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Increased urinary zinc level

MedGen UID:
1686216
•Concept ID:
C5139105
•
Finding
HPO: HP:0025639

Definition

An abnormally elevated amount of zinc in the urine, typically as assessed by a 24 hour urine collection. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased urinary zinc level

Professional guidelines

PubMed

Zinc deficiency and its association with treatment-related toxicity in children with cancer.
Chung JH, Phalke N, Hastings C, Killilea DW, Feusner JH, Fung EB
Pediatr Blood Cancer 2021 Sep;68(9):e29104. Epub 2021 Jun 1 doi: 10.1002/pbc.29104. PMID: 34061438
Association between dexamethasone treatment and alterations in serum concentrations of trace metals.
Yamashita K, Ogihara T, Hayashi M, Nakagawa T, Ishizaki Y, Kume M, Yano I, Niigata R, Hiraoka J, Yasui H, Nakamura T
Pharmazie 2020 May 1;75(5):218-222. doi: 10.1691/ph.2020.0341. PMID: 32393433
Wilson disease--a practical approach to diagnosis, treatment and follow-up.
Medici V, Rossaro L, Sturniolo GC
Dig Liver Dis 2007 Jul;39(7):601-9. Epub 2007 Mar 26 doi: 10.1016/j.dld.2006.12.095. PMID: 17382611

Recent clinical studies

Etiology

Circulating levels of micronutrients and risk of infections: a Mendelian randomization study.
Flatby HM, Ravi A, Damås JK, Solligård E, Rogne T
BMC Med 2023 Mar 8;21(1):84. doi: 10.1186/s12916-023-02780-3. PMID: 36882828Free PMC Article
Urinary Zinc and Incident Type 2 Diabetes: Prospective Evidence From the Strong Heart Study.
Galvez-Fernandez M, Powers M, Grau-Perez M, Domingo-Relloso A, Lolacono N, Goessler W, Zhang Y, Fretts A, Umans JG, Maruthur N, Navas-Acien A
Diabetes Care 2022 Nov 1;45(11):2561-2569. doi: 10.2337/dc22-1152. PMID: 36134919Free PMC Article
Anti-Inflammatory Diet Prevents Subclinical Colonic Inflammation and Alters Metabolomic Profile of Ulcerative Colitis Patients in Clinical Remission.
Keshteli AH, Valcheva R, Nickurak C, Park H, Mandal R, van Diepen K, Kroeker KI, van Zanten SV, Halloran B, Wishart DS, Madsen KL, Dieleman LA
Nutrients 2022 Aug 11;14(16) doi: 10.3390/nu14163294. PMID: 36014800Free PMC Article
The role of zinc in urinary stone disease.
Negri AL
Int Urol Nephrol 2018 May;50(5):879-883. Epub 2018 Jan 17 doi: 10.1007/s11255-017-1784-7. PMID: 29344880
Cadmium, environmental exposure, and health outcomes.
Satarug S, Garrett SH, Sens MA, Sens DA
Environ Health Perspect 2010 Feb;118(2):182-90. doi: 10.1289/ehp.0901234. PMID: 20123617Free PMC Article

Diagnosis

Circulating levels of micronutrients and risk of infections: a Mendelian randomization study.
Flatby HM, Ravi A, Damås JK, Solligård E, Rogne T
BMC Med 2023 Mar 8;21(1):84. doi: 10.1186/s12916-023-02780-3. PMID: 36882828Free PMC Article
Urinary Zinc and Incident Type 2 Diabetes: Prospective Evidence From the Strong Heart Study.
Galvez-Fernandez M, Powers M, Grau-Perez M, Domingo-Relloso A, Lolacono N, Goessler W, Zhang Y, Fretts A, Umans JG, Maruthur N, Navas-Acien A
Diabetes Care 2022 Nov 1;45(11):2561-2569. doi: 10.2337/dc22-1152. PMID: 36134919Free PMC Article
Relationship of serum copper and zinc with kidney function and urinary albumin to creatinine ratio: Cross-sectional data from the NHANES 2011-2016.
Jiang C, Ye H, Cui L, Pai P, Wang G
Eur J Clin Nutr 2022 Dec;76(12):1748-1754. Epub 2022 Jul 29 doi: 10.1038/s41430-022-01181-8. PMID: 35906329
Zinc deficiency and its association with treatment-related toxicity in children with cancer.
Chung JH, Phalke N, Hastings C, Killilea DW, Feusner JH, Fung EB
Pediatr Blood Cancer 2021 Sep;68(9):e29104. Epub 2021 Jun 1 doi: 10.1002/pbc.29104. PMID: 34061438
Discerning the Mauve factor, Part 2.
McGinnis WR, Audhya T, Walsh WJ, Jackson JA, McLaren-Howard J, Lewis A, Lauda PH, Bibus DM, Jurnak F, Lietha R, Hoffer A
Altern Ther Health Med 2008 May-Jun;14(3):56-62. PMID: 18517107

Therapy

Circulating levels of micronutrients and risk of infections: a Mendelian randomization study.
Flatby HM, Ravi A, Damås JK, Solligård E, Rogne T
BMC Med 2023 Mar 8;21(1):84. doi: 10.1186/s12916-023-02780-3. PMID: 36882828Free PMC Article
Anti-Inflammatory Diet Prevents Subclinical Colonic Inflammation and Alters Metabolomic Profile of Ulcerative Colitis Patients in Clinical Remission.
Keshteli AH, Valcheva R, Nickurak C, Park H, Mandal R, van Diepen K, Kroeker KI, van Zanten SV, Halloran B, Wishart DS, Madsen KL, Dieleman LA
Nutrients 2022 Aug 11;14(16) doi: 10.3390/nu14163294. PMID: 36014800Free PMC Article
Role of Zinc in Diabetic Kidney Disease.
Gembillo G, Visconti L, Giuffrida AE, Labbozzetta V, Peritore L, Lipari A, Calabrese V, Piccoli GB, Torreggiani M, Siligato R, Santoro D
Nutrients 2022 Mar 24;14(7) doi: 10.3390/nu14071353. PMID: 35405968Free PMC Article
Vegan Diet and Bone Health-Results from the Cross-Sectional RBVD Study.
Menzel J, Abraham K, Stangl GI, Ueland PM, Obeid R, Schulze MB, Herter-Aeberli I, Schwerdtle T, Weikert C
Nutrients 2021 Feb 21;13(2) doi: 10.3390/nu13020685. PMID: 33669942Free PMC Article
Cadmium, environmental exposure, and health outcomes.
Satarug S, Garrett SH, Sens MA, Sens DA
Environ Health Perspect 2010 Feb;118(2):182-90. doi: 10.1289/ehp.0901234. PMID: 20123617Free PMC Article

Prognosis

Role of Zinc in Diabetic Kidney Disease.
Gembillo G, Visconti L, Giuffrida AE, Labbozzetta V, Peritore L, Lipari A, Calabrese V, Piccoli GB, Torreggiani M, Siligato R, Santoro D
Nutrients 2022 Mar 24;14(7) doi: 10.3390/nu14071353. PMID: 35405968Free PMC Article
Cross-sectional and longitudinal associations between urinary zinc and lung function among urban adults in China.
Zhou M, Xiao L, Yang S, Wang B, Shi T, Tan A, Wang X, Mu G, Chen W
Thorax 2020 Sep;75(9):771-779. Epub 2020 Jul 6 doi: 10.1136/thoraxjnl-2019-213909. PMID: 32631935
Cadmium, environmental exposure, and health outcomes.
Satarug S, Garrett SH, Sens MA, Sens DA
Environ Health Perspect 2010 Feb;118(2):182-90. doi: 10.1289/ehp.0901234. PMID: 20123617Free PMC Article
Serum zinc response in thermal injury.
Boosalis MG, Solem LD, McCall JT, Ahrenholz DH, McClain CJ
J Am Coll Nutr 1988 Feb;7(1):69-76. doi: 10.1080/07315724.1988.10720222. PMID: 3278040
Serum zinc levels and urinary zinc excretion in patients with bronchogenic carcinoma. Effects of tumor resection.
Voyatzoglou V, Mountokalakis T, Tsata-Voyatzoglou V, Koutselinis A, Skalkeas G
Am J Surg 1982 Sep;144(3):355-8. doi: 10.1016/0002-9610(82)90019-8. PMID: 7114378

Clinical prediction guides

Circulating levels of micronutrients and risk of infections: a Mendelian randomization study.
Flatby HM, Ravi A, Damås JK, Solligård E, Rogne T
BMC Med 2023 Mar 8;21(1):84. doi: 10.1186/s12916-023-02780-3. PMID: 36882828Free PMC Article
Urinary Zinc and Incident Type 2 Diabetes: Prospective Evidence From the Strong Heart Study.
Galvez-Fernandez M, Powers M, Grau-Perez M, Domingo-Relloso A, Lolacono N, Goessler W, Zhang Y, Fretts A, Umans JG, Maruthur N, Navas-Acien A
Diabetes Care 2022 Nov 1;45(11):2561-2569. doi: 10.2337/dc22-1152. PMID: 36134919Free PMC Article
Vegan Diet and Bone Health-Results from the Cross-Sectional RBVD Study.
Menzel J, Abraham K, Stangl GI, Ueland PM, Obeid R, Schulze MB, Herter-Aeberli I, Schwerdtle T, Weikert C
Nutrients 2021 Feb 21;13(2) doi: 10.3390/nu13020685. PMID: 33669942Free PMC Article
The associations of zinc and GRIN2B genetic polymorphisms with the risk of dyslexia.
Liu Q, Zhu B, Xue Q, Xie X, Zhou Y, Zhu K, Wan Z, Wu H, Zhang J, Song R
Environ Res 2020 Dec;191:110207. Epub 2020 Sep 13 doi: 10.1016/j.envres.2020.110207. PMID: 32937172
Cadmium, environmental exposure, and health outcomes.
Satarug S, Garrett SH, Sens MA, Sens DA
Environ Health Perspect 2010 Feb;118(2):182-90. doi: 10.1289/ehp.0901234. PMID: 20123617Free PMC Article

Recent systematic reviews

Nutrients, vitamins, probiotics and herbal products: an update of their role in urolithogenesis.
Pedro RN, Aslam AU, Bello JO, Bhatti KH, Philipraj J, Sissoko I, Vasconcellos GS, Trinchieri A, Buchholz N
Urolithiasis 2020 Aug;48(4):285-301. Epub 2020 Mar 2 doi: 10.1007/s00240-020-01182-x. PMID: 32123972
Immediate Effects of Aerobic Exercise on Plasma/Serum Zinc Levels: A Meta-analysis.
Chu A, Petocz P, Samman S
Med Sci Sports Exerc 2016 Apr;48(4):726-33. doi: 10.1249/MSS.0000000000000805. PMID: 26540263
Pharmaco-nutrient interactions - a systematic review of zinc and antihypertensive therapy.
Braun LA, Rosenfeldt F
Int J Clin Pract 2013 Aug;67(8):717-25. Epub 2012 Dec 26 doi: 10.1111/ijcp.12040. PMID: 23279674
Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration.
Evans JR, Lawrenson JG
Cochrane Database Syst Rev 2012 Nov 14;11:CD000254. doi: 10.1002/14651858.CD000254.pub3. PMID: 23152201

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