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Malignant Retropharyngeal Neoplasm

MedGen UID:
1706499
•Concept ID:
C5206838
•
Neoplastic Process

Definition

A primary or metastatic malignant neoplasm that affects the retropharyngeal space. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Retropharyngeal Neoplasm

Professional guidelines

PubMed

Management of Retropharyngeal Lymph Node Metastases in Differentiated Thyroid Carcinoma.
Harries V, McGill M, Tuttle RM, Shaha AR, Wong RJ, Shah JP, Patel SG, Ganly I
Thyroid 2020 May;30(5):688-695. Epub 2020 Feb 7 doi: 10.1089/thy.2019.0359. PMID: 31910129Free PMC Article
Evaluation and management of neck masses in children.
Meier JD, Grimmer JF
Am Fam Physician 2014 Mar 1;89(5):353-8. PMID: 24695506
Metastatic retropharyngeal lymph nodes in nasopharyngeal carcinoma: imaging criteria.
Sharma M, Bartlett E, Yu E
Expert Rev Anticancer Ther 2010 Nov;10(11):1703-6. doi: 10.1586/era.10.159. PMID: 21080798

Recent clinical studies

Etiology

Prevalence and risk factors for retropharyngeal and retro-styloid lymph node metastasis in hypopharyngeal carcinoma.
Toya R, Matsuyama T, Saito T, Fukugawa Y, Watakabe T, Shiraishi S, Murakami D, Orita Y, Hirai T, Oya N
Radiat Oncol 2023 Aug 11;18(1):134. doi: 10.1186/s13014-023-02322-4. PMID: 37568173Free PMC Article
Medial retropharyngeal nodal region sparing radiotherapy versus standard radiotherapy in patients with nasopharyngeal carcinoma: open label, non-inferiority, multicentre, randomised, phase 3 trial.
Mao YP, Wang SX, Gao TS, Zhang N, Liang XY, Xie FY, Zhang Y, Zhou GQ, Guo R, Luo WJ, Li YJ, Liang SQ, Lin L, Li WF, Liu X, Xu C, Chen YP, Lv JW, Huang SH, Liu LZ, Li JB, Tang LL, Chen L, Sun Y, Ma J
BMJ 2023 Feb 6;380:e072133. doi: 10.1136/bmj-2022-072133. PMID: 36746459Free PMC Article
Elective upper-neck versus whole-neck irradiation of the uninvolved neck in patients with nasopharyngeal carcinoma: an open-label, non-inferiority, multicentre, randomised phase 3 trial.
Tang LL, Huang CL, Zhang N, Jiang W, Wu YS, Huang SH, Mao YP, Liu Q, Li JB, Liang SQ, Qin GJ, Hu WH, Sun Y, Xie FY, Chen L, Zhou GQ, Ma J
Lancet Oncol 2022 Apr;23(4):479-490. Epub 2022 Feb 28 doi: 10.1016/S1470-2045(22)00058-4. PMID: 35240053
Retropharyngeal Internal Carotid Artery Management in TORS Using Microvascular Reconstruction.
Parhar HS, Brody RM, Shimunov D, Rajasekaran K, Rassekh CH, Basu D, O'Malley BW Jr, Chalian AA, Newman JG, Loevner L, Lazor JW, Weinstein GS, Cannady SB
Laryngoscope 2021 Mar;131(3):E821-E827. Epub 2020 Jul 4 doi: 10.1002/lary.28876. PMID: 32621638
Intravoxel incoherent motion diffusion-weighted imaging for discrimination of benign and malignant retropharyngeal nodes.
So TY, Ai QH, Lam WKJ, Qamar S, Poon DMC, Hui EP, Mo FKF, Chan KCA, King AD
Neuroradiology 2020 Dec;62(12):1667-1676. Epub 2020 Jul 16 doi: 10.1007/s00234-020-02494-w. PMID: 32676831

Diagnosis

Medial retropharyngeal nodal region sparing radiotherapy versus standard radiotherapy in patients with nasopharyngeal carcinoma: open label, non-inferiority, multicentre, randomised, phase 3 trial.
Mao YP, Wang SX, Gao TS, Zhang N, Liang XY, Xie FY, Zhang Y, Zhou GQ, Guo R, Luo WJ, Li YJ, Liang SQ, Lin L, Li WF, Liu X, Xu C, Chen YP, Lv JW, Huang SH, Liu LZ, Li JB, Tang LL, Chen L, Sun Y, Ma J
BMJ 2023 Feb 6;380:e072133. doi: 10.1136/bmj-2022-072133. PMID: 36746459Free PMC Article
Pitfalls in the staging of cancer of thyroid.
Saindane AM
Neuroimaging Clin N Am 2013 Feb;23(1):123-45. doi: 10.1016/j.nic.2012.08.010. PMID: 23199665
Retropharyngeal and prevertebral spaces: anatomic imaging and diagnosis.
Debnam JM, Guha-Thakurta N
Otolaryngol Clin North Am 2012 Dec;45(6):1293-310. doi: 10.1016/j.otc.2012.08.004. PMID: 23153750Free PMC Article
Oral cavity and pharynx.
Yousem DM, Chalian AA
Radiol Clin North Am 1998 Sep;36(5):967-81, vii. doi: 10.1016/s0033-8389(05)70071-3. PMID: 9747196
Parapharyngeal and retropharyngeal space diseases.
Batsakis JG, Sneige N
Ann Otol Rhinol Laryngol 1989 Apr;98(4 Pt 1):320-1. doi: 10.1177/000348948909800416. PMID: 2650597

Therapy

Medial retropharyngeal nodal region sparing radiotherapy versus standard radiotherapy in patients with nasopharyngeal carcinoma: open label, non-inferiority, multicentre, randomised, phase 3 trial.
Mao YP, Wang SX, Gao TS, Zhang N, Liang XY, Xie FY, Zhang Y, Zhou GQ, Guo R, Luo WJ, Li YJ, Liang SQ, Lin L, Li WF, Liu X, Xu C, Chen YP, Lv JW, Huang SH, Liu LZ, Li JB, Tang LL, Chen L, Sun Y, Ma J
BMJ 2023 Feb 6;380:e072133. doi: 10.1136/bmj-2022-072133. PMID: 36746459Free PMC Article
Elective upper-neck versus whole-neck irradiation of the uninvolved neck in patients with nasopharyngeal carcinoma: an open-label, non-inferiority, multicentre, randomised phase 3 trial.
Tang LL, Huang CL, Zhang N, Jiang W, Wu YS, Huang SH, Mao YP, Liu Q, Li JB, Liang SQ, Qin GJ, Hu WH, Sun Y, Xie FY, Chen L, Zhou GQ, Ma J
Lancet Oncol 2022 Apr;23(4):479-490. Epub 2022 Feb 28 doi: 10.1016/S1470-2045(22)00058-4. PMID: 35240053
Retropharyngeal abscess after chemotherapy.
Mettias B, Robertson S, Buchanan MA
BMJ Case Rep 2018 Mar 5;2018 doi: 10.1136/bcr-2017-222610. PMID: 29507016Free PMC Article
Management of retropharyngeal node metastases from thyroid carcinoma.
Hartl DM, Leboulleux S, Vélayoudom-Céphise FL, Mirghani H, Déandréis D, Schlumberger M
World J Surg 2015 May;39(5):1274-81. doi: 10.1007/s00268-015-2947-2. PMID: 25585526
Hypopharyngeal carcinoma.
Hinerman RW, Amdur RJ, Mendenhall WM, Villaret DB, Robbins KT
Curr Treat Options Oncol 2002 Feb;3(1):41-9. doi: 10.1007/s11864-002-0040-1. PMID: 12057086

Prognosis

Integrating pretreatment MRI-detected nodal features and Epstein-Barr virus DNA to identify optimal candidates for intensity-modulated radiotherapy alone in patients with stage II nasopharyngeal carcinoma.
Guo J, He Y, Lin C, Jiang Q, Xing HW, Zhang YC, Shen GZ, Lin HX, Guo L, Yang Q
Oral Oncol 2023 Nov;146:106574. Epub 2023 Sep 22 doi: 10.1016/j.oraloncology.2023.106574. PMID: 37741017
Prognostic nomograms for nasopharyngeal carcinoma with nodal features and potential indication for N staging system: Validation and comparison of seven N stage schemes.
Peng WS, Xing X, Li YJ, Ding JH, Mo M, Xu TT, Zhou X, Hu CS
Oral Oncol 2023 Sep;144:106438. Epub 2023 Jul 10 doi: 10.1016/j.oraloncology.2023.106438. PMID: 37437499
Patterns and prognosis of regional recurrence in nasopharyngeal carcinoma after intensity-modulated radiotherapy.
Xiao XT, Wu YS, Chen YP, Liu X, Guo R, Tang LL, Ma J, Li WF
Cancer Med 2023 Jan;12(2):1399-1408. Epub 2022 Jul 13 doi: 10.1002/cam4.5020. PMID: 35822664Free PMC Article
Prevalence, prognosis, and treatment implications of retropharyngeal nodes in unknown primary head and neck carcinoma.
Horowitz G, Hosni A, Yu E, Xu W, Lu L, Au M, Dixon PR, Brown D, Chepeha DB, Gilbert RW, Goldstein DP, Gullane PJ, Irish JC, Bayley A, Cho J, Giuliani M, Huang SH, Hope A, Kim J, O'Sullivan B, Ringash J, Waldron J, Weinreb I, Perez-Ordonez B, Bratman SV, de Almeida JR
Oral Oncol 2018 Jul;82:162-167. Epub 2018 Jun 1 doi: 10.1016/j.oraloncology.2018.05.023. PMID: 29909891
Imaging of Anaplastic Thyroid Carcinoma.
Ahmed S, Ghazarian MP, Cabanillas ME, Zafereo ME, Williams MD, Vu T, Schomer DF, Debnam JM
AJNR Am J Neuroradiol 2018 Mar;39(3):547-551. Epub 2017 Dec 14 doi: 10.3174/ajnr.A5487. PMID: 29242360Free PMC Article

Clinical prediction guides

Integrating pretreatment MRI-detected nodal features and Epstein-Barr virus DNA to identify optimal candidates for intensity-modulated radiotherapy alone in patients with stage II nasopharyngeal carcinoma.
Guo J, He Y, Lin C, Jiang Q, Xing HW, Zhang YC, Shen GZ, Lin HX, Guo L, Yang Q
Oral Oncol 2023 Nov;146:106574. Epub 2023 Sep 22 doi: 10.1016/j.oraloncology.2023.106574. PMID: 37741017
Prognostic nomograms for nasopharyngeal carcinoma with nodal features and potential indication for N staging system: Validation and comparison of seven N stage schemes.
Peng WS, Xing X, Li YJ, Ding JH, Mo M, Xu TT, Zhou X, Hu CS
Oral Oncol 2023 Sep;144:106438. Epub 2023 Jul 10 doi: 10.1016/j.oraloncology.2023.106438. PMID: 37437499
Medial retropharyngeal nodal region sparing radiotherapy versus standard radiotherapy in patients with nasopharyngeal carcinoma: open label, non-inferiority, multicentre, randomised, phase 3 trial.
Mao YP, Wang SX, Gao TS, Zhang N, Liang XY, Xie FY, Zhang Y, Zhou GQ, Guo R, Luo WJ, Li YJ, Liang SQ, Lin L, Li WF, Liu X, Xu C, Chen YP, Lv JW, Huang SH, Liu LZ, Li JB, Tang LL, Chen L, Sun Y, Ma J
BMJ 2023 Feb 6;380:e072133. doi: 10.1136/bmj-2022-072133. PMID: 36746459Free PMC Article
Prevalence and prognostic impact of retropharyngeal lymph nodes metastases in oropharyngeal squamous cell carcinoma: Meta-analysis of published literature.
Tirelli G, Gardenal N, Zanelli E, Borsetto D, Phillips V, Marcuzzo AV, Fussey J, Polesel J, Boscolo-Rizzo P
Head Neck 2022 Oct;44(10):2265-2276. Epub 2022 Aug 1 doi: 10.1002/hed.27166. PMID: 35913029Free PMC Article
Elective upper-neck versus whole-neck irradiation of the uninvolved neck in patients with nasopharyngeal carcinoma: an open-label, non-inferiority, multicentre, randomised phase 3 trial.
Tang LL, Huang CL, Zhang N, Jiang W, Wu YS, Huang SH, Mao YP, Liu Q, Li JB, Liang SQ, Qin GJ, Hu WH, Sun Y, Xie FY, Chen L, Zhou GQ, Ma J
Lancet Oncol 2022 Apr;23(4):479-490. Epub 2022 Feb 28 doi: 10.1016/S1470-2045(22)00058-4. PMID: 35240053

Recent systematic reviews

Performance of axial diameter on MR imaging for identification of retropharyngeal lymph node metastases in head and neck cancer: a systematic review and meta-analysis.
Baba A, Kurokawa R, Kurokawa M, Rivera-de Choudens R, Srinivasan A
Neuroradiology 2023 Sep;65(9):1363-1369. Epub 2023 Jul 31 doi: 10.1007/s00234-023-03205-x. PMID: 37522935
Prevalence and prognostic impact of retropharyngeal lymph nodes metastases in oropharyngeal squamous cell carcinoma: Meta-analysis of published literature.
Tirelli G, Gardenal N, Zanelli E, Borsetto D, Phillips V, Marcuzzo AV, Fussey J, Polesel J, Boscolo-Rizzo P
Head Neck 2022 Oct;44(10):2265-2276. Epub 2022 Aug 1 doi: 10.1002/hed.27166. PMID: 35913029Free PMC Article
Retropharyngeal lymph node metastasis in oral cancer. Systematic review and survival analysis.
Abdelrahman A, McGoldrick D, Aggarwal A, Idle MR, Praveen P, Martin T, Parmar S
Br J Oral Maxillofac Surg 2022 Jun;60(5):563-569. Epub 2021 Jun 10 doi: 10.1016/j.bjoms.2021.06.001. PMID: 35337688
Metastatic thyroid carcinoma to the parapharyngeal and retropharyngeal spaces: Systematic review with seven newly reported cases describing an uncommon presentation of a common disease.
Sandler ML, Xing MH, Levy JC, Chai RL, Khorsandi AS, Gonzalez-Velazquez C, Urken ML
Head Neck 2021 Apr;43(4):1331-1344. Epub 2020 Dec 9 doi: 10.1002/hed.26572. PMID: 33295689
Hybrid PET/MRI in major cancers: a scoping review.
Morsing A, Hildebrandt MG, Vilstrup MH, Wallenius SE, Gerke O, Petersen H, Johansen A, Andersen TL, Høilund-Carlsen PF
Eur J Nucl Med Mol Imaging 2019 Sep;46(10):2138-2151. Epub 2019 Jul 2 doi: 10.1007/s00259-019-04402-8. PMID: 31267161

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