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Elevated fecal sodium

MedGen UID:
1695106
•Concept ID:
C5139375
•
Finding
Synonym: Elevated faecal sodium
 
HPO: HP:0032484

Definition

An elevated concentration of sodium in feces. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated fecal sodium

Conditions with this feature

Congenital secretory sodium diarrhea 8
MedGen UID:
1783137
•Concept ID:
C5441928
•
Disease or Syndrome
Any secretory diarrhea in which the cause of the disease is a mutation in the SLC9A3 gene.
See: Condition Record
Congenital secretory sodium diarrhea 8

Professional guidelines

PubMed

Pathophysiology and clinical management of hyperkalemia in chronic kidney disease.
Palmer BF, Clegg DJ
Minerva Med 2023 Oct;114(5):719-735. Epub 2023 Mar 13 doi: 10.23736/S0026-4806.23.08465-3. PMID: 36912858
New Therapeutic Approaches for the Treatment of Hyperkalemia in Patients Treated with Renin-Angiotensin-Aldosterone System Inhibitors.
Tamargo J, Caballero R, Delpón E
Cardiovasc Drugs Ther 2018 Feb;32(1):99-119. doi: 10.1007/s10557-017-6767-5. PMID: 29372448
Vasoactive Intestinal Peptide Nanomedicine for the Management of Inflammatory Bowel Disease.
Jayawardena D, Anbazhagan AN, Guzman G, Dudeja PK, Onyuksel H
Mol Pharm 2017 Nov 6;14(11):3698-3708. Epub 2017 Oct 19 doi: 10.1021/acs.molpharmaceut.7b00452. PMID: 28991483Free PMC Article

Recent clinical studies

Etiology

Bacteroides thetaiotaomicron and Faecalibacterium prausnitzii served as key components of fecal microbiota transplantation to alleviate colitis.
Xu B, Fu Y, Yin N, Qin W, Huang Z, Xiao W, Huang H, Mei Q, Fan J, Zeng Y, Huang C
Am J Physiol Gastrointest Liver Physiol 2024 May 1;326(5):G607-G621. Epub 2024 Mar 19 doi: 10.1152/ajpgi.00303.2023. PMID: 38502145
GPR65 (TDAG8) inhibits intestinal inflammation and colitis-associated colorectal cancer development in experimental mouse models.
Marie MA, Sanderlin EJ, Satturwar S, Hong H, Lertpiriyapong K, Donthi D, Yang LV
Biochim Biophys Acta Mol Basis Dis 2022 Jan 1;1868(1):166288. Epub 2021 Oct 8 doi: 10.1016/j.bbadis.2021.166288. PMID: 34628032Free PMC Article
Hypoalbuminemia: a risk factor in patients with STEC-associated hemolytic uremic syndrome.
Cobeñas CJ, Lombardi LL, Pereyra P, De Rose E, Gogorza MJ, Spizzirri AP, Ruscasso JD, Ferradas SL, Suárez ÁDC, Amoreo OR, Zalba JH, Risso P
Pediatr Nephrol 2021 Sep;36(9):2739-2746. Epub 2021 Mar 13 doi: 10.1007/s00467-021-05017-8. PMID: 33712864
Intestinal Flora Modulates Blood Pressure by Regulating the Synthesis of Intestinal-Derived Corticosterone in High Salt-Induced Hypertension.
Yan X, Jin J, Su X, Yin X, Gao J, Wang X, Zhang S, Bu P, Wang M, Zhang Y, Wang Z, Zhang Q
Circ Res 2020 Mar 27;126(7):839-853. Epub 2020 Feb 13 doi: 10.1161/CIRCRESAHA.119.316394. PMID: 32078445
New Therapeutic Approaches for the Treatment of Hyperkalemia in Patients Treated with Renin-Angiotensin-Aldosterone System Inhibitors.
Tamargo J, Caballero R, Delpón E
Cardiovasc Drugs Ther 2018 Feb;32(1):99-119. doi: 10.1007/s10557-017-6767-5. PMID: 29372448

Diagnosis

Gut Microbiome-Generated Phenylacetylglutamine from Dietary Protein is Associated with Crohn's Disease and Exacerbates Colitis in Mouse Model Possibly via Platelet Activation.
Feng R, Tian Z, Mao R, Ma R, Luo W, Zhao M, Li X, Liu Y, Huang K, Xiang L, Zhuang X, Huo B, Yu T, Chen S, Chen M, Zhu Y
J Crohns Colitis 2023 Nov 24;17(11):1833-1846. doi: 10.1093/ecco-jcc/jjad098. PMID: 37350766
New Therapeutic Approaches for the Treatment of Hyperkalemia in Patients Treated with Renin-Angiotensin-Aldosterone System Inhibitors.
Tamargo J, Caballero R, Delpón E
Cardiovasc Drugs Ther 2018 Feb;32(1):99-119. doi: 10.1007/s10557-017-6767-5. PMID: 29372448
Oral sodium phosphate solution: a review of its use as a colorectal cleanser.
Curran MP, Plosker GL
Drugs 2004;64(15):1697-714. doi: 10.2165/00003495-200464150-00009. PMID: 15257632
Investigation and diagnosis of diarrhea caused by sodium phosphate.
Fine KD, Ogunji F, Florio R, Porter J, Ana CS
Dig Dis Sci 1998 Dec;43(12):2708-14. doi: 10.1023/a:1026611629624. PMID: 9881503
Congenital chloride diarrhoea.
Holmberg C
Clin Gastroenterol 1986 Jul;15(3):583-602. PMID: 3527496

Therapy

Lactobacillus Intestinalis Primes Epithelial Cells to Suppress Colitis-Related Th17 Response by Host-Microbe Retinoic Acid Biosynthesis.
Wang QW, Jia DJ, He JM, Sun Y, Qian Y, Ge QW, Qi YD, Wang QY, Hu YY, Wang L, Fang YF, He HQ, Luo M, Feng LJ, Si JM, Song ZF, Wang LJ, Chen SJ
Adv Sci (Weinh) 2023 Dec;10(36):e2303457. Epub 2023 Nov 20 doi: 10.1002/advs.202303457. PMID: 37983567Free PMC Article
Lactate-utilizing bacteria ameliorates DSS-induced colitis in mice.
Chen L, Li R, Wang Z, Zhang Z, Wang J, Qiao Y, Huang Y, Liu W
Life Sci 2022 Jan 1;288:120179. Epub 2021 Nov 25 doi: 10.1016/j.lfs.2021.120179. PMID: 34838850
Vitamin E delta-tocotrienol and metabolite 13'-carboxychromanol inhibit colitis-associated colon tumorigenesis and modulate gut microbiota in mice.
Yang C, Zhao Y, Im S, Nakatsu C, Jones-Hall Y, Jiang Q
J Nutr Biochem 2021 Mar;89:108567. Epub 2021 Jan 9 doi: 10.1016/j.jnutbio.2020.108567. PMID: 33347911
Intestinal Flora Modulates Blood Pressure by Regulating the Synthesis of Intestinal-Derived Corticosterone in High Salt-Induced Hypertension.
Yan X, Jin J, Su X, Yin X, Gao J, Wang X, Zhang S, Bu P, Wang M, Zhang Y, Wang Z, Zhang Q
Circ Res 2020 Mar 27;126(7):839-853. Epub 2020 Feb 13 doi: 10.1161/CIRCRESAHA.119.316394. PMID: 32078445
New Therapeutic Approaches for the Treatment of Hyperkalemia in Patients Treated with Renin-Angiotensin-Aldosterone System Inhibitors.
Tamargo J, Caballero R, Delpón E
Cardiovasc Drugs Ther 2018 Feb;32(1):99-119. doi: 10.1007/s10557-017-6767-5. PMID: 29372448

Prognosis

Impact of Dextran-Sodium-Sulfate-Induced Enteritis on Murine Cytomegalovirus Reactivation.
Jentzer A, Fauteux-Daniel S, Verhoeven P, Cantais A, Novoa MY, Jospin F, Chanut B, Rochereau N, Bourlet T, Roblin X, Pozzetto B, Pillet S
Viruses 2022 Nov 22;14(12) doi: 10.3390/v14122595. PMID: 36560599Free PMC Article
Hypoalbuminemia: a risk factor in patients with STEC-associated hemolytic uremic syndrome.
Cobeñas CJ, Lombardi LL, Pereyra P, De Rose E, Gogorza MJ, Spizzirri AP, Ruscasso JD, Ferradas SL, Suárez ÁDC, Amoreo OR, Zalba JH, Risso P
Pediatr Nephrol 2021 Sep;36(9):2739-2746. Epub 2021 Mar 13 doi: 10.1007/s00467-021-05017-8. PMID: 33712864
Cideb Deficiency Aggravates Dextran Sulfate Sodium-induced Ulcerative Colitis in Mice by Exacerbating the Oxidative Burden in Colonic Mucosa.
Sun C, Zhao Y, Gao X, Yuan Y, Wang C, Wang Y, Zhang L, Gu Y, Zhang F, Hu P, Wang Z, Li Z, Shi J, Li S, Cao K, Ren B, Yu M, Liang W, Li Z, Ye J
Inflamm Bowel Dis 2017 Aug;23(8):1338-1347. doi: 10.1097/MIB.0000000000001196. PMID: 28719542
Clevidipine: a review of its use in the management of acute hypertension.
Deeks ED, Keating GM, Keam SJ
Am J Cardiovasc Drugs 2009;9(2):117-34. doi: 10.2165/00129784-200909020-00006. PMID: 19331440
Congenital chloride diarrhoea.
Holmberg C
Clin Gastroenterol 1986 Jul;15(3):583-602. PMID: 3527496

Clinical prediction guides

Gut Microbiota and Biomarkers of Endothelial Dysfunction in Cirrhosis.
Efremova I, Maslennikov R, Poluektova E, Medvedev O, Kudryavtseva A, Krasnov G, Fedorova M, Romanikhin F, Bakhitov V, Aliev S, Sedova N, Kuropatkina T, Ivanova A, Zharkova M, Pervushova E, Ivashkin V
Int J Mol Sci 2024 Feb 6;25(4) doi: 10.3390/ijms25041988. PMID: 38396668Free PMC Article
Potassium sodium hydrogen citrate intervention on gut microbiota and clinical features in uric acid stone patients.
Cao C, Li F, Ding Q, Jin X, Tu W, Zhu H, Sun M, Zhu J, Yang D, Fan B
Appl Microbiol Biotechnol 2024 Dec;108(1):51. Epub 2024 Jan 6 doi: 10.1007/s00253-023-12953-y. PMID: 38183479Free PMC Article
Lactobacillus Intestinalis Primes Epithelial Cells to Suppress Colitis-Related Th17 Response by Host-Microbe Retinoic Acid Biosynthesis.
Wang QW, Jia DJ, He JM, Sun Y, Qian Y, Ge QW, Qi YD, Wang QY, Hu YY, Wang L, Fang YF, He HQ, Luo M, Feng LJ, Si JM, Song ZF, Wang LJ, Chen SJ
Adv Sci (Weinh) 2023 Dec;10(36):e2303457. Epub 2023 Nov 20 doi: 10.1002/advs.202303457. PMID: 37983567Free PMC Article
GPR65 (TDAG8) inhibits intestinal inflammation and colitis-associated colorectal cancer development in experimental mouse models.
Marie MA, Sanderlin EJ, Satturwar S, Hong H, Lertpiriyapong K, Donthi D, Yang LV
Biochim Biophys Acta Mol Basis Dis 2022 Jan 1;1868(1):166288. Epub 2021 Oct 8 doi: 10.1016/j.bbadis.2021.166288. PMID: 34628032Free PMC Article
Hypoalbuminemia: a risk factor in patients with STEC-associated hemolytic uremic syndrome.
Cobeñas CJ, Lombardi LL, Pereyra P, De Rose E, Gogorza MJ, Spizzirri AP, Ruscasso JD, Ferradas SL, Suárez ÁDC, Amoreo OR, Zalba JH, Risso P
Pediatr Nephrol 2021 Sep;36(9):2739-2746. Epub 2021 Mar 13 doi: 10.1007/s00467-021-05017-8. PMID: 33712864

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