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Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck

MedGen UID:
1694931
•Concept ID:
C5206867
•
Neoplastic Process

Definition

Cutaneous squamous cell carcinoma of the head and neck that is amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVResectable Cutaneous Squamous Cell Carcinoma of the Head and Neck

Professional guidelines

PubMed

Management of Advanced Basal Cell Carcinoma of the Head and Neck.
Monroe M, Kakarala K
Otolaryngol Clin North Am 2021 Apr;54(2):271-280. doi: 10.1016/j.otc.2020.11.003. PMID: 33743886
Head and Neck Cancer International Group (HNCIG) Consensus Guidelines for the Delivery of Postoperative Radiation Therapy in Complex Cutaneous Squamous Cell Carcinoma of the Head and Neck (cSCCHN).
Porceddu SV, Daniels C, Yom SS, Liu H, Waldron J, Gregoire V, Moore A, Veness M, Yao M, Johansen J, Mehanna H, Rischin D, Le QT
Int J Radiat Oncol Biol Phys 2020 Jul 15;107(4):641-651. Epub 2020 Apr 11 doi: 10.1016/j.ijrobp.2020.03.024. PMID: 32289475
Treatment of Metastatic Eyelid Carcinoma.
Bonavolontà P, Dell'Aversana Orabona G, Abbate V, Iaconetta G, Bonavolontà G, Califano L
J Craniofac Surg 2017 Nov;28(8):e722-e725. doi: 10.1097/SCS.0000000000003847. PMID: 28885435

Recent clinical studies

Etiology

Neoadjuvant cemiplimab and surgery for stage II-IV cutaneous squamous-cell carcinoma: follow-up and survival outcomes of a single-arm, multicentre, phase 2 study.
Gross ND, Miller DM, Khushalani NI, Divi V, Ruiz ES, Lipson EJ, Meier F, Su YB, Swiecicki PL, Atlas J, Geiger JL, Hauschild A, Choe JH, Hughes BGM, Schadendorf D, Patel VA, Homsi J, Taube JM, Lim AM, Ferrarotto R, Yoo SY, Mathias M, Han H, Seebach F, Lowy I, Fury MG, Rischin D
Lancet Oncol 2023 Nov;24(11):1196-1205. Epub 2023 Oct 21 doi: 10.1016/S1470-2045(23)00459-X. PMID: 37875144
Management of Advanced Basal Cell Carcinoma of the Head and Neck.
Monroe M, Kakarala K
Otolaryngol Clin North Am 2021 Apr;54(2):271-280. doi: 10.1016/j.otc.2020.11.003. PMID: 33743886
The role of parotidectomy for advanced cutaneous squamous cell carcinoma of the head and neck.
Kampel L, Dorman A, Horovitz G, Warshavsky A, Gutfeld O, Muhanna N
Eur Arch Otorhinolaryngol 2021 Oct;278(10):3955-3963. Epub 2021 Jan 6 doi: 10.1007/s00405-020-06574-8. PMID: 33404750
Squamous Cell Carcinoma and Its Variants.
Mani N, Shah JP
Adv Otorhinolaryngol 2020;84:124-136. Epub 2020 Jul 30 doi: 10.1159/000457932. PMID: 32731225
Head and Neck Cancer International Group (HNCIG) Consensus Guidelines for the Delivery of Postoperative Radiation Therapy in Complex Cutaneous Squamous Cell Carcinoma of the Head and Neck (cSCCHN).
Porceddu SV, Daniels C, Yom SS, Liu H, Waldron J, Gregoire V, Moore A, Veness M, Yao M, Johansen J, Mehanna H, Rischin D, Le QT
Int J Radiat Oncol Biol Phys 2020 Jul 15;107(4):641-651. Epub 2020 Apr 11 doi: 10.1016/j.ijrobp.2020.03.024. PMID: 32289475

Diagnosis

Treatment of advanced cutaneous squamous cell carcinoma: a Mohs surgery and dermatologic oncology perspective.
Wilmas KM, Nguyen QB, Patel J, Silapunt S, Migden MR
Future Oncol 2021 Dec;17(35):4971-4982. Epub 2021 Oct 5 doi: 10.2217/fon-2021-0901. PMID: 34608809
Pilot Phase II Trial of Neoadjuvant Immunotherapy in Locoregionally Advanced, Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck.
Ferrarotto R, Amit M, Nagarajan P, Rubin ML, Yuan Y, Bell D, El-Naggar AK, Johnson JM, Morrison WH, Rosenthal DI, Glisson BS, Johnson FM, Lu C, Mott FE, Esmaeli B, Diaz EM Jr, Gidley PW, Goepfert RP, Lewis CM, Weber RS, Wargo JA, Basu S, Duan F, Yadav SS, Sharma P, Allison JP, Myers JN, Gross ND
Clin Cancer Res 2021 Aug 15;27(16):4557-4565. Epub 2021 Jun 29 doi: 10.1158/1078-0432.CCR-21-0585. PMID: 34187851Free PMC Article
Squamous Cell Carcinoma and Its Variants.
Mani N, Shah JP
Adv Otorhinolaryngol 2020;84:124-136. Epub 2020 Jul 30 doi: 10.1159/000457932. PMID: 32731225
Survival Outcomes for Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck.
Sullivan CB, Andresen NS, Kendell N, Al-Qurayshi Z, Pagedar NA
Ann Otol Rhinol Laryngol 2019 Oct;128(10):949-955. Epub 2019 May 15 doi: 10.1177/0003489419848786. PMID: 31091995
Cutaneous head and neck basal and squamous cell carcinomas with perineural invasion.
Mendenhall WM, Ferlito A, Takes RP, Bradford CR, Corry J, Fagan JJ, Rinaldo A, Strojan P, Rodrigo JP
Oral Oncol 2012 Oct;48(10):918-922. Epub 2012 Mar 15 doi: 10.1016/j.oraloncology.2012.02.015. PMID: 22425152

Therapy

Neoadjuvant cemiplimab and surgery for stage II-IV cutaneous squamous-cell carcinoma: follow-up and survival outcomes of a single-arm, multicentre, phase 2 study.
Gross ND, Miller DM, Khushalani NI, Divi V, Ruiz ES, Lipson EJ, Meier F, Su YB, Swiecicki PL, Atlas J, Geiger JL, Hauschild A, Choe JH, Hughes BGM, Schadendorf D, Patel VA, Homsi J, Taube JM, Lim AM, Ferrarotto R, Yoo SY, Mathias M, Han H, Seebach F, Lowy I, Fury MG, Rischin D
Lancet Oncol 2023 Nov;24(11):1196-1205. Epub 2023 Oct 21 doi: 10.1016/S1470-2045(23)00459-X. PMID: 37875144
Neoadjuvant Cemiplimab for Stage II to IV Cutaneous Squamous-Cell Carcinoma.
Gross ND, Miller DM, Khushalani NI, Divi V, Ruiz ES, Lipson EJ, Meier F, Su YB, Swiecicki PL, Atlas J, Geiger JL, Hauschild A, Choe JH, Hughes BGM, Schadendorf D, Patel VA, Homsi J, Taube JM, Lim AM, Ferrarotto R, Kaufman HL, Seebach F, Lowy I, Yoo SY, Mathias M, Fenech K, Han H, Fury MG, Rischin D
N Engl J Med 2022 Oct 27;387(17):1557-1568. Epub 2022 Sep 12 doi: 10.1056/NEJMoa2209813. PMID: 36094839Free PMC Article
Treatment of advanced cutaneous squamous cell carcinoma: a Mohs surgery and dermatologic oncology perspective.
Wilmas KM, Nguyen QB, Patel J, Silapunt S, Migden MR
Future Oncol 2021 Dec;17(35):4971-4982. Epub 2021 Oct 5 doi: 10.2217/fon-2021-0901. PMID: 34608809
Pilot Phase II Trial of Neoadjuvant Immunotherapy in Locoregionally Advanced, Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck.
Ferrarotto R, Amit M, Nagarajan P, Rubin ML, Yuan Y, Bell D, El-Naggar AK, Johnson JM, Morrison WH, Rosenthal DI, Glisson BS, Johnson FM, Lu C, Mott FE, Esmaeli B, Diaz EM Jr, Gidley PW, Goepfert RP, Lewis CM, Weber RS, Wargo JA, Basu S, Duan F, Yadav SS, Sharma P, Allison JP, Myers JN, Gross ND
Clin Cancer Res 2021 Aug 15;27(16):4557-4565. Epub 2021 Jun 29 doi: 10.1158/1078-0432.CCR-21-0585. PMID: 34187851Free PMC Article
Postoperative Concurrent Chemoradiotherapy Versus Postoperative Radiotherapy in High-Risk Cutaneous Squamous Cell Carcinoma of the Head and Neck: The Randomized Phase III TROG 05.01 Trial.
Porceddu SV, Bressel M, Poulsen MG, Stoneley A, Veness MJ, Kenny LM, Wratten C, Corry J, Cooper S, Fogarty GB, Collins M, Collins MK, Macann AMJ, Milross CG, Penniment MG, Liu HY, King MT, Panizza BJ, Rischin D
J Clin Oncol 2018 May 1;36(13):1275-1283. Epub 2018 Mar 14 doi: 10.1200/JCO.2017.77.0941. PMID: 29537906

Prognosis

Neoadjuvant cemiplimab and surgery for stage II-IV cutaneous squamous-cell carcinoma: follow-up and survival outcomes of a single-arm, multicentre, phase 2 study.
Gross ND, Miller DM, Khushalani NI, Divi V, Ruiz ES, Lipson EJ, Meier F, Su YB, Swiecicki PL, Atlas J, Geiger JL, Hauschild A, Choe JH, Hughes BGM, Schadendorf D, Patel VA, Homsi J, Taube JM, Lim AM, Ferrarotto R, Yoo SY, Mathias M, Han H, Seebach F, Lowy I, Fury MG, Rischin D
Lancet Oncol 2023 Nov;24(11):1196-1205. Epub 2023 Oct 21 doi: 10.1016/S1470-2045(23)00459-X. PMID: 37875144
Adjuvant therapy for high-risk cutaneous squamous cell carcinoma: 10-year review.
Newman JG, Hall MA, Kurley SJ, Cook RW, Farberg AS, Geiger JL, Koyfman SA
Head Neck 2021 Sep;43(9):2822-2843. Epub 2021 Jun 7 doi: 10.1002/hed.26767. PMID: 34096664Free PMC Article
The role of parotidectomy for advanced cutaneous squamous cell carcinoma of the head and neck.
Kampel L, Dorman A, Horovitz G, Warshavsky A, Gutfeld O, Muhanna N
Eur Arch Otorhinolaryngol 2021 Oct;278(10):3955-3963. Epub 2021 Jan 6 doi: 10.1007/s00405-020-06574-8. PMID: 33404750
Squamous Cell Carcinoma and Its Variants.
Mani N, Shah JP
Adv Otorhinolaryngol 2020;84:124-136. Epub 2020 Jul 30 doi: 10.1159/000457932. PMID: 32731225
Postoperative Concurrent Chemoradiotherapy Versus Postoperative Radiotherapy in High-Risk Cutaneous Squamous Cell Carcinoma of the Head and Neck: The Randomized Phase III TROG 05.01 Trial.
Porceddu SV, Bressel M, Poulsen MG, Stoneley A, Veness MJ, Kenny LM, Wratten C, Corry J, Cooper S, Fogarty GB, Collins M, Collins MK, Macann AMJ, Milross CG, Penniment MG, Liu HY, King MT, Panizza BJ, Rischin D
J Clin Oncol 2018 May 1;36(13):1275-1283. Epub 2018 Mar 14 doi: 10.1200/JCO.2017.77.0941. PMID: 29537906

Clinical prediction guides

Neoadjuvant cemiplimab and surgery for stage II-IV cutaneous squamous-cell carcinoma: follow-up and survival outcomes of a single-arm, multicentre, phase 2 study.
Gross ND, Miller DM, Khushalani NI, Divi V, Ruiz ES, Lipson EJ, Meier F, Su YB, Swiecicki PL, Atlas J, Geiger JL, Hauschild A, Choe JH, Hughes BGM, Schadendorf D, Patel VA, Homsi J, Taube JM, Lim AM, Ferrarotto R, Yoo SY, Mathias M, Han H, Seebach F, Lowy I, Fury MG, Rischin D
Lancet Oncol 2023 Nov;24(11):1196-1205. Epub 2023 Oct 21 doi: 10.1016/S1470-2045(23)00459-X. PMID: 37875144
Neoadjuvant Cemiplimab for Stage II to IV Cutaneous Squamous-Cell Carcinoma.
Gross ND, Miller DM, Khushalani NI, Divi V, Ruiz ES, Lipson EJ, Meier F, Su YB, Swiecicki PL, Atlas J, Geiger JL, Hauschild A, Choe JH, Hughes BGM, Schadendorf D, Patel VA, Homsi J, Taube JM, Lim AM, Ferrarotto R, Kaufman HL, Seebach F, Lowy I, Yoo SY, Mathias M, Fenech K, Han H, Fury MG, Rischin D
N Engl J Med 2022 Oct 27;387(17):1557-1568. Epub 2022 Sep 12 doi: 10.1056/NEJMoa2209813. PMID: 36094839Free PMC Article
Epidemiology and treatment outcomes of cutaneous squamous cell carcinoma extending to the temporal bone.
Schachtel MJC, Gandhi M, Bowman JJ, Porceddu SV, Panizza BJ
Head Neck 2022 Dec;44(12):2727-2743. Epub 2022 Sep 9 doi: 10.1002/hed.27185. PMID: 36082824Free PMC Article
Redefining Perineural Invasion in Head and Neck Cutaneous Squamous Cell Carcinoma.
Cohen ER, Misztal C, Dable C, Gomez-Fernandez C, Bhatia RG, Roth P, Ma R, Trosman S, Green C, Nicolli E, Dinh CT, Sargi ZB
Otolaryngol Head Neck Surg 2022 Oct;167(4):705-715. Epub 2022 Feb 8 doi: 10.1177/01945998221076110. PMID: 35133896
Squamous Cell Carcinoma and Its Variants.
Mani N, Shah JP
Adv Otorhinolaryngol 2020;84:124-136. Epub 2020 Jul 30 doi: 10.1159/000457932. PMID: 32731225

Recent systematic reviews

Electrochemotherapy vs radiotherapy in the treatment of primary cutaneous malignancies or cutaneous metastases from primary solid organ malignancies: A systematic review and narrative synthesis.
McMillan AT, McElroy L, O'Toole L, Matteucci P, Totty JP
PLoS One 2023;18(7):e0288251. Epub 2023 Jul 13 doi: 10.1371/journal.pone.0288251. PMID: 37440502Free PMC Article

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