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Increased Tn-antigen level

MedGen UID:
1687356
•Concept ID:
C5139533
•
Finding
Synonym: Increased O-GalNac on glycoprotein concentration
 
HPO: HP:0410372

Definition

An abnormal increase in the concentration of Tn antigen on glycoproteins. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased Tn-antigen level

Professional guidelines

PubMed

Single CAR-T cell treatment controls disseminated ovarian cancer in a syngeneic mouse model.
Ranoa DRE, Sharma P, Schane CP, Lewis AN, Valdez E, Marada VVVR, Hager MV, Montgomery W, Wolf SP, Schreiber K, Schreiber H, Bailey K, Fan TM, Hergenrother PJ, Roy EJ, Kranz DM
J Immunother Cancer 2023 May;11(5) doi: 10.1136/jitc-2022-006509. PMID: 37258040Free PMC Article
Amniotic fluid embolism: pathophysiology and new strategies for management.
Kanayama N, Tamura N
J Obstet Gynaecol Res 2014 Jun;40(6):1507-17. doi: 10.1111/jog.12428. PMID: 24888909

Recent clinical studies

Etiology

The level of IgG antibodies reactive to TF, Tn and alpha-Gal polyacrylamide-glycoconjugates in breast cancer patients: relation to survival.
Smorodin EP, Sergeyev BL
Exp Oncol 2016 Jun;38(2):117-21. PMID: 27356581
ABO blood group IgM isoagglutinins interact with tumor-associated O-glycan structures in pancreatic cancer.
Hofmann BT, Stehr A, Dohrmann T, Güngör C, Herich L, Hiller J, Harder S, Ewald F, Gebauer F, Tachezy M, Precht C, Izbicki JR, Bockhorn M, Wagener C, Wolters-Eisfeld G
Clin Cancer Res 2014 Dec 1;20(23):6117-26. Epub 2014 Oct 15 doi: 10.1158/1078-0432.CCR-14-0716. PMID: 25320359
The relation of the level of serum anti-TF, -Tn and -alpha-Gal IgG to survival in gastrointestinal cancer patients.
Smorodin E, Sergeyev B, Klaamas K, Chuzmarov V, Kurtenkov O
Int J Med Sci 2013;10(12):1674-82. Epub 2013 Sep 23 doi: 10.7150/ijms.6841. PMID: 24151439Free PMC Article
Differential glycosylation of MUC1 and CEACAM5 between normal mucosa and tumour tissue of colon cancer patients.
Saeland E, Belo AI, Mongera S, van Die I, Meijer GA, van Kooyk Y
Int J Cancer 2012 Jul 1;131(1):117-28. Epub 2011 Nov 28 doi: 10.1002/ijc.26354. PMID: 21823122
Differences in prognosis of colorectal cancer patients based on the expression of sialyl Lewisa, sialyl Lewisx and sialyl Tn antigens in serum and tumor tissue.
Akamine S, Nakagoe T, Sawai T, Tsuji T, Tanaka K, Hidaka S, Shibasaki S, Nanashima A, Yamaguchi H, Nagayasu T, Yasutake T
Anticancer Res 2004 Jul-Aug;24(4):2541-6. PMID: 15330211

Diagnosis

Evaluation of serum CA125-Tn glycoform in peritoneal dissemination and surgical completeness of high-grade serous ovarian cancer.
Jin X, Du M, Wang Y, Wang Y, Lu Y, Xu C, Zhang X
J Ovarian Res 2022 Dec 23;15(1):134. doi: 10.1186/s13048-022-01066-1. PMID: 36564848Free PMC Article
Cosmc transfection decreases malignant behavior of Tn(+) cells and enhances sensitivity to apoptosis when induced by Apo2L/TRAIL via alteration of O-glycan structure.
Ding R, Hu X, Hu W, Du Z, Huang P, Wang M, Sheng J, Ma Y, Wang A, Luan X, Dong M, Cao Q, Zou Y, Hu T
Aging (Albany NY) 2021 Oct 13;13(19):23393-23406. doi: 10.18632/aging.203633. PMID: 34644263Free PMC Article
The level of IgG antibodies reactive to TF, Tn and alpha-Gal polyacrylamide-glycoconjugates in breast cancer patients: relation to survival.
Smorodin EP, Sergeyev BL
Exp Oncol 2016 Jun;38(2):117-21. PMID: 27356581
Different levels of sialyl-Tn antigen expressed on MUC16 in patients with endometriosis and ovarian cancer.
Akita K, Yoshida S, Ikehara Y, Shirakawa S, Toda M, Inoue M, Kitawaki J, Nakanishi H, Narimatsu H, Nakada H
Int J Gynecol Cancer 2012 May;22(4):531-8. doi: 10.1097/IGC.0b013e3182473292. PMID: 22367369
Mucins and mucin binding proteins in colorectal cancer.
Byrd JC, Bresalier RS
Cancer Metastasis Rev 2004 Jan-Jun;23(1-2):77-99. doi: 10.1023/a:1025815113599. PMID: 15000151

Therapy

Purified human anti-Tn and anti-T antibodies specifically recognize carcinoma tissues.
Zlocowski N, Grupe V, Garay YC, Nores GA, Lardone RD, Irazoqui FJ
Sci Rep 2019 May 30;9(1):8097. doi: 10.1038/s41598-019-44601-9. PMID: 31147593Free PMC Article
IgG immune response to tumor-associated carbohydrate antigens (TF, Tn, alphaGal) in patients with breast cancer: impact of neoadjuvant chemotherapy and relation to the survival.
Kurtenkov O, Klaamas K, Rittenhouse-Olson K, Vahter L, Sergejev B, Miljukhina L, Shljapnikova L
Exp Oncol 2005 Jun;27(2):136-40. PMID: 15995632
Evidence of a cellular immune response against sialyl-Tn in breast and ovarian cancer patients after high-dose chemotherapy, stem cell rescue, and immunization with Theratope STn-KLH cancer vaccine.
Sandmaier BM, Oparin DV, Holmberg LA, Reddish MA, MacLean GD, Longenecker BM
J Immunother 1999 Jan;22(1):54-66. doi: 10.1097/00002371-199901000-00008. PMID: 9924700
Antibodies against mucin-associated sialyl-Tn epitopes correlate with survival of metastatic adenocarcinoma patients undergoing active specific immunotherapy with synthetic STn vaccine.
MacLean GD, Reddish MA, Koganty RR, Longenecker BM
J Immunother Emphasis Tumor Immunol 1996 Jan;19(1):59-68. doi: 10.1097/00002371-199601000-00007. PMID: 8859725
Immunization of colorectal cancer patients with modified ovine submaxillary gland mucin and adjuvants induces IgM and IgG antibodies to sialylated Tn.
O'Boyle KP, Zamore R, Adluri S, Cohen A, Kemeny N, Welt S, Lloyd KO, Oettgen HF, Old LJ, Livingston PO
Cancer Res 1992 Oct 15;52(20):5663-7. PMID: 1394190

Prognosis

Side population cells derived from hUCMSCs and hPMSCs could inhibit the malignant behaviors of Tn(+) colorectal cancer cells from modifying their O-glycosylation status.
Hu W, Ding R, Wang M, Huang P, Wei X, Hu X, Hu T
Stem Cell Res Ther 2023 May 26;14(1):145. doi: 10.1186/s13287-023-03334-3. PMID: 37237420Free PMC Article
Evaluation of serum CA125-Tn glycoform in peritoneal dissemination and surgical completeness of high-grade serous ovarian cancer.
Jin X, Du M, Wang Y, Wang Y, Lu Y, Xu C, Zhang X
J Ovarian Res 2022 Dec 23;15(1):134. doi: 10.1186/s13048-022-01066-1. PMID: 36564848Free PMC Article
GALNTs: master regulators of metastasis-associated epithelial-mesenchymal transition (EMT)?
Beaman EM, Carter DRF, Brooks SA
Glycobiology 2022 Jun 13;32(7):556-579. doi: 10.1093/glycob/cwac014. PMID: 35312770
The level of IgG antibodies reactive to TF, Tn and alpha-Gal polyacrylamide-glycoconjugates in breast cancer patients: relation to survival.
Smorodin EP, Sergeyev BL
Exp Oncol 2016 Jun;38(2):117-21. PMID: 27356581
Mucins and mucin binding proteins in colorectal cancer.
Byrd JC, Bresalier RS
Cancer Metastasis Rev 2004 Jan-Jun;23(1-2):77-99. doi: 10.1023/a:1025815113599. PMID: 15000151

Clinical prediction guides

Single CAR-T cell treatment controls disseminated ovarian cancer in a syngeneic mouse model.
Ranoa DRE, Sharma P, Schane CP, Lewis AN, Valdez E, Marada VVVR, Hager MV, Montgomery W, Wolf SP, Schreiber K, Schreiber H, Bailey K, Fan TM, Hergenrother PJ, Roy EJ, Kranz DM
J Immunother Cancer 2023 May;11(5) doi: 10.1136/jitc-2022-006509. PMID: 37258040Free PMC Article
Evaluation of serum CA125-Tn glycoform in peritoneal dissemination and surgical completeness of high-grade serous ovarian cancer.
Jin X, Du M, Wang Y, Wang Y, Lu Y, Xu C, Zhang X
J Ovarian Res 2022 Dec 23;15(1):134. doi: 10.1186/s13048-022-01066-1. PMID: 36564848Free PMC Article
GALNTs: master regulators of metastasis-associated epithelial-mesenchymal transition (EMT)?
Beaman EM, Carter DRF, Brooks SA
Glycobiology 2022 Jun 13;32(7):556-579. doi: 10.1093/glycob/cwac014. PMID: 35312770
Overexpression of Cosmc suppresses cell migration and invasion in different subtypes of breast cancer cells via Tn and T glycans.
Liu J, Xu F, Li J, Jiang H
Biosci Rep 2020 Jun 26;40(6) doi: 10.1042/BSR20191062. PMID: 32452513Free PMC Article
Glycosylation characteristics of colorectal cancer.
Holst S, Wuhrer M, Rombouts Y
Adv Cancer Res 2015;126:203-56. Epub 2015 Feb 7 doi: 10.1016/bs.acr.2014.11.004. PMID: 25727149

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