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Classical Leptomeningeal Disease Finding

MedGen UID:
1706924
•Concept ID:
C5206872
•
Finding
Synonym: Classical Leptomeningeal Disease

Definition

A finding of diffuse spread of neoplastic cells to the leptomeninges that may be characterized by thin, linear leptomeningeal enhancement in the central nervous system on MRI. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVClassical Leptomeningeal Disease Finding

Professional guidelines

PubMed

Medulloblastoma in adults: an analysis of clinico-pathological, molecular and treatment factors.
Franchino F, Morra I, Forni M, Bertero L, Zanini C, Roveta F, Ricardi U, Mantovani C, Carpaneto A, Migliore E, Pellerino A, Ferrio F, Cassoni P, Garbossa D, Soffietti R, Rudà R
J Neurosurg Sci 2024 Jun;68(3):260-269. Epub 2021 Nov 11 doi: 10.23736/S0390-5616.21.05548-X. PMID: 34763393
Diagnostic Criteria and Treatment Algorithm for Susac Syndrome.
Egan RA
J Neuroophthalmol 2019 Mar;39(1):60-67. doi: 10.1097/WNO.0000000000000677. PMID: 29933288
Susac Syndrome: A differential diagnosis of white matter lesions.
Marrodan M, Correale J, Alessandro L, Amaya M, Fracaro ME, Köhler AA, Fiol M
Mult Scler Relat Disord 2017 Jul;15:42-46. Epub 2017 May 3 doi: 10.1016/j.msard.2017.04.007. PMID: 28641772

Recent clinical studies

Etiology

Identification of risk factors associated with leptomeningeal disease after resection of brain metastases.
Morshed RA, Saggi S, Cummins DD, Molinaro AM, Young JS, Viner JA, Villanueva-Meyer JE, Goldschmidt E, Boreta L, Braunstein SE, Chang EF, McDermott MW, Berger MS, Theodosopoulos PV, Hervey-Jumper SL, Aghi MK, Daras M
J Neurosurg 2023 Aug 1;139(2):402-413. Epub 2023 Jan 13 doi: 10.3171/2022.12.JNS221490. PMID: 36640095
Preoperative Radiosurgery for Resected Brain Metastases: The PROPS-BM Multicenter Cohort Study.
Prabhu RS, Dhakal R, Vaslow ZK, Dan T, Mishra MV, Murphy ES, Patel TR, Asher AL, Yang K, Manning MA, Stern JD, Patel AR, Wardak Z, Woodworth GF, Chao ST, Mohammadi A, Burri SH
Int J Radiat Oncol Biol Phys 2021 Nov 1;111(3):764-772. Epub 2021 May 29 doi: 10.1016/j.ijrobp.2021.05.124. PMID: 34058254
Stereotactic Radiosurgery for Resected Brain Metastases: Single-Institutional Experience of Over 500 Cavities.
Shi S, Sandhu N, Jin MC, Wang E, Jaoude JA, Schofield K, Zhang C, Liu E, Gibbs IC, Hancock SL, Chang SD, Li G, Hayden-Gephart M, Adler JR, Soltys SG, Pollom EL
Int J Radiat Oncol Biol Phys 2020 Mar 15;106(4):764-771. Epub 2019 Nov 27 doi: 10.1016/j.ijrobp.2019.11.022. PMID: 31785338
Predictors of leptomeningeal disease following hypofractionated stereotactic radiotherapy for intact and resected brain metastases.
Nguyen TK, Sahgal A, Detsky J, Atenafu EG, Myrehaug S, Tseng CL, Husain Z, Heyn C, Maralani P, Ruschin M, Perry J, Soliman H
Neuro Oncol 2020 Jan 11;22(1):84-93. doi: 10.1093/neuonc/noz144. PMID: 31412120Free PMC Article
Vitiligo: Not Simply a Skin Disease.
Ahluwalia J, Correa-Selm LM, Rao BK
Skinmed 2017;15(2):125-127. Epub 2017 Apr 1 PMID: 28528606

Diagnosis

Tuberculosis revisted: classic imaging findings in childhood.
Mahomed N, Kilborn T, Smit EJ, Chu WCW, Young CYM, Koranteng N, Kasznia-Brown J, Winant AJ, Lee EY, Sodhi KS
Pediatr Radiol 2023 Aug;53(9):1799-1828. Epub 2023 May 23 doi: 10.1007/s00247-023-05648-z. PMID: 37217783Free PMC Article
Predictors of leptomeningeal disease following hypofractionated stereotactic radiotherapy for intact and resected brain metastases.
Nguyen TK, Sahgal A, Detsky J, Atenafu EG, Myrehaug S, Tseng CL, Husain Z, Heyn C, Maralani P, Ruschin M, Perry J, Soliman H
Neuro Oncol 2020 Jan 11;22(1):84-93. doi: 10.1093/neuonc/noz144. PMID: 31412120Free PMC Article
Diagnostic Criteria and Treatment Algorithm for Susac Syndrome.
Egan RA
J Neuroophthalmol 2019 Mar;39(1):60-67. doi: 10.1097/WNO.0000000000000677. PMID: 29933288
Vitiligo: Not Simply a Skin Disease.
Ahluwalia J, Correa-Selm LM, Rao BK
Skinmed 2017;15(2):125-127. Epub 2017 Apr 1 PMID: 28528606
Patterns of contrast enhancement in the brain and meninges.
Smirniotopoulos JG, Murphy FM, Rushing EJ, Rees JH, Schroeder JW
Radiographics 2007 Mar-Apr;27(2):525-51. doi: 10.1148/rg.272065155. PMID: 17374867

Therapy

Identification of risk factors associated with leptomeningeal disease after resection of brain metastases.
Morshed RA, Saggi S, Cummins DD, Molinaro AM, Young JS, Viner JA, Villanueva-Meyer JE, Goldschmidt E, Boreta L, Braunstein SE, Chang EF, McDermott MW, Berger MS, Theodosopoulos PV, Hervey-Jumper SL, Aghi MK, Daras M
J Neurosurg 2023 Aug 1;139(2):402-413. Epub 2023 Jan 13 doi: 10.3171/2022.12.JNS221490. PMID: 36640095
Diffuse leptomeningeal glioneuronal tumour (DLGNT) in children: the emerging role of genomic analysis.
Manoharan N, Ajuyah P, Senapati A, Wong M, Mullins A, Rodriguez M, Doyle H, McCowage G, Lau LMS, Ekert PG, Ziegler DS
Acta Neuropathol Commun 2021 Sep 7;9(1):147. doi: 10.1186/s40478-021-01248-w. PMID: 34493325Free PMC Article
Preoperative Radiosurgery for Resected Brain Metastases: The PROPS-BM Multicenter Cohort Study.
Prabhu RS, Dhakal R, Vaslow ZK, Dan T, Mishra MV, Murphy ES, Patel TR, Asher AL, Yang K, Manning MA, Stern JD, Patel AR, Wardak Z, Woodworth GF, Chao ST, Mohammadi A, Burri SH
Int J Radiat Oncol Biol Phys 2021 Nov 1;111(3):764-772. Epub 2021 May 29 doi: 10.1016/j.ijrobp.2021.05.124. PMID: 34058254
Stereotactic Radiosurgery for Resected Brain Metastases: Single-Institutional Experience of Over 500 Cavities.
Shi S, Sandhu N, Jin MC, Wang E, Jaoude JA, Schofield K, Zhang C, Liu E, Gibbs IC, Hancock SL, Chang SD, Li G, Hayden-Gephart M, Adler JR, Soltys SG, Pollom EL
Int J Radiat Oncol Biol Phys 2020 Mar 15;106(4):764-771. Epub 2019 Nov 27 doi: 10.1016/j.ijrobp.2019.11.022. PMID: 31785338
Diagnostic Criteria and Treatment Algorithm for Susac Syndrome.
Egan RA
J Neuroophthalmol 2019 Mar;39(1):60-67. doi: 10.1097/WNO.0000000000000677. PMID: 29933288

Prognosis

Tuberculosis revisted: classic imaging findings in childhood.
Mahomed N, Kilborn T, Smit EJ, Chu WCW, Young CYM, Koranteng N, Kasznia-Brown J, Winant AJ, Lee EY, Sodhi KS
Pediatr Radiol 2023 Aug;53(9):1799-1828. Epub 2023 May 23 doi: 10.1007/s00247-023-05648-z. PMID: 37217783Free PMC Article
Identification of risk factors associated with leptomeningeal disease after resection of brain metastases.
Morshed RA, Saggi S, Cummins DD, Molinaro AM, Young JS, Viner JA, Villanueva-Meyer JE, Goldschmidt E, Boreta L, Braunstein SE, Chang EF, McDermott MW, Berger MS, Theodosopoulos PV, Hervey-Jumper SL, Aghi MK, Daras M
J Neurosurg 2023 Aug 1;139(2):402-413. Epub 2023 Jan 13 doi: 10.3171/2022.12.JNS221490. PMID: 36640095
Stereotactic Radiosurgery for Resected Brain Metastases: Single-Institutional Experience of Over 500 Cavities.
Shi S, Sandhu N, Jin MC, Wang E, Jaoude JA, Schofield K, Zhang C, Liu E, Gibbs IC, Hancock SL, Chang SD, Li G, Hayden-Gephart M, Adler JR, Soltys SG, Pollom EL
Int J Radiat Oncol Biol Phys 2020 Mar 15;106(4):764-771. Epub 2019 Nov 27 doi: 10.1016/j.ijrobp.2019.11.022. PMID: 31785338
Predictors of leptomeningeal disease following hypofractionated stereotactic radiotherapy for intact and resected brain metastases.
Nguyen TK, Sahgal A, Detsky J, Atenafu EG, Myrehaug S, Tseng CL, Husain Z, Heyn C, Maralani P, Ruschin M, Perry J, Soliman H
Neuro Oncol 2020 Jan 11;22(1):84-93. doi: 10.1093/neuonc/noz144. PMID: 31412120Free PMC Article
Vitiligo: Not Simply a Skin Disease.
Ahluwalia J, Correa-Selm LM, Rao BK
Skinmed 2017;15(2):125-127. Epub 2017 Apr 1 PMID: 28528606

Clinical prediction guides

Identification of risk factors associated with leptomeningeal disease after resection of brain metastases.
Morshed RA, Saggi S, Cummins DD, Molinaro AM, Young JS, Viner JA, Villanueva-Meyer JE, Goldschmidt E, Boreta L, Braunstein SE, Chang EF, McDermott MW, Berger MS, Theodosopoulos PV, Hervey-Jumper SL, Aghi MK, Daras M
J Neurosurg 2023 Aug 1;139(2):402-413. Epub 2023 Jan 13 doi: 10.3171/2022.12.JNS221490. PMID: 36640095
Preoperative Radiosurgery for Resected Brain Metastases: The PROPS-BM Multicenter Cohort Study.
Prabhu RS, Dhakal R, Vaslow ZK, Dan T, Mishra MV, Murphy ES, Patel TR, Asher AL, Yang K, Manning MA, Stern JD, Patel AR, Wardak Z, Woodworth GF, Chao ST, Mohammadi A, Burri SH
Int J Radiat Oncol Biol Phys 2021 Nov 1;111(3):764-772. Epub 2021 May 29 doi: 10.1016/j.ijrobp.2021.05.124. PMID: 34058254
Nodular Leptomeningeal Disease-A Distinct Pattern of Recurrence After Postresection Stereotactic Radiosurgery for Brain Metastases: A Multi-institutional Study of Interobserver Reliability.
Turner BE, Prabhu RS, Burri SH, Brown PD, Pollom EL, Milano MT, Weiss SE, Iv M, Fischbein N, Soliman H, Lo SS, Chao ST, Cox BW, Murphy JD, Li G, Gephart MH, Nagpal S, Atalar B, Azoulay M, Thomas R, Tillman G, Durkee BY, Shah JL, Soltys SG
Int J Radiat Oncol Biol Phys 2020 Mar 1;106(3):579-586. Epub 2019 Oct 10 doi: 10.1016/j.ijrobp.2019.10.002. PMID: 31605786Free PMC Article
Predictors of leptomeningeal disease following hypofractionated stereotactic radiotherapy for intact and resected brain metastases.
Nguyen TK, Sahgal A, Detsky J, Atenafu EG, Myrehaug S, Tseng CL, Husain Z, Heyn C, Maralani P, Ruschin M, Perry J, Soliman H
Neuro Oncol 2020 Jan 11;22(1):84-93. doi: 10.1093/neuonc/noz144. PMID: 31412120Free PMC Article
Susac Syndrome: A differential diagnosis of white matter lesions.
Marrodan M, Correale J, Alessandro L, Amaya M, Fracaro ME, Köhler AA, Fiol M
Mult Scler Relat Disord 2017 Jul;15:42-46. Epub 2017 May 3 doi: 10.1016/j.msard.2017.04.007. PMID: 28641772

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