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Positive blood 1,3 beta glucan test

MedGen UID:
1685365
•Concept ID:
C5209247
•
Laboratory or Test Result
HPO: HP:0020153

Definition

Beta-1,3-glucan is a major constituent of all of the characterized fungal cell walls, making up between 30-80 percent of the mass of the wall. It is a biomarker of fungal infections such as invasive pulmonary aspergillosis. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPositive blood 1,3 beta glucan test

Professional guidelines

PubMed

Difficulties in using 1,3-{beta}-D-glucan as the screening test for the early diagnosis of invasive fungal infections in patients with haematological malignancies--high frequency of false-positive results and their analysis.
Racil Z, Kocmanova I, Lengerova M, Weinbergerova B, Buresova L, Toskova M, Winterova J, Timilsina S, Rodriguez I, Mayer J
J Med Microbiol 2010 Sep;59(Pt 9):1016-1022. Epub 2010 May 20 doi: 10.1099/jmm.0.019299-0. PMID: 20488937
Management of invasive pulmonary aspergillosis in non-neutropenic critically ill patients.
Trof RJ, Beishuizen A, Debets-Ossenkopp YJ, Girbes AR, Groeneveld AB
Intensive Care Med 2007 Oct;33(10):1694-703. Epub 2007 Jul 24 doi: 10.1007/s00134-007-0791-z. PMID: 17646966Free PMC Article
Contribution of (1->3)-beta-D-glucan chromogenic assay to diagnosis and therapeutic monitoring of invasive aspergillosis in neutropenic adult patients: a comparison with serial screening for circulating galactomannan.
Pazos C, Pontón J, Del Palacio A
J Clin Microbiol 2005 Jan;43(1):299-305. doi: 10.1128/JCM.43.1.299-305.2005. PMID: 15634986Free PMC Article

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