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Increased number of lymph nodes

MedGen UID:
1700647
•Concept ID:
C5139411
•
Finding
HPO: HP:0032536

Definition

An abnormally elevated number of lymph nodes in an anatomical region. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased number of lymph nodes

Professional guidelines

PubMed

Association of demographic and treatment variables in long-term colon cancer survival.
Lincourt AE, Sing RF, Kercher KW, Stewart A, Demeter BL, Hope WW, Lang NP, Greene, Heniford BT
Surg Innov 2008 Mar;15(1):17-25. Epub 2008 Apr 2 doi: 10.1177/1553350608315955. PMID: 18388001

Recent clinical studies

Etiology

Pathology of sentinel lymph nodes: historical perspective and current applications in gynecologic cancer.
Euscher E
Int J Gynecol Cancer 2020 Mar;30(3):394-401. Epub 2020 Feb 19 doi: 10.1136/ijgc-2019-001022. PMID: 32079711
An atlas to aid delineation of para-aortic lymph node region in cervical cancer: Design and validation of contouring guidelines.
Keenan LG, Rock K, Azmi A, Salib O, Gillham C, McArdle O
Radiother Oncol 2018 Jun;127(3):417-422. Epub 2018 Mar 6 doi: 10.1016/j.radonc.2018.02.013. PMID: 29523410
Mediastinal incidentalomas.
Stigt JA, Boers JE, Oostdijk AH, van den Berg JW, Groen HJ
J Thorac Oncol 2011 Aug;6(8):1345-9. doi: 10.1097/JTO.0b013e31821d41c8. PMID: 21587083
New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1).
Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, Dancey J, Arbuck S, Gwyther S, Mooney M, Rubinstein L, Shankar L, Dodd L, Kaplan R, Lacombe D, Verweij J
Eur J Cancer 2009 Jan;45(2):228-47. doi: 10.1016/j.ejca.2008.10.026. PMID: 19097774
GEWF solution.
Newell KJ, Sawka BW, Rudrick BF, Driman DK
Arch Pathol Lab Med 2001 May;125(5):642-5. doi: 10.5858/2001-125-0642-GS. PMID: 11300935

Diagnosis

A nomogram model based on the number of examined lymph nodes-related signature to predict prognosis and guide clinical therapy in gastric cancer.
Li H, Lin D, Yu Z, Li H, Zhao S, Hainisayimu T, Liu L, Wang K
Front Immunol 2022;13:947802. Epub 2022 Nov 2 doi: 10.3389/fimmu.2022.947802. PMID: 36405735Free PMC Article
Pelvic lymph node dissection in high-risk prostate cancer.
Haiquel L, Cathelineau X, Sanchez-Salas R, Macek P, Secin F
Int Braz J Urol 2022 Jan-Feb;48(1):54-66. doi: 10.1590/S1677-5538.IBJU.2020.1063. PMID: 33861538Free PMC Article
Risk factor analysis for predicting cervical lymph node metastasis in papillary thyroid carcinoma: a study of 966 patients.
Liu C, Xiao C, Chen J, Li X, Feng Z, Gao Q, Liu Z
BMC Cancer 2019 Jun 25;19(1):622. doi: 10.1186/s12885-019-5835-6. PMID: 31238891Free PMC Article
Completion Dissection or Observation for Sentinel-Node Metastasis in Melanoma.
Faries MB, Thompson JF, Cochran AJ, Andtbacka RH, Mozzillo N, Zager JS, Jahkola T, Bowles TL, Testori A, Beitsch PD, Hoekstra HJ, Moncrieff M, Ingvar C, Wouters MWJM, Sabel MS, Levine EA, Agnese D, Henderson M, Dummer R, Rossi CR, Neves RI, Trocha SD, Wright F, Byrd DR, Matter M, Hsueh E, MacKenzie-Ross A, Johnson DB, Terheyden P, Berger AC, Huston TL, Wayne JD, Smithers BM, Neuman HB, Schneebaum S, Gershenwald JE, Ariyan CE, Desai DC, Jacobs L, McMasters KM, Gesierich A, Hersey P, Bines SD, Kane JM, Barth RJ, McKinnon G, Farma JM, Schultz E, Vidal-Sicart S, Hoefer RA, Lewis JM, Scheri R, Kelley MC, Nieweg OE, Noyes RD, Hoon DSB, Wang HJ, Elashoff DA, Elashoff RM
N Engl J Med 2017 Jun 8;376(23):2211-2222. doi: 10.1056/NEJMoa1613210. PMID: 28591523Free PMC Article
Mediastinal incidentalomas.
Stigt JA, Boers JE, Oostdijk AH, van den Berg JW, Groen HJ
J Thorac Oncol 2011 Aug;6(8):1345-9. doi: 10.1097/JTO.0b013e31821d41c8. PMID: 21587083

Therapy

Radiotherapy to regional nodes in early breast cancer: an individual patient data meta-analysis of 14 324 women in 16 trials.
Early Breast Cancer Trialists' Collaborative Group (EBCTCG)
Lancet 2023 Nov 25;402(10416):1991-2003. Epub 2023 Nov 3 doi: 10.1016/S0140-6736(23)01082-6. PMID: 37931633
Lobar or Sublobar Resection for Peripheral Stage IA Non-Small-Cell Lung Cancer.
Altorki N, Wang X, Kozono D, Watt C, Landrenau R, Wigle D, Port J, Jones DR, Conti M, Ashrafi AS, Liberman M, Yasufuku K, Yang S, Mitchell JD, Pass H, Keenan R, Bauer T, Miller D, Kohman LJ, Stinchcombe TE, Vokes E
N Engl J Med 2023 Feb 9;388(6):489-498. doi: 10.1056/NEJMoa2212083. PMID: 36780674Free PMC Article
Safety and Efficacy of Indocyanine Green Tracer-Guided Lymph Node Dissection During Laparoscopic Radical Gastrectomy in Patients With Gastric Cancer: A Randomized Clinical Trial.
Chen QY, Xie JW, Zhong Q, Wang JB, Lin JX, Lu J, Cao LL, Lin M, Tu RH, Huang ZN, Lin JL, Zheng HL, Li P, Zheng CH, Huang CM
JAMA Surg 2020 Apr 1;155(4):300-311. doi: 10.1001/jamasurg.2019.6033. PMID: 32101269
Completion Dissection or Observation for Sentinel-Node Metastasis in Melanoma.
Faries MB, Thompson JF, Cochran AJ, Andtbacka RH, Mozzillo N, Zager JS, Jahkola T, Bowles TL, Testori A, Beitsch PD, Hoekstra HJ, Moncrieff M, Ingvar C, Wouters MWJM, Sabel MS, Levine EA, Agnese D, Henderson M, Dummer R, Rossi CR, Neves RI, Trocha SD, Wright F, Byrd DR, Matter M, Hsueh E, MacKenzie-Ross A, Johnson DB, Terheyden P, Berger AC, Huston TL, Wayne JD, Smithers BM, Neuman HB, Schneebaum S, Gershenwald JE, Ariyan CE, Desai DC, Jacobs L, McMasters KM, Gesierich A, Hersey P, Bines SD, Kane JM, Barth RJ, McKinnon G, Farma JM, Schultz E, Vidal-Sicart S, Hoefer RA, Lewis JM, Scheri R, Kelley MC, Nieweg OE, Noyes RD, Hoon DSB, Wang HJ, Elashoff DA, Elashoff RM
N Engl J Med 2017 Jun 8;376(23):2211-2222. doi: 10.1056/NEJMoa1613210. PMID: 28591523Free PMC Article
New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1).
Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, Dancey J, Arbuck S, Gwyther S, Mooney M, Rubinstein L, Shankar L, Dodd L, Kaplan R, Lacombe D, Verweij J
Eur J Cancer 2009 Jan;45(2):228-47. doi: 10.1016/j.ejca.2008.10.026. PMID: 19097774

Prognosis

Finding the minimum number of retrieved lymph nodes in node-negative colorectal cancer using Real-world Data and the SEER database.
Qiao Y, Zhu J, Han T, Jiang X, Wang K, Chen R, Du Y, Li J, Sun L
Int J Surg 2023 Dec 1;109(12):4173-4184. doi: 10.1097/JS9.0000000000000746. PMID: 37755374Free PMC Article
The number of metastatic lymph nodes is more predictive of prognosis than location-based N stage for nonsmall cell lung cancer: a retrospective cohort study.
Xu L, Si H, Su H, Wang F, Wu J, She Y, Hu X, Xie D, Zhao D, Li Q, Guo J, Chen C; Surgical Thoracic Alliance of Rising Star Group
Int J Surg 2023 Dec 1;109(12):4126-4134. doi: 10.1097/JS9.0000000000000723. PMID: 37755369Free PMC Article
Adjuvant lymph-node field radiotherapy versus observation only in patients with melanoma at high risk of further lymph-node field relapse after lymphadenectomy (ANZMTG 01.02/TROG 02.01): 6-year follow-up of a phase 3, randomised controlled trial.
Henderson MA, Burmeister BH, Ainslie J, Fisher R, Di Iulio J, Smithers BM, Hong A, Shannon K, Scolyer RA, Carruthers S, Coventry BJ, Babington S, Duprat J, Hoekstra HJ, Thompson JF
Lancet Oncol 2015 Sep;16(9):1049-1060. Epub 2015 Jul 20 doi: 10.1016/S1470-2045(15)00187-4. PMID: 26206146
Colorectal cancer and lymph nodes: the obsession with the number 12.
Li Destri G, Di Carlo I, Scilletta R, Scilletta B, Puleo S
World J Gastroenterol 2014 Feb 28;20(8):1951-60. doi: 10.3748/wjg.v20.i8.1951. PMID: 24587671Free PMC Article
Mediastinal incidentalomas.
Stigt JA, Boers JE, Oostdijk AH, van den Berg JW, Groen HJ
J Thorac Oncol 2011 Aug;6(8):1345-9. doi: 10.1097/JTO.0b013e31821d41c8. PMID: 21587083

Clinical prediction guides

A nomogram model based on the number of examined lymph nodes-related signature to predict prognosis and guide clinical therapy in gastric cancer.
Li H, Lin D, Yu Z, Li H, Zhao S, Hainisayimu T, Liu L, Wang K
Front Immunol 2022;13:947802. Epub 2022 Nov 2 doi: 10.3389/fimmu.2022.947802. PMID: 36405735Free PMC Article
Risk factor analysis for predicting cervical lymph node metastasis in papillary thyroid carcinoma: a study of 966 patients.
Liu C, Xiao C, Chen J, Li X, Feng Z, Gao Q, Liu Z
BMC Cancer 2019 Jun 25;19(1):622. doi: 10.1186/s12885-019-5835-6. PMID: 31238891Free PMC Article
Completion Dissection or Observation for Sentinel-Node Metastasis in Melanoma.
Faries MB, Thompson JF, Cochran AJ, Andtbacka RH, Mozzillo N, Zager JS, Jahkola T, Bowles TL, Testori A, Beitsch PD, Hoekstra HJ, Moncrieff M, Ingvar C, Wouters MWJM, Sabel MS, Levine EA, Agnese D, Henderson M, Dummer R, Rossi CR, Neves RI, Trocha SD, Wright F, Byrd DR, Matter M, Hsueh E, MacKenzie-Ross A, Johnson DB, Terheyden P, Berger AC, Huston TL, Wayne JD, Smithers BM, Neuman HB, Schneebaum S, Gershenwald JE, Ariyan CE, Desai DC, Jacobs L, McMasters KM, Gesierich A, Hersey P, Bines SD, Kane JM, Barth RJ, McKinnon G, Farma JM, Schultz E, Vidal-Sicart S, Hoefer RA, Lewis JM, Scheri R, Kelley MC, Nieweg OE, Noyes RD, Hoon DSB, Wang HJ, Elashoff DA, Elashoff RM
N Engl J Med 2017 Jun 8;376(23):2211-2222. doi: 10.1056/NEJMoa1613210. PMID: 28591523Free PMC Article
Adjuvant lymph-node field radiotherapy versus observation only in patients with melanoma at high risk of further lymph-node field relapse after lymphadenectomy (ANZMTG 01.02/TROG 02.01): 6-year follow-up of a phase 3, randomised controlled trial.
Henderson MA, Burmeister BH, Ainslie J, Fisher R, Di Iulio J, Smithers BM, Hong A, Shannon K, Scolyer RA, Carruthers S, Coventry BJ, Babington S, Duprat J, Hoekstra HJ, Thompson JF
Lancet Oncol 2015 Sep;16(9):1049-1060. Epub 2015 Jul 20 doi: 10.1016/S1470-2045(15)00187-4. PMID: 26206146
Mediastinal incidentalomas.
Stigt JA, Boers JE, Oostdijk AH, van den Berg JW, Groen HJ
J Thorac Oncol 2011 Aug;6(8):1345-9. doi: 10.1097/JTO.0b013e31821d41c8. PMID: 21587083

Recent systematic reviews

Comparison of robotic right colectomy and laparoscopic right colectomy: a systematic review and meta-analysis.
Zheng J, Zhao S, Chen W, Zhang M, Wu J
Tech Coloproctol 2023 Jul;27(7):521-535. Epub 2023 May 15 doi: 10.1007/s10151-023-02821-2. PMID: 37184773
A systematic review and meta-analysis of vascularized lymph node transfer for breast cancer-related lymphedema.
Winters H, Tielemans HJP, Paulus V, Hummelink S, Slater NJ, Ulrich DJO
J Vasc Surg Venous Lymphat Disord 2022 May;10(3):786-795.e1. Epub 2021 Sep 8 doi: 10.1016/j.jvsv.2021.08.023. PMID: 34508873
Radiotherapy of oligometastatic prostate cancer: a systematic review.
Rogowski P, Roach M 3rd, Schmidt-Hegemann NS, Trapp C, von Bestenbostel R, Shi R, Buchner A, Stief C, Belka C, Li M
Radiat Oncol 2021 Mar 9;16(1):50. doi: 10.1186/s13014-021-01776-8. PMID: 33750437Free PMC Article
Robotic pancreatoduodenectomy with vascular resection.
Kauffmann EF, Napoli N, Menonna F, Vistoli F, Amorese G, Campani D, Pollina LE, Funel N, Cappelli C, Caramella D, Boggi U
Langenbecks Arch Surg 2016 Dec;401(8):1111-1122. Epub 2016 Aug 24 doi: 10.1007/s00423-016-1499-8. PMID: 27553112
Incidence of unilateral arm lymphoedema after breast cancer: a systematic review and meta-analysis.
DiSipio T, Rye S, Newman B, Hayes S
Lancet Oncol 2013 May;14(6):500-15. Epub 2013 Mar 27 doi: 10.1016/S1470-2045(13)70076-7. PMID: 23540561

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