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Monoclonal elevation of circulating IgE

MedGen UID:
1685197
•Concept ID:
C5139279
•
Finding
HPO: HP:0032337

Definition

An increase in circulating IgE characterized by one predominant band in serum electrophoresis but not the broad diffuse band that characterizes a polyclonal increase in circulating immunoglobulins. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMonoclonal elevation of circulating IgE

Recent clinical studies

Etiology

Clinical efficacy of omalizumab in chronic spontaneous urticaria is associated with a reduction of FcεRI-positive cells in the skin.
Metz M, Staubach P, Bauer A, Brehler R, Gericke J, Kangas M, Ashton-Chess J, Jarvis P, Georgiou P, Canvin J, Hillenbrand R, Erpenbeck VJ, Maurer M
Theranostics 2017;7(5):1266-1276. Epub 2017 Mar 6 doi: 10.7150/thno.18304. PMID: 28435464Free PMC Article
Elevated serum concentrations of beta-tryptase, but not alpha-tryptase, in Sudden Infant Death Syndrome (SIDS). An investigation of anaphylactic mechanisms.
Buckley MG, Variend S, Walls AF
Clin Exp Allergy 2001 Nov;31(11):1696-704. doi: 10.1046/j.1365-2222.2001.01213.x. PMID: 11696045
Quantitative analysis of T-lymphocyte subsets in atopic eczema, using monoclonal antibodies and flow cytofluorimetry.
Zachary CB, MacDonald DM
Br J Dermatol 1983 Apr;108(4):411-22. doi: 10.1111/j.1365-2133.1983.tb04593.x. PMID: 6220732

Diagnosis

Successful treatment of dupilumab in Kimura disease independent of IgE: A case report with literature review.
Yang B, Yu H, Jia M, Yao W, Diao R, Li B, Wang Y, Li T, Ge L, Wang H
Front Immunol 2022;13:1084879. Epub 2022 Dec 14 doi: 10.3389/fimmu.2022.1084879. PMID: 36591252Free PMC Article
Elevated serum concentrations of beta-tryptase, but not alpha-tryptase, in Sudden Infant Death Syndrome (SIDS). An investigation of anaphylactic mechanisms.
Buckley MG, Variend S, Walls AF
Clin Exp Allergy 2001 Nov;31(11):1696-704. doi: 10.1046/j.1365-2222.2001.01213.x. PMID: 11696045
Sézary syndrome with elevated serum IgE and hypereosinophilia: role of dysregulated cytokine production.
Borish L, Dishuck J, Cox L, Mascali JJ, Williams J, Rosenwasser LJ
J Allergy Clin Immunol 1993 Jul;92(1 Pt 1):123-31. doi: 10.1016/0091-6749(93)90046-i. PMID: 8335848
Episodic angioedema with eosinophilia.
Wolf C, Pehamberger H, Breyer S, Leiferman KM, Wolff K
J Am Acad Dermatol 1989 Jan;20(1):21-7. doi: 10.1016/s0190-9622(89)70003-7. PMID: 2521494

Therapy

Successful treatment of dupilumab in Kimura disease independent of IgE: A case report with literature review.
Yang B, Yu H, Jia M, Yao W, Diao R, Li B, Wang Y, Li T, Ge L, Wang H
Front Immunol 2022;13:1084879. Epub 2022 Dec 14 doi: 10.3389/fimmu.2022.1084879. PMID: 36591252Free PMC Article
Clinical efficacy of omalizumab in chronic spontaneous urticaria is associated with a reduction of FcεRI-positive cells in the skin.
Metz M, Staubach P, Bauer A, Brehler R, Gericke J, Kangas M, Ashton-Chess J, Jarvis P, Georgiou P, Canvin J, Hillenbrand R, Erpenbeck VJ, Maurer M
Theranostics 2017;7(5):1266-1276. Epub 2017 Mar 6 doi: 10.7150/thno.18304. PMID: 28435464Free PMC Article
Changes of immunomodulatory cytokines associated with omalizumab therapy for severe persistent asthma.
Shimizu Y, Dobashi K, Fueki N, Fueki M, Okada T, Tomioka S, Makino S, Mori M
J Biol Regul Homeost Agents 2011 Apr-Jun;25(2):177-86. PMID: 21880206
Attainments in atop: special aspects of allergy and IgE.
Milgrom H
Adv Pediatr 2002;49:273-97. PMID: 12214775

Clinical prediction guides

Clinical efficacy of omalizumab in chronic spontaneous urticaria is associated with a reduction of FcεRI-positive cells in the skin.
Metz M, Staubach P, Bauer A, Brehler R, Gericke J, Kangas M, Ashton-Chess J, Jarvis P, Georgiou P, Canvin J, Hillenbrand R, Erpenbeck VJ, Maurer M
Theranostics 2017;7(5):1266-1276. Epub 2017 Mar 6 doi: 10.7150/thno.18304. PMID: 28435464Free PMC Article
Changes of immunomodulatory cytokines associated with omalizumab therapy for severe persistent asthma.
Shimizu Y, Dobashi K, Fueki N, Fueki M, Okada T, Tomioka S, Makino S, Mori M
J Biol Regul Homeost Agents 2011 Apr-Jun;25(2):177-86. PMID: 21880206
Cellular and humoral observations in a patient with allergic bronchopulmonary aspergillosis during a nonasthmatic exacerbation.
Kauffman HF, Koëter GH, van der Heide S, de Monchy JG, Kloprogge E, de Vries K
J Allergy Clin Immunol 1989 Apr;83(4):829-38. doi: 10.1016/0091-6749(89)90022-5. PMID: 2708743
Deficiency of suppressor T cells in the hyperimmunoglobulin E syndrome.
Geha RS, Reinherz E, Leung D, McKee KT Jr, Schlossman S, Rosen FS
J Clin Invest 1981 Sep;68(3):783-91. doi: 10.1172/jci110315. PMID: 6456275Free PMC Article

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