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Abnormal circulating free T3 concentration

MedGen UID:
1689152
•Concept ID:
C5139194
•
Finding
Synonyms: Abnormal circulating free T3 level; Abnormal circulating free triiodotyronine concentration
 
HPO: HP:0032209

Definition

A deviation from the normal concentration of free triiodothyronine (T3) in the blood circulation. A proportion of T3 is bound to plasma proteins in the blood, including mainly thyroxine binding globulin, transthyretin, and albumin. T3 that is not bound to a protein is referred to as free T3. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal circulating free T3 concentration

Conditions with this feature

Thyroid hormone metabolism, abnormal, 3
MedGen UID:
1824065
•Concept ID:
C5774292
•
Disease or Syndrome
Abnormal thyroid hormone metabolism-3 (THMA3) is characterized by euthyroid hyperthyroxinemia, with elevated free T4 and reverse T3 levels, and normal TSH (see 188540) and free T3 levels. Patients also show low plasma selenium levels and reduced levels of stress-related selenoproteins (Schoenmakers et al., 2016; Geslot et al., 2021). For a discussion of genetic heterogeneity of abnormal thyroid hormone metabolism, see THMA1 (609698).
See: Condition Record
Thyroid hormone metabolism, abnormal, 3

Recent clinical studies

Etiology

Decreased circulating levels of free triiodothyronine in Sepsis children and correlation analysis.
Fu L, Long W, Liu T, Chen Y, Wu S, Li D, Liu K, Gao Y, Luo X
BMC Pediatr 2022 Nov 29;22(1):687. doi: 10.1186/s12887-022-03756-7. PMID: 36447149Free PMC Article
The Association of TSH and Thyroid Hormones With Lymphopenia in Bacterial Sepsis and COVID-19.
Grondman I, de Nooijer AH, Antonakos N, Janssen NAF, Mouktaroudi M, Leventogiannis K, Medici M, Smit JWA, van Herwaarden AE, Joosten LAB, van de Veerdonk FL, Pickkers P, Kox M, Jaeger M, Netea MG, Giamarellos-Bourboulis EJ, Netea-Maier RT
J Clin Endocrinol Metab 2021 Jun 16;106(7):1994-2009. doi: 10.1210/clinem/dgab148. PMID: 33713408Free PMC Article
Central hypothyroidism - a neglected thyroid disorder.
Beck-Peccoz P, Rodari G, Giavoli C, Lania A
Nat Rev Endocrinol 2017 Oct;13(10):588-598. Epub 2017 May 26 doi: 10.1038/nrendo.2017.47. PMID: 28549061
Subclinical thyroid disease in elderly subjects.
Ceresini G, Morganti S, Maggio M, Usberti E, Fiorino I, Artoni A, Teresi G, Belli S, Ridolfi V, Valenti G, Ceda GP
Acta Biomed 2010;81 Suppl 1:31-6. PMID: 20518189
Circulating lipids and minor abnormalities of thyroid function.
Parle JV, Franklyn JA, Cross KW, Jones SR, Sheppard MC
Clin Endocrinol (Oxf) 1992 Nov;37(5):411-4. doi: 10.1111/j.1365-2265.1992.tb02351.x. PMID: 1486690

Diagnosis

The Association of TSH and Thyroid Hormones With Lymphopenia in Bacterial Sepsis and COVID-19.
Grondman I, de Nooijer AH, Antonakos N, Janssen NAF, Mouktaroudi M, Leventogiannis K, Medici M, Smit JWA, van Herwaarden AE, Joosten LAB, van de Veerdonk FL, Pickkers P, Kox M, Jaeger M, Netea MG, Giamarellos-Bourboulis EJ, Netea-Maier RT
J Clin Endocrinol Metab 2021 Jun 16;106(7):1994-2009. doi: 10.1210/clinem/dgab148. PMID: 33713408Free PMC Article
Central hypothyroidism - a neglected thyroid disorder.
Beck-Peccoz P, Rodari G, Giavoli C, Lania A
Nat Rev Endocrinol 2017 Oct;13(10):588-598. Epub 2017 May 26 doi: 10.1038/nrendo.2017.47. PMID: 28549061
Subclinical thyroid disease in elderly subjects.
Ceresini G, Morganti S, Maggio M, Usberti E, Fiorino I, Artoni A, Teresi G, Belli S, Ridolfi V, Valenti G, Ceda GP
Acta Biomed 2010;81 Suppl 1:31-6. PMID: 20518189
Are thyroid function tests too frequently and inappropriately requested?
Roti E, Gardini E, Magotti MG, Pilla S, Minelli R, Salvi M, Monica C, Maestri D, Cencetti S, Braverman LE
J Endocrinol Invest 1999 Mar;22(3):184-90. doi: 10.1007/BF03343539. PMID: 10219885
Thyroid hormones in conditions of chronic malnutrition. A study with special reference to cancer cachexia.
Persson H, Bennegård K, Lundberg PA, Svaninger G, Lundholm K
Ann Surg 1985 Jan;201(1):45-52. PMID: 3917657Free PMC Article

Therapy

Central hypothyroidism - a neglected thyroid disorder.
Beck-Peccoz P, Rodari G, Giavoli C, Lania A
Nat Rev Endocrinol 2017 Oct;13(10):588-598. Epub 2017 May 26 doi: 10.1038/nrendo.2017.47. PMID: 28549061
Resistance to thyroid hormone caused by a mutation in thyroid hormone receptor (TR)α1 and TRα2: clinical, biochemical, and genetic analyses of three related patients.
Moran C, Agostini M, Visser WE, Schoenmakers E, Schoenmakers N, Offiah AC, Poole K, Rajanayagam O, Lyons G, Halsall D, Gurnell M, Chrysis D, Efthymiadou A, Buchanan C, Aylwin S, Chatterjee KK
Lancet Diabetes Endocrinol 2014 Aug;2(8):619-26. Epub 2014 Jun 23 doi: 10.1016/S2213-8587(14)70111-1. PMID: 24969835Free PMC Article
The thyroid--too much and too little across the ages. The consequences of subclinical thyroid dysfunction.
Franklyn JA
Clin Endocrinol (Oxf) 2013 Jan;78(1):1-8. doi: 10.1111/cen.12011. PMID: 22891671
The significance of TSH values measured in a sensitive assay in the follow-up of hyperthyroid patients treated with radioiodine.
Davies PH, Franklyn JA, Daykin J, Sheppard MC
J Clin Endocrinol Metab 1992 May;74(5):1189-94. doi: 10.1210/jcem.74.5.1569166. PMID: 1569166
Thyroid function in nonthyroidal illnesses.
Chopra IJ, Hershman JM, Pardridge WM, Nicoloff JT
Ann Intern Med 1983 Jun;98(6):946-57. doi: 10.7326/0003-4819-98-6-946. PMID: 6407376

Prognosis

Decreased circulating levels of free triiodothyronine in Sepsis children and correlation analysis.
Fu L, Long W, Liu T, Chen Y, Wu S, Li D, Liu K, Gao Y, Luo X
BMC Pediatr 2022 Nov 29;22(1):687. doi: 10.1186/s12887-022-03756-7. PMID: 36447149Free PMC Article
The significance of TSH values measured in a sensitive assay in the follow-up of hyperthyroid patients treated with radioiodine.
Davies PH, Franklyn JA, Daykin J, Sheppard MC
J Clin Endocrinol Metab 1992 May;74(5):1189-94. doi: 10.1210/jcem.74.5.1569166. PMID: 1569166
Thyroid function in nonthyroidal illnesses.
Chopra IJ, Hershman JM, Pardridge WM, Nicoloff JT
Ann Intern Med 1983 Jun;98(6):946-57. doi: 10.7326/0003-4819-98-6-946. PMID: 6407376

Clinical prediction guides

Decreased circulating levels of free triiodothyronine in Sepsis children and correlation analysis.
Fu L, Long W, Liu T, Chen Y, Wu S, Li D, Liu K, Gao Y, Luo X
BMC Pediatr 2022 Nov 29;22(1):687. doi: 10.1186/s12887-022-03756-7. PMID: 36447149Free PMC Article
Central hypothyroidism - a neglected thyroid disorder.
Beck-Peccoz P, Rodari G, Giavoli C, Lania A
Nat Rev Endocrinol 2017 Oct;13(10):588-598. Epub 2017 May 26 doi: 10.1038/nrendo.2017.47. PMID: 28549061
Are thyroid function tests too frequently and inappropriately requested?
Roti E, Gardini E, Magotti MG, Pilla S, Minelli R, Salvi M, Monica C, Maestri D, Cencetti S, Braverman LE
J Endocrinol Invest 1999 Mar;22(3):184-90. doi: 10.1007/BF03343539. PMID: 10219885
Circulating lipids and minor abnormalities of thyroid function.
Parle JV, Franklyn JA, Cross KW, Jones SR, Sheppard MC
Clin Endocrinol (Oxf) 1992 Nov;37(5):411-4. doi: 10.1111/j.1365-2265.1992.tb02351.x. PMID: 1486690
Raised total thyroxine and free thyroxine index but normal free thyroxine. A serum abnormality due to inherited increased affinity of iodothyronines for serum binding protein.
Hennemann G, Docter R, Krenning EP, Bos G, Otten M, Visser TJ
Lancet 1979 Mar 24;1(8117):639-42. doi: 10.1016/s0140-6736(79)91080-8. PMID: 85873

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