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ASPH-Positive Head and Neck Squamous Cell Carcinoma

MedGen UID:
1705140
•Concept ID:
C5206812
•
Neoplastic Process

Definition

A head and neck squamous cell carcinoma in which the malignant cells are positive for ASPH gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVASPH-Positive Head and Neck Squamous Cell Carcinoma

Professional guidelines

PubMed

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors.
Kuan EC, Wang EW, Adappa ND, Beswick DM, London NR Jr, Su SY, Wang MB, Abuzeid WM, Alexiev B, Alt JA, Antognoni P, Alonso-Basanta M, Batra PS, Bhayani M, Bell D, Bernal-Sprekelsen M, Betz CS, Blay JY, Bleier BS, Bonilla-Velez J, Callejas C, Carrau RL, Casiano RR, Castelnuovo P, Chandra RK, Chatzinakis V, Chen SB, Chiu AG, Choby G, Chowdhury NI, Citardi MJ, Cohen MA, Dagan R, Dalfino G, Dallan I, Dassi CS, de Almeida J, Dei Tos AP, DelGaudio JM, Ebert CS, El-Sayed IH, Eloy JA, Evans JJ, Fang CH, Farrell NF, Ferrari M, Fischbein N, Folbe A, Fokkens WJ, Fox MG, Lund VJ, Gallia GL, Gardner PA, Geltzeiler M, Georgalas C, Getz AE, Govindaraj S, Gray ST, Grayson JW, Gross BA, Grube JG, Guo R, Ha PK, Halderman AA, Hanna EY, Harvey RJ, Hernandez SC, Holtzman AL, Hopkins C, Huang Z, Huang Z, Humphreys IM, Hwang PH, Iloreta AM, Ishii M, Ivan ME, Jafari A, Kennedy DW, Khan M, Kimple AJ, Kingdom TT, Knisely A, Kuo YJ, Lal D, Lamarre ED, Lan MY, Le H, Lechner M, Lee NY, Lee JK, Lee VH, Levine CG, Lin JC, Lin DT, Lobo BC, Locke T, Luong AU, Magliocca KR, Markovic SN, Matnjani G, McKean EL, Meço C, Mendenhall WM, Michel L, Na'ara S, Nicolai P, Nuss DW, Nyquist GG, Oakley GM, Omura K, Orlandi RR, Otori N, Papagiannopoulos P, Patel ZM, Pfister DG, Phan J, Psaltis AJ, Rabinowitz MR, Ramanathan M Jr, Rimmer R, Rosen MR, Sanusi O, Sargi ZB, Schafhausen P, Schlosser RJ, Sedaghat AR, Senior BA, Shrivastava R, Sindwani R, Smith TL, Smith KA, Snyderman CH, Solares CA, Sreenath SB, Stamm A, Stölzel K, Sumer B, Surda P, Tajudeen BA, Thompson LDR, Thorp BD, Tong CCL, Tsang RK, Turner JH, Turri-Zanoni M, Udager AM, van Zele T, VanKoevering K, Welch KC, Wise SK, Witterick IJ, Won TB, Wong SN, Woodworth BA, Wormald PJ, Yao WC, Yeh CF, Zhou B, Palmer JN
Int Forum Allergy Rhinol 2024 Feb;14(2):149-608. Epub 2024 Jan 2 doi: 10.1002/alr.23262. PMID: 37658764
HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management.
Lechner M, Liu J, Masterson L, Fenton TR
Nat Rev Clin Oncol 2022 May;19(5):306-327. Epub 2022 Feb 1 doi: 10.1038/s41571-022-00603-7. PMID: 35105976Free PMC Article
Delineation of the primary tumour Clinical Target Volumes (CTV-P) in laryngeal, hypopharyngeal, oropharyngeal and oral cavity squamous cell carcinoma: AIRO, CACA, DAHANCA, EORTC, GEORCC, GORTEC, HKNPCSG, HNCIG, IAG-KHT, LPRHHT, NCIC CTG, NCRI, NRG Oncology, PHNS, SBRT, SOMERA, SRO, SSHNO, TROG consensus guidelines.
Grégoire V, Evans M, Le QT, Bourhis J, Budach V, Chen A, Eisbruch A, Feng M, Giralt J, Gupta T, Hamoir M, Helito JK, Hu C, Hunter K, Johansen J, Kaanders J, Laskar SG, Lee A, Maingon P, Mäkitie A, Micciche' F, Nicolai P, O'Sullivan B, Poitevin A, Porceddu S, Składowski K, Tribius S, Waldron J, Wee J, Yao M, Yom SS, Zimmermann F, Grau C
Radiother Oncol 2018 Jan;126(1):3-24. Epub 2017 Nov 24 doi: 10.1016/j.radonc.2017.10.016. PMID: 29180076

Recent clinical studies

Etiology

Overview of oral cavity squamous cell carcinoma: Risk factors, mechanisms, and diagnostics.
Chamoli A, Gosavi AS, Shirwadkar UP, Wangdale KV, Behera SK, Kurrey NK, Kalia K, Mandoli A
Oral Oncol 2021 Oct;121:105451. Epub 2021 Jul 28 doi: 10.1016/j.oraloncology.2021.105451. PMID: 34329869
An Immune-Related Gene Prognostic Index for Head and Neck Squamous Cell Carcinoma.
Chen Y, Li ZY, Zhou GQ, Sun Y
Clin Cancer Res 2021 Jan 1;27(1):330-341. Epub 2020 Oct 23 doi: 10.1158/1078-0432.CCR-20-2166. PMID: 33097495
Squamous cell carcinoma of head and neck: what internists should know.
Jung K, Narwal M, Min SY, Keam B, Kang H
Korean J Intern Med 2020 Sep;35(5):1031-1044. Epub 2020 Jul 14 doi: 10.3904/kjim.2020.078. PMID: 32663913Free PMC Article
Head and Neck Cancer International Group (HNCIG) Consensus Guidelines for the Delivery of Postoperative Radiation Therapy in Complex Cutaneous Squamous Cell Carcinoma of the Head and Neck (cSCCHN).
Porceddu SV, Daniels C, Yom SS, Liu H, Waldron J, Gregoire V, Moore A, Veness M, Yao M, Johansen J, Mehanna H, Rischin D, Le QT
Int J Radiat Oncol Biol Phys 2020 Jul 15;107(4):641-651. Epub 2020 Apr 11 doi: 10.1016/j.ijrobp.2020.03.024. PMID: 32289475
Head and neck squamous cell carcinoma: Genomics and emerging biomarkers for immunomodulatory cancer treatments.
Solomon B, Young RJ, Rischin D
Semin Cancer Biol 2018 Oct;52(Pt 2):228-240. Epub 2018 Jan 31 doi: 10.1016/j.semcancer.2018.01.008. PMID: 29355614

Diagnosis

Treating Head and Neck Cancer in the Age of Immunotherapy: A 2023 Update.
Bhatia A, Burtness B
Drugs 2023 Feb;83(3):217-248. Epub 2023 Jan 16 doi: 10.1007/s40265-023-01835-2. PMID: 36645621
Overview of oral cavity squamous cell carcinoma: Risk factors, mechanisms, and diagnostics.
Chamoli A, Gosavi AS, Shirwadkar UP, Wangdale KV, Behera SK, Kurrey NK, Kalia K, Mandoli A
Oral Oncol 2021 Oct;121:105451. Epub 2021 Jul 28 doi: 10.1016/j.oraloncology.2021.105451. PMID: 34329869
Current Trends and Future Prospects of Molecular Targeted Therapy in Head and Neck Squamous Cell Carcinoma.
Kitamura N, Sento S, Yoshizawa Y, Sasabe E, Kudo Y, Yamamoto T
Int J Mol Sci 2020 Dec 29;22(1) doi: 10.3390/ijms22010240. PMID: 33383632Free PMC Article
Head and neck squamous cell carcinoma.
Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR
Nat Rev Dis Primers 2020 Nov 26;6(1):92. doi: 10.1038/s41572-020-00224-3. PMID: 33243986Free PMC Article
Squamous cell carcinoma of head and neck: what internists should know.
Jung K, Narwal M, Min SY, Keam B, Kang H
Korean J Intern Med 2020 Sep;35(5):1031-1044. Epub 2020 Jul 14 doi: 10.3904/kjim.2020.078. PMID: 32663913Free PMC Article

Therapy

Treating Head and Neck Cancer in the Age of Immunotherapy: A 2023 Update.
Bhatia A, Burtness B
Drugs 2023 Feb;83(3):217-248. Epub 2023 Jan 16 doi: 10.1007/s40265-023-01835-2. PMID: 36645621
Improving head and neck cancer therapies by immunomodulation of the tumour microenvironment.
Ruffin AT, Li H, Vujanovic L, Zandberg DP, Ferris RL, Bruno TC
Nat Rev Cancer 2023 Mar;23(3):173-188. Epub 2022 Dec 1 doi: 10.1038/s41568-022-00531-9. PMID: 36456755Free PMC Article
Neoadjuvant immunotherapy with nivolumab and ipilimumab induces major pathological responses in patients with head and neck squamous cell carcinoma.
Vos JL, Elbers JBW, Krijgsman O, Traets JJH, Qiao X, van der Leun AM, Lubeck Y, Seignette IM, Smit LA, Willems SM, van den Brekel MWM, Dirven R, Baris Karakullukcu M, Karssemakers L, Klop WMC, Lohuis PJFM, Schreuder WH, Smeele LE, van der Velden LA, Bing Tan I, Onderwater S, Jasperse B, Vogel WV, Al-Mamgani A, Keijser A, van der Noort V, Broeks A, Hooijberg E, Peeper DS, Schumacher TN, Blank CU, de Boer JP, Haanen JBAG, Zuur CL
Nat Commun 2021 Dec 22;12(1):7348. doi: 10.1038/s41467-021-26472-9. PMID: 34937871Free PMC Article
Current Trends and Future Prospects of Molecular Targeted Therapy in Head and Neck Squamous Cell Carcinoma.
Kitamura N, Sento S, Yoshizawa Y, Sasabe E, Kudo Y, Yamamoto T
Int J Mol Sci 2020 Dec 29;22(1) doi: 10.3390/ijms22010240. PMID: 33383632Free PMC Article
Head and neck squamous cell carcinoma.
Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR
Nat Rev Dis Primers 2020 Nov 26;6(1):92. doi: 10.1038/s41572-020-00224-3. PMID: 33243986Free PMC Article

Prognosis

An Immunogenic Cell Death-Related Classification Predicts Prognosis and Response to Immunotherapy in Head and Neck Squamous Cell Carcinoma.
Wang X, Wu S, Liu F, Ke D, Wang X, Pan D, Xu W, Zhou L, He W
Front Immunol 2021;12:781466. Epub 2021 Nov 19 doi: 10.3389/fimmu.2021.781466. PMID: 34868055Free PMC Article
An Immune-Related Gene Prognostic Index for Head and Neck Squamous Cell Carcinoma.
Chen Y, Li ZY, Zhou GQ, Sun Y
Clin Cancer Res 2021 Jan 1;27(1):330-341. Epub 2020 Oct 23 doi: 10.1158/1078-0432.CCR-20-2166. PMID: 33097495
Head and neck squamous cell carcinoma.
Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR
Nat Rev Dis Primers 2020 Nov 26;6(1):92. doi: 10.1038/s41572-020-00224-3. PMID: 33243986Free PMC Article
Long-term Survival in Head and Neck Cancer: Impact of Site, Stage, Smoking, and Human Papillomavirus Status.
Du E, Mazul AL, Farquhar D, Brennan P, Anantharaman D, Abedi-Ardekani B, Weissler MC, Hayes DN, Olshan AF, Zevallos JP
Laryngoscope 2019 Nov;129(11):2506-2513. Epub 2019 Jan 13 doi: 10.1002/lary.27807. PMID: 30637762Free PMC Article
Head and neck squamous cell carcinoma: Genomics and emerging biomarkers for immunomodulatory cancer treatments.
Solomon B, Young RJ, Rischin D
Semin Cancer Biol 2018 Oct;52(Pt 2):228-240. Epub 2018 Jan 31 doi: 10.1016/j.semcancer.2018.01.008. PMID: 29355614

Clinical prediction guides

Pharmacogenomic landscape of head and neck squamous cell carcinoma informs precision oncology therapy.
Gu Z, Yao Y, Yang G, Zhu G, Tian Z, Wang R, Wu Q, Wang Y, Wu Y, Chen L, Wang C, Gao J, Kang X, Zhang J, Wang L, Duan S, Zhao Z, Zhang Z, Sun S
Sci Transl Med 2022 Sep 7;14(661):eabo5987. doi: 10.1126/scitranslmed.abo5987. PMID: 36070368
An Immunogenic Cell Death-Related Classification Predicts Prognosis and Response to Immunotherapy in Head and Neck Squamous Cell Carcinoma.
Wang X, Wu S, Liu F, Ke D, Wang X, Pan D, Xu W, Zhou L, He W
Front Immunol 2021;12:781466. Epub 2021 Nov 19 doi: 10.3389/fimmu.2021.781466. PMID: 34868055Free PMC Article
An Immune-Related Gene Prognostic Index for Head and Neck Squamous Cell Carcinoma.
Chen Y, Li ZY, Zhou GQ, Sun Y
Clin Cancer Res 2021 Jan 1;27(1):330-341. Epub 2020 Oct 23 doi: 10.1158/1078-0432.CCR-20-2166. PMID: 33097495
Head and neck squamous cell carcinoma.
Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR
Nat Rev Dis Primers 2020 Nov 26;6(1):92. doi: 10.1038/s41572-020-00224-3. PMID: 33243986Free PMC Article
Head and neck squamous cell carcinoma: Genomics and emerging biomarkers for immunomodulatory cancer treatments.
Solomon B, Young RJ, Rischin D
Semin Cancer Biol 2018 Oct;52(Pt 2):228-240. Epub 2018 Jan 31 doi: 10.1016/j.semcancer.2018.01.008. PMID: 29355614

Recent systematic reviews

Oral squamous cell carcinoma around dental implants: a systematic review.
Ramos JC, Dos Santos ES, Normando AGC, Alves FA, Kowalski LP, Santos-Silva AR, Vargas PA, Lopes MA
Oral Surg Oral Med Oral Pathol Oral Radiol 2021 Jun;131(6):660-674. Epub 2021 Jan 27 doi: 10.1016/j.oooo.2021.01.019. PMID: 33653646
Paediatric laryngeal squamous cell carcinoma: Systematic review and pooled analysis.
Mur T, Jaleel Z, Agarwal P, Edwards H, Levi JR
Clin Otolaryngol 2021 May;46(3):494-500. Epub 2021 Feb 2 doi: 10.1111/coa.13719. PMID: 33475248
Human papillomavirus infection and oral squamous cell carcinoma - a systematic review.
Melo BAC, Vilar LG, Oliveira NR, Lima PO, Pinheiro MB, Domingueti CP, Pereira MC
Braz J Otorhinolaryngol 2021 May-Jun;87(3):346-352. Epub 2020 Nov 29 doi: 10.1016/j.bjorl.2020.10.017. PMID: 33339760Free PMC Article
Head and neck cancer patient-derived xenograft models - A systematic review.
Schuch LF, Silveira FM, Wagner VP, Borgato GB, Rocha GZ, Castilho RM, Vargas PA, Martins MD
Crit Rev Oncol Hematol 2020 Nov;155:103087. Epub 2020 Sep 1 doi: 10.1016/j.critrevonc.2020.103087. PMID: 32992152
Association Between Marijuana Use and Risk of Cancer: A Systematic Review and Meta-analysis.
Ghasemiesfe M, Barrow B, Leonard S, Keyhani S, Korenstein D
JAMA Netw Open 2019 Nov 1;2(11):e1916318. doi: 10.1001/jamanetworkopen.2019.16318. PMID: 31774524Free PMC Article

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