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Decreased post-bronchodilator forced vital capacity

MedGen UID:
1685757
•Concept ID:
C5139290
•
Finding
Synonyms: Decreased post bronchodilator forced vital capacity; Decreased postbronchodilator forced vital capacity
 
HPO: HP:0032357

Definition

An abnormal reduction in the amount of air a person can expel following maximal insipiration, with the test being performed after the administration of a bronchodilating medication. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased post-bronchodilator forced vital capacity

Professional guidelines

PubMed

Self-management interventions for people with chronic obstructive pulmonary disease.
Schrijver J, Lenferink A, Brusse-Keizer M, Zwerink M, van der Valk PD, van der Palen J, Effing TW
Cochrane Database Syst Rev 2022 Jan 10;1(1):CD002990. doi: 10.1002/14651858.CD002990.pub4. PMID: 35001366Free PMC Article
Assessing two spirometric criteria of pre-bronchodilator and post-bronchodilator FEV1/FVC ratio in detecting air flow obstruction.
Waheed Z, Irfan M, Haque AS, Siddiqui NH, Awan S, Syed B, Khan JA
J Pak Med Assoc 2011 Dec;61(12):1172-5. PMID: 22355960
Post-bronchodilator spirometry reference values in adults and implications for disease management.
Johannessen A, Lehmann S, Omenaas ER, Eide GE, Bakke PS, Gulsvik A
Am J Respir Crit Care Med 2006 Jun 15;173(12):1316-25. Epub 2006 Mar 23 doi: 10.1164/rccm.200601-023OC. PMID: 16556696

Recent clinical studies

Etiology

Pulmonary Function Trajectories in People with HIV: Analysis of the Pittsburgh HIV Lung Cohort.
Konstantinidis I, Qin S, Fitzpatrick M, Kessinger C, Gentry H, McMahon D, Weinman RD, Tien P, Huang L, McCormack M, Barjaktarevic I, Reddy D, Foronjy R, Lazarous D, Cohen MH, McKay H, Adimora AA, Moran C, Fischl MA, Dionne-Odom J, Stosor V, Drummond MB, Cribbs SK, Kunisaki K, Rinaldo C, Morris A, Nouraie SM
Ann Am Thorac Soc 2022 Dec;19(12):2013-2020. doi: 10.1513/AnnalsATS.202204-332OC. PMID: 35939796Free PMC Article
Clinical Implications of Bronchodilator Testing: Diagnosing and Differentiating COPD and Asthma-COPD Overlap.
Annangi S, Coz-Yataco AO
Respir Care 2022 Apr;67(4):440-447. doi: 10.4187/respcare.09215. PMID: 35338095
Self-management interventions for people with chronic obstructive pulmonary disease.
Schrijver J, Lenferink A, Brusse-Keizer M, Zwerink M, van der Valk PD, van der Palen J, Effing TW
Cochrane Database Syst Rev 2022 Jan 10;1(1):CD002990. doi: 10.1002/14651858.CD002990.pub4. PMID: 35001366Free PMC Article
Prevalence of paradoxical bronchoconstriction after inhaled albuterol.
Schissler AJ, Celli BR
Respir Med 2018 Aug;141:100-102. Epub 2018 Jun 30 doi: 10.1016/j.rmed.2018.06.028. PMID: 30053954
Can roflumilast, a phosphodiesterase-4 inhibitor, improve clinical outcomes in patients with moderate-to-severe chronic obstructive pulmonary disease? A meta-analysis.
Luo J, Wang K, Liu D, Liang BM, Liu CT
Respir Res 2016 Feb 17;17:18. doi: 10.1186/s12931-016-0330-y. PMID: 26887407Free PMC Article

Diagnosis

Preserved ratio impaired spirometry is associated with small airway dysfunction and reduced total lung capacity.
Zhao N, Wu F, Peng J, Zheng Y, Tian H, Yang H, Deng Z, Wang Z, Li H, Wen X, Xiao S, Huang P, Dai C, Lu L, Zhou K, Chen S, Zhou Y, Ran P
Respir Res 2022 Oct 31;23(1):298. doi: 10.1186/s12931-022-02216-1. PMID: 36316732Free PMC Article
Clinical Implications of Bronchodilator Testing: Diagnosing and Differentiating COPD and Asthma-COPD Overlap.
Annangi S, Coz-Yataco AO
Respir Care 2022 Apr;67(4):440-447. doi: 10.4187/respcare.09215. PMID: 35338095
Self-management interventions for people with chronic obstructive pulmonary disease.
Schrijver J, Lenferink A, Brusse-Keizer M, Zwerink M, van der Valk PD, van der Palen J, Effing TW
Cochrane Database Syst Rev 2022 Jan 10;1(1):CD002990. doi: 10.1002/14651858.CD002990.pub4. PMID: 35001366Free PMC Article
Forced Oscillation Technique and Small Airway Involvement in Chronic Hypersensitivity Pneumonitis.
Dias OM, Baldi BG, Chate RC, Ribeiro de Carvalho CR, Dellacà RL, Milesi I, Pereira de Albuquerque AL
Arch Bronconeumol (Engl Ed) 2019 Oct;55(10):519-525. Epub 2019 Apr 8 doi: 10.1016/j.arbres.2019.01.022. PMID: 30975515
Evaluating How Post-Bronchodilator Vital Capacities Affect the Diagnosis of Obstruction in Pulmonary Function Tests.
Blagev DP, Sorenson D, Linares-Perdomo O, Bamberg S, Hegewald M, Morris AH
Respir Care 2016 Nov;61(11):1523-1529. Epub 2016 Sep 13 doi: 10.4187/respcare.04611. PMID: 27624631

Therapy

Clinical Implications of Bronchodilator Testing: Diagnosing and Differentiating COPD and Asthma-COPD Overlap.
Annangi S, Coz-Yataco AO
Respir Care 2022 Apr;67(4):440-447. doi: 10.4187/respcare.09215. PMID: 35338095
Self-management interventions for people with chronic obstructive pulmonary disease.
Schrijver J, Lenferink A, Brusse-Keizer M, Zwerink M, van der Valk PD, van der Palen J, Effing TW
Cochrane Database Syst Rev 2022 Jan 10;1(1):CD002990. doi: 10.1002/14651858.CD002990.pub4. PMID: 35001366Free PMC Article
Reduced lung elastic recoil and fixed airflow obstruction in asthma.
Tonga KO, Chapman DG, Farah CS, Oliver BG, Zimmermann SC, Milne S, Sanai F, Jetmalani K, Berend N, Thamrin C, King GG
Respirology 2020 Jun;25(6):613-619. Epub 2019 Sep 3 doi: 10.1111/resp.13688. PMID: 31482693
Prevalence of paradoxical bronchoconstriction after inhaled albuterol.
Schissler AJ, Celli BR
Respir Med 2018 Aug;141:100-102. Epub 2018 Jun 30 doi: 10.1016/j.rmed.2018.06.028. PMID: 30053954
Can roflumilast, a phosphodiesterase-4 inhibitor, improve clinical outcomes in patients with moderate-to-severe chronic obstructive pulmonary disease? A meta-analysis.
Luo J, Wang K, Liu D, Liang BM, Liu CT
Respir Res 2016 Feb 17;17:18. doi: 10.1186/s12931-016-0330-y. PMID: 26887407Free PMC Article

Prognosis

Preserved ratio impaired spirometry is associated with small airway dysfunction and reduced total lung capacity.
Zhao N, Wu F, Peng J, Zheng Y, Tian H, Yang H, Deng Z, Wang Z, Li H, Wen X, Xiao S, Huang P, Dai C, Lu L, Zhou K, Chen S, Zhou Y, Ran P
Respir Res 2022 Oct 31;23(1):298. doi: 10.1186/s12931-022-02216-1. PMID: 36316732Free PMC Article
Significance of FEV(3)/FEV(6) in Recognition of Early Airway Disease in Smokers at Risk of Development of COPD: Analysis of the SPIROMICS Cohort.
Yee N, Markovic D, Buhr RG, Fortis S, Arjomandi M, Couper D, Anderson WH, Paine R 3rd, Woodruff PG, Han MK, Martinez FJ, Barr RG, Wells JM, Ortega VE, Hoffman EA, Kim V, Drummond MB, Bowler RP, Curtis JL, Cooper CB, Tashkin DP, Barjaktarevic IZ
Chest 2022 Apr;161(4):949-959. Epub 2021 Nov 10 doi: 10.1016/j.chest.2021.10.046. PMID: 34767825Free PMC Article
Forced Oscillation Technique and Small Airway Involvement in Chronic Hypersensitivity Pneumonitis.
Dias OM, Baldi BG, Chate RC, Ribeiro de Carvalho CR, Dellacà RL, Milesi I, Pereira de Albuquerque AL
Arch Bronconeumol (Engl Ed) 2019 Oct;55(10):519-525. Epub 2019 Apr 8 doi: 10.1016/j.arbres.2019.01.022. PMID: 30975515
Evaluating How Post-Bronchodilator Vital Capacities Affect the Diagnosis of Obstruction in Pulmonary Function Tests.
Blagev DP, Sorenson D, Linares-Perdomo O, Bamberg S, Hegewald M, Morris AH
Respir Care 2016 Nov;61(11):1523-1529. Epub 2016 Sep 13 doi: 10.4187/respcare.04611. PMID: 27624631
Post-bronchodilator spirometry reference values in adults and implications for disease management.
Johannessen A, Lehmann S, Omenaas ER, Eide GE, Bakke PS, Gulsvik A
Am J Respir Crit Care Med 2006 Jun 15;173(12):1316-25. Epub 2006 Mar 23 doi: 10.1164/rccm.200601-023OC. PMID: 16556696

Clinical prediction guides

Preserved ratio impaired spirometry is associated with small airway dysfunction and reduced total lung capacity.
Zhao N, Wu F, Peng J, Zheng Y, Tian H, Yang H, Deng Z, Wang Z, Li H, Wen X, Xiao S, Huang P, Dai C, Lu L, Zhou K, Chen S, Zhou Y, Ran P
Respir Res 2022 Oct 31;23(1):298. doi: 10.1186/s12931-022-02216-1. PMID: 36316732Free PMC Article
Self-management interventions for people with chronic obstructive pulmonary disease.
Schrijver J, Lenferink A, Brusse-Keizer M, Zwerink M, van der Valk PD, van der Palen J, Effing TW
Cochrane Database Syst Rev 2022 Jan 10;1(1):CD002990. doi: 10.1002/14651858.CD002990.pub4. PMID: 35001366Free PMC Article
Significance of FEV(3)/FEV(6) in Recognition of Early Airway Disease in Smokers at Risk of Development of COPD: Analysis of the SPIROMICS Cohort.
Yee N, Markovic D, Buhr RG, Fortis S, Arjomandi M, Couper D, Anderson WH, Paine R 3rd, Woodruff PG, Han MK, Martinez FJ, Barr RG, Wells JM, Ortega VE, Hoffman EA, Kim V, Drummond MB, Bowler RP, Curtis JL, Cooper CB, Tashkin DP, Barjaktarevic IZ
Chest 2022 Apr;161(4):949-959. Epub 2021 Nov 10 doi: 10.1016/j.chest.2021.10.046. PMID: 34767825Free PMC Article
Reduced lung elastic recoil and fixed airflow obstruction in asthma.
Tonga KO, Chapman DG, Farah CS, Oliver BG, Zimmermann SC, Milne S, Sanai F, Jetmalani K, Berend N, Thamrin C, King GG
Respirology 2020 Jun;25(6):613-619. Epub 2019 Sep 3 doi: 10.1111/resp.13688. PMID: 31482693
Forced Oscillation Technique and Small Airway Involvement in Chronic Hypersensitivity Pneumonitis.
Dias OM, Baldi BG, Chate RC, Ribeiro de Carvalho CR, Dellacà RL, Milesi I, Pereira de Albuquerque AL
Arch Bronconeumol (Engl Ed) 2019 Oct;55(10):519-525. Epub 2019 Apr 8 doi: 10.1016/j.arbres.2019.01.022. PMID: 30975515

Recent systematic reviews

Self-management interventions for people with chronic obstructive pulmonary disease.
Schrijver J, Lenferink A, Brusse-Keizer M, Zwerink M, van der Valk PD, van der Palen J, Effing TW
Cochrane Database Syst Rev 2022 Jan 10;1(1):CD002990. doi: 10.1002/14651858.CD002990.pub4. PMID: 35001366Free PMC Article
Can roflumilast, a phosphodiesterase-4 inhibitor, improve clinical outcomes in patients with moderate-to-severe chronic obstructive pulmonary disease? A meta-analysis.
Luo J, Wang K, Liu D, Liang BM, Liu CT
Respir Res 2016 Feb 17;17:18. doi: 10.1186/s12931-016-0330-y. PMID: 26887407Free PMC Article
Regular inhaled short acting beta2 agonists for the management of stable chronic obstructive pulmonary disease: Cochrane systematic review and meta-analysis.
Ram FS, Sestini P
Thorax 2003 Jul;58(7):580-4. doi: 10.1136/thorax.58.7.580. PMID: 12832670Free PMC Article

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