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Bladder Granular Cell Tumor

MedGen UID:
1704182
•Concept ID:
C5204621
•
Neoplastic Process

Definition

A rare granular cell tumor arising from the bladder. Most tumors are benign. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBladder Granular Cell Tumor

Professional guidelines

PubMed

Diagnostic pathways and treatment strategies in upper tract urothelial carcinoma in Sweden between 2015 and 2021: a population-based survey.
Liedberg F, Hagberg O, Aljabery F, Gårdmark T, Jahnson S, Jerlström T, Ströck V, Söderkvist K, Ullén A, Bobjer J
Scand J Urol 2024 Jan 16;59:19-25. doi: 10.2340/sju.v59.16281. PMID: 38226846

Recent clinical studies

Etiology

POU2F3-positive small cell carcinoma of the bladder: A clinicopathologic analysis of 4 cases and literature review.
Cai Z, Cheng X, Liao S, Zou W, Li L, Liu F, Huang W
Pathol Res Pract 2024 May;257:155296. Epub 2024 Apr 11 doi: 10.1016/j.prp.2024.155296. PMID: 38615507
Epstein-Barr Virus-associated Mixed Lymphoepithelioma-like Carcinoma and Adenocarcinoma of the Gall Bladder: An Unusual Entity.
Jain N, Goyal S, Sakhuja P, Saluja S
Korean J Gastroenterol 2021 Sep 25;78(3):188-194. doi: 10.4166/kjg.2021.045. PMID: 34565789
Granular Cell Tumor of the Bladder: A Report of Six Cases.
Sun Y, Reuter VE, Magi-Galluzzi C, Sankin A, Epstein JI
Urology 2018 Nov;121:203.e1-203.e5. Epub 2018 Aug 29 doi: 10.1016/j.urology.2018.08.018. PMID: 30170086Free PMC Article
Clinicopathologic Features of Benign Neurogenic Tumor of Urinary Bladder.
Lee C, Kim B, Song B, Park JH, Moon KC
Int J Surg Pathol 2018 May;26(3):221-228. Epub 2017 Nov 26 doi: 10.1177/1066896917742722. PMID: 29172920
Granular cell tumors of the urinary bladder.
Abbas F, Memon A, Siddiqui T, Kayani N, Ahmad NA
World J Surg Oncol 2007 Mar 13;5:33. doi: 10.1186/1477-7819-5-33. PMID: 17355632Free PMC Article

Diagnosis

GAD2 Is a Highly Specific Marker for Neuroendocrine Neoplasms of the Pancreas.
Lennartz M, Benjamin Dünnebier N, Höflmayer D, Dwertmann Rico S, Kind S, Reiswich V, Viehweger F, Lutz F, Fraune C, Gorbokon N, Luebke AM, Hube-Magg C, Büscheck F, Menz A, Uhlig R, Krech T, Hinsch A, Burandt E, Sauter G, Simon R, Kluth M, Steurer S, Marx AH, Lebok P, Dum D, Minner S, Jacobsen F, Clauditz TS, Bernreuther C
Am J Surg Pathol 2024 Apr 1;48(4):377-386. Epub 2024 Jan 25 doi: 10.1097/PAS.0000000000002186. PMID: 38271200Free PMC Article
Perivascular Epithelioid Cell Tumor of Urinary Bladder.
Wu YL, Lang L, Ma Q, Wu F, Zhang Y, Chen W, Yan XC, Duan GJ
Am J Clin Pathol 2021 Jun 17;156(1):56-71. doi: 10.1093/ajcp/aqaa204. PMID: 33336255
Granular Cell Tumor of the Bladder: A Report of Six Cases.
Sun Y, Reuter VE, Magi-Galluzzi C, Sankin A, Epstein JI
Urology 2018 Nov;121:203.e1-203.e5. Epub 2018 Aug 29 doi: 10.1016/j.urology.2018.08.018. PMID: 30170086Free PMC Article
Clinicopathologic Features of Benign Neurogenic Tumor of Urinary Bladder.
Lee C, Kim B, Song B, Park JH, Moon KC
Int J Surg Pathol 2018 May;26(3):221-228. Epub 2017 Nov 26 doi: 10.1177/1066896917742722. PMID: 29172920
Perineurial cells in granular cell tumors and neoplasms with perineural invasion: an immunohistochemical study.
Izquierdo F, Suárez-Vilela D, Honrado E
Am J Dermatopathol 2012 Dec;34(8):800-9. doi: 10.1097/DAD.0b013e31824ba93b. PMID: 22668577

Therapy

Granular Cell Tumor of the Bladder: A Report of Six Cases.
Sun Y, Reuter VE, Magi-Galluzzi C, Sankin A, Epstein JI
Urology 2018 Nov;121:203.e1-203.e5. Epub 2018 Aug 29 doi: 10.1016/j.urology.2018.08.018. PMID: 30170086Free PMC Article
Possible role of cyclooxygenase-2 in schistosomal and non-schistosomal-associated bladder cancer.
Hammam OA, Aziz AA, Roshdy MS, Abdel Hadi AM
Medscape J Med 2008 Mar 11;10(3):60. PMID: 18449376Free PMC Article
Ultrastructural analysis of nucleolar transcription in cells microinjected with 5-bromo-UTP.
Cmarko D, Verschure PJ, Rothblum LI, Hernandez-Verdun D, Amalric F, van Driel R, Fakan S
Histochem Cell Biol 2000 Mar;113(3):181-7. doi: 10.1007/s004180050437. PMID: 10817672
Determination and reversal of resistance to epirubicin intravesical chemotherapy. A confocal imaging study.
Duffy PM, Hayes MC, Gatrell SK, Cooper A, Smart CJ
Br J Urol 1996 Jun;77(6):824-9. doi: 10.1046/j.1464-410x.1996.09539.x. PMID: 8705215
Activation by the protein-bound polysaccharide PSK (krestin) of cytotoxic lymphocytes that act on fresh autologous tumor cells and T24 human urinary bladder transitional carcinoma cell line in patients with urinary bladder cancer.
Mizutani Y, Yoshida O
J Urol 1991 May;145(5):1082-7. doi: 10.1016/s0022-5347(17)38539-7. PMID: 2016797

Prognosis

Bladder cancer patients have increased NETosis and impaired DNaseI-mediated NET degradation that can be therapeutically restored in vitro.
Herranz R, Oto J, Hueso M, Plana E, Cana F, Castaño M, Cordón L, Ramos-Soler D, Bonanad S, Vera-Donoso CD, Martínez-Sarmiento M, Medina P
Front Immunol 2023;14:1171065. Epub 2023 May 19 doi: 10.3389/fimmu.2023.1171065. PMID: 37275882Free PMC Article
Perivascular Epithelioid Cell Tumor of Urinary Bladder.
Wu YL, Lang L, Ma Q, Wu F, Zhang Y, Chen W, Yan XC, Duan GJ
Am J Clin Pathol 2021 Jun 17;156(1):56-71. doi: 10.1093/ajcp/aqaa204. PMID: 33336255
Granular Cell Tumor of the Bladder: A Report of Six Cases.
Sun Y, Reuter VE, Magi-Galluzzi C, Sankin A, Epstein JI
Urology 2018 Nov;121:203.e1-203.e5. Epub 2018 Aug 29 doi: 10.1016/j.urology.2018.08.018. PMID: 30170086Free PMC Article
Clinicopathologic Features of Benign Neurogenic Tumor of Urinary Bladder.
Lee C, Kim B, Song B, Park JH, Moon KC
Int J Surg Pathol 2018 May;26(3):221-228. Epub 2017 Nov 26 doi: 10.1177/1066896917742722. PMID: 29172920
Granular cell tumor of the urinary bladder with pseudoepitheliomatous hyperplasia and colocalization with adenocarcinoma.
Eandi JA, Asuncion A, Vandewalker KN, Javidan J
Int J Urol 2007 Sep;14(9):862-4. doi: 10.1111/j.1442-2042.2007.01827.x. PMID: 17760758

Clinical prediction guides

POU2F3-positive small cell carcinoma of the bladder: A clinicopathologic analysis of 4 cases and literature review.
Cai Z, Cheng X, Liao S, Zou W, Li L, Liu F, Huang W
Pathol Res Pract 2024 May;257:155296. Epub 2024 Apr 11 doi: 10.1016/j.prp.2024.155296. PMID: 38615507
Clear cell urothelial carcinoma of the urinary bladder: a case report and review of the literature.
Knez VM, Barrow W, Lucia MS, Wilson S, La Rosa FG
J Med Case Rep 2014 Aug 14;8:275. doi: 10.1186/1752-1947-8-275. PMID: 25124389Free PMC Article
Granular cell tumor of the urinary bladder with pseudoepitheliomatous hyperplasia and colocalization with adenocarcinoma.
Eandi JA, Asuncion A, Vandewalker KN, Javidan J
Int J Urol 2007 Sep;14(9):862-4. doi: 10.1111/j.1442-2042.2007.01827.x. PMID: 17760758
Comparative genomic hybridization study of perivascular epithelioid cell tumor: molecular genetic evidence of perivascular epithelioid cell tumor as a distinctive neoplasm.
Pan CC, Jong YJ, Chai CY, Huang SH, Chen YJ
Hum Pathol 2006 May;37(5):606-12. doi: 10.1016/j.humpath.2006.01.008. PMID: 16647959
Epidermal growth factor in the normal and neoplastic kidney and bladder.
Lau JL, Fowler JE Jr, Ghosh L
J Urol 1988 Jan;139(1):170-5. doi: 10.1016/s0022-5347(17)42347-0. PMID: 3275797

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