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Abnormal circulating leucine concentration

MedGen UID:
1684887
•Concept ID:
C5139040
•
Finding
Synonym: Abnormality of leucine metabolism
 
HPO: HP:0004357

Definition

Any deviation from the normal circulation of leucine in the blood circulation. [from HPO]

Recent clinical studies

Etiology

Methods for measuring sulfur amino acid metabolism.
Hoffer LJ
Curr Opin Clin Nutr Metab Care 2002 Sep;5(5):511-7. doi: 10.1097/00075197-200209000-00009. PMID: 12172474
Ovarian hyperandrogenism is associated with insulin resistance to both peripheral carbohydrate and whole-body protein metabolism in postpubertal young females: a metabolic study.
Mauras N, Welch S, Rini A, Haymond MW
J Clin Endocrinol Metab 1998 Jun;83(6):1900-5. doi: 10.1210/jcem.83.6.4866. PMID: 9626116
Estrogens do not affect whole-body protein metabolism in the prepubertal female.
Mauras N
J Clin Endocrinol Metab 1995 Oct;80(10):2842-5. doi: 10.1210/jcem.80.10.7559861. PMID: 7559861

Diagnosis

IGF-I treatment in adults with type 1 diabetes: effects on glucose and protein metabolism in the fasting state and during a hyperinsulinemic-euglycemic amino acid clamp.
Carroll PV, Christ ER, Umpleby AM, Gowrie I, Jackson N, Bowes SB, Hovorka R, Croos P, Sönksen PH, Russell-Jones DL
Diabetes 2000 May;49(5):789-96. doi: 10.2337/diabetes.49.5.789. PMID: 10905488

Therapy

Insulin effect on serum potassium and auto-inhibition of insulin secretion is intact in a patient with leprechaunism despite severe impairment of substrates metabolism.
Luzi L, Zoppini G, Targher G, Battezzati A, Muggeo M, Bonora E
Diabetes Metab Res Rev 2008 Mar-Apr;24(3):205-10. doi: 10.1002/dmrr.771. PMID: 17968975
IGF-I treatment in adults with type 1 diabetes: effects on glucose and protein metabolism in the fasting state and during a hyperinsulinemic-euglycemic amino acid clamp.
Carroll PV, Christ ER, Umpleby AM, Gowrie I, Jackson N, Bowes SB, Hovorka R, Croos P, Sönksen PH, Russell-Jones DL
Diabetes 2000 May;49(5):789-96. doi: 10.2337/diabetes.49.5.789. PMID: 10905488
The nutritional/metabolic and hormonal effects of 8 weeks of continuous ambulatory peritoneal dialysis with a 1% amino acid solution.
Arfeen S, Goodship TH, Kirkwood A, Ward MK
Clin Nephrol 1990 Apr;33(4):192-99. PMID: 2190721

Prognosis

Methods for measuring sulfur amino acid metabolism.
Hoffer LJ
Curr Opin Clin Nutr Metab Care 2002 Sep;5(5):511-7. doi: 10.1097/00075197-200209000-00009. PMID: 12172474

Clinical prediction guides

Methods for measuring sulfur amino acid metabolism.
Hoffer LJ
Curr Opin Clin Nutr Metab Care 2002 Sep;5(5):511-7. doi: 10.1097/00075197-200209000-00009. PMID: 12172474
Metabolic abnormalities of apolipoprotein B-containing lipoproteins in non-insulin-dependent diabetes: a stable isotope kinetic study.
Duvillard L, Pont F, Florentin E, Galland-Jos C, Gambert P, Vergès B
Eur J Clin Invest 2000 Aug;30(8):685-94. PMID: 10964160
IGF-I treatment in adults with type 1 diabetes: effects on glucose and protein metabolism in the fasting state and during a hyperinsulinemic-euglycemic amino acid clamp.
Carroll PV, Christ ER, Umpleby AM, Gowrie I, Jackson N, Bowes SB, Hovorka R, Croos P, Sönksen PH, Russell-Jones DL
Diabetes 2000 May;49(5):789-96. doi: 10.2337/diabetes.49.5.789. PMID: 10905488
Estrogens do not affect whole-body protein metabolism in the prepubertal female.
Mauras N
J Clin Endocrinol Metab 1995 Oct;80(10):2842-5. doi: 10.1210/jcem.80.10.7559861. PMID: 7559861
Mutation in the human gene for 3 beta-hydroxysteroid dehydrogenase type II leading to male pseudohermaphroditism without salt loss.
Russell AJ, Wallace AM, Forest MG, Donaldson MD, Edwards CR, Sutcliffe RG
J Mol Endocrinol 1994 Apr;12(2):225-37. doi: 10.1677/jme.0.0120225. PMID: 8060486

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