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Prostate Granular Cell Tumor

MedGen UID:
1699070
•Concept ID:
C5205912
•
Neoplastic Process

Definition

A rare granular cell tumor that arises from the prostate gland. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProstate Granular Cell Tumor

Professional guidelines

PubMed

α-Methylacyl-CoA racemase (P504S) is a useful marker for the differential diagnosis of solid pseudopapillary neoplasm of the pancreas.
Shen Y, Wang Z, Zhu J, Chen Y, Gu W, Liu Q
Ann Diagn Pathol 2014 Jun;18(3):146-50. Epub 2014 Feb 25 doi: 10.1016/j.anndiagpath.2014.02.006. PMID: 24675392

Recent clinical studies

Etiology

Examining the Relationship and Prognostic Significance of Cell-Free DNA Levels and the PSMA-Positive Tumor Volume in Men with Prostate Cancer: A Retrospective-Prospective [(68)Ga]Ga-PSMA-11 PET/CT Study.
Kluge K, Einspieler H, Haberl D, Spielvogel C, Stoiber S, Vraka C, Papp L, Wunsch S, Egger G, Kramer G, Grubmüller B, Shariat S, Hacker M, Kenner L, Haug A
J Nucl Med 2024 Jan 2;65(1):63-70. doi: 10.2967/jnumed.123.266158. PMID: 38050125Free PMC Article
Predicting Outcomes in Men With Metastatic Nonseminomatous Germ Cell Tumors (NSGCT): Results From the IGCCCG Update Consortium.
Gillessen S, Sauvé N, Collette L, Daugaard G, de Wit R, Albany C, Tryakin A, Fizazi K, Stahl O, Gietema JA, De Giorgi U, Cafferty FH, Hansen AR, Tandstad T, Huddart RA, Necchi A, Sweeney CJ, Garcia-Del-Muro X, Heng DYC, Lorch A, Chovanec M, Winquist E, Grimison P, Feldman DR, Terbuch A, Hentrich M, Bokemeyer C, Negaard H, Fankhauser C, Shamash J, Vaughn DJ, Sternberg CN, Heidenreich A, Beyer J; International Germ Cell Cancer Classification Update Consortium
J Clin Oncol 2021 May 10;39(14):1563-1574. Epub 2021 Apr 6 doi: 10.1200/JCO.20.03296. PMID: 33822655Free PMC Article
De novo neuroendocrine transdifferentiation in primary prostate cancer-a phenotype associated with advanced clinico-pathologic features and aggressive outcome.
Abdulfatah E, Reichert ZR, Davenport MS, Chinnaiyan AM, Dadhania V, Wang X, Mannan R, Kunju LP, Hollenbeck BK, Montgomery JS, Kaffenberger SD, Morgan TM, Alva AS, Palapattu GS, Vaishampayan UN, Alumkal JJ, Spratt DE, Udager AM, Mehra R
Med Oncol 2021 Feb 14;38(3):26. doi: 10.1007/s12032-021-01473-2. PMID: 33586037
Small cell-like glandular proliferation of prostate: a rare lesion not related to small cell prostate cancer.
Kryvenko ON, Williamson SR, Trpkov K, Gupta NS, Athanazio D, Selig MK, Smith PT, Magi-Galluzzi C, Jorda M
Virchows Arch 2017 Jan;470(1):47-54. Epub 2016 Oct 14 doi: 10.1007/s00428-016-2033-7. PMID: 27743032
Discovered on gastrointestinal stromal tumours 1 (DOG1) expression in non-gastrointestinal stromal tumour (GIST) neoplasms.
Hemminger J, Iwenofu OH
Histopathology 2012 Aug;61(2):170-7. Epub 2012 May 9 doi: 10.1111/j.1365-2559.2011.04150.x. PMID: 22571292

Diagnosis

Examining the Relationship and Prognostic Significance of Cell-Free DNA Levels and the PSMA-Positive Tumor Volume in Men with Prostate Cancer: A Retrospective-Prospective [(68)Ga]Ga-PSMA-11 PET/CT Study.
Kluge K, Einspieler H, Haberl D, Spielvogel C, Stoiber S, Vraka C, Papp L, Wunsch S, Egger G, Kramer G, Grubmüller B, Shariat S, Hacker M, Kenner L, Haug A
J Nucl Med 2024 Jan 2;65(1):63-70. doi: 10.2967/jnumed.123.266158. PMID: 38050125Free PMC Article
Mycobacterial Spindle Cell Pseudotumor of the Nasal Cavity.
Argyris PP, Wakely PE Jr
Head Neck Pathol 2023 Sep;17(3):782-787. Epub 2023 Apr 7 doi: 10.1007/s12105-023-01550-0. PMID: 37027086Free PMC Article
Utilization of NKX3.1, P501S, Prostate-Specific Antigen, and Steroidogenic Factor 1 to Distinguish Malignant Leydig Cell Tumor From Metastatic Prostatic Adenocarcinoma to the Testis.
Erak E, Ulbright TM, Epstein J
Arch Pathol Lab Med 2023 Dec 1;147(12):1458-1460. doi: 10.5858/arpa.2022-0424-OA. PMID: 36881770
Prostate Benign Diseases.
Guimaraes CTS, Sauer LJ, Romano RFT, Pacheco EO, Bittencourt LK
Top Magn Reson Imaging 2020 Feb;29(1):1-16. doi: 10.1097/RMR.0000000000000227. PMID: 32015291
Perineurial cells in granular cell tumors and neoplasms with perineural invasion: an immunohistochemical study.
Izquierdo F, Suárez-Vilela D, Honrado E
Am J Dermatopathol 2012 Dec;34(8):800-9. doi: 10.1097/DAD.0b013e31824ba93b. PMID: 22668577

Therapy

Predicting Outcomes in Men With Metastatic Nonseminomatous Germ Cell Tumors (NSGCT): Results From the IGCCCG Update Consortium.
Gillessen S, Sauvé N, Collette L, Daugaard G, de Wit R, Albany C, Tryakin A, Fizazi K, Stahl O, Gietema JA, De Giorgi U, Cafferty FH, Hansen AR, Tandstad T, Huddart RA, Necchi A, Sweeney CJ, Garcia-Del-Muro X, Heng DYC, Lorch A, Chovanec M, Winquist E, Grimison P, Feldman DR, Terbuch A, Hentrich M, Bokemeyer C, Negaard H, Fankhauser C, Shamash J, Vaughn DJ, Sternberg CN, Heidenreich A, Beyer J; International Germ Cell Cancer Classification Update Consortium
J Clin Oncol 2021 May 10;39(14):1563-1574. Epub 2021 Apr 6 doi: 10.1200/JCO.20.03296. PMID: 33822655Free PMC Article
Transformation of prostatic adenocarcinoma to well-differentiated neuroendocrine tumor after hormonal treatment.
Gilani S, Guo CC, Li-Ning EM, Pettaway C, Troncoso P
Hum Pathol 2017 Jun;64:186-190. Epub 2017 Jan 31 doi: 10.1016/j.humpath.2017.01.006. PMID: 28159676

Prognosis

Examining the Relationship and Prognostic Significance of Cell-Free DNA Levels and the PSMA-Positive Tumor Volume in Men with Prostate Cancer: A Retrospective-Prospective [(68)Ga]Ga-PSMA-11 PET/CT Study.
Kluge K, Einspieler H, Haberl D, Spielvogel C, Stoiber S, Vraka C, Papp L, Wunsch S, Egger G, Kramer G, Grubmüller B, Shariat S, Hacker M, Kenner L, Haug A
J Nucl Med 2024 Jan 2;65(1):63-70. doi: 10.2967/jnumed.123.266158. PMID: 38050125Free PMC Article
Mycobacterial Spindle Cell Pseudotumor of the Nasal Cavity.
Argyris PP, Wakely PE Jr
Head Neck Pathol 2023 Sep;17(3):782-787. Epub 2023 Apr 7 doi: 10.1007/s12105-023-01550-0. PMID: 37027086Free PMC Article
Predicting Outcomes in Men With Metastatic Nonseminomatous Germ Cell Tumors (NSGCT): Results From the IGCCCG Update Consortium.
Gillessen S, Sauvé N, Collette L, Daugaard G, de Wit R, Albany C, Tryakin A, Fizazi K, Stahl O, Gietema JA, De Giorgi U, Cafferty FH, Hansen AR, Tandstad T, Huddart RA, Necchi A, Sweeney CJ, Garcia-Del-Muro X, Heng DYC, Lorch A, Chovanec M, Winquist E, Grimison P, Feldman DR, Terbuch A, Hentrich M, Bokemeyer C, Negaard H, Fankhauser C, Shamash J, Vaughn DJ, Sternberg CN, Heidenreich A, Beyer J; International Germ Cell Cancer Classification Update Consortium
J Clin Oncol 2021 May 10;39(14):1563-1574. Epub 2021 Apr 6 doi: 10.1200/JCO.20.03296. PMID: 33822655Free PMC Article
De novo neuroendocrine transdifferentiation in primary prostate cancer-a phenotype associated with advanced clinico-pathologic features and aggressive outcome.
Abdulfatah E, Reichert ZR, Davenport MS, Chinnaiyan AM, Dadhania V, Wang X, Mannan R, Kunju LP, Hollenbeck BK, Montgomery JS, Kaffenberger SD, Morgan TM, Alva AS, Palapattu GS, Vaishampayan UN, Alumkal JJ, Spratt DE, Udager AM, Mehra R
Med Oncol 2021 Feb 14;38(3):26. doi: 10.1007/s12032-021-01473-2. PMID: 33586037
The expression of syndecan-1 and -2 is associated with Gleason score and epithelial-mesenchymal transition markers, E-cadherin and beta-catenin, in prostate cancer.
Contreras HR, Ledezma RA, Vergara J, Cifuentes F, Barra C, Cabello P, Gallegos I, Morales B, Huidobro C, Castellón EA
Urol Oncol 2010 Sep-Oct;28(5):534-40. Epub 2009 May 17 doi: 10.1016/j.urolonc.2009.03.018. PMID: 19450993

Clinical prediction guides

Mycobacterial Spindle Cell Pseudotumor of the Nasal Cavity.
Argyris PP, Wakely PE Jr
Head Neck Pathol 2023 Sep;17(3):782-787. Epub 2023 Apr 7 doi: 10.1007/s12105-023-01550-0. PMID: 37027086Free PMC Article
Utilization of NKX3.1, P501S, Prostate-Specific Antigen, and Steroidogenic Factor 1 to Distinguish Malignant Leydig Cell Tumor From Metastatic Prostatic Adenocarcinoma to the Testis.
Erak E, Ulbright TM, Epstein J
Arch Pathol Lab Med 2023 Dec 1;147(12):1458-1460. doi: 10.5858/arpa.2022-0424-OA. PMID: 36881770
De novo neuroendocrine transdifferentiation in primary prostate cancer-a phenotype associated with advanced clinico-pathologic features and aggressive outcome.
Abdulfatah E, Reichert ZR, Davenport MS, Chinnaiyan AM, Dadhania V, Wang X, Mannan R, Kunju LP, Hollenbeck BK, Montgomery JS, Kaffenberger SD, Morgan TM, Alva AS, Palapattu GS, Vaishampayan UN, Alumkal JJ, Spratt DE, Udager AM, Mehra R
Med Oncol 2021 Feb 14;38(3):26. doi: 10.1007/s12032-021-01473-2. PMID: 33586037
Small cell-like glandular proliferation of prostate: a rare lesion not related to small cell prostate cancer.
Kryvenko ON, Williamson SR, Trpkov K, Gupta NS, Athanazio D, Selig MK, Smith PT, Magi-Galluzzi C, Jorda M
Virchows Arch 2017 Jan;470(1):47-54. Epub 2016 Oct 14 doi: 10.1007/s00428-016-2033-7. PMID: 27743032
Clear cell urothelial carcinoma of the urinary bladder: a case report and review of the literature.
Knez VM, Barrow W, Lucia MS, Wilson S, La Rosa FG
J Med Case Rep 2014 Aug 14;8:275. doi: 10.1186/1752-1947-8-275. PMID: 25124389Free PMC Article

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