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Thyroid Gland Noninvasive Follicular Neoplasm with Papillary-Like Nuclear Features

MedGen UID:
1696992
•Concept ID:
C5230684
•
Neoplastic Process
Synonyms: NIFTP - non-invasive follicular thyroid neoplasm with papillary like nuclear features; Non-invasive follicular thyroid neoplasm with papillary like nuclear features; Noninvasive Follicular Thyroid Gland Neoplasm with Papillary-Like Nuclear Features; Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features; Thyroid Gland Noninvasive Follicular Tumor with Papillary-Like Nuclear Features
SNOMED CT: Non-invasive follicular thyroid neoplasm with papillary like nuclear features (789731003); NIFTP - non-invasive follicular thyroid neoplasm with papillary like nuclear features (789731003)

Definition

A non-invasive neoplasm of thyroid follicular cells with a follicular growth pattern and nuclear features of papillary thyroid carcinoma that has an extremely low malignant potential. These tumors were formerly classified as non-invasive encapsulated follicular variant of papillary thyroid carcinoma or well-differentiated tumor of uncertain malignant potential. (WHO) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThyroid Gland Noninvasive Follicular Neoplasm with Papillary-Like Nuclear Features

Professional guidelines

PubMed

Ultrasound and cytopathological characteristics of thyroid tumours of uncertain malignant potential - from diagnosis to treatment.
Żyłka A, Dobruch-Sobczak K, Piotrzkowska-Wróblewska H, Jędrzejczyk M, Góralski P, Gałczyński J, Bakuła-Zalewska E, Dedecjus M
Endokrynol Pol 2024;75(2):170-178. Epub 2024 Apr 22 doi: 10.5603/ep.98488. PMID: 38646986
NCCN Guidelines Insights: Thyroid Carcinoma, Version 2.2018.
Haddad RI, Nasr C, Bischoff L, Busaidy NL, Byrd D, Callender G, Dickson P, Duh QY, Ehya H, Goldner W, Haymart M, Hoh C, Hunt JP, Iagaru A, Kandeel F, Kopp P, Lamonica DM, McIver B, Raeburn CD, Ridge JA, Ringel MD, Scheri RP, Shah JP, Sippel R, Smallridge RC, Sturgeon C, Wang TN, Wirth LJ, Wong RJ, Johnson-Chilla A, Hoffmann KG, Gurski LA
J Natl Compr Canc Netw 2018 Dec;16(12):1429-1440. doi: 10.6004/jnccn.2018.0089. PMID: 30545990
Clinical utility of EZH1 mutations in the diagnosis of follicular-patterned thyroid tumors.
Jung CK, Kim Y, Jeon S, Jo K, Lee S, Bae JS
Hum Pathol 2018 Nov;81:9-17. Epub 2018 May 1 doi: 10.1016/j.humpath.2018.04.018. PMID: 29723601

Recent clinical studies

Etiology

Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Noninvasive Follicular Tumor With Papillary-like Nuclear Features: A Practice Changer in Thyroid Pathology.
LiVolsi VA, Baloch Z
Arch Pathol Lab Med 2021 Jun 1;145(6):659-663. doi: 10.5858/arpa.2019-0689-RA. PMID: 32223558
Non-invasive follicular thyroid neoplasm with papillary-like nuclearfeatures (NIFTP): a review and update.
Geramizadeh B, Maleki Z
Endocrine 2019 Jun;64(3):433-440. Epub 2019 Mar 13 doi: 10.1007/s12020-019-01887-z. PMID: 30868412
Updates in Thyroid Cytology.
Nishino M, Krane JF
Surg Pathol Clin 2018 Sep;11(3):467-487. doi: 10.1016/j.path.2018.05.002. PMID: 30190135
Noninvasive follicular thyroid neoplasm with papillary-like nuclear features: A distinct clinicopathologic entity.
Fonseca D, Bhuyan S, Murthy SS, Rao V, Rao C, N Raju KVV, Sundaram C
Indian J Pathol Microbiol 2018 Jul-Sep;61(3):380-382. doi: 10.4103/IJPM.IJPM_185_17. PMID: 30004059

Diagnosis

Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Updates in Thyroid Cytology.
Nishino M, Krane JF
Surg Pathol Clin 2018 Sep;11(3):467-487. doi: 10.1016/j.path.2018.05.002. PMID: 30190135
Noninvasive follicular thyroid neoplasm with papillary-like nuclear features: A distinct clinicopathologic entity.
Fonseca D, Bhuyan S, Murthy SS, Rao V, Rao C, N Raju KVV, Sundaram C
Indian J Pathol Microbiol 2018 Jul-Sep;61(3):380-382. doi: 10.4103/IJPM.IJPM_185_17. PMID: 30004059
Thyroid FNAC: Causes of false-positive results.
Malheiros DC, Canberk S, Poller DN, Schmitt F
Cytopathology 2018 Oct;29(5):407-417. Epub 2018 Jun 14 doi: 10.1111/cyt.12575. PMID: 29768677
The evolving diagnosis of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP).
Lloyd RV, Asa SL, LiVolsi VA, Sadow PM, Tischler AS, Ghossein RA, Tuttle RM, Nikiforov YE
Hum Pathol 2018 Apr;74:1-4. Epub 2018 Jan 16 doi: 10.1016/j.humpath.2017.12.027. PMID: 29339178

Therapy

Digital image-assisted quantitative nuclear analysis improves diagnostic accuracy of thyroid fine-needle aspiration cytology.
Chain K, Legesse T, Heath JE, Staats PN
Cancer Cytopathol 2019 Aug;127(8):501-513. Epub 2019 May 31 doi: 10.1002/cncy.22120. PMID: 31150162
The use of The Bethesda System for Reporting Thyroid Cytopathology in a Chinese population: An analysis of 13 351 specimens.
Ke J, Jianyong L, Ying L, Genpeng L, Linlin S, Zhihui L, Jinnan L, Xueying S, Yong J, Jingqiang Z
Diagn Cytopathol 2019 Sep;47(9):876-880. Epub 2019 May 9 doi: 10.1002/dc.24207. PMID: 31074206
Extending expressed RNA genomics from surgical decision making for cytologically indeterminate thyroid nodules to targeting therapies for metastatic thyroid cancer.
Ali SZ, Siperstein A, Sadow PM, Golding AC, Kennedy GC, Kloos RT, Ladenson PW
Cancer Cytopathol 2019 Jun;127(6):362-369. Epub 2019 Apr 24 doi: 10.1002/cncy.22132. PMID: 31017745Free PMC Article
NCCN Guidelines Insights: Thyroid Carcinoma, Version 2.2018.
Haddad RI, Nasr C, Bischoff L, Busaidy NL, Byrd D, Callender G, Dickson P, Duh QY, Ehya H, Goldner W, Haymart M, Hoh C, Hunt JP, Iagaru A, Kandeel F, Kopp P, Lamonica DM, McIver B, Raeburn CD, Ridge JA, Ringel MD, Scheri RP, Shah JP, Sippel R, Smallridge RC, Sturgeon C, Wang TN, Wirth LJ, Wong RJ, Johnson-Chilla A, Hoffmann KG, Gurski LA
J Natl Compr Canc Netw 2018 Dec;16(12):1429-1440. doi: 10.6004/jnccn.2018.0089. PMID: 30545990
Cancer Risk Associated with Nuclear Atypia in Cytologically Indeterminate Thyroid Nodules: A Systematic Review and Meta-Analysis.
Valderrabano P, Khazai L, Thompson ZJ, Sharpe SC, Tarasova VD, Otto KJ, Hallanger-Johnson JE, Wadsworth JT, Wenig BM, Chung CH, Centeno BA, McIver B
Thyroid 2018 Feb;28(2):210-219. Epub 2017 Dec 21 doi: 10.1089/thy.2017.0419. PMID: 29160163Free PMC Article

Prognosis

Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features: From Echography to Genetic Profile.
Maletta F, Falco EC, Gambella A, Metovic J, Papotti M
Tohoku J Exp Med 2020 Nov;252(3):209-218. doi: 10.1620/tjem.252.209. PMID: 33087681
Non-invasive follicular thyroid neoplasm with papillary-like nuclearfeatures (NIFTP): a review and update.
Geramizadeh B, Maleki Z
Endocrine 2019 Jun;64(3):433-440. Epub 2019 Mar 13 doi: 10.1007/s12020-019-01887-z. PMID: 30868412
Updates in Thyroid Cytology.
Nishino M, Krane JF
Surg Pathol Clin 2018 Sep;11(3):467-487. doi: 10.1016/j.path.2018.05.002. PMID: 30190135
Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): impact on the reclassification of thyroid nodules.
Amendoeira I, Maia T, Sobrinho-Simões M
Endocr Relat Cancer 2018 Apr;25(4):R247-R258. Epub 2018 Feb 9 doi: 10.1530/ERC-17-0513. PMID: 29439059

Clinical prediction guides

TROP-2 and 5hmC expression in follicular-patterned thyroid neoplasm emphasizing tiny well-formed papillae.
Seok JY, Fan X
Ann Diagn Pathol 2022 Apr;57:151903. Epub 2022 Jan 31 doi: 10.1016/j.anndiagpath.2022.151903. PMID: 35121239
Non-Invasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features Is Not a Cytological Diagnosis, but It Influences Cytological Diagnosis Outcomes: A Systematic Review and Meta-Analysis.
Haaga E, Kalfert D, Ludvíková M, Kholová I
Acta Cytol 2022;66(2):85-105. Epub 2021 Nov 15 doi: 10.1159/000519757. PMID: 34781293Free PMC Article
Non-invasive follicular thyroid neoplasm with papillary-like nuclearfeatures (NIFTP): a review and update.
Geramizadeh B, Maleki Z
Endocrine 2019 Jun;64(3):433-440. Epub 2019 Mar 13 doi: 10.1007/s12020-019-01887-z. PMID: 30868412
Updates in Thyroid Cytology.
Nishino M, Krane JF
Surg Pathol Clin 2018 Sep;11(3):467-487. doi: 10.1016/j.path.2018.05.002. PMID: 30190135
Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): impact on the reclassification of thyroid nodules.
Amendoeira I, Maia T, Sobrinho-Simões M
Endocr Relat Cancer 2018 Apr;25(4):R247-R258. Epub 2018 Feb 9 doi: 10.1530/ERC-17-0513. PMID: 29439059

Recent systematic reviews

Non-Invasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features Is Not a Cytological Diagnosis, but It Influences Cytological Diagnosis Outcomes: A Systematic Review and Meta-Analysis.
Haaga E, Kalfert D, Ludvíková M, Kholová I
Acta Cytol 2022;66(2):85-105. Epub 2021 Nov 15 doi: 10.1159/000519757. PMID: 34781293Free PMC Article
Causes of misdiagnoses by thyroid fine-needle aspiration cytology (FNAC): our experience and a systematic review.
Zhu Y, Song Y, Xu G, Fan Z, Ren W
Diagn Pathol 2020 Jan 3;15(1):1. doi: 10.1186/s13000-019-0924-z. PMID: 31900180Free PMC Article
Italian consensus for the classification and reporting of thyroid cytology: the risk of malignancy between indeterminate lesions at low or high risk. A systematic review and meta-analysis.
Trimboli P, Crescenzi A, Castellana M, Giorgino F, Giovanella L, Bongiovanni M
Endocrine 2019 Mar;63(3):430-438. Epub 2018 Dec 5 doi: 10.1007/s12020-018-1825-8. PMID: 30519908
Cytological Diagnoses Associated with Noninvasive Follicular Thyroid Neoplasms with Papillary-Like Nuclear Features According to the Bethesda System for Reporting Thyroid Cytopathology: A Systematic Review and Meta-Analysis.
Bongiovanni M, Giovanella L, Romanelli F, Trimboli P
Thyroid 2019 Feb;29(2):222-228. Epub 2018 Dec 21 doi: 10.1089/thy.2018.0394. PMID: 30426887
Cancer Risk Associated with Nuclear Atypia in Cytologically Indeterminate Thyroid Nodules: A Systematic Review and Meta-Analysis.
Valderrabano P, Khazai L, Thompson ZJ, Sharpe SC, Tarasova VD, Otto KJ, Hallanger-Johnson JE, Wadsworth JT, Wenig BM, Chung CH, Centeno BA, McIver B
Thyroid 2018 Feb;28(2):210-219. Epub 2017 Dec 21 doi: 10.1089/thy.2017.0419. PMID: 29160163Free PMC Article

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