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Positive blood acetaminophen test

MedGen UID:
1685019
•Concept ID:
C5139448
•
Finding
Synonyms: Positive blood paracetamol test; Positive blood Tylenol test
 
HPO: HP:0410283

Definition

Detection of acetaminophen in the blood. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPositive blood acetaminophen test

Professional guidelines

PubMed

The limited utility of screening laboratory tests and electrocardiograms in the management of unintentional asymptomatic pediatric ingestions.
Wang GS, Deakyne S, Bajaj L, Yin S, Heard K, Roosevelt G
J Emerg Med 2013 Jul;45(1):34-8. Epub 2013 Apr 2 doi: 10.1016/j.jemermed.2012.11.056. PMID: 23561311

Recent clinical studies

Etiology

Acetaminophen Inhibits the Neutrophil Oxidative Burst: Implications for Diagnostic Testing.
Almutairi A, Zaman F, Day-Lewis M, Tsitsikov E, Reiter A, Xue K, Geha RS, Chou J, Yee CSK
J Allergy Clin Immunol Pract 2020 Nov-Dec;8(10):3543-3548. Epub 2020 Jul 21 doi: 10.1016/j.jaip.2020.07.012. PMID: 32707237
Dexmedetomidine and intravenous acetaminophen for the prevention of postoperative delirium following cardiac surgery (DEXACET trial): protocol for a prospective randomized controlled trial.
Shankar P, Mueller A, Packiasabapathy S, Gasangwa D, Patxot M, O'Gara B, Shaefi S, Marcantonio ER, Subramaniam B
Trials 2018 Jun 22;19(1):326. doi: 10.1186/s13063-018-2718-0. PMID: 29929533Free PMC Article
An Immunoassay to Rapidly Measure Acetaminophen Protein Adducts Accurately Identifies Patients With Acute Liver Injury or Failure.
Roberts DW, Lee WM, Hinson JA, Bai S, Swearingen CJ, Stravitz RT, Reuben A, Letzig L, Simpson PM, Rule J, Fontana RJ, Ganger D, Reddy KR, Liou I, Fix O, James LP
Clin Gastroenterol Hepatol 2017 Apr;15(4):555-562.e3. Epub 2016 Sep 15 doi: 10.1016/j.cgh.2016.09.007. PMID: 27641661Free PMC Article
Peptide YY3-36 and glucagon-like peptide-1 in functional dyspepsia. Secretion and role in symptom generation.
Witte AB, Hilsted L, Holst JJ, Schmidt PT
Scand J Gastroenterol 2016;51(4):400-9. Epub 2015 Oct 26 doi: 10.3109/00365521.2015.1101780. PMID: 26503455
Acute pain transfusion reaction.
Hardwick J, Osswald M, Walker D
Oncol Nurs Forum 2013 Nov;40(6):543-5. doi: 10.1188/13.CJON.543-545. PMID: 24161631

Diagnosis

Chronic kidney disease linked to SARS-CoV-2 infection: a case report.
Tarris G, de Rougemont A, Estienney MA, Journet J, Lariotte AC, Aubignat D, Rebibou JM, De La Vega MF, Legendre M, Belliot G, Martin L
BMC Nephrol 2021 Aug 10;22(1):278. doi: 10.1186/s12882-021-02490-z. PMID: 34376184Free PMC Article
Acetaminophen Inhibits the Neutrophil Oxidative Burst: Implications for Diagnostic Testing.
Almutairi A, Zaman F, Day-Lewis M, Tsitsikov E, Reiter A, Xue K, Geha RS, Chou J, Yee CSK
J Allergy Clin Immunol Pract 2020 Nov-Dec;8(10):3543-3548. Epub 2020 Jul 21 doi: 10.1016/j.jaip.2020.07.012. PMID: 32707237
Simultaneous quantification of acetaminophen and structurally related compounds in human serum and plasma.
Bylda C, Thiele R, Kobold U, Volmer DA
Drug Test Anal 2014 May;6(5):451-60. Epub 2013 Sep 2 doi: 10.1002/dta.1527. PMID: 24000098
Acute pain transfusion reaction.
Hardwick J, Osswald M, Walker D
Oncol Nurs Forum 2013 Nov;40(6):543-5. doi: 10.1188/13.CJON.543-545. PMID: 24161631
Anaphylaxis to paracetamol.
Galindo PA, Borja J, Mur P, Feo F, Gómez E, García R
Allergol Immunopathol (Madr) 1998 Jul-Aug;26(4):199-200. PMID: 9816409

Therapy

ADO09, a co-formulation of the amylin analogue pramlintide and the insulin analogue A21G, lowers postprandial blood glucose versus insulin lispro in type 1 diabetes.
Andersen G, Meiffren G, Famulla S, Heise T, Ranson A, Seroussi C, Eloy R, Gaudier M, Charvet R, Chan YP, Soula O, DeVries JH
Diabetes Obes Metab 2021 Apr;23(4):961-970. Epub 2021 Jan 18 doi: 10.1111/dom.14302. PMID: 33336850
Successful orthotopic liver transplantation in a patient with a positive SARS-CoV2 test and acute liver failure secondary to acetaminophen overdose.
Rouphael C, D'Amico G, Ricci K, Cywinski J, Miranda C, Koval C, Duggal A, Quintini C, Menon KVN, Miller C, Modaresi Esfeh J
Am J Transplant 2021 Mar;21(3):1312-1316. Epub 2020 Oct 23 doi: 10.1111/ajt.16330. PMID: 33017864Free PMC Article
Mycoprotein reduces energy intake and postprandial insulin release without altering glucagon-like peptide-1 and peptide tyrosine-tyrosine concentrations in healthy overweight and obese adults: a randomised-controlled trial.
Bottin JH, Swann JR, Cropp E, Chambers ES, Ford HE, Ghatei MA, Frost GS
Br J Nutr 2016 Jul;116(2):360-74. Epub 2016 May 20 doi: 10.1017/S0007114516001872. PMID: 27198187Free PMC Article
Acute pain transfusion reaction.
Hardwick J, Osswald M, Walker D
Oncol Nurs Forum 2013 Nov;40(6):543-5. doi: 10.1188/13.CJON.543-545. PMID: 24161631
Anaphylaxis to paracetamol.
Galindo PA, Borja J, Mur P, Feo F, Gómez E, García R
Allergol Immunopathol (Madr) 1998 Jul-Aug;26(4):199-200. PMID: 9816409

Prognosis

Chronic kidney disease linked to SARS-CoV-2 infection: a case report.
Tarris G, de Rougemont A, Estienney MA, Journet J, Lariotte AC, Aubignat D, Rebibou JM, De La Vega MF, Legendre M, Belliot G, Martin L
BMC Nephrol 2021 Aug 10;22(1):278. doi: 10.1186/s12882-021-02490-z. PMID: 34376184Free PMC Article
An Immunoassay to Rapidly Measure Acetaminophen Protein Adducts Accurately Identifies Patients With Acute Liver Injury or Failure.
Roberts DW, Lee WM, Hinson JA, Bai S, Swearingen CJ, Stravitz RT, Reuben A, Letzig L, Simpson PM, Rule J, Fontana RJ, Ganger D, Reddy KR, Liou I, Fix O, James LP
Clin Gastroenterol Hepatol 2017 Apr;15(4):555-562.e3. Epub 2016 Sep 15 doi: 10.1016/j.cgh.2016.09.007. PMID: 27641661Free PMC Article
Vesicular Contact Reaction May Progress into Erythema Multiforme.
Czarnecka-Operacz M, Jenerowicz D, Szulczyńska-Gabor J, Teresiak-Mikołajczak E, Szyfter-Harris J, Bowszyc-Dmochowska M
Acta Dermatovenerol Croat 2016 Dec;24(4):307-309. PMID: 28128086
Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital.
Antoine DJ, Dear JW, Lewis PS, Platt V, Coyle J, Masson M, Thanacoody RH, Gray AJ, Webb DJ, Moggs JG, Bateman DN, Goldring CE, Park BK
Hepatology 2013 Aug;58(2):777-87. Epub 2013 Jul 2 doi: 10.1002/hep.26294. PMID: 23390034Free PMC Article
A new combined test with flowcytometric basophil activation and determination of sulfidoleukotrienes is useful for in vitro diagnosis of hypersensitivity to aspirin and other nonsteroidal anti-inflammatory drugs.
Sanz ML, Gamboa P, de Weck AL
Int Arch Allergy Immunol 2005 Jan;136(1):58-72. Epub 2004 Dec 8 doi: 10.1159/000082586. PMID: 15608437

Clinical prediction guides

Chronic kidney disease linked to SARS-CoV-2 infection: a case report.
Tarris G, de Rougemont A, Estienney MA, Journet J, Lariotte AC, Aubignat D, Rebibou JM, De La Vega MF, Legendre M, Belliot G, Martin L
BMC Nephrol 2021 Aug 10;22(1):278. doi: 10.1186/s12882-021-02490-z. PMID: 34376184Free PMC Article
Predictive factors of dengue severity in hospitalized children and adolescents in Rio de Janeiro, Brazil.
Ferreira RAX, Kubelka CF, Velarde LGC, Matos JPS, Ferreira LC, Reid MM, Setúbal S, Oliveira SA
Rev Soc Bras Med Trop 2018 Nov-Dec;51(6):753-760. doi: 10.1590/0037-8682-0036-2018. PMID: 30517528
An Immunoassay to Rapidly Measure Acetaminophen Protein Adducts Accurately Identifies Patients With Acute Liver Injury or Failure.
Roberts DW, Lee WM, Hinson JA, Bai S, Swearingen CJ, Stravitz RT, Reuben A, Letzig L, Simpson PM, Rule J, Fontana RJ, Ganger D, Reddy KR, Liou I, Fix O, James LP
Clin Gastroenterol Hepatol 2017 Apr;15(4):555-562.e3. Epub 2016 Sep 15 doi: 10.1016/j.cgh.2016.09.007. PMID: 27641661Free PMC Article
Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital.
Antoine DJ, Dear JW, Lewis PS, Platt V, Coyle J, Masson M, Thanacoody RH, Gray AJ, Webb DJ, Moggs JG, Bateman DN, Goldring CE, Park BK
Hepatology 2013 Aug;58(2):777-87. Epub 2013 Jul 2 doi: 10.1002/hep.26294. PMID: 23390034Free PMC Article
Genotoxic activities of aniline and its metabolites and their relationship to the carcinogenicity of aniline in the spleen of rats.
Bomhard EM, Herbold BA
Crit Rev Toxicol 2005 Dec;35(10):783-835. doi: 10.1080/10408440500442384. PMID: 16468500

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