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Advanced NUT Carcinoma

MedGen UID:
1704266
•Concept ID:
C5205120
•
Neoplastic Process

Definition

NUT carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced NUT Carcinoma

Professional guidelines

PubMed

Treatment outcomes of unknown primary squamous cell carcinoma of the head and neck.
Hung YH, Liu SA, Wang CC, Wang CP, Jiang RS, Wu SH
PLoS One 2018;13(10):e0205365. Epub 2018 Oct 18 doi: 10.1371/journal.pone.0205365. PMID: 30335795Free PMC Article
Surgical treatment of oral verrucous carcinoma.
Kang CJ, Chang JT, Chen TM, Chen IH, Liao CT
Chang Gung Med J 2003 Nov;26(11):807-12. PMID: 14765750
Oral cancer. The importance of early diagnosis and treatment.
Sciubba JJ
Am J Clin Dermatol 2001;2(4):239-51. doi: 10.2165/00128071-200102040-00005. PMID: 11705251

Recent clinical studies

Etiology

NUT carcinoma in children, adolescents and young adults.
Lemelle L, Moya-Plana A, Dumont B, Fresneau B, Laprie A, Claude L, Deneuve S, Cordero C, Pierron G, Couloigner V, Bernard S, Cardoen L, Brisse HJ, Jehanno N, Metayer L, Fréneaux P, Helfre S, Kolb F, Thariat J, Réguerre Y, Orbach D
Bull Cancer 2022 Apr;109(4):491-504. Epub 2022 Apr 12 doi: 10.1016/j.bulcan.2022.01.015. PMID: 35428456
Overview of oral cavity squamous cell carcinoma: Risk factors, mechanisms, and diagnostics.
Chamoli A, Gosavi AS, Shirwadkar UP, Wangdale KV, Behera SK, Kurrey NK, Kalia K, Mandoli A
Oral Oncol 2021 Oct;121:105451. Epub 2021 Jul 28 doi: 10.1016/j.oraloncology.2021.105451. PMID: 34329869
High-Grade Sinonasal Carcinoma: Classification Through Molecular Profiling.
Guilmette J, Sadow PM
Arch Pathol Lab Med 2019 Nov;143(11):1416-1419. Epub 2019 Feb 19 doi: 10.5858/arpa.2018-0224-RS. PMID: 30779592Free PMC Article
The 2015 World Health Organization Classification of Lung Tumors: Impact of Genetic, Clinical and Radiologic Advances Since the 2004 Classification.
Travis WD, Brambilla E, Nicholson AG, Yatabe Y, Austin JHM, Beasley MB, Chirieac LR, Dacic S, Duhig E, Flieder DB, Geisinger K, Hirsch FR, Ishikawa Y, Kerr KM, Noguchi M, Pelosi G, Powell CA, Tsao MS, Wistuba I; WHO Panel
J Thorac Oncol 2015 Sep;10(9):1243-1260. doi: 10.1097/JTO.0000000000000630. PMID: 26291008
Oral and oropharyngeal cancer.
Huber MA, Tantiwongkosi B
Med Clin North Am 2014 Nov;98(6):1299-321. Epub 2014 Sep 20 doi: 10.1016/j.mcna.2014.08.005. PMID: 25443678

Diagnosis

Overview of oral cavity squamous cell carcinoma: Risk factors, mechanisms, and diagnostics.
Chamoli A, Gosavi AS, Shirwadkar UP, Wangdale KV, Behera SK, Kurrey NK, Kalia K, Mandoli A
Oral Oncol 2021 Oct;121:105451. Epub 2021 Jul 28 doi: 10.1016/j.oraloncology.2021.105451. PMID: 34329869
NUT carcinoma of the lung.
Lantuejoul S, Pissaloux D, Ferretti GR, McLeer A
Semin Diagn Pathol 2021 Sep;38(5):72-82. Epub 2021 Jun 16 doi: 10.1053/j.semdp.2021.06.005. PMID: 34176698
Role of Oral Microbiome Signatures in Diagnosis and Prognosis of Oral Cancer.
Chattopadhyay I, Verma M, Panda M
Technol Cancer Res Treat 2019 Jan 1;18:1533033819867354. doi: 10.1177/1533033819867354. PMID: 31370775Free PMC Article
The 2015 World Health Organization Classification of Lung Tumors: Impact of Genetic, Clinical and Radiologic Advances Since the 2004 Classification.
Travis WD, Brambilla E, Nicholson AG, Yatabe Y, Austin JHM, Beasley MB, Chirieac LR, Dacic S, Duhig E, Flieder DB, Geisinger K, Hirsch FR, Ishikawa Y, Kerr KM, Noguchi M, Pelosi G, Powell CA, Tsao MS, Wistuba I; WHO Panel
J Thorac Oncol 2015 Sep;10(9):1243-1260. doi: 10.1097/JTO.0000000000000630. PMID: 26291008
Oral and oropharyngeal cancer.
Huber MA, Tantiwongkosi B
Med Clin North Am 2014 Nov;98(6):1299-321. Epub 2014 Sep 20 doi: 10.1016/j.mcna.2014.08.005. PMID: 25443678

Therapy

Initial Chemotherapy for Locally Advanced and Metastatic NUT Carcinoma.
Luo J, Sanchez M, Lee E, Hertzler H, Luong N, Mazzola E, Finstein B, Tamen R, Brisbane G, Nguyen T, Paik PK, Chaft JE, Cheng ML, Khalil H, Piha-Paul SA, Sholl LM, Nishino M, Jänne PA, DuBois SG, Hanna GJ, Shapiro GI, French CA
J Thorac Oncol 2024 May;19(5):829-838. Epub 2023 Dec 27 doi: 10.1016/j.jtho.2023.12.022. PMID: 38154515Free PMC Article
Fusion-positive non-small cell lung carcinoma: Biological principles, clinical practice, and diagnostic implications.
Kazdal D, Hofman V, Christopoulos P, Ilié M, Stenzinger A, Hofman P
Genes Chromosomes Cancer 2022 May;61(5):244-260. Epub 2022 Jan 22 doi: 10.1002/gcc.23022. PMID: 34997651
Systemic therapy in non-conventional cancers of the larynx.
Tan E, Mody MD, Saba NF
Oral Oncol 2018 Jul;82:61-68. Epub 2018 May 26 doi: 10.1016/j.oraloncology.2018.05.005. PMID: 29909903
Oral and oropharyngeal cancer.
Huber MA, Tantiwongkosi B
Med Clin North Am 2014 Nov;98(6):1299-321. Epub 2014 Sep 20 doi: 10.1016/j.mcna.2014.08.005. PMID: 25443678
Carcinoma of the head and neck in the HPV era.
Cardesa A, Nadal A
Acta Dermatovenerol Alp Pannonica Adriat 2011 Sep;20(3):161-73. PMID: 22131117

Prognosis

Initial Chemotherapy for Locally Advanced and Metastatic NUT Carcinoma.
Luo J, Sanchez M, Lee E, Hertzler H, Luong N, Mazzola E, Finstein B, Tamen R, Brisbane G, Nguyen T, Paik PK, Chaft JE, Cheng ML, Khalil H, Piha-Paul SA, Sholl LM, Nishino M, Jänne PA, DuBois SG, Hanna GJ, Shapiro GI, French CA
J Thorac Oncol 2024 May;19(5):829-838. Epub 2023 Dec 27 doi: 10.1016/j.jtho.2023.12.022. PMID: 38154515Free PMC Article
NUT carcinoma in children, adolescents and young adults.
Lemelle L, Moya-Plana A, Dumont B, Fresneau B, Laprie A, Claude L, Deneuve S, Cordero C, Pierron G, Couloigner V, Bernard S, Cardoen L, Brisse HJ, Jehanno N, Metayer L, Fréneaux P, Helfre S, Kolb F, Thariat J, Réguerre Y, Orbach D
Bull Cancer 2022 Apr;109(4):491-504. Epub 2022 Apr 12 doi: 10.1016/j.bulcan.2022.01.015. PMID: 35428456
NUT carcinoma of the lung.
Lantuejoul S, Pissaloux D, Ferretti GR, McLeer A
Semin Diagn Pathol 2021 Sep;38(5):72-82. Epub 2021 Jun 16 doi: 10.1053/j.semdp.2021.06.005. PMID: 34176698
Role of Oral Microbiome Signatures in Diagnosis and Prognosis of Oral Cancer.
Chattopadhyay I, Verma M, Panda M
Technol Cancer Res Treat 2019 Jan 1;18:1533033819867354. doi: 10.1177/1533033819867354. PMID: 31370775Free PMC Article
Oral and oropharyngeal cancer.
Huber MA, Tantiwongkosi B
Med Clin North Am 2014 Nov;98(6):1299-321. Epub 2014 Sep 20 doi: 10.1016/j.mcna.2014.08.005. PMID: 25443678

Clinical prediction guides

NUT carcinoma of the lung.
Lantuejoul S, Pissaloux D, Ferretti GR, McLeer A
Semin Diagn Pathol 2021 Sep;38(5):72-82. Epub 2021 Jun 16 doi: 10.1053/j.semdp.2021.06.005. PMID: 34176698
Nut consumption and the prevalence and severity of non-alcoholic fatty liver disease.
Semmler G, Bachmayer S, Wernly S, Wernly B, Niederseer D, Huber-Schönauer U, Stickel F, Aigner E, Datz C
PLoS One 2020;15(12):e0244514. Epub 2020 Dec 31 doi: 10.1371/journal.pone.0244514. PMID: 33382757Free PMC Article
Role of Oral Microbiome Signatures in Diagnosis and Prognosis of Oral Cancer.
Chattopadhyay I, Verma M, Panda M
Technol Cancer Res Treat 2019 Jan 1;18:1533033819867354. doi: 10.1177/1533033819867354. PMID: 31370775Free PMC Article
Clinicopathological and Preclinical Findings of NUT Carcinoma: A Multicenter Study.
Jung M, Kim S, Lee JK, Yoon SO, Park HS, Hong SW, Park WS, Kim JE, Kim J, Keam B, Kim HJ, Kang HJ, Kim DW, Jung KC, Kim YT, Heo DS, Kim TM, Jeon YK
Oncologist 2019 Aug;24(8):e740-e748. Epub 2019 Jan 29 doi: 10.1634/theoncologist.2018-0477. PMID: 30696721Free PMC Article
Diagnostic and Predictive Immunohistochemistry for Non-Small Cell Lung Carcinomas.
Hung YP, Sholl LM
Adv Anat Pathol 2018 Nov;25(6):374-386. doi: 10.1097/PAP.0000000000000206. PMID: 30188361

Recent systematic reviews

A systematic review on the mechanisms of malignant transformation of oral submucous fibrosis.
Phulari RGS, Dave EJ
Eur J Cancer Prev 2020 Sep;29(5):470-473. doi: 10.1097/CEJ.0000000000000575. PMID: 32740174

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