariotti S
Eur J Nucl Med Mol Imaging 2004 Dec;31(12):1639-44. Epub 2004 Jul 31 doi: 10.1007/s00259-004-1625-7. PMID: 15290119
Human ACTH hypersensitivity syndrome associated with abnormalities of the ACTH receptor gene.
Hiroi N, Yakushiji F, Shimojo M, Watanabe S, Sugano S, Yamaguchi N, Miyachi Y
Clin Endocrinol (Oxf) 1998 Feb;48(2):129-34. doi: 10.1046/j.1365-2265.1998.3971187.x. PMID: 9579221
The effect of a subnormal vitamin B-6 status on homocysteine metabolism.
Ubbink JB, van der Merwe A, Delport R, Allen RH, Stabler SP, Riezler R, Vermaak WJ
J Clin Invest 1996 Jul 1;98(1):177-84. doi: 10.1172/JCI118763. PMID: 8690790Free PMC Article

Prognosis

Methods for measuring sulfur amino acid metabolism.
Hoffer LJ
Curr Opin Clin Nutr Metab Care 2002 Sep;5(5):511-7. doi: 10.1097/00075197-200209000-00009. PMID: 12172474

Clinical prediction guides

Plasma L-cystine/L-glutamate imbalance increases tumor necrosis factor-alpha from CD14+ circulating monocytes in patients with advanced cirrhosis.
Kakazu E, Ueno Y, Kondo Y, Inoue J, Ninomiya M, Kimura O, Wakui Y, Fukushima K, Tamai K, Shimosegawa T
PLoS One 2011;6(8):e23402. Epub 2011 Aug 17 doi: 10.1371/journal.pone.0023402. PMID: 21858100Free PMC Article
Attention deficit/hyperactivity disorder: is there a correlation between dopamine transporter density and cerebral blood flow?
da Silva N Jr, Szobot CM, Anselmi CE, Jackowski AP, Chi SM, Hoexter MQ, Anselmi OE, Pechansky F, Bressan RA, Rohde LA
Clin Nucl Med 2011 Aug;36(8):656-60. doi: 10.1097/RLU.0b013e318219b49d. PMID: 21716015
Recombinant hemoglobin betaG83C-F41Y.
Vasseur-Godbillon C, Sahu SC, Domingues E, Fablet C, Giovannelli JL, Tam TC, Ho NT, Ho C, Marden MC, Baudin-Creuza V
FEBS J 2006 Jan;273(1):230-41. doi: 10.1111/j.1742-4658.2005.05063.x. PMID: 16367763
Brain perfusion abnormalities in patients with euthyroid autoimmune thyroiditis.
Piga M, Serra A, Deiana L, Loi GL, Satta L, Di Liberto M, Mariotti S
Eur J Nucl Med Mol Imaging 2004 Dec;31(12):1639-44. Epub 2004 Jul 31 doi: 10.1007/s00259-004-1625-7. PMID: 15290119
Methods for measuring sulfur amino acid metabolism.
Hoffer LJ
Curr Opin Clin Nutr Metab Care 2002 Sep;5(5):511-7. doi: 10.1097/00075197-200209000-00009. PMID: 12172474

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