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Abnormality of neutrophil morphology in CSF

MedGen UID:
1702901
•Concept ID:
C5139472
•
Finding
Synonym: Abnormality of neutrophil morphology in cerebrospinal fluid
 
HPO: HP:0410310

Definition

An abnormal form or size of neutrophils in the cerebrospinal fluid. [from HPO]

Professional guidelines

PubMed

Model analysis of the contrasting effects of GM-CSF and G-CSF treatment on peripheral blood neutrophils observed in three patients with childhood-onset cyclic neutropenia.
Schmitz S, Franke H, Loeffler M, Wichmann HE, Diehl V
Br J Haematol 1996 Dec;95(4):616-25. doi: 10.1046/j.1365-2141.1996.d01-1948.x. PMID: 8982036
Treatment of myelodysplastic syndromes with recombinant human granulocyte colony-stimulating factor. A phase I-II trial.
Negrin RS, Haeuber DH, Nagler A, Olds LC, Donlon T, Souza LM, Greenberg PL
Ann Intern Med 1989 Jun 15;110(12):976-84. doi: 10.7326/0003-4819-110-12-976. PMID: 2471429

Recent clinical studies

Etiology

Investigation of CD26, a potential SARS-CoV-2 receptor, as a biomarker of age and pathology.
Raha AA, Chakraborty S, Henderson J, Mukaetova-Ladinska E, Zaman S, Trowsdale J, Raha-Chowdhury R
Biosci Rep 2020 Dec 23;40(12) doi: 10.1042/BSR20203092. PMID: 33205807Free PMC Article
The lower risk MDS patient at risk of rapid progression.
Mittelman M, Oster HS, Hoffman M, Neumann D
Leuk Res 2010 Dec;34(12):1551-5. Epub 2010 Jun 22 doi: 10.1016/j.leukres.2010.05.023. PMID: 20573398
Pulmonary alveolar proteinosis: a bench-to-bedside story of granulocyte-macrophage colony-stimulating factor dysfunction.
Greenhill SR, Kotton DN
Chest 2009 Aug;136(2):571-577. doi: 10.1378/chest.08-2943. PMID: 19666756
Risk of myelodysplastic syndrome and acute myeloid leukemia in congenital neutropenias.
Freedman MH, Alter BP
Semin Hematol 2002 Apr;39(2):128-33. doi: 10.1053/shem.2002.31912. PMID: 11957196
Myelodysplastic syndromes.
Lowenthal RM, Marsden KA
Int J Hematol 1997 Jun;65(4):319-38. doi: 10.1016/s0925-5710(96)00566-x. PMID: 9195773

Diagnosis

Varicella zoster virus vasculopathy: clinical features and pathogenesis.
Nagel MA
J Neurovirol 2014 Apr;20(2):157-63. Epub 2013 Aug 6 doi: 10.1007/s13365-013-0183-9. PMID: 23918503Free PMC Article
Clinical and genetic features of Warts, Hypogammaglobulinemia, Infections and Myelokathexis (WHIM) syndrome.
Dotta L, Tassone L, Badolato R
Curr Mol Med 2011 Jun;11(4):317-25. doi: 10.2174/156652411795677963. PMID: 21506920
Herpes simplex virus, meningitis and encephalitis in neonates.
Kimberlin D
Herpes 2004 Jun;11 Suppl 2:65A-76A. PMID: 15319092
West Nile virus infection: a new acute paralytic illness.
Jeha LE, Sila CA, Lederman RJ, Prayson RA, Isada CM, Gordon SM
Neurology 2003 Jul 8;61(1):55-9. doi: 10.1212/01.wnl.0000073617.08185.0a. PMID: 12847156
Myelodysplastic syndromes.
Lowenthal RM, Marsden KA
Int J Hematol 1997 Jun;65(4):319-38. doi: 10.1016/s0925-5710(96)00566-x. PMID: 9195773

Therapy

The role of G-CSF neuroprotective effects in neonatal hypoxic-ischemic encephalopathy (HIE): current status.
Dumbuya JS, Chen L, Wu JY, Wang B
J Neuroinflammation 2021 Feb 21;18(1):55. doi: 10.1186/s12974-021-02084-4. PMID: 33612099Free PMC Article
Effect of the unfolded protein response and oxidative stress on mutagenesis in CSF3R: a model for evolution of severe congenital neutropenia to myelodysplastic syndrome/acute myeloid leukemia.
Sapra A, Jaksik R, Mehta H, Biesiadny S, Kimmel M, Corey SJ
Mutagenesis 2020 Dec 1;35(5):381-389. doi: 10.1093/mutage/geaa027. PMID: 33511998Free PMC Article
Herpes simplex virus, meningitis and encephalitis in neonates.
Kimberlin D
Herpes 2004 Jun;11 Suppl 2:65A-76A. PMID: 15319092
Risk of myelodysplastic syndrome and acute myeloid leukemia in congenital neutropenias.
Freedman MH, Alter BP
Semin Hematol 2002 Apr;39(2):128-33. doi: 10.1053/shem.2002.31912. PMID: 11957196
Myelodysplastic syndromes.
Lowenthal RM, Marsden KA
Int J Hematol 1997 Jun;65(4):319-38. doi: 10.1016/s0925-5710(96)00566-x. PMID: 9195773

Prognosis

Case Report: Chronic Fungal Meningitis Masquerading as Tubercular Meningitis.
Hesarur N, Seshagiri DV, Nagappa M, Rao S, Santosh V, Chandrashekar N, Reddy N, Sharma PP, Kumari P, Pruthi N, Shukla D, Saini J, Taly AB, Sinha S
Am J Trop Med Hyg 2020 Oct;103(4):1473-1479. doi: 10.4269/ajtmh.19-0885. PMID: 32876006Free PMC Article
The lower risk MDS patient at risk of rapid progression.
Mittelman M, Oster HS, Hoffman M, Neumann D
Leuk Res 2010 Dec;34(12):1551-5. Epub 2010 Jun 22 doi: 10.1016/j.leukres.2010.05.023. PMID: 20573398
Pulmonary alveolar proteinosis: a bench-to-bedside story of granulocyte-macrophage colony-stimulating factor dysfunction.
Greenhill SR, Kotton DN
Chest 2009 Aug;136(2):571-577. doi: 10.1378/chest.08-2943. PMID: 19666756
Clinical features of myelokathexis and treatment with hematopoietic cytokines: a case report of two patients and review of the literature.
Hord JD, Whitlock JA, Gay JC, Lukens JN
J Pediatr Hematol Oncol 1997 Sep-Oct;19(5):443-8. doi: 10.1097/00043426-199709000-00007. PMID: 9329467
Myelodysplastic syndromes.
Lowenthal RM, Marsden KA
Int J Hematol 1997 Jun;65(4):319-38. doi: 10.1016/s0925-5710(96)00566-x. PMID: 9195773

Clinical prediction guides

Effect of the unfolded protein response and oxidative stress on mutagenesis in CSF3R: a model for evolution of severe congenital neutropenia to myelodysplastic syndrome/acute myeloid leukemia.
Sapra A, Jaksik R, Mehta H, Biesiadny S, Kimmel M, Corey SJ
Mutagenesis 2020 Dec 1;35(5):381-389. doi: 10.1093/mutage/geaa027. PMID: 33511998Free PMC Article
The clinical and imaging features of hypertrophic pachymeningitis: a clinical analysis on 22 patients.
Chen H, Zhang W, Jing J, Raza HK, Zhang Z, Zhu J, Liu Y, Cui G, Hua F, Dong L
Neurol Sci 2019 Feb;40(2):269-274. Epub 2018 Oct 30 doi: 10.1007/s10072-018-3619-4. PMID: 30377845
Effects of cancer on platelets.
van Es N, Sturk A, Middeldorp S, Nieuwland R
Semin Oncol 2014 Jun;41(3):311-8. Epub 2014 Apr 24 doi: 10.1053/j.seminoncol.2014.04.015. PMID: 25023347
Pulmonary alveolar proteinosis: a bench-to-bedside story of granulocyte-macrophage colony-stimulating factor dysfunction.
Greenhill SR, Kotton DN
Chest 2009 Aug;136(2):571-577. doi: 10.1378/chest.08-2943. PMID: 19666756
Risk of myelodysplastic syndrome and acute myeloid leukemia in congenital neutropenias.
Freedman MH, Alter BP
Semin Hematol 2002 Apr;39(2):128-33. doi: 10.1053/shem.2002.31912. PMID: 11957196

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