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Semidominant inheritance

MedGen UID:
1693292
Concept ID:
C5139139
Genetic Function
Synonyms: semi-dominant; Semidominant mode of inheritance
 
HPO: HP:0032113
Orphanet: ORPHA409937

Definition

A mode of inheritance that is observed for traits related to a gene encoded on chromosomes in which a trait can manifest in a monoallelic (e.g. heterozygotes) and biallelic (e.g. homozygotes, compound heterozygotes) state, with similar or differing phenotype severity present dependent on the number of alleles affected. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSemidominant inheritance

Professional guidelines

PubMed

Huang YT, Chien Y-, Yeh HY, Lin SJ, Lu FL, Chou SP, Lin JM, Chiang SC, Hwu WL
J Formos Med Assoc 2003 Dec;102(12):851-6. PMID: 14976564

Recent systematic reviews

Bekircan-Kurt CE, Çetinkaya A, Gocmen R, Koşukcu C, Soylemezoglu F, Arsava EM, Tuncer A, Erdem-Ozdamar S, Akarsu NA, Topcuoglu MA
J Stroke Cerebrovasc Dis 2021 Sep;30(9):105997. Epub 2021 Jul 21 doi: 10.1016/j.jstrokecerebrovasdis.2021.105997. PMID: 34303089

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