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Increased CSF tyrosine concentration

MedGen UID:
1686509
•Concept ID:
C5139605
•
Finding
Synonym: High tyrosine levels in cerebrospinal fluid
 
HPO: HP:0500220

Definition

Abnormally increased levels of tyrosine in cerebrospinal fluid. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased CSF tyrosine concentration

Professional guidelines

PubMed

Blood D-serine levels correlate with aging and dopaminergic treatment in Parkinson's disease.
Imarisio A, Yahyavi I, Avenali M, Di Maio A, Buongarzone G, Galandra C, Picascia M, Filosa A, Gasparri C, Monti MC, Rondanelli M, Pacchetti C, Errico F, Valente EM, Usiello A
Neurobiol Dis 2024 Mar;192:106413. Epub 2024 Jan 20 doi: 10.1016/j.nbd.2024.106413. PMID: 38253208
Endotype-phenotyping may predict a treatment response in progressive fibrosing interstitial lung disease.
Hoffmann-Vold AM, Weigt SS, Saggar R, Palchevskiy V, Volkmann ER, Liang LL, Ross D, Ardehali A, Lynch JP 3rd, Belperio JA
EBioMedicine 2019 Dec;50:379-386. Epub 2019 Nov 12 doi: 10.1016/j.ebiom.2019.10.050. PMID: 31732480Free PMC Article
Oxidative damage in glutaric aciduria type I patients and the protective effects of l-carnitine treatment.
Guerreiro G, Faverzani J, Jacques CED, Marchetti DP, Sitta A, de Moura Coelho D, Kayser A, Kok F, Athayde L, Manfredini V, Wajner M, Vargas CR
J Cell Biochem 2018 Dec;119(12):10021-10032. Epub 2018 Aug 20 doi: 10.1002/jcb.27332. PMID: 30129250

Recent clinical studies

Etiology

Decreased pain sensitivity and alterations of cerebrospinal fluid and plasma inflammatory mediators after total hip arthroplasty in patients with disabling osteoarthritis.
Bjurström MF, Bodelsson M, Irwin MR, Orbjörn C, Hansson O, Mattsson-Carlgren N
Pain Pract 2022 Jan;22(1):66-82. Epub 2021 Jul 24 doi: 10.1111/papr.13051. PMID: 34143556
Novel Protein Biomarkers of Monoamine Metabolism Defects Correlate with Disease Severity.
Tristán-Noguero A, Borràs E, Molero-Luis M, Wassenberg T, Peters T, Verbeek MM, Willemsen M, Opladen T, Jeltsch K, Pons R, Thony B, Horvath G, Yapici Z, Friedman J, Hyland K, Agosta GE, López-Laso E, Artuch R, Sabidó E, García-Cazorla À
Mov Disord 2021 Mar;36(3):690-703. Epub 2020 Nov 5 doi: 10.1002/mds.28362. PMID: 33152132
Cytokine and Chemokine Concentration in the Tear of Patients with Age-Related Cataract.
Engelbrecht C, Sardinha LR, Rizzo LV
Curr Eye Res 2020 Sep;45(9):1101-1106. Epub 2020 Jan 24 doi: 10.1080/02713683.2020.1715445. PMID: 31928443
Homovanillic acid in CSF of mild stage Parkinson's disease patients correlates with motor impairment.
Stefani A, Pierantozzi M, Olivola E, Galati S, Cerroni R, D'Angelo V, Hainsworth AH, Saviozzi V, Fedele E, Liguori C
Neurochem Int 2017 May;105:58-63. Epub 2017 Jan 18 doi: 10.1016/j.neuint.2017.01.007. PMID: 28108196
Tyrosine metabolism during interferon-alpha administration: association with fatigue and CSF dopamine concentrations.
Felger JC, Li L, Marvar PJ, Woolwine BJ, Harrison DG, Raison CL, Miller AH
Brain Behav Immun 2013 Jul;31:153-60. Epub 2012 Oct 13 doi: 10.1016/j.bbi.2012.10.010. PMID: 23072726Free PMC Article

Diagnosis

Decreased pain sensitivity and alterations of cerebrospinal fluid and plasma inflammatory mediators after total hip arthroplasty in patients with disabling osteoarthritis.
Bjurström MF, Bodelsson M, Irwin MR, Orbjörn C, Hansson O, Mattsson-Carlgren N
Pain Pract 2022 Jan;22(1):66-82. Epub 2021 Jul 24 doi: 10.1111/papr.13051. PMID: 34143556
TLR4, RAGE, and p-JNK/JNK mediated inflammatory aggression in osteoathritic human chondrocytes are counteracted by redox-sensitive phenolic olive compounds: Comparison with ibuprofen.
Elmazoglu Z, Bek ZA, Sarıbaş GS, Özoğul C, Goker B, Bitik B, Aktekin CN, Karasu Ç
J Tissue Eng Regen Med 2020 Dec;14(12):1841-1857. Epub 2020 Oct 5 doi: 10.1002/term.3138. PMID: 33010113
Homovanillic acid in CSF of mild stage Parkinson's disease patients correlates with motor impairment.
Stefani A, Pierantozzi M, Olivola E, Galati S, Cerroni R, D'Angelo V, Hainsworth AH, Saviozzi V, Fedele E, Liguori C
Neurochem Int 2017 May;105:58-63. Epub 2017 Jan 18 doi: 10.1016/j.neuint.2017.01.007. PMID: 28108196
Cerebrospinal fluid brain-derived proteins in the diagnosis of Alzheimer's disease and Creutzfeldt-Jakob disease.
Green AJ
Neuropathol Appl Neurobiol 2002 Dec;28(6):427-40. doi: 10.1046/j.1365-2990.2002.t01-2-00427.x. PMID: 12445159
Biochemical investigations in patients with dementia.
Green A
Ann Clin Biochem 2002 May;39(Pt 3):211-20. doi: 10.1258/0004563021902143. PMID: 12038595

Therapy

Blood D-serine levels correlate with aging and dopaminergic treatment in Parkinson's disease.
Imarisio A, Yahyavi I, Avenali M, Di Maio A, Buongarzone G, Galandra C, Picascia M, Filosa A, Gasparri C, Monti MC, Rondanelli M, Pacchetti C, Errico F, Valente EM, Usiello A
Neurobiol Dis 2024 Mar;192:106413. Epub 2024 Jan 20 doi: 10.1016/j.nbd.2024.106413. PMID: 38253208
Decreased pain sensitivity and alterations of cerebrospinal fluid and plasma inflammatory mediators after total hip arthroplasty in patients with disabling osteoarthritis.
Bjurström MF, Bodelsson M, Irwin MR, Orbjörn C, Hansson O, Mattsson-Carlgren N
Pain Pract 2022 Jan;22(1):66-82. Epub 2021 Jul 24 doi: 10.1111/papr.13051. PMID: 34143556
ATP13A2 levels in serum and cerebrospinal fluid in patients with idiopathic Parkinson's disease.
Fernández-Espejo E, Rodriguez de Fonseca F, Suárez J, González-Aparicio R, Santurtún A
Parkinsonism Relat Disord 2021 Jul;88:3-9. Epub 2021 May 26 doi: 10.1016/j.parkreldis.2021.05.014. PMID: 34090180
Anesthesia and tau pathology.
Whittington RA, Bretteville A, Dickler MF, Planel E
Prog Neuropsychopharmacol Biol Psychiatry 2013 Dec 2;47:147-55. Epub 2013 Mar 25 doi: 10.1016/j.pnpbp.2013.03.004. PMID: 23535147Free PMC Article
Tyrosine metabolism during interferon-alpha administration: association with fatigue and CSF dopamine concentrations.
Felger JC, Li L, Marvar PJ, Woolwine BJ, Harrison DG, Raison CL, Miller AH
Brain Behav Immun 2013 Jul;31:153-60. Epub 2012 Oct 13 doi: 10.1016/j.bbi.2012.10.010. PMID: 23072726Free PMC Article

Prognosis

Investigation of Newly Diagnosed Drug-Naive Patients with Systemic Autoimmune Diseases Revealed the Cleaved Peptide Tyrosine Tyrosine (PYY 3-36) as a Specific Plasma Biomarker of Rheumatoid Arthritis.
Balog JA, Kemeny A, Puskas LG, Burcsar S, Balog A, Szebeni GJ
Mediators Inflamm 2021;2021:5523582. Epub 2021 Jun 17 doi: 10.1155/2021/5523582. PMID: 34239365Free PMC Article
Novel Protein Biomarkers of Monoamine Metabolism Defects Correlate with Disease Severity.
Tristán-Noguero A, Borràs E, Molero-Luis M, Wassenberg T, Peters T, Verbeek MM, Willemsen M, Opladen T, Jeltsch K, Pons R, Thony B, Horvath G, Yapici Z, Friedman J, Hyland K, Agosta GE, López-Laso E, Artuch R, Sabidó E, García-Cazorla À
Mov Disord 2021 Mar;36(3):690-703. Epub 2020 Nov 5 doi: 10.1002/mds.28362. PMID: 33152132
Endotype-phenotyping may predict a treatment response in progressive fibrosing interstitial lung disease.
Hoffmann-Vold AM, Weigt SS, Saggar R, Palchevskiy V, Volkmann ER, Liang LL, Ross D, Ardehali A, Lynch JP 3rd, Belperio JA
EBioMedicine 2019 Dec;50:379-386. Epub 2019 Nov 12 doi: 10.1016/j.ebiom.2019.10.050. PMID: 31732480Free PMC Article
Selective decrease in central nervous system serotonin turnover in children with dopa-nonresponsive dystonia.
Assmann B, Köhler M, Hoffmann GF, Heales S, Surtees R
Pediatr Res 2002 Jul;52(1):91-4. doi: 10.1203/00006450-200207000-00017. PMID: 12084853
Use of 14-3-3 and other brain-specific proteins in CSF in the diagnosis of variant Creutzfeldt-Jakob disease.
Green AJ, Thompson EJ, Stewart GE, Zeidler M, McKenzie JM, MacLeod MA, Ironside JW, Will RG, Knight RS
J Neurol Neurosurg Psychiatry 2001 Jun;70(6):744-8. doi: 10.1136/jnnp.70.6.744. PMID: 11385008Free PMC Article

Clinical prediction guides

The CSF-1R inhibitor pexidartinib affects FLT3-dependent DC differentiation and may antagonize durvalumab effect in patients with advanced cancers.
Voissière A, Gomez-Roca C, Chabaud S, Rodriguez C, Nkodia A, Berthet J, Montane L, Bidaux AS, Treilleux I, Eberst L, Terret C, Korakis I, Garin G, Pérol D, Delord JP, Caux C, Dubois B, Ménétrier-Caux C, Bendriss-Vermare N, Cassier PA
Sci Transl Med 2024 Jan 24;16(731):eadd1834. doi: 10.1126/scitranslmed.add1834. PMID: 38266104
ATP13A2 levels in serum and cerebrospinal fluid in patients with idiopathic Parkinson's disease.
Fernández-Espejo E, Rodriguez de Fonseca F, Suárez J, González-Aparicio R, Santurtún A
Parkinsonism Relat Disord 2021 Jul;88:3-9. Epub 2021 May 26 doi: 10.1016/j.parkreldis.2021.05.014. PMID: 34090180
Novel Protein Biomarkers of Monoamine Metabolism Defects Correlate with Disease Severity.
Tristán-Noguero A, Borràs E, Molero-Luis M, Wassenberg T, Peters T, Verbeek MM, Willemsen M, Opladen T, Jeltsch K, Pons R, Thony B, Horvath G, Yapici Z, Friedman J, Hyland K, Agosta GE, López-Laso E, Artuch R, Sabidó E, García-Cazorla À
Mov Disord 2021 Mar;36(3):690-703. Epub 2020 Nov 5 doi: 10.1002/mds.28362. PMID: 33152132
The response of human macrophages to β-glucans depends on the inflammatory milieu.
Municio C, Alvarez Y, Montero O, Hugo E, Rodríguez M, Domingo E, Alonso S, Fernández N, Crespo MS
PLoS One 2013;8(4):e62016. Epub 2013 Apr 24 doi: 10.1371/journal.pone.0062016. PMID: 23637950Free PMC Article
Increase of CSF tyrosine and impaired serotonin turnover in tyrosinemia type I.
Thimm E, Herebian D, Assmann B, Klee D, Mayatepek E, Spiekerkoetter U
Mol Genet Metab 2011 Feb;102(2):122-5. Epub 2010 Nov 10 doi: 10.1016/j.ymgme.2010.11.003. PMID: 21112803

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