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Penile Adenosquamous Carcinoma

MedGen UID:
1692838
•Concept ID:
C5204292
•
Neoplastic Process
Synonym: Adenosquamous Carcinoma of the Penis

Definition

An extremely rare carcinoma that arises from the penis and is characterized by the presence of glandular and squamous components. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPenile Adenosquamous Carcinoma

Recent clinical studies

Etiology

Tumor lesions of penis and scrotum according to WHO classification 2022.
Michalová K, Beniač P, Kacerovská D
Cesk Patol 2022 Fall;67(4):192-197. PMID: 36513504
Penile warty mucoepidermoid carcinoma with features of stratified mucin-producing intra-epithelial lesion and invasive stratified mucin-producing carcinoma.
Yorita K, Kuroda N, Naroda T, Tamura M, Ohe C, Divatia M, Amin MB, Cubilla AL, Kazakov DV, Hes O, Michal M, Michal M
Histopathology 2018 Apr;72(5):867-873. Epub 2018 Jan 14 doi: 10.1111/his.13438. PMID: 29144557
Developments in the pathology of penile squamous cell carcinomas.
Chaux A, Velazquez EF, Algaba F, Ayala G, Cubilla AL
Urology 2010 Aug;76(2 Suppl 1):S7-S14. doi: 10.1016/j.urology.2010.02.038. PMID: 20691888
Comparison of subtypes of penile squamous cell carcinoma from high and low incidence geographical regions.
Chaux A, Lezcano C, Cubilla AL, Tamboli P, Ro J, Ayala A
Int J Surg Pathol 2010 Aug;18(4):268-77. Epub 2009 Jul 3 doi: 10.1177/1066896909339184. PMID: 19578046
Penile squamous cell carcinoma clinicopathological features, nodal metastasis and outcome in 333 cases.
Guimarães GC, Cunha IW, Soares FA, Lopes A, Torres J, Chaux A, Velazquez EF, Ayala G, Cubilla AL
J Urol 2009 Aug;182(2):528-34; discussion 534. Epub 2009 Jun 13 doi: 10.1016/j.juro.2009.04.028. PMID: 19524964

Diagnosis

Primary cutaneous adenosquamous carcinoma of the penis: the first characterization of HPV status in this rare and diagnostically challenging entity with review of glandular carcinomas of the penis.
Rush PS, Shiau JM, Hibler BP, Longley BJ, Downs TM, Bennett DD
J Cutan Pathol 2016 Dec;43(12):1226-1230. doi: 10.1111/cup.12835. PMID: 27696488
Diagnostic problems in precancerous lesions and invasive carcinomas of the penis.
Chaux A, Cubilla AL
Semin Diagn Pathol 2012 May;29(2):72-82. doi: 10.1053/j.semdp.2011.08.002. PMID: 22641956
Advances in the pathology of penile carcinomas.
Chaux A, Cubilla AL
Hum Pathol 2012 Jun;43(6):771-89. doi: 10.1016/j.humpath.2012.01.014. PMID: 22595011
Penile squamous cell carcinoma clinicopathological features, nodal metastasis and outcome in 333 cases.
Guimarães GC, Cunha IW, Soares FA, Lopes A, Torres J, Chaux A, Velazquez EF, Ayala G, Cubilla AL
J Urol 2009 Aug;182(2):528-34; discussion 534. Epub 2009 Jun 13 doi: 10.1016/j.juro.2009.04.028. PMID: 19524964
Penile squamous cell carcinoma: anatomic, pathologic and viral studies in Paraguay (1993-2007).
Velazquez EF, Cubilla AL
Anal Quant Cytol Histol 2007 Aug;29(4):185-98. PMID: 17879626

Prognosis

Primary cutaneous adenosquamous carcinoma of the penis: the first characterization of HPV status in this rare and diagnostically challenging entity with review of glandular carcinomas of the penis.
Rush PS, Shiau JM, Hibler BP, Longley BJ, Downs TM, Bennett DD
J Cutan Pathol 2016 Dec;43(12):1226-1230. doi: 10.1111/cup.12835. PMID: 27696488
Diagnostic problems in precancerous lesions and invasive carcinomas of the penis.
Chaux A, Cubilla AL
Semin Diagn Pathol 2012 May;29(2):72-82. doi: 10.1053/j.semdp.2011.08.002. PMID: 22641956
Advances in the pathology of penile carcinomas.
Chaux A, Cubilla AL
Hum Pathol 2012 Jun;43(6):771-89. doi: 10.1016/j.humpath.2012.01.014. PMID: 22595011
Penile squamous cell carcinoma clinicopathological features, nodal metastasis and outcome in 333 cases.
Guimarães GC, Cunha IW, Soares FA, Lopes A, Torres J, Chaux A, Velazquez EF, Ayala G, Cubilla AL
J Urol 2009 Aug;182(2):528-34; discussion 534. Epub 2009 Jun 13 doi: 10.1016/j.juro.2009.04.028. PMID: 19524964
Penile squamous cell carcinoma: anatomic, pathologic and viral studies in Paraguay (1993-2007).
Velazquez EF, Cubilla AL
Anal Quant Cytol Histol 2007 Aug;29(4):185-98. PMID: 17879626

Clinical prediction guides

Metastatic prostate adenocarcinoma to the penis: a series of 29 cases with predilection for ductal adenocarcinoma.
Ellis CL, Epstein JI
Am J Surg Pathol 2015 Jan;39(1):67-74. doi: 10.1097/PAS.0000000000000289. PMID: 25025445
Advances in the pathology of penile carcinomas.
Chaux A, Cubilla AL
Hum Pathol 2012 Jun;43(6):771-89. doi: 10.1016/j.humpath.2012.01.014. PMID: 22595011
Metastatic tumors to the penis: a report of 17 cases and review of the literature.
Chaux A, Amin M, Cubilla AL, Young RH
Int J Surg Pathol 2011 Oct;19(5):597-606. Epub 2010 Jan 14 doi: 10.1177/1066896909350468. PMID: 20075023
Penile squamous cell carcinoma clinicopathological features, nodal metastasis and outcome in 333 cases.
Guimarães GC, Cunha IW, Soares FA, Lopes A, Torres J, Chaux A, Velazquez EF, Ayala G, Cubilla AL
J Urol 2009 Aug;182(2):528-34; discussion 534. Epub 2009 Jun 13 doi: 10.1016/j.juro.2009.04.028. PMID: 19524964
Expression pattern and subcellular localization of human papillomavirus minor capsid protein L2.
Lin Z, Yemelyanova AV, Gambhira R, Jagu S, Meyers C, Kirnbauer R, Ronnett BM, Gravitt PE, Roden RB
Am J Pathol 2009 Jan;174(1):136-43. Epub 2008 Dec 18 doi: 10.2353/ajpath.2009.080588. PMID: 19095951Free PMC Article

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